Geerten P. van Nieuw Amerongen Department of Physiology Institute for Cardiovascular Research, VU University Medical Center Biography Publications Institution JoVE Articles Geerten P. van Nieuw Amerongen has not added a biography. If you are Geerten P. van Nieuw Amerongen and would like to personalize this page please email our Author Liaison for assistance. Publications Regulation of the Endothelial Barrier Function: a Filum Granum of Cellular Forces, Rho-GTPase Signaling and Microenvironment Cell and Tissue Research. Mar, 2014 | Pubmed ID: 24633925 Plasma Biomarkers for Acute Respiratory Distress Syndrome: a Systematic Review and Meta-analysis* Critical Care Medicine. Mar, 2014 | Pubmed ID: 24158164 Reversal of Vascular Leak with Imatinib American Journal of Respiratory and Critical Care Medicine. Nov, 2013 | Pubmed ID: 24180451 Localized RhoA GTPase Activity Regulates Dynamics of Endothelial Monolayer Integrity Cardiovascular Research. Aug, 2013 | Pubmed ID: 23536606 Effective Treatment of Edema and Endothelial Barrier Dysfunction with Imatinib Circulation. Dec, 2012 | Pubmed ID: 23099479 Successful Treatment of Diffuse Pulmonary Lymphangiomatosis with Bevacizumab Annals of Internal Medicine. Jun, 2012 | Pubmed ID: 22665821 Nitric Oxide-dependent Src Activation and Resultant Caveolin-1 Phosphorylation Promote ENOS/caveolin-1 Binding and ENOS Inhibition Molecular Biology of the Cell. Apr, 2012 | Pubmed ID: 22323292 Predictors of Pulmonary Edema Formation During Fluid Loading in the Critically Ill with Presumed Hypovolemia* Critical Care Medicine. Mar, 2012 | Pubmed ID: 22080639 Homocysteine Induces Phosphatidylserine Exposure in Cardiomyocytes Through Inhibition of Rho Kinase and Flippase Activity Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2011 | Pubmed ID: 21865848 Opposing Effects of the Angiopoietins on the Thrombin-induced Permeability of Human Pulmonary Microvascular Endothelial Cells PloS One. 2011 | Pubmed ID: 21858121 Plasma Protein Levels Are Markers of Pulmonary Vascular Permeability and Degree of Lung Injury in Critically Ill Patients with or at Risk for Acute Lung Injury/acute Respiratory Distress Syndrome Critical Care Medicine. Jan, 2011 | Pubmed ID: 21057316 Substrate Stiffening Promotes Endothelial Monolayer Disruption Through Enhanced Physical Forces American Journal of Physiology. Cell Physiology. Jan, 2011 | Pubmed ID: 20861463 Fibrin β15-42 Domain is Cryptic in Intact Fibrinogen: Comment on the Study by A. Sahni Et Al International Journal of Cancer. Journal International Du Cancer. Dec, 2010 | Pubmed ID: 21351277 Inhibition of Rho-ROCK Signaling Induces Apoptotic and Non-apoptotic PS Exposure in Cardiomyocytes Via Inhibition of Flippase Journal of Molecular and Cellular Cardiology. Nov, 2010 | Pubmed ID: 20691698 A Plethora of Angiopoietin-2 Effects During Clinical Sepsis Critical Care (London, England). 2010 | Pubmed ID: 20587077 Role of Protein Kinase Czeta in Thrombin-induced RhoA Activation and Inter-endothelial Gap Formation of Human Dermal Microvessel Endothelial Cell Monolayers Microvascular Research. Sep, 2010 | Pubmed ID: 20417648 Activation of AMP-activated Protein Kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the Muscle Microcirculation Increases Nitric Oxide Synthesis and Microvascular Perfusion Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2010 | Pubmed ID: 20224051 Driving Rho GTPase Activity in Endothelial Cells Regulates Barrier Integrity Thrombosis and Haemostasis. Jan, 2010 | Pubmed ID: 20062930 KLF2-induced Actin Shear Fibers Control Both Alignment to Flow and JNK Signaling in Vascular Endothelium Blood. Mar, 2010 | Pubmed ID: 20032497 The Interaction of Soluble Tie2 with Angiopoietins and Pulmonary Vascular Permeability in Septic and Nonseptic Critically Ill Patients Shock (Augusta, Ga.). Mar, 2010 | Pubmed ID: 19543148 Activated Protein C in the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome Expert Opinion on Drug Discovery. Mar, 2009 | Pubmed ID: 23489122 Circulating Angiopoietin-2 Levels in the Course of Septic Shock: Relation with Fluid Balance, Pulmonary Dysfunction and Mortality Intensive Care Medicine. Sep, 2009 | Pubmed ID: 19551369 Endothelin Receptor Blockade Combined with