Ferry Ossendorp

Publications

• Cationic Synthetic Long Peptides-loaded Nanogels: An Efficient Therapeutic Vaccine Formulation for Induction of T-cell Responses
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2019  |   Pubmed ID: 31672626
• A Poly-neoantigen DNA Vaccine Synergizes with PD-1 Blockade to Induce T Cell-mediated Tumor Control
  Oncoimmunology. 2019  |   Pubmed ID: 31646082
• Effective Chemoimmunotherapy by Co-delivery of Doxorubicin and Immune Adjuvants in Biodegradable Nanoparticles
  Theranostics. 2019  |   Pubmed ID: 31588231
• PD-L1 Blockade Engages Tumor-infiltrating Lymphocytes to Co-express Targetable Activating and Inhibitory Receptors
  Journal for Immunotherapy of Cancer. Aug, 2019  |   Pubmed ID: 31412943
• Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models
  Cells. 04, 2019  |   Pubmed ID: 30959852
• Peptides Conjugated to 2-alkoxy-8-oxo-adenine As Potential Synthetic Vaccines Triggering TLR7
  Bioorganic & Medicinal Chemistry Letters. Jun, 2019  |   Pubmed ID: 30952595
• Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells
  Bioconjugate Chemistry. Apr, 2019  |   Pubmed ID: 30865430
• FcγR Interaction is Not Required for Effective Anti-PD-L1 Immunotherapy but Can Add Additional Benefit Depending on the Tumor Model
  International Journal of Cancer. 01, 2019  |   Pubmed ID: 30259976
• A Dual-Color Bioluminescence Reporter Mouse for Simultaneous Imaging of T Cell Localization and Function
  Frontiers in Immunology. 2018  |   Pubmed ID: 30671062
• Novel TLR2-binding Adjuvant Induces Enhanced T Cell Responses and Tumor Eradication
  Journal for Immunotherapy of Cancer. 12, 2018  |   Pubmed ID: 30541631
• Tumor-draining Lymph Nodes Are Pivotal in PD-1/PD-L1 Checkpoint Therapy
  JCI Insight. 12, 2018  |   Pubmed ID: 30518694
• : A Workflow for Visual and Quantitative Analysis of Flow and Mass Cytometry Data to Discover Immune Signatures and Correlations
  Computational and Structural Biotechnology Journal. 2018  |   Pubmed ID: 30450167
• High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy
  Journal of Immunology (Baltimore, Md. : 1950). 12, 2018  |   Pubmed ID: 30397036
• FcγRI Expression on Macrophages is Required for Antibody-mediated Tumor Protection by Cytomegalovirus-based Vaccines
  Oncotarget. Jun, 2018  |   Pubmed ID: 30034625
• Combinatory Therapy Adopting Nanoparticle-based Cancer Vaccination with Immune Checkpoint Blockade for Treatment of Post-surgical Tumor Recurrences
  Journal of Controlled Release : Official Journal of the Controlled Release Society. 09, 2018  |   Pubmed ID: 30008371
• Approaches to Improve Chemically Defined Synthetic Peptide Vaccines
  Frontiers in Immunology. 2018  |   Pubmed ID: 29755468
• Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System
  Journal of Immunology (Baltimore, Md. : 1950). 07, 2018  |   Pubmed ID: 29752315
• Chemical Control over T-Cell Activation in Vivo Using Deprotection of Trans-Cyclooctene-Modified Epitopes
  ACS Chemical Biology. 06, 2018  |   Pubmed ID: 29733186
• Sustained Cross-presentation Capacity of Murine Splenic Dendritic Cell Subsets in Vivo
  European Journal of Immunology. 07, 2018  |   Pubmed ID: 29676785
• A Restricted Role for FcγR in the Regulation of Adaptive Immunity
  Journal of Immunology (Baltimore, Md. : 1950). 04, 2018  |   Pubmed ID: 29523656
• Linking T Cell Epitopes to a Common Linear B Cell Epitope: A Targeting and Adjuvant Strategy to Improve T Cell Responses
  Molecular Immunology. 01, 2018  |   Pubmed ID: 29175591
• Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 T Cells
  Cancer Immunology Research. 10, 2017  |   Pubmed ID: 28851692
• PD-L1 Immune Suppression in Cancer: Tumor Cells or Host Cells?
