Huijun SUn Department of Clinical Pharmacology Dalian Medical University Biography Publications Institution JoVE Articles Huijun SUn Professor of Pharmacology, majoring in the research of metabolic disease pharmacology. Publications Activation of PGC-1α Via Isoliquiritigenin-induced Downregulation of MiR-138-5p Alleviates Nonalcoholic Fatty Liver Disease Phytotherapy Research : PTR. Jan, 2022 | Pubmed ID: 35041255 Isoliquiritigenin-mediated MiR-23a-3p Inhibition Activates PGC-1α to Alleviate Alcoholic Liver Injury Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Feb, 2022 | Pubmed ID: 34785106 Identifying the Dominant Contribution of Human Cytochrome P450 2J2 to the Metabolism of Rivaroxaban, an Oral Anticoagulant Cardiovascular Drugs and Therapy. Feb, 2022 | Pubmed ID: 33411110 Isoliquiritigenin Alleviates LPS/ D-GalN-induced Acute Liver Failure by Activating the PGC-1α/ Nrf2 Pathway to Reduce Oxidative Stress and Inflammatory Response International Immunopharmacology. Nov, 2021 | Pubmed ID: 34555641 In Vitro Measurement and In Vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity Current Drug Metabolism. Month, 2021 | Pubmed ID: 34473615 Kaempferol-induced GPER Upregulation Attenuates Atherosclerosis Via the PI3K/AKT/Nrf2 Pathway Pharmaceutical Biology. Dec, 2021 | Pubmed ID: 34403325 Yangonin Modulates Lipid Homeostasis, Ameliorates Cholestasis and Cellular Senescence in Alcoholic Liver Disease Via Activating Nuclear Receptor FXR Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Sep, 2021 | Pubmed ID: 34304130 Noncovalent EGFR T790M/L858R Inhibitors Based on Diphenylpyrimidine Scaffold: Design, Synthesis, and Bioactivity Evaluation for the Treatment of NSCLC European Journal of Medicinal Chemistry. Nov, 2021 | Pubmed ID: 34218082 Synthesis and Biological Evaluation of Selenogefitinib for Reducing Bleomycin-induced Pulmonary Fibrosis Bioorganic & Medicinal Chemistry Letters. 09, 2021 | Pubmed ID: 34216747 Luteolin Ameliorates LPS-induced Acute Liver Injury by Inhibiting TXNIP-NLRP3 Inflammasome in Mice Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Jul, 2021 | Pubmed ID: 34044253 Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole Against Human Carboxylesterase 2 Current Drug Metabolism. Month, 2021 | Pubmed ID: 33568030 Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity Through the Mitochondrial-Dependent Pathway Without Compromising Its Anticancer Properties Oxidative Medicine and Cellular Longevity. Month, 2021 | Pubmed ID: 33510841 Synthesis and Biological Activity of Imidazole Group-substituted Arylaminopyrimidines (IAAPs) As Potent BTK Inhibitors Against B-cell Lymphoma and AML Bioorganic Chemistry. 01, 2021 | Pubmed ID: 33272709 Phosphocreatine Promotes Osteoblastic Activities in HO-Induced MC3T3-E1 Cells by Regulating SIRT1/FOXO1/PGC-1α Signaling Pathway Current Pharmaceutical Biotechnology. Month, 2021 | Pubmed ID: 33198615 Puerarin Sensitized K562/ADR Cells by Inhibiting NF-κB Pathway and Inducing Autophagy Phytotherapy Research : PTR. Mar, 2021 | Pubmed ID: 33141989 Yangonin Inhibits Ethanol-induced Hepatocyte Senescence Via MiR-194/FXR Axis European Journal of Pharmacology. Jan, 2021 | Pubmed ID: 33068587 Rosmarinic Acid Exerts an Antagonistic Effect on Nonalcoholic Fatty Liver Disease by Regulating the YAP1/TAZ-PPARγ/PGC-1α Signaling Pathway Phytotherapy Research : PTR. Feb, 2021 | Pubmed ID: 32914480 Author Correction: Potent Effects