George K. Gittes Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh University of Pittsburgh School of Medicine Biography Publications Institution JoVE Articles George K. Gittes has not added a biography. If you are George K. Gittes and would like to personalize this page please email our Author Liaison for assistance. Publications Intra-Amniotic Sildenafil and Rosiglitazone Late in Gestation Ameliorate the Pulmonary Hypertension Phenotype in Congenital Diaphragmatic Hernia Journal of Pediatric Surgery. Jan, 2024 | Pubmed ID: 38350773 Intra-amniotic Sildenafil Treatment Improves Lung Blood Flow and Pulmonary Hypertension in Congenital Diaphragmatic Hernia Rats Frontiers in Bioengineering and Biotechnology. 2023 | Pubmed ID: 37545896 Time-dependent Effects of Endogenous Hyperglucagonemia on Glucose Homeostasis and Hepatic Glucagon Action JCI Insight. Jun, 2023 | Pubmed ID: 37140984 Intra-amniotic Sildenafil Administration in Rabbits: Safety, Pharmacokinetics, Organ Distribution and Histologic Evaluation Toxicology and Applied Pharmacology. Jun, 2023 | Pubmed ID: 37080362 A Neurodevelopmental Epigenetic Programme Mediated by SMARCD3-DAB1-Reelin Signalling is Hijacked to Promote Medulloblastoma Metastasis Nature Cell Biology. Mar, 2023 | Pubmed ID: 36849558 Bone-marrow Derived Cells Do Not Contribute to New Beta-cells in the Inflamed Pancreas Frontiers in Immunology. 2023 | Pubmed ID: 36733483 Ionizable Lipid Nanoparticles Deliver MRNA to Pancreatic β Cells Via Macrophage-mediated Gene Transfer Science Advances. Jan, 2023 | Pubmed ID: 36706177 Polarized Macrophages Promote Gestational Beta Cell Growth Through Extracellular Signal-regulated Kinase 5 Signalling Diabetes, Obesity & Metabolism. Sep, 2022 | Pubmed ID: 35546452 Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 () Mutants Frontiers in Physiology. 2021 | Pubmed ID: 34366878 Chitinase-3-like 1 Protein Complexes Modulate Macrophage-mediated Immune Suppression in Glioblastoma The Journal of Clinical Investigation. Aug, 2021 | Pubmed ID: 34228644 Insulin-positive Ductal Cells Do Not Migrate into Preexisting Islets During Pregnancy Experimental & Molecular Medicine. Apr, 2021 | Pubmed ID: 33820959 Chemical Pancreatectomy Treats Chronic Pancreatitis While Preserving Endocrine Function in Preclinical Models The Journal of Clinical Investigation. Feb, 2021 | Pubmed ID: 33351784 Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia Diabetes. Feb, 2021 | Pubmed ID: 33239450 Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality Frontiers in Physiology. 2020 | Pubmed ID: 33192543 Intra-Amniotic Sildenafil Treatment Promotes Lung Growth and Attenuates Vascular Remodeling in an Experimental Model of Congenital Diaphragmatic Hernia Fetal Diagnosis and Therapy. 2020 | Pubmed ID: 32663823 Placental Growth Factor in Beta Cells Plays an Essential Role in Gestational Beta-cell Growth BMJ Open Diabetes Research & Care. 03, 2020 | Pubmed ID: 32144129 SMAD7 Enhances Adult β-cell Proliferation Without Significantly Affecting β-cell Function in Mice The Journal of Biological Chemistry. 04, 2020 | Pubmed ID: 32122971 Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture Journal of the Endocrine Society. Nov, 2019 | Pubmed ID: 31620668 Evidence of a Developmental Origin for β-cell Heterogeneity Using a Dual Lineage-tracing Technology Development (Cambridge, England). 06, 2019 | Pubmed ID: 31160417 Islet α-cell Inflammation Induced By NF-κB Inducing Kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice Theranostics. 2018 | Pubmed ID: 30613274 Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes Cell Stem Cell. 01, 2018 | Pubmed ID: 29304344 Autophagy Protects Pancreatic Beta Cell Mass and Function in the Setting of a High-fat and High-glucose Diet Scientific Reports. 11, 2017 | Pubmed ID: 29180700 Loss of MTORC1 Signaling Alters Pancreatic α Cell Mass and Impairs Glucagon Secretion The Journal of Clinical Investigation. Dec, 2017 | Pubmed ID: 29106387 Gcg Knockin Mice As a Tool for Genetic Manipulation in Pancreatic Alpha Cells Diabetologia. 12, 2017 | Pubmed ID: 28884202 GLP-1/Exendin-4 Induces β-cell Proliferation Via the Epidermal Growth Factor Receptor Scientific Reports. 08, 2017 | Pubmed ID: 28831150 SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes Diabetes. 10, 2017 | Pubmed ID: 28775125 Targeted Inhibition of Pancreatic Acinar Cell Calcineurin is a Novel Strategy to Prevent Post-ERCP Pancreatitis Cellular and Molecular Gastroenterology and Hepatology. Jan, 2017 | Pubmed ID: 28090570 Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice The Journal of Biological Chemistry. 