Eric A. Miska Gurdon Institute University of Cambridge Biography Publications Institution JoVE Articles Eric A. Miska has not added a biography. If you are Eric A. Miska and would like to personalize this page please email our Author Liaison for assistance. Publications A Family of Argonaute-Interacting Proteins Gates Nuclear RNAi Molecular Cell. Apr, 2020 | Pubmed ID: 32348780 Cysteine Synthases CYSL-1 and CYSL-2 Mediate C. Elegans Heritable Adaptation to P. Vranovensis Infection Nature Communications. Apr, 2020 | Pubmed ID: 32269224 Ancestral Hybridization Facilitated Species Diversification in the Lake Malawi Cichlid Fish Adaptive Radiation Molecular Biology and Evolution. Apr, 2020 | Pubmed ID: 31821500 Epigenetic Remodelling Licences Adult Cholangiocytes for Organoid Formation and Liver Regeneration Nature Cell Biology. 11, 2019 | Pubmed ID: 31685987 Publisher Correction: Sequencing Cell-type-specific Transcriptomes with SLAM-ITseq Nature Protocols. Aug, 2019 | Pubmed ID: 31296964 NSUN2 Introduces 5-methylcytosines in Mammalian Mitochondrial TRNAs Nucleic Acids Research. 09, 2019 | Pubmed ID: 31276587 Sequencing Cell-type-specific Transcriptomes with SLAM-ITseq Nature Protocols. 08, 2019 | Pubmed ID: 31243395 Mature Sperm Small-RNA Profile in the Sparrow: Implications for Transgenerational Effects of Age on Fitness Environmental Epigenetics. Apr, 2019 | Pubmed ID: 31139435 A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly Molecular Cell. 05, 2019 | Pubmed ID: 31051140 Identification of Functional Long Non-coding RNAs in C. Elegans BMC Biology. 02, 2019 | Pubmed ID: 30777050 Tissue- and Sex-specific Small RNAomes Reveal Sex Differences in Response to the Environment PLoS Genetics. 02, 2019 | Pubmed ID: 30735500 The USTC Co-opts an Ancient Machinery to Drive PiRNA Transcription in Genes & Development. 01, 2019 | Pubmed ID: 30567997 Whole-genome Sequences of Malawi Cichlids Reveal Multiple Radiations Interconnected by Gene Flow Nature Ecology & Evolution. 12, 2018 | Pubmed ID: 30455444 Alterations in Sperm Long RNA Contribute to the Epigenetic Inheritance of the Effects of Postnatal Trauma Molecular Psychiatry. Oct, 2018 | Pubmed ID: 30374190 COMRADES Determines in Vivo RNA Structures and Interactions Nature Methods. 10, 2018 | Pubmed ID: 30202058 Terminal Uridylyltransferases Target RNA Viruses As Part of the Innate Immune System Nature Structural & Molecular Biology. 09, 2018 | Pubmed ID: 30104661 SLAM-ITseq: Sequencing Cell Type-specific Transcriptomes Without Cell Sorting Development (Cambridge, England). 07, 2018 | Pubmed ID: 29945865 Pan-arthropod Analysis Reveals Somatic PiRNAs As an Ancestral Defence Against Transposable Elements Nature Ecology & Evolution. Jan, 2018 | Pubmed ID: 29203920 An Alternative STAT Signaling Pathway Acts in Viral Immunity in MBio. 09, 2017 | Pubmed ID: 28874466 The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription Developmental Cell. 08, 2017 | Pubmed ID: 28787591 The Profile and Dynamics of RNA Modifications in Animals Chembiochem : a European Journal of Chemical Biology. 06, 2017 | Pubmed ID: 28449301 A Team of Heterochromatin Factors Collaborates with Small RNA Pathways to Combat Repetitive Elements and Germline Stress ELife. 03, 2017 | Pubmed ID: 28294943 2'-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA Journal of the American Chemical Society. 02, 2017 | Pubmed ID: 28107630 Selective Inhibitors of Trypanosomal Uridylyl Transferase RET1 Establish Druggability of RNA Post-transcriptional Modifications RNA Biology. 05, 2017 | Pubmed ID: 26786754 Oral Transfer of Chemical Cues, Growth Proteins and Hormones in Social Insects ELife. 11, 2016 | Pubmed ID: 27894417 Transgenerational Inheritance: Models and Mechanisms of Non-DNA Sequence-based Inheritance Science (New York, N.Y.). 