of Dioscin Against Obesity in Mice Scientific Reports. Oct, 2020 | Pubmed ID: 33093537 CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism Frontiers in Pharmacology. Month, 2020 | Pubmed ID: 32792941 Targeting Renal OATs to Develop Renal Protective Agent from Traditional Chinese Medicines: Protective Effect of Apigenin Against Imipenem-induced Nephrotoxicity Phytotherapy Research : PTR. Nov, 2020 | Pubmed ID: 32468621 Organic Anion Transporters Also Mediate the Drug-drug Interaction Between Imipenem and Cilastatin Asian Journal of Pharmaceutical Sciences. Mar, 2020 | Pubmed ID: 32373203 Molecular Pharmacokinetic Mechanism of the Drug-drug Interaction Between Genistein and Repaglinide Mediated by P-gp Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. May, 2020 | Pubmed ID: 32187961 A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases Frontiers in Pharmacology. Month, 2020 | Pubmed ID: 32184728 Macrophage-derived MMP-9 Enhances the Progression of Atherosclerotic Lesions and Vascular Calcification in Transgenic Rabbits Journal of Cellular and Molecular Medicine. 04, 2020 | Pubmed ID: 32126159 Targeting of MiR-96-5p by Catalpol Ameliorates Oxidative Stress and Hepatic Steatosis in LDLr-/- Mice Via P66shc/cytochrome C Cascade Aging. 02, 2020 | Pubmed ID: 32023549 Protective Effect of Cilastatin Against Diclofenac-induced Nephrotoxicity Through Interaction with Diclofenac Acyl Glucuronide Via Organic Anion Transporters British Journal of Pharmacology. 05, 2020 | Pubmed ID: 32000294 Corrigendum to "Disocin Prevents Postmenopausal Atherosclerosis in Ovariectomized LDLR-/mice Through a PGC-1α/ERα Pathway Leading to Promotion of Autophagy and Inhibition of Oxidative Stress, Inflammation and Apoptosis" [Pharmacol. Res. 148 (2019) 104414] Pharmacological Research. Mar, 2020 | Pubmed ID: 31926782 Synthesis and Biological Activity of Thieno[3,2-d]pyrimidines As Potent JAK3 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis Bioorganic & Medicinal Chemistry. 01, 2020 | Pubmed ID: 31866272 Corrigendum to "Dioscin Reduces Ovariectomy-induced Bone Loss by Enhancing Osteoblastogenesis and Inhibiting Osteoclastogenesis" [Pharmacol. Res. 108 (2016) 90-101] Pharmacological Research. Jan, 2020 | Pubmed ID: 31780339 Organic Anion Transporters and PI3K-AKT-mTOR Pathway Mediate the Synergistic Anticancer Effect of Pemetrexed and Rhein Journal of Cellular Physiology. 04, 2020 | Pubmed ID: 31587272 Piperacillin Enhances the Inhibitory Effect of Tazobactam on β-lactamase Through Inhibition of Organic Anion Transporter 1/3 in Rats Asian Journal of Pharmaceutical Sciences. Nov, 2019 | Pubmed ID: 32104494 Biomineralized Gd O @HSA Nanoparticles As a Versatile Platform for Dual-Modal Imaging and Chemo-Phototherapy-Synergized Tumor Ablation Advanced Healthcare Materials. 12, 2019 | Pubmed ID: 31738019 Corrigendum to "Dioscin Attenuates Renal Ischemia/reperfusion Injury by Inhibiting TheTLR4/MyD88 Signaling Pathway Via Up-regulation of HSP70" [Pharmacol. Res. 100 (2015) 341-352] Pharmacological Research. Dec, 2019 | Pubmed ID: 31699473 Cilastatin Protects Against Imipenem-induced Nephrotoxicity Inhibition of Renal Organic Anion Transporters (OATs) Acta Pharmaceutica Sinica. B. Sep, 2019 | Pubmed ID: 31649848 Hepatoprotection of Yangonin Against Hepatic Fibrosis in Mice Via Farnesoid X Receptor Activation International Immunopharmacology. Oct, 2019 | Pubmed ID: 31450152 Disocin Prevents Postmenopausal Atherosclerosis in Ovariectomized LDLR-/- Mice Through a PGC-1α/ERα Pathway Leading to Promotion of Autophagy and Inhibition of Oxidative Stress, Inflammation and Apoptosis Pharmacological Research. 