Phosphodiesterase-5 Inhibition Increases Right Ventricular Mitochondrial Capacity in Pulmonary Arterial Hypertension American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2009 | Pubmed ID: 19395550 RhoA-ROCK Signaling is Involved in Contraction-mediated Inhibition of SERCA2a Expression in Cardiomyocytes Pflügers Archiv : European Journal of Physiology. Aug, 2009 | Pubmed ID: 19294414 Crystalloid or Colloid Fluid Loading and Pulmonary Permeability, Edema, and Injury in Septic and Nonseptic Critically Ill Patients with Hypovolemia Critical Care Medicine. Apr, 2009 | Pubmed ID: 19242338 Role of ROCK I/II in Vascular Branching American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2009 | Pubmed ID: 19218507 The Angiopoietin-Tie2 System As a Therapeutic Target in Sepsis and Acute Lung Injury Expert Opinion on Therapeutic Targets. Jan, 2009 | Pubmed ID: 19063705 Interference with Actin Dynamics is Superior to Disturbance of Microtubule Function in the Inhibition of Human Ovarian Cancer Cell Motility Biochemical Pharmacology. Sep, 2008 | Pubmed ID: 18644348 Nuclear Targeting of Beta-catenin and P120ctn During Thrombin-induced Endothelial Barrier Dysfunction Cardiovascular Research. Sep, 2008 | Pubmed ID: 18490349 Rho-kinase-dependent F-actin Rearrangement is Involved in the Inhibition of PI3-kinase/Akt During Ischemia-reperfusion-induced Endothelial Cell Apoptosis Apoptosis : an International Journal on Programmed Cell Death. Mar, 2008 | Pubmed ID: 18165899 Endogenous RhoA Inhibitor Protects Endothelial Barrier Circulation Research. Jul, 2007 | Pubmed ID: 17615376 Microtubule-targeting Agents Inhibit Angiogenesis at Subtoxic Concentrations, a Process Associated with Inhibition of Rac1 and Cdc42 Activity and Changes in the Endothelial Cytoskeleton Molecular Cancer Therapeutics. Sep, 2006 | Pubmed ID: 16985069 Direct Grafting of RGD-motif-containing Peptide on the Surface of Polycaprolactone Films Journal of Biomaterials Science. Polymer Edition. 2006 | Pubmed ID: 16800155 Physiological Concentrations of Insulin Induce Endothelin-dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor-alpha Dependence on C-Jun N-terminal Kinase Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2006 | Pubmed ID: 16322532 Vascular Endothelial Growth Factor Overexpression in Ischemic Skeletal Muscle Enhances Myoglobin Expression in Vivo Circulation Research. Jul, 2004 | Pubmed ID: 15155530 Vasoconstrictor Effects of Insulin in Skeletal Muscle Arterioles Are Mediated by ERK1/2 Activation in Endothelium American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2004 | Pubmed ID: 15059773 GIT1 Mediates Thrombin Signaling in Endothelial Cells: Role in Turnover of RhoA-type Focal Adhesions Circulation Research. Apr, 2004 | Pubmed ID: 15016733 Smooth Muscle F-actin Disassembly and RhoA/Rho-kinase Signaling During Endotoxin-induced Alterations in Pulmonary Arterial Compliance American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2004 | Pubmed ID: 14514519 Involvement of RhoA/Rho Kinase Signaling in VEGF-induced Endothelial Cell Migration and Angiogenesis in Vitro Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2003 | Pubmed ID: 12588761 Targets for Pharmacological Intervention of Endothelial Hyperpermeability and Barrier Function Vascular Pharmacology. Nov, 2002 | Pubmed ID: 12747965 Endothelial Hyperpermeability in Vascular Leakage Vascular Pharmacology. Nov, 2002 | Pubmed ID: 12747957 Intracellular Signalling Involved in Modulating Human Endothelial Barrier Function Journal of Anatomy. Jun, 2002 | Pubmed ID: 12162723 Elektrisk cell-substrat Impedans Sensing för kvantifiering av Endothelial Proliferation, barriärfunktion, och Motility Robert Szulcek1, Harm Jan Bogaard1, Geerten P. van Nieuw Amerongen2 1Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, 2Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center JoVE 51300 Bioengineering
Elektrisk cell-substrat Impedans Sensing för kvantifiering av Endothelial Proliferation, barriärfunktion, och Motility Robert Szulcek1, Harm Jan Bogaard1, Geerten P. van Nieuw Amerongen2 1Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, 2Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center JoVE 51300 Bioengineering