10, 2016 | Pubmed ID: 27846492 Identification of Small Molecule Inhibitors of the Lin28-mediated Blockage of Pre-let-7g Processing Organic & Biomolecular Chemistry. Nov, 2016 | Pubmed ID: 27731469 Wolbachia Blocks Viral Genome Replication Early in Infection Without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways PLoS Pathogens. Apr, 2016 | Pubmed ID: 27089431 TRNA Fragments: Novel Players in Intergenerational Inheritance Cell Research. Apr, 2016 | Pubmed ID: 26902286 Genomic Islands of Speciation Separate Cichlid Ecomorphs in an East African Crater Lake Science (New York, N.Y.). Dec, 2015 | Pubmed ID: 26680190 Antiviral RNA Interference Against Orsay Virus Is Neither Systemic nor Transgenerational in Caenorhabditis Elegans Journal of Virology. Dec, 2015 | Pubmed ID: 26401037 E. Coli OxyS Non-coding RNA Does Not Trigger RNAi in C. Elegans Scientific Reports. Apr, 2015 | Pubmed ID: 25873159 Tertiary SiRNAs Mediate Paramutation in C. Elegans PLoS Genetics. Mar, 2015 | Pubmed ID: 25811365 Formation and Abundance of 5-hydroxymethylcytosine in RNA Chembiochem : a European Journal of Chemical Biology. Mar, 2015 | Pubmed ID: 25676849 Caenorhabditis Elegans RSD-2 and RSD-6 Promote Germ Cell Immortality by Maintaining Small Interfering RNA Populations Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25258416 PiRNAs: from Biogenesis to Function Development (Cambridge, England). Sep, 2014 | Pubmed ID: 25183868 Considerations when Investigating LncRNA Function in Vivo ELife. Aug, 2014 | Pubmed ID: 25124674 Small RNAs Break Out: the Molecular Cell Biology of Mobile Small RNAs Nature Reviews. Molecular Cell Biology. Aug, 2014 | Pubmed ID: 25053358 Getting a Grip on PiRNA Cluster Transcription Cell. Jun, 2014 | Pubmed ID: 24906143 Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis Elegans Piwi Mutants Cell Reports. May, 2014 | Pubmed ID: 24767993 PRDE-1 is a Nuclear Factor Essential for the Biogenesis of Ruby Motif-dependent PiRNAs in C. Elegans Genes & Development. Apr, 2014 | Pubmed ID: 24696457 Betaine Acts on a Ligand-gated Ion Channel in the Nervous System of the Nematode C. Elegans Nature Neuroscience. Dec, 2013 | Pubmed ID: 24212673 Antiviral RNA Interference in Animals: Piecing Together the Evidence Nature Structural & Molecular Biology. Nov, 2013 | Pubmed ID: 24197164 A Deletion Polymorphism in the Caenorhabditis Elegans RIG-I Homolog Disables Viral RNA Dicing and Antiviral Immunity ELife. Oct, 2013 | Pubmed ID: 24137537 MiR-210 is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production Journal of Immunology (Baltimore, Md. : 1950). Sep, 2013 | Pubmed ID: 23960236 Molecular Biology. Is There Social RNA? Science (New York, N.Y.). Aug, 2013 | Pubmed ID: 23908213 RNAi Pathways in the Recognition of Foreign RNA: Antiviral Responses and Host-parasite Interactions in Nematodes Biochemical Society Transactions. Aug, 2013 | Pubmed ID: 23863148 Competition Between Virus-derived and Endogenous Small RNAs Regulates Gene Expression in Caenorhabditis Elegans Genome Research. Aug, 2013 | Pubmed ID: 23811144 The Shaping and Functional Consequences of the MicroRNA Landscape in Breast Cancer Nature. May, 2013 | Pubmed ID: 23644459 A Study of Caenorhabditis Elegans DAF-2 Mutants by Metabolomics and Differential Correlation Networks Molecular BioSystems. Jul, 2013 | Pubmed ID: 23475189 Post-developmental MicroRNA Expression is Required for Normal Physiology, and Regulates Aging in Parallel to Insulin/IGF-1 Signaling in C. Elegans RNA (New York, N.Y.). Dec, 2012 | Pubmed ID: 23097426 Differential Impact of the HEN1 Homolog HENN-1 on 21U and 26G RNAs in the Germline of Caenorhabditis Elegans PLoS Genetics. 2012 | Pubmed ID: 22829772 PiRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. Elegans Cell. Jul, 2012 | Pubmed ID: 22738725 Function, Targets, and Evolution of Caenorhabditis Elegans PiRNAs Science (New York, N.Y.). Aug, 2012 | Pubmed ID: 22700655 RIP-chip-SRM--a New Combinatorial Large-scale Approach Identifies a Set of Translationally Regulated Bantam/miR-58 Targets in C. Elegans Genome Research. Jul, 2012 | Pubmed ID: 22454234 Developmental Characterization of the MicroRNA-specific C. Elegans Argonautes Alg-1 and Alg-2 PloS One. 2012 | Pubmed ID: 22448270 A Metabolomic Strategy Defines the Regulation of Lipid Content and Global Metabolism by Δ9 Desaturases in Caenorhabditis Elegans BMC Genomics. Jan, 2012 | Pubmed ID: 22264337 MiR-124 Acts Through CoREST to Control Onset of Sema3A Sensitivity in Navigating Retinal Growth Cones Nature Neuroscience. Dec, 2011 | Pubmed ID: 22138647 A LIN28-dependent Structural Change in Pre-let-7g Directly Inhibits Dicer Processing Biochemistry. Sep, 2011 | Pubmed ID: 21815640 Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses PLoS Biology. Jan, 2011 | Pubmed ID: 21283608 Regulation of Pre-miRNA Processing Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 