10, 2019 | Pubmed ID: 31449974 Catalpol Alleviates Adriamycin-induced Nephropathy by Activating the SIRT1 Signalling Pathway in Vivo and in Vitro British Journal of Pharmacology. 12, 2019 | Pubmed ID: 31378931 Yangonin Protects Against Estrogen-induced Cholestasis in a Farnesoid X Receptor-dependent Manner European Journal of Pharmacology. Aug, 2019 | Pubmed ID: 31220436 An Interspecies Study of Lipid Profiles and Atherosclerosis in Familial Hypercholesterolemia Animal Models with Low-density Lipoprotein Receptor Deficiency American Journal of Translational Research. Month, 2019 | Pubmed ID: 31217881 Hepatoprotection of Auraptene from the Peels of Citrus Fruits Against 17α-ethinylestradiol-induced Cholestasis in Mice by Activating Farnesoid X Receptor Food & Function. Jul, 2019 | Pubmed ID: 31210195 Scutellarin Exerts Protective Effects Against Atherosclerosis in Rats by Regulating the Hippo-FOXO3A and PI3K/AKT Signaling Pathways Journal of Cellular Physiology. 08, 2019 | Pubmed ID: 30891776 Rosmarinic Acid Exerts an Antagonistic Effect on Vascular Calcification by Regulating the Nrf2 Signalling Pathway Free Radical Research. Feb, 2019 | Pubmed ID: 30864863 Potent Effects of Dioscin Against Hepatocellular Carcinoma Through Regulating TP53-induced Glycolysis and Apoptosis Regulator (TIGAR)-mediated Apoptosis, Autophagy, and DNA Damage British Journal of Pharmacology. 04, 2019 | Pubmed ID: 30710454 Facile Synthesis of Fluorescent Carbon Dots from Prunus Cerasifera Fruits for Fluorescent Ink, Fe Ion Detection and Cell Imaging Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy. Apr, 2019 | Pubmed ID: 30703711 Yangonin Protects Against Non-alcoholic Fatty Liver Disease Through Farnesoid X Receptor Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Feb, 2019 | Pubmed ID: 30668392 Resveratrol Enhances the Protective Effects of JBP485 Against Indomethacin-induced Rat Intestinal Damage in Vivo and Vitro Through Up-regulating Oligopeptide Transporter 1 (Pept1) Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Mar, 2019 | Pubmed ID: 30590313 Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation Via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells Inflammation. Feb, 2019 | Pubmed ID: 30315526 Luteolin Attenuates Glucocorticoid-induced Osteoporosis by Regulating ERK/Lrp-5/GSK-3β Signaling Pathway in Vivo and in Vitro Journal of Cellular Physiology. 04, 2019 | Pubmed ID: 30192012 Combination of Dihydromyricetin and Ondansetron Strengthens Antiproliferative Efficiency of Adriamycin in K562/ADR Through Downregulation of SORCIN: A New Strategy of Inhibiting P-glycoprotein Journal of Cellular Physiology. 04, 2019 | Pubmed ID: 30171603 MiR-125a-5p Ameliorates Hepatic Glycolipid Metabolism Disorder in Type 2 Diabetes Mellitus Through Targeting of STAT3 Theranostics. Month, 2018 | Pubmed ID: 30555566 Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. Month, 2018 | Pubmed ID: 30497065 Protective Effects of Dioscin Against Cartilage Destruction in a Monosodium Iodoacetate (MIA)-indcued Osteoarthritis Rat Model Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Dec, 2018 | Pubmed ID: 30372803 Involvement of Organic Cation Transporter 2 in the Metformin-associated