  Oncoimmunology. 2017  |   Pubmed ID: 28811961
• CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors Upon TLR7/8 Agonist Therapy
  Cancer Immunology Research. 08, 2017  |   Pubmed ID: 28637878
• PD-L1 Expression on Malignant Cells is No Prerequisite for Checkpoint Therapy
  Oncoimmunology. 2017  |   Pubmed ID: 28507803
• C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes
  Journal of Immunology (Baltimore, Md. : 1950). 06, 2017  |   Pubmed ID: 28432146
• Self-Assembling Peptide Epitopes As Novel Platform for Anticancer Vaccination
  Molecular Pharmaceutics. 05, 2017  |   Pubmed ID: 28088862
• Strong in Vivo Antitumor Responses Induced by an Antigen Immobilized in Nanogels Via Reducible Bonds
  Nanoscale. Dec, 2016  |   Pubmed ID: 27748778
• The Optimization of Bioorthogonal Epitope Ligation Within MHC-I Complexes
  ACS Chemical Biology. 11, 2016  |   Pubmed ID: 27704768
• TLR2 Ligand-synthetic Long Peptide Conjugates Effectively Stimulate Tumor-draining Lymph Node T Cells of Cervical Cancer Patients
  Oncotarget. Oct, 2016  |   Pubmed ID: 27564262
• Glycan Modification of Antigen Alters Its Intracellular Routing in Dendritic Cells, Promoting Priming of T Cells
  ELife. Mar, 2016  |   Pubmed ID: 26999763
• Vaccines for Established Cancer: Overcoming the Challenges Posed by Immune Evasion
  Nature Reviews. Cancer. Apr, 2016  |   Pubmed ID: 26965076
• TAP-independent Self-peptides Enhance T Cell Recognition of Immune-escaped Tumors
  The Journal of Clinical Investigation. Feb, 2016  |   Pubmed ID: 26784543
• Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2016  |   Pubmed ID: 26546617
• The Viral Context Instructs the Redundancy of Costimulatory Pathways in Driving CD8(+) T Cell Expansion
  ELife. Aug, 2015  |   Pubmed ID: 26263500
• Therapeutic Cancer Vaccines
  The Journal of Clinical Investigation. Sep, 2015  |   Pubmed ID: 26214521
• Polymeric Microparticles for Sustained and Local Delivery of AntiCD40 and AntiCTLA-4 in Immunotherapy of Cancer
  Biomaterials. Aug, 2015  |   Pubmed ID: 25993015
• The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-presentation to CD8(+) T Cells
  Immunity. May, 2015  |   Pubmed ID: 25979419
• Polymeric Nanoparticles for Co-delivery of Synthetic Long Peptide Antigen and Poly IC As Therapeutic Cancer Vaccine Formulation
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2015  |   Pubmed ID: 25660830
• Vaccine-induced Tumor Necrosis Factor-producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2015  |   Pubmed ID: 25501579
• CD40-targeted Dendritic Cell Delivery of PLGA-nanoparticle Vaccines Induce Potent Anti-tumor Responses
  Biomaterials. Feb, 2015  |   Pubmed ID: 25465442
• Near-infrared Labeled, Ovalbumin Loaded Polymeric Nanoparticles Based on a Hydrophilic Polyester As Model Vaccine: In Vivo Tracking and Evaluation of Antigen-specific CD8(+) T Cell Immune Response
  Biomaterials. Jan, 2015  |   Pubmed ID: 25453974
• Two in One: Improving Synthetic Long Peptide Vaccines by Combining Antigen and Adjuvant in One Molecule
  Oncoimmunology. 2014  |   Pubmed ID: 25610736
• FcRγ-chain ITAM Signaling is Critically Required for Cross-presentation of Soluble Antibody-antigen Complexes by Dendritic Cells
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014  |   Pubmed ID: 25355925
• Enhanced Cross-presentation and Improved CD8+ T Cell Responses After Mannosylation of Synthetic Long Peptides in Mice
  PloS One. 2014  |   Pubmed ID: 25137039
• Targeting Nanoparticles to CD40, DEC-205 or CD11c Molecules on Dendritic Cells for Efficient CD8(+) T Cell Response: a Comparative Study
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2014  |   Pubmed ID: 25068703
• Dominant Contribution of the Proteasome and Metalloproteinases to TAP-independent MHC-I Peptide Repertoire
  Molecular Immunology. Nov, 2014  |   Pubmed ID: 24983205