21627031 Genome-wide Identification of Targets and Function of Individual MicroRNAs in Mouse Embryonic Stem Cells PLoS Genetics. Oct, 2010 | Pubmed ID: 20975942 A Quantitative Targeted Proteomics Approach to Validate Predicted MicroRNA Targets in C. Elegans Nature Methods. Oct, 2010 | Pubmed ID: 20835247 The MicroRNAs of Caenorhabditis Elegans Seminars in Cell & Developmental Biology. Sep, 2010 | Pubmed ID: 20637886 The Conserved MiR-51 MicroRNA Family is Redundantly Required for Embryonic Development and Pharynx Attachment in Caenorhabditis Elegans Genetics. Jul, 2010 | Pubmed ID: 20421599 The MicroRNA MiR-124 Controls Gene Expression in the Sensory Nervous System of Caenorhabditis Elegans Nucleic Acids Research. Jun, 2010 | Pubmed ID: 20176573 Characterisation of MicroRNA Expression in Post-natal Mouse Mammary Gland Development BMC Genomics. Nov, 2009 | Pubmed ID: 19930549 LIN-28 and the Poly(U) Polymerase PUP-2 Regulate Let-7 MicroRNA Processing in Caenorhabditis Elegans Nature Structural & Molecular Biology. Oct, 2009 | Pubmed ID: 19713957 Abundant and Dynamically Expressed MiRNAs, PiRNAs, and Other Small RNAs in the Vertebrate Xenopus Tropicalis Genome Research. Oct, 2009 | Pubmed ID: 19628731 Two Piwi Proteins, Xiwi and Xili, Are Expressed in the Xenopus Female Germline RNA (New York, N.Y.). Feb, 2009 | Pubmed ID: 19144913 Piwi and PiRNAs Act Upstream of an Endogenous SiRNA Pathway to Suppress Tc3 Transposon Mobility in the Caenorhabditis Elegans Germline Molecular Cell. Jul, 2008 | Pubmed ID: 18571451 Functional Genomic, Computational and Proteomic Analysis of C. Elegans MicroRNAs Briefings in Functional Genomics & Proteomics. May, 2008 | Pubmed ID: 18565984 A Comparative Metabolomic Study of NHR-49 in Caenorhabditis Elegans and PPAR-alpha in the Mouse FEBS Letters. May, 2008 | Pubmed ID: 18435929 MicroRNA Biogenesis is Required for Mouse Primordial Germ Cell Development and Spermatogenesis PloS One. Mar, 2008 | Pubmed ID: 18320056 MicroRNA: Implications for Cancer Virchows Archiv : an International Journal of Pathology. Jan, 2008 | Pubmed ID: 18040713 MicroRNA-155 Regulates the Generation of Immunoglobulin Class-switched Plasma Cells Immunity. Dec, 2007 | Pubmed ID: 18055230 MicroRNA Expression Profiling of Human Breast Cancer Identifies New Markers of Tumor Subtype Genome Biology. 2007 | Pubmed ID: 17922911 A Slicer-independent Role for Argonaute 2 in Hematopoiesis and the MicroRNA Pathway Genes & Development. Aug, 2007 | Pubmed ID: 17626790 MiRNAs in Cancer: Approaches, Aetiology, Diagnostics and Therapy Human Molecular Genetics. Apr, 2007 | Pubmed ID: 17613543 Requirement of Bic/microRNA-155 for Normal Immune Function Science (New York, N.Y.). Apr, 2007 | Pubmed ID: 17463290 Caenorhabditis Elegans and Friends in Los Angeles Genome Biology. 2005 | Pubmed ID: 16277759 MicroRNA Functions in Animal Development and Human Disease Development (Cambridge, England). Nov, 2005 | Pubmed ID: 16224045 How MicroRNAs Control Cell Division, Differentiation and Death Current Opinion in Genetics & Development. Oct, 2005 | Pubmed ID: 16099643 Acetylation of Beta-catenin by CREB-binding Protein (CBP) The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11973335 Differential Localization of HDAC4 Orchestrates Muscle Differentiation Nucleic Acids Research. Aug, 2001 | Pubmed ID: 11504882 High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology Laetitia Chauve*1, Jérémie Le Pen*2,3,5, Francesca Hodge1, Pia Todtenhaupt1, Laura Biggins1, Eric A. Miska2,3,4, Simon Andrews1, Olivia Casanueva1 1Babraham Institute, 2Gurdon Institute, University of Cambridge, 3Department of Genetics, University of Cambridge, 4Wellcome Trust Genome Campus, Wellcome Trust Sanger Institute, 5Laboratory of Virology and Infectious Disease, The Rockefeller University JoVE 61132 Genetics
High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology Laetitia Chauve*1, Jérémie Le Pen*2,3,5, Francesca Hodge1, Pia Todtenhaupt1, Laura Biggins1, Eric A. Miska2,3,4, Simon Andrews1, Olivia Casanueva1 1Babraham Institute, 2Gurdon Institute, University of Cambridge, 3Department of Genetics, University of Cambridge, 4Wellcome Trust Genome Campus, Wellcome Trust Sanger Institute, 5Laboratory of Virology and Infectious Disease, The Rockefeller University JoVE 61132 Genetics