Increased Lactate Levels Caused by Contrast-induced Nephropathy Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Oct, 2018 | Pubmed ID: 30119251 Pharmacokinetic Changes of Cefdinir and Cefditoren and Its Molecular Mechanisms in Acute Kidney Injury in Rats The Journal of Pharmacy and Pharmacology. Nov, 2018 | Pubmed ID: 30047127 Activating the PGC-1/TERT Pathway by Catalpol Ameliorates Atherosclerosis Via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link Oxidative Medicine and Cellular Longevity. Month, 2018 | Pubmed ID: 30046372 Hepatoprotective Effect of Rhein Against Methotrexate-induced Liver Toxicity European Journal of Pharmacology. Sep, 2018 | Pubmed ID: 30031796 Structural Optimization of Diphenylpyrimidine Scaffold As Potent and Selective Epidermal Growth Factor Receptor Inhibitors Against L858R/T790M Resistance Mutation in Nonsmall Cell Lung Cancer Chemical Biology & Drug Design. 12, 2018 | Pubmed ID: 30030903 Ginsenoside Rg1 Protects Against Acetaminophen-induced Liver Injury Via Activating Nrf2 Signaling Pathway in Vivo and in Vitro Regulatory Toxicology and Pharmacology : RTP. Oct, 2018 | Pubmed ID: 30030101 Novel Amino Acid-substituted Diphenylpyrimidine Derivatives As Potent BTK Inhibitors Against B Cell Lymphoma Cell Lines Bioorganic & Medicinal Chemistry. 08, 2018 | Pubmed ID: 30006143 Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. Month, 2018 | Pubmed ID: 29975924 Hepatoprotective Effect of Ginsenoside Rg1 from Panax Ginseng on Carbon Tetrachloride-induced Acute Liver Injury by Activating Nrf2 Signaling Pathway in Mice Environmental Toxicology. Oct, 2018 | Pubmed ID: 29964319 JBP485 Attenuates Vancomycin-induced Nephrotoxicity by Regulating the Expressions of Organic Anion Transporter (Oat) 1, Oat3, Organic Cation Transporter 2 (Oct2), Multidrug Resistance-associated Protein 2 (Mrp2) and P-glycoprotein (P-gp) in Rats Toxicology Letters. Oct, 2018 | Pubmed ID: 29964132 MicroRNA-351-5p Aggravates Intestinal Ischaemia/reperfusion Injury Through the Targeting of MAPK13 and Sirtuin-6 British Journal of Pharmacology. 09, 2018 | Pubmed ID: 29952043 Protective Effects of Ginsenoside Rg1 Against Lipopolysaccharide/d-galactosamine-induced Acute Liver Injury in Mice Through Inhibiting Toll-like Receptor 4 Signaling Pathway International Immunopharmacology. Aug, 2018 | Pubmed ID: 29902710 Hepatoprotection of Auraptene from Peels of Citrus Fruits Against Thioacetamide-induced Hepatic Fibrosis in Mice by Activating Farnesoid X Receptor Food & Function. May, 2018 | Pubmed ID: 29721568 Puerarin Improves Methotrexate-induced Renal Damage by Up-regulating Renal Expression of Oat1 and Oat3 in Vivo and in Vitro Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Jul, 2018 | Pubmed ID: 29710508 Icariin Promotes Stable Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Self‑assembling Peptide Nanofiber Hydrogel Scaffolds Molecular Medicine Reports. Jun, 2018 | Pubmed ID: 29693145 Yangonin Protects Against Cholestasis and Hepatotoxity Via Activation of Farnesoid X Receptor in Vivo and in Vitro Toxicology and Applied Pharmacology. 06, 2018 | Pubmed ID: 29660435 P-gp is Involved in the Intestinal Absorption and Biliary Excretion of Afatinib in Vitro and in Rats Pharmacological Reports : PR. Apr, 2018 | Pubmed ID: 29475007 Protective Effects of Yangonin from an Edible Botanical Kava Against Lithocholic Acid-induced Cholestasis and Hepatotoxicity European Journal of Pharmacology. Apr, 2018 | Pubmed ID: 29427579 Scutellarin Ameliorates Nonalcoholic Fatty Liver Disease Through the PPARγ/PGC-1α-Nrf2 Pathway Free Radical Research. Feb, 2018 | Pubmed ID: 29400110 Catalpol Ameliorates Hepatic Insulin Resistance in Type 2 Diabetes Through Acting on AMPK/NOX4/PI3K/AKT Pathway Pharmacological Research. 