• Ovalbumin-coated PH-sensitive Microneedle Arrays Effectively Induce Ovalbumin-specific Antibody and T-cell Responses in Mice
  European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Oct, 2014  |   Pubmed ID: 24820032
• IgG-mediated Anaphylaxis to a Synthetic Long Peptide Vaccine Containing a B Cell Epitope Can Be Avoided by Slow-release Formulation
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014  |   Pubmed ID: 24813207
• Effectiveness of Slow-release Systems in CD40 Agonistic Antibody Immunotherapy of Cancer
  Vaccine. Mar, 2014  |   Pubmed ID: 24508038
• Local Immunomodulation for Cancer Therapy: Providing Treatment Where Needed
  Oncoimmunology. Nov, 2013  |   Pubmed ID: 24490127
• New Role of Signal Peptide Peptidase to Liberate C-terminal Peptides for MHC Class I Presentation
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013  |   Pubmed ID: 24048903
• Dendritic Cells Process Synthetic Long Peptides Better Than Whole Protein, Improving Antigen Presentation and T-cell Activation
  European Journal of Immunology. Oct, 2013  |   Pubmed ID: 23836147
• Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-cell-dependent Tumor Eradication and Decreases Risk of Toxic Side Effects
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2013  |   Pubmed ID: 23788581
• Prospects of Combinatorial Synthetic Peptide Vaccine-based Immunotherapy Against Cancer
  Seminars in Immunology. Apr, 2013  |   Pubmed ID: 23706598
• Efficient Ex Vivo Induction of T Cells with Potent Anti-tumor Activity by Protein Antigen Encapsulated in Nanoparticles
  Cancer Immunology, Immunotherapy : CII. Jul, 2013  |   Pubmed ID: 23613147
• Vaccine-induced Effector-memory CD8+ T Cell Responses Predict Therapeutic Efficacy Against Tumors
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2012  |   Pubmed ID: 22914049
• Fcγ Receptor IIb Strongly Regulates Fcγ Receptor-facilitated T Cell Activation by Dendritic Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2012  |   Pubmed ID: 22649202
• Circulating Specific Antibodies Enhance Systemic Cross-priming by Delivery of Complexed Antigen to Dendritic Cells in Vivo
  European Journal of Immunology. Mar, 2012  |   Pubmed ID: 22488363
• The Inhibiting Fc Receptor for IgG, FcγRIIB, is a Modifier of Autoimmune Susceptibility
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011  |   Pubmed ID: 21724994
• Discovery of Low-affinity Preproinsulin Epitopes and Detection of Autoreactive CD8 T-cells Using Combinatorial MHC Multimers
  Journal of Autoimmunity. Nov, 2011  |   Pubmed ID: 21636247
• Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
  PloS One. Feb, 2011  |   Pubmed ID: 21347234
• Antigen Processing by Nardilysin and Thimet Oligopeptidase Generates Cytotoxic T Cell Epitopes
  Nature Immunology. Jan, 2011  |   Pubmed ID: 21151101
• Activity-based Profiling Reveals Reactivity of the Murine Thymoproteasome-specific Subunit Beta5t
  Chemistry & Biology. Aug, 2010  |   Pubmed ID: 20797608
• Effective CD8(+) T Cell Priming and Tumor Protection by Enterotoxin B Subunit-conjugated Peptides Targeted to Dendritic Cells
  Vaccine. Aug, 2009  |   Pubmed ID: 19576942
• DC-induced CD8(+) T-cell Response is Inhibited by MHC Class II-dependent DX5(+)CD4(+) Treg
  European Journal of Immunology. Jul, 2009  |   Pubmed ID: 19544486
• Antigen Storage Compartments in Mature Dendritic Cells Facilitate Prolonged Cytotoxic T Lymphocyte Cross-priming Capacity
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009  |   Pubmed ID: 19346487
• Steric Hindrance and Fast Dissociation Explain the Lack of Immunogenicity of the Minor Histocompatibility HA-1Arg Null Allele
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009  |   Pubmed ID: 19342659
• A Novel Role of Complement Factor C1q in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8+ T Lymphocytes