02, 2017 | Pubmed ID: 28057752 Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice The Journal of Biological Chemistry. Oct, 2016 | Pubmed ID: 27587395 A Synopsis of Factors Regulating Beta Cell Development and Beta Cell Mass Cellular and Molecular Life Sciences : CMLS. 10, 2016 | Pubmed ID: 27105622 Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects Against Experimental Murine Colitis The Journal of Biological Chemistry. May, 2016 | Pubmed ID: 26969166 PNA Lectin for Purifying Mouse Acinar Cells from the Inflamed Pancreas Scientific Reports. Feb, 2016 | Pubmed ID: 26884345 Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation Endocrinology. Apr, 2016 | Pubmed ID: 26872091 Multiple Roles for TGFβ Receptor Type II in Regulating the Pancreatic Response in Acute Pancreatitis The Journal of Pathology. Apr, 2016 | Pubmed ID: 26608971 Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells Endocrinology. Jan, 2016 | Pubmed ID: 26505114 The Role of ARF6 in Biliary Atresia PloS One. 2015 | Pubmed ID: 26379158 Defective Parasympathetic Innervation is Associated with Airway Branching Abnormalities in Experimental CDH American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2015 | Pubmed ID: 25934671 Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation Stem Cells Translational Medicine. Jun, 2015 | Pubmed ID: 25900729 Dynamic Imaging of Pancreatic Nuclear Factor κB (NF-κB) Activation in Live Mice Using Adeno-associated Virus (AAV) Infusion and Bioluminescence The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25802340 Pancreatic Cell Tracing, Lineage Tagging and Targeted Genetic Manipulations in Multiple Cell Types Using Pancreatic Ductal Infusion of Adeno-associated Viral Vectors And/or Cell-tagging Dyes Nature Protocols. Dec, 2014 | Pubmed ID: 25356582 Renal Blood Flow and Oxygenation Drive Nephron Progenitor Differentiation American Journal of Physiology. Renal Physiology. Aug, 2014 | Pubmed ID: 24920757 M2 Macrophages Promote Beta-cell Proliferation by Up-regulation of SMAD7 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24639504 Pancreatic Duct Cells As a Source of VEGF in Mice Diabetologia. May, 2014 | Pubmed ID: 24535231 Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis The Journal of Biological Chemistry. Apr, 2014 | Pubmed ID: 24519940 α-Cells Are Dispensable in Postnatal Morphogenesis and Maturation of Mouse Pancreatic Islets American Journal of Physiology. Endocrinology and Metabolism. Oct, 2013 | Pubmed ID: 23982158 Neurogenin3 Activation is Not Sufficient to Direct Duct-to-beta Cell Transdifferentiation in the Adult Pancreas The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23867457 No Evidence for β Cell Neogenesis in Murine Adult Pancreas The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23619362 Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells As a Regulator of Beta Cell Mass The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23378532 TGFβ Receptor Signaling is Essential for Inflammation-induced but Not β-cell Workload-induced β-cell Proliferation Diabetes. Apr, 2013 | Pubmed ID: 23248173 Intestinal Epithelial Toll-like Receptor 4 Regulates Goblet Cell Development and is Required for Necrotizing Enterocolitis in Mice Gastroenterology. Sep, 2012 | Pubmed ID: 22796522 Amniotic Fluid Inhibits Toll-like Receptor 4 Signaling in the Fetal and Neonatal Intestinal Epithelium Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22733781 Defective Pulmonary Innervation and Autonomic Imbalance in Congenital Diaphragmatic Hernia American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2012 | Pubmed ID: 22114150 Assessing Vesicoureteral Reflux in Live Inbred Mice Via Ultrasound with a Microbubble Contrast Agent American Journal of Physiology. Renal Physiology. May, 2011 | Pubmed ID: 21325495 Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009 | Pubmed ID: 19109197 Developmental Biology of the Pancreas: a Comprehensive Review Developmental Biology. Feb, 2009 | Pubmed ID: 19013144 TGF-beta Isoform Signaling Regulates Secondary Transition and Mesenchymal-induced Endocrine Development in the Embryonic Mouse Pancreas Developmental Biology. May, 2007 | Pubmed ID: 17418116 Author Spotlight: Advancing Gene Therapy Research with High-Titer Adeno-Associated Virus Vector Production Ting Zhang1, Vinitha Dhamotharan1, Yu Xiao1,2, Sydne Ballengee1,3, Jill Pollon1,4, George K. Gittes1 1Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 2North Allegheny High School, 3Wright State University Boonshoft School of Medicine, 4College of Engineering, University of Michigan JoVE 66741 Bioengineering Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery Joseph C. Fusco*1, Chen Congde*2, Xiangwei Xiao1, Krishna Prasadan1, David Ricks1, George K. Gittes1 1Department of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, 2Department of Pediatric Surgery, The 2nd Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University JoVE 55332 Medicine
Author Spotlight: Advancing Gene Therapy Research with High-Titer Adeno-Associated Virus Vector Production Ting Zhang1, Vinitha Dhamotharan1, Yu Xiao1,2, Sydne Ballengee1,3, Jill Pollon1,4, George K. Gittes1 1Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 2North Allegheny High School, 3Wright State University Boonshoft School of Medicine, 4College of Engineering, University of Michigan JoVE 66741 Bioengineering
Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery Joseph C. Fusco*1, Chen Congde*2, Xiangwei Xiao1, Krishna Prasadan1, David Ricks1, George K. Gittes1 1Department of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, 2Department of Pediatric Surgery, The 2nd Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University JoVE 55332 Medicine