04, 2018 | Pubmed ID: 29284152 OAT1 and OAT3 Also Mediate the Drug-drug Interaction Between Piperacillin and Tazobactam International Journal of Pharmaceutics. Feb, 2018 | Pubmed ID: 29277663 Effects of Calycosin Against High-fat Diet-induced Nonalcoholic Fatty Liver Disease in Mice Journal of Gastroenterology and Hepatology. Feb, 2018 | Pubmed ID: 28699662 Targeting P-glycoprotein and SORCIN: Dihydromyricetin Strengthens Anti-proliferative Efficiency of Adriamycin Via MAPK/ERK and Ca -mediated Apoptosis Pathways in MCF-7/ADR and K562/ADR Journal of Cellular Physiology. 04, 2018 | Pubmed ID: 28681913 Computational Discovery and Experimental Verification of Farnesoid X Receptor Agonist Auraptene to Protect Against Cholestatic Liver Injury Biochemical Pharmacology. 12, 2017 | Pubmed ID: 28987596 Organic Anion-Transporting Polypeptide and Efflux Transporter-Mediated Hepatic Uptake and Biliary Excretion of Cilostazol and Its Metabolites in Rats and Humans Journal of Pharmaceutical Sciences. 09, 2017 | Pubmed ID: 28535976 Protective Effects of Glycyrrhizic Acid Against Non-alcoholic Fatty Liver Disease in Mice European Journal of Pharmacology. Jul, 2017 | Pubmed ID: 28414056 Targeting Oct2 and P53: Formononetin Prevents Cisplatin-induced Acute Kidney Injury Toxicology and Applied Pharmacology. 07, 2017 | Pubmed ID: 28414026 Protective Effects of Dioscin Against Lipopolysaccharide-Induced Acute Lung Injury Through Inhibition of Oxidative Stress and Inflammation Frontiers in Pharmacology. Month, 2017 | Pubmed ID: 28377715 Calycosin Attenuates Triglyceride Accumulation and Hepatic Fibrosis in Murine Model of Non-alcoholic Steatohepatitis Via Activating Farnesoid X Receptor Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Feb, 2017 | Pubmed ID: 28190475 Targeting P-glycoprotein Function, P53 and Energy Metabolism: Combination of Metformin and 2-deoxyglucose Reverses the Multidrug Resistance of MCF-7/Dox Cells to Doxorubicin Oncotarget. Jan, 2017 | Pubmed ID: 28052008 Design and Synthesis of Phosphoryl-substituted Diphenylpyrimidines (Pho-DPPYs) As Potent Bruton's Tyrosine Kinase (BTK) Inhibitors: Targeted Treatment of B Lymphoblastic Leukemia Cell Lines Bioorganic & Medicinal Chemistry. 01, 2017 | Pubmed ID: 27956037 Protective Effects of Glycyrrhizic Acid from Edible Botanical Glycyrrhiza Glabra Against Non-alcoholic Steatohepatitis in Mice Food & Function. Sep, 2016 | Pubmed ID: 27487733 Dioscin Alleviates Lipopolysaccharide-induced Inflammatory Kidney Injury Via the MicroRNA Let-7i/TLR4/MyD88 Signaling Pathway Pharmacological Research. 09, 2016 | Pubmed ID: 27431331 P-gp, MRP2 and OAT1/OAT3 Mediate the Drug-drug Interaction Between Resveratrol and Methotrexate Toxicology and Applied Pharmacology. 09, 2016 | Pubmed ID: 27377006 Dioscin Strengthens the Efficiency of Adriamycin in MCF-7 and MCF-7/ADR Cells Through Autophagy Induction: More Than Just Down-regulation of MDR1 Scientific Reports. 06, 2016 | Pubmed ID: 27329817 Dioscin Protects Against ANIT-induced Cholestasis Via Regulating Oatps, Mrp2 and Bsep Expression in Rats Toxicology and Applied Pharmacology. 