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007  |   Pubmed ID: 17548593
• Dendritic Cells, but Not Macrophages or B Cells, Activate Major Histocompatibility Complex Class II-restricted CD4+ T Cells Upon Immune-complex Uptake in Vivo
  Immunology. Dec, 2006  |   Pubmed ID: 16995881
• Immune Complex-loaded Dendritic Cells Are Superior to Soluble Immune Complexes As Antitumor Vaccine
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006  |   Pubmed ID: 16585547
• Selective Cytotoxic T-lymphocyte Targeting of Tumor Immune Escape Variants
  Nature Medicine. Apr, 2006  |   Pubmed ID: 16550190
• Murine Fc Receptors for IgG Are Redundant in Facilitating Presentation of Immune Complex Derived Antigen to CD8+ T Cells in Vivo
  Molecular Immunology. May, 2006  |   Pubmed ID: 16513171
• Autoreactive CD8 T Cells Associated with Beta Cell Destruction in Type 1 Diabetes
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005  |   Pubmed ID: 16339897
• Differential Expression Regulation of the Alpha and Beta Subunits of the PA28 Proteasome Activator in Mature Dendritic Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2005  |   Pubmed ID: 15944286
• Gamma Irradiation or CD4+-T-cell Depletion Causes Reactivation of Latent Salmonella Enterica Serovar Typhimurium Infection in C3H/HeN Mice
  Infection and Immunity. May, 2005  |   Pubmed ID: 15845491
• New Chelation Strategy Allows for Quick and Clean 99mTc-labeling of Synthetic Peptides
  Nuclear Medicine and Biology. Aug, 2004  |   Pubmed ID: 15246374
• Prolongation of Skin Graft Survival by Modulation of the Alloimmune Response with Alternatively Activated Dendritic Cells
  Transplantation. Dec, 2003  |   Pubmed ID: 14702533
• The Minor Histocompatibility Antigen HA-3 Arises from Differential Proteasome-mediated Cleavage of the Lymphoid Blast Crisis (Lbc) Oncoprotein
  Blood. Jul, 2003  |   Pubmed ID: 12663445
• Effective Therapeutic Anticancer Vaccines Based on Precision Guiding of Cytolytic T Lymphocytes
  Immunological Reviews. Oct, 2002  |   Pubmed ID: 12445291
• Antitumor Efficacy of Wild-type P53-specific CD4(+) T-helper Cells
  Cancer Research. Nov, 2002  |   Pubmed ID: 12414646
• Identification of a Novel HLA-B60-restricted T Cell Epitope of the Minor Histocompatibility Antigen HA-1 Locus
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002  |   Pubmed ID: 12218130
• Antigen-antibody Immune Complexes Empower Dendritic Cells to Efficiently Prime Specific CD8+ CTL Responses in Vivo
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2002  |   Pubmed ID: 11859111
• Reorganization of Multivesicular Bodies Regulates MHC Class II Antigen Presentation by Dendritic Cells
  The Journal of Cell Biology. Oct, 2001  |   Pubmed ID: 11581285
• Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte-induced Apoptosis: Differential Modulation by T Helper Type 1 and Type 2 Cells
  The Journal of Experimental Medicine. Sep, 2001  |   Pubmed ID: 11535633
• Efficient Identification of Novel HLA-A(*)0201-presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen PRAME by Proteasome-mediated Digestion Analysis
  The Journal of Experimental Medicine. Jan, 2001  |   Pubmed ID: 11136822
• Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or PA28
  The Journal of Experimental Medicine. Aug, 2000  |   Pubmed ID: 10952718
• Immature Dendritic Cells Acquire CD8(+) Cytotoxic T Lymphocyte Priming Capacity Upon Activation by T Helper Cell-independent or -dependent Stimuli
  The Journal of Experimental Medicine. Jul, 2000  |   Pubmed ID: 10880536
• CD4 T Cells and Their Role in Antitumor Immune Responses
  The Journal of Experimental Medicine. Mar, 1999  |   Pubmed ID: 10049938
• Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes Against Major Histocompatibility Complex Class II Negative Tumors
  The Journal of Experimental Medicine. Mar, 1998  |   Pubmed ID: 9480979