Douglas K. Graham Department of Pediatrics University of Colorado Anschutz Medical Campus Biography Publications Institution JoVE Articles Douglas K. Graham has not added a biography. If you are Douglas K. Graham and would like to personalize this page please email our Author Liaison for assistance. Publications UNC569, a Novel Small Molecule Mer Inhibitor with Efficacy Against Acute Lymphoblastic Leukemia in Vitro and in Vivo Molecular Cancer Therapeutics. Aug, 2013 | Pubmed ID: 23997116 MerTK Inhibition in Tumor Leukocytes Decreases Tumor Growth and Metastasis The Journal of Clinical Investigation. Aug, 2013 | Pubmed ID: 23867499 Mer Receptor Tyrosine Kinase is a Therapeutic Target in Pre-B-cell Acute Lymphoblastic Leukemia Blood. Aug, 2013 | Pubmed ID: 23861246 Molecular Pathways: MERTK Signaling in Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23833304 UNC1062, a New and Potent Mer Inhibitor European Journal of Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23693152 Dual ALK and MYC Rearrangements Leading to an Aggressive Variant of Anaplastic Large Cell Lymphoma Journal of Pediatric Hematology/oncology. Jul, 2013 | Pubmed ID: 23619105 MERTK Receptor Tyrosine Kinase is a Therapeutic Target in Melanoma The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23585477 Bioluminescence Imaging of Leukemia Cell Lines in Vitro and in Mouse Xenografts: Effects of Monoclonal and Polyclonal Cell Populations on Intensity and Kinetics of Photon Emission Journal of Hematology & Oncology. 2013 | Pubmed ID: 23343252 Moderate Aplastic Anemia in Children: Preliminary Outcomes for Treatment Versus Observation from a Single-institutional Experience Journal of Pediatric Hematology/oncology. Mar, 2013 | Pubmed ID: 23128338 Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia ACS Medicinal Chemistry Letters. Feb, 2012 | Pubmed ID: 22662287 Prolonged Exposure to a Mer Ligand in Leukemia: Gas6 Favors Expression of a Partial Mer Glycoform and Reveals a Novel Role for Mer in the Nucleus PloS One. 2012 | Pubmed ID: 22363695 TAM Receptors in Leukemia: Expression, Signaling, and Therapeutic Implications Critical Reviews in Oncogenesis. 2011 | Pubmed ID: 22150307 Constitutive Induction of Pro-inflammatory and Chemotactic Cytokines in Cystathionine Beta-synthase Deficient Homocystinuria Molecular Genetics and Metabolism. Aug, 2011 | Pubmed ID: 21601502 Gray Zone Lymphomas in Pediatric Patients Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2011 | Pubmed ID: 20331368 Targeting Paediatric Acute Lymphoblastic Leukaemia: Novel Therapies Currently in Development British Journal of Haematology. Nov, 2010 | Pubmed ID: 20813012 Taking Aim at Mer and Axl Receptor Tyrosine Kinases As Novel Therapeutic Targets in Solid Tumors Expert Opinion on Therapeutic Targets. Oct, 2010 | Pubmed ID: 20809868 Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity Molecular Cancer Therapeutics. May, 2010 | Pubmed ID: 20423999 Thymoma in Children: Report of 2 Cases and Review of the Literature Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. May-Jun, 2010 | Pubmed ID: 20055684 Mer Receptor Tyrosine Kinase is a Novel Therapeutic Target in Pediatric B-cell Acute Lymphoblastic Leukemia Blood. Sep, 2009 | Pubmed ID: 19643988 Mer Tyrosine Kinase (MerTK) Promotes Macrophage Survival Following Exposure to Oxidative Stress Journal of Leukocyte Biology. Jul, 2009 | Pubmed ID: 19386698 Tacrolimus As an Alternative to Cyclosporine in the Maintenance Phase of Immunosuppressive Therapy for Severe Aplastic Anemia in Children Pediatric Blood & Cancer. May, 2009 | Pubmed ID: 19148946 Pediatric Developmental Therapies: Interesting New Drugs Now in Early-stage Clinical Trials Current Oncology Reports. Nov, 2008 | Pubmed ID: 18928662 TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer Advances in Cancer Research. 2008 | Pubmed ID: 18620092 BAC to the Future? Comparative Genomic Hybridization and Genotyping Pediatric Leukemia Cytogenetic Abnormalities Pediatric Blood & Cancer. Aug, 2008 | Pubmed ID: 18300321 Natural Killer Cell Neoplasms Cancer. Apr, 2008 | Pubmed ID: 18286525 Precursor Natural Killer Cell Leukemia Pediatric Blood & Cancer. Apr, 2008 | Pubmed ID: 17417789 A Soluble Form of the Mer Receptor Tyrosine Kinase Inhibits Macrophage Clearance of Apoptotic Cells and Platelet Aggregation Blood. Feb, 2007 | Pubmed ID: 17047157 Ectopic Expression of the Proto-oncogene Mer in Pediatric T-cell Acute Lymphoblastic Leukemia Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2006 | Pubmed ID: 16675557 Successful Treatment of Severe Aplastic Anemia in Children Using Standardized Immunosuppressive Therapy with Antithymocyte Globulin and Cyclosporine A Pediatric Blood & Cancer. Dec, 2004 | Pubmed ID: 15390303 Disseminated Nasopharyngeal Natural Killer Cell Lymphoblastic Lymphoma in a Child Medical and Pediatric Oncology. Apr, 2003 | Pubmed ID: 12555256 Molecular Genetic Analysis of a Small Bowel Primitive Neuroectodermal Tumor Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2002 | Pubmed ID: 11815873 Доклинические Оценка тирозинкиназы ингибиторов для лечения острого лейкоза Sandra Christoph1,2, Alisa B. Lee-Sherick1, Susan Sather1, Deborah DeRyckere1, Douglas K. Graham1 1Department of Pediatrics, University of Colorado Anschutz Medical Campus, 2Department of Bone Marrow Transplantation, University Hospital of Essen JoVE 50720 Medicine
Доклинические Оценка тирозинкиназы ингибиторов для лечения острого лейкоза Sandra Christoph1,2, Alisa B. Lee-Sherick1, Susan Sather1, Deborah DeRyckere1, Douglas K. Graham1 1Department of Pediatrics, University of Colorado Anschutz Medical Campus, 2Department of Bone Marrow Transplantation, University Hospital of Essen JoVE 50720 Medicine