08, 2016 | Pubmed ID: 27317372 Dioscin Reduces Ovariectomy-induced Bone Loss by Enhancing Osteoblastogenesis and Inhibiting Osteoclastogenesis Pharmacological Research. 06, 2016 | Pubmed ID: 27155058 Alpha-lipoic Acid Defends Homocysteine-induced Endoplasmic Reticulum and Oxidative Stress in HAECs Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. May, 2016 | Pubmed ID: 27133040 Chondroprotective Effects of Alpha-lipoic Acid in a Rat Model of Osteoarthritis Free Radical Research. Jul, 2016 | Pubmed ID: 27055478 Targeting P-glycoprotein Expression and Cancer Cell Energy Metabolism: Combination of Metformin and 2-deoxyglucose Reverses the Multidrug Resistance of K562/Dox Cells to Doxorubicin Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Jul, 2016 | Pubmed ID: 26733176 Bezafibrate-mizoribine Interaction: Involvement of Organic Anion Transporters OAT1 and OAT3 in Rats European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2016 | Pubmed ID: 26474691 Enhancement Effect of Resveratrol on the Intestinal Absorption of Bestatin by Regulating PEPT1, MDR1 and MRP2 in Vivo and in Vitro International Journal of Pharmaceutics. Nov, 2015 | Pubmed ID: 26394120 Dioscin Attenuates Renal Ischemia/reperfusion Injury by Inhibiting the TLR4/MyD88 Signaling Pathway Via Up-regulation of HSP70 Pharmacological Research. Oct, 2015 | Pubmed ID: 26348276 Protective Effects of Alisol B 23-Acetate Via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Estrogen-Induced Cholestatic Liver Injury in Mice Pharmaceutical Research. Nov, 2015 | Pubmed ID: 26040663 Potent Effects of Dioscin Against Liver Fibrosis Scientific Reports. Apr, 2015 | Pubmed ID: 25853178 Protective Effects of Alisol B 23-acetate from Edible Botanical Rhizoma Alismatis Against Carbon Tetrachloride-induced Hepatotoxicity in Mice Food & Function. Apr, 2015 | Pubmed ID: 25747392 Decreased Liver Distribution of Entecavir is Related to Down-regulation of Oat2/Oct1 and Up-regulation of Mrp1/2/3/5 in Rat Liver Fibrosis European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Apr, 2015 | Pubmed ID: 25712368 Potent Effects of Dioscin Against Obesity in Mice Scientific Reports. Jan, 2015 | Pubmed ID: 25609476 Potent Anti-inflammatory Effect of Dioscin Mediated by Suppression Of TNF-α-induced VCAM-1, ICAM-1and EL Expression Via the NF-κB Pathway Biochimie. Mar, 2015 | Pubmed ID: 25577996 Dasatinib Reverses the Multidrug Resistance of Breast Cancer MCF-7 Cells to Doxorubicin by Downregulating P-gp Expression Via Inhibiting the Activation of ERK Signaling Pathway Cancer Biology & Therapy. Month, 2015 | Pubmed ID: 25482933 Rhizoma Dioscoreae Nipponicae Polysaccharides Protect HUVECs from H2O2-induced Injury by Regulating PPARγ Factor and the NADPH Oxidase/ROS-NF-κB Signal Pathway Toxicology Letters. Jan, 2015 | Pubmed ID: 25305479 Protective Effects of Calycosin Against CCl4-induced Liver Injury with Activation of FXR and STAT3 in Mice Pharmaceutical Research. Feb, 2015 | Pubmed ID: 25143196 Naringin Inhibits TNF-α Induced Oxidative Stress and Inflammatory Response in HUVECs Via Nox4/NF-κ B and PI3K/Akt Pathways Current Pharmaceutical Biotechnology. Month, 2014 | Pubmed ID: 25391245 Alisol B 23-acetate Promotes Liver Regeneration in Mice After Partial Hepatectomy Via Activating Farnesoid X Receptor Biochemical Pharmacology. Nov, 2014 | Pubmed ID: 25278094 PEPT1- and OAT1/3-mediated Drug-drug Interactions Between Bestatin and Cefixime in Vivo and in Vitro in Rats, and in Vitro in Human European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Oct, 2014 | Pubmed ID: 25016073 OATP and MRP2-mediated Hepatic Uptake and Biliary Excretion of Eprosartan in Rat and Human Pharmacological Reports : PR. Apr, 2014 | Pubmed ID: 24911086 Dioscin Promotes Osteoblastic Proliferation and Differentiation Via Lrp5 and ER Pathway in Mouse and Human Osteoblast-like Cell Lines Journal of Biomedical Science. Apr, 2014 | Pubmed ID: 24742230 Aspirin and Probenecid Inhibit Organic Anion Transporter 3-mediated Renal Uptake of Cilostazol and Probenecid Induces Metabolism of Cilostazol in the Rat Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2014 | Pubmed ID: 24692216 Dioscin Enhances Methotrexate Absorption by Down-regulating MDR1 in Vitro and in Vivo Toxicology and Applied Pharmacology. Jun, 2014 | Pubmed ID: 24680847 Luteolin Protects HUVECs from TNF-α-induced Oxidative Stress and Inflammation Via Its Effects on the Nox4/ROS-NF-κB and MAPK Pathways Journal of Atherosclerosis and Thrombosis. Month, 2014 | Pubmed ID: 24621786 Methotrexate-bestatin Interaction: Involvement of P-glycoprotein and Organic Anion Transporters in Rats International Journal of Pharmaceutics. Apr, 2014 | Pubmed ID: 24530518 Inhibitory Effect of Valsartan on the Intestinal Absorption and Renal Excretion of Bestatin in Rats Journal of Pharmaceutical Sciences. Feb, 2014 | Pubmed ID: 24338900 MDR1 and OAT1/OAT3 Mediate the Drug-drug Interaction Between Puerarin and Methotrexate Pharmaceutical Research. May, 2014 | Pubmed ID: 24242937 The Oligopeptide Transporter 2-mediated Reabsorption of Entecavir in Rat Kidney European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Feb, 2014 | Pubmed ID: 24184752 Enhancement Effect of P-gp Inhibitors on the Intestinal Absorption and Antiproliferative Activity of Bestatin European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2013 | Pubmed ID: 23981338 Anti-cancer Effects of Dioscin on Three Kinds of Human Lung Cancer Cell Lines Through Inducing DNA Damage and Activating Mitochondrial Signal Pathway Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Sep, 2013 | Pubmed ID: 23764357 Benzylpenicillin Inhibits the Renal Excretion of Acyclovir by OAT1 and OAT3 Pharmacological Reports : PR. Month, 2013 | Pubmed ID: 23744435 JBP485 Improves Gentamicin-induced Acute Renal Failure by Regulating the Expression and Function of Oat1 and Oat3 in Rats Toxicology and Applied Pharmacology. May, 2013 | Pubmed ID: 23707770 Dioscin Restores the Activity of the Anticancer Agent Adriamycin in Multidrug-Resistant Human Leukemia K562/Adriamycin Cells by Down-Regulating MDR1 Via a Mechanism Involving NF-κB Signaling Inhibition Journal of Natural Products. May, 2013 | Pubmed ID: 23621869 Involvement of Organic Anion-transporting Polypeptides in the Hepatic Uptake of Dioscin in Rats and Humans Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2013 | Pubmed ID: 23396419 OAT1 and OAT3: Targets of Drug-drug Interaction Between Entecavir and JBP485 European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Mar, 2013 | Pubmed ID: 23313623 Inhibitory Effect of 1α,25-dihydroxyvitamin D₃ on Excretion of JBP485 Via Organic Anion Transporters in Rats European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2013 | Pubmed ID: 23201003 Changes in Expression of Renal Oat1, Oat3 and Mrp2 in Cisplatin-induced Acute Renal Failure After Treatment of JBP485 in Rats Toxicology and Applied Pharmacology. Nov, 2012 | Pubmed ID: 22992436 Inhibitory Effect of JBP485 on Renal Excretion of Acyclovir by the Inhibition of OAT1 and OAT3 European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Sep, 2012 | Pubmed ID: 22728397 Effect of JBP485 on Obstructive Jaundice is Related to Regulation of Renal Oat1, Oat3 and Mrp2 Expression in ANIT-treated Rats Peptides. Jul, 2012 | Pubmed ID: 22521734 Construction, Identification and Application of HeLa Cells Stably Transfected with Human PEPT1 and PEPT2 Peptides. Apr, 2012 | Pubmed ID: 22369721 Organic Anion Transporters Involved in the Excretion of Bestatin in the Kidney Peptides. Feb, 2012 | Pubmed ID: 22273603 Subchronic Toxicity Study of the Total Flavonoids from Rosa Laevigata Michx Fruit in Rats Regulatory Toxicology and Pharmacology : RTP. Mar, 2012 | Pubmed ID: 22226919 Peptide Cotransporter 1 in Intestine and Organic Anion Transporters in Kidney Are Targets of Interaction Between JBP485 and Lisinopril in Rats Drug Metabolism and Pharmacokinetics. Month, 2012 | Pubmed ID: 22123131 Molecular Mechanisms of Biliary Excretion of Cefditoren and the Effects of Cefditoren on the Expression Levels of Hepatic Transporters Drug Metabolism and Pharmacokinetics. Month, 2010 | Pubmed ID: 20814152 Pharmacokinetic Interaction Between JBP485 and Cephalexin in Rats Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2010 | Pubmed ID: 20219852 Laennec Protects Murine from Concanavalin A-induced Liver Injury Through Inhibition of Inflammatory Reactions and Hepatocyte Apoptosis Biological & Pharmaceutical Bulletin. Nov, 2008 | Pubmed ID: 18981570 Protective Effect of JBP485 on Concanavalin A-induced Hepatocyte Toxicity in Primary Cultured Rat Hepatocytes European Journal of Pharmacology. Jul, 2008 | Pubmed ID: 18571156 Increased Expression of Human Macrophage Metalloelastase (MMP-12) is Associated with the Invasion of Endometrial Adenocarcinoma Pathology, Research and Practice. Month, 2007 | Pubmed ID: 17574772 C-reactive Protein in Atherosclerotic Lesions: Its Origin and Pathophysiological Significance The American Journal of Pathology. Oct, 2005 | Pubmed ID: 16192648 Association of Increased Expression of Macrophage Elastase (matrix Metalloproteinase 12) with Rheumatoid Arthritis Arthritis and Rheumatism. Oct, 2004 | Pubmed ID: 15476203 Overexpression of Human Matrix Metalloproteinase-12 Enhances the Development of Inflammatory Arthritis in Transgenic Rabbits The American Journal of Pathology. Oct, 2004 | Pubmed ID: 15466401 Generación y caracterización del infarto de miocardio del ventrículo derecho inducido por ligadura permanente de la arteria coronaria derecha en ratones Ruoxi Liao1, Mingyuan He2, Donghong Hu2, Chengzheng Gong1, Huiying Du1, Hairuo Lin2, Huijun Sun3 1The First Clinical College of Dalian Medical University, 2Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, 3College of Pharmacy, Dalian Medical University JoVE 63508 Medicine
Generación y caracterización del infarto de miocardio del ventrículo derecho inducido por ligadura permanente de la arteria coronaria derecha en ratones Ruoxi Liao1, Mingyuan He2, Donghong Hu2, Chengzheng Gong1, Huiying Du1, Hairuo Lin2, Huijun Sun3 1The First Clinical College of Dalian Medical University, 2Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, 3College of Pharmacy, Dalian Medical University JoVE 63508 Medicine
