Joseph M. Hyser Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology Baylor College of Medicine Biography Publications Institution JoVE Articles Joseph M. Hyser has not added a biography. If you are Joseph M. Hyser and would like to personalize this page please email our Author Liaison for assistance. Publications Host IPR Channels Are Dispensable for Rotavirus Ca Signaling but Critical for Intercellular Ca Waves That Prime Uninfected Cells for Rapid Virus Spread MBio. Jan, 2024 | Pubmed ID: 38112482 Distribution of P2Y and P2X Purinergic Receptor Expression Within the Intestine American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2024 | Pubmed ID: 37987757 A Bioengineered Probiotic for the Oral Delivery of a Peptide Kv1.3 Channel Blocker to Treat Rheumatoid Arthritis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2023 | Pubmed ID: 36595694 Acute High-fat Diet Impairs Macrophage-supported Intestinal Damage Resolution JCI Insight. Feb, 2023 | Pubmed ID: 36538527 Gastrointestinal Organoids in the Study of Viral Infections American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2023 | Pubmed ID: 36414538 -derived Y-glutamylcysteine Suppresses ER-mediated Goblet Cell Stress and Reduces TNBS-driven Colonic Inflammation Gut Microbes. 2021 | Pubmed ID: 33985416 Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation MBio. Mar, 2021 | Pubmed ID: 33653893 Bacteroides Ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid-Driven Colonic Inflammation The American Journal of Pathology. Apr, 2021 | Pubmed ID: 33516788 Mucin-Degrading Microbes Release Monosaccharides That Chemoattract and Facilitate Colonization of the Human Intestinal Mucus Layer ACS Infectious Diseases. May, 2021 | Pubmed ID: 33176423 Human-Derived Bifidobacterium Dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis Cellular and Molecular Gastroenterology and Hepatology. 2021 | Pubmed ID: 32795610 Rotavirus Induces Intercellular Calcium Waves Through ADP Signaling Science (New York, N.Y.). 11, 2020 | Pubmed ID: 33214249 Enteroaggregative E. Coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection PLoS Pathogens. 09, 2020 | Pubmed ID: 32986782 Reuterin Disrupts Metabolism and Pathogenicity Through Reactive Oxygen Species Generation Gut Microbes. Nov, 2020 | Pubmed ID: 32804011 Rotavirus Infection Induces Glycan Availability to Promote Ileum-specific Changes in the Microbiome Aiding Rotavirus Virulence Gut Microbes. Sep, 2020 | Pubmed ID: 32404017 Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors Through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex Cells. Mar, 2020 | Pubmed ID: 32235678 Human Intestinal Enteroids As a Model of -induced Enteritis American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2020 | Pubmed ID: 32223302 Discovery of a Bacterial Peptide As a Modulator of GLP-1 and Metabolic Disease Scientific Reports. Mar, 2020 | Pubmed ID: 32188864 Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System Journal of Virology. Dec, 2019 | Pubmed ID: 31597761 Recovirus NS1-2 Has Viroporin Activity That Induces Aberrant Cellular Calcium Signaling To Facilitate Virus Replication MSphere. Sep, 2019 | Pubmed ID: 31533997 Rotavirus Calcium Dysregulation Manifests As Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum Scientific Reports. 07, 2019 | Pubmed ID: 31346185 Bifidobacterium Dentium Fortifies the Intestinal Mucus Layer Via Autophagy and Calcium Signaling Pathways MBio. Jun, 2019 | Pubmed ID: 31213556 Human Intestinal Enteroids With Inducible Neurogenin-3 Expression As a Novel Model of Gut Hormone Secretion Cellular and Molecular Gastroenterology and Hepatology. Apr, 2019 | Pubmed ID: 31029854 The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel Scientific Reports. Mar, 2017 | Pubmed ID: 28256607 Pathophysiological Consequences of Calcium-Conducting Viroporins Annual Review of Virology. Nov, 2015 | Pubmed ID: 26958925 Use of Genetically-encoded Calcium Indicators for Live Cell Calcium Imaging and Localization in Virus-infected Cells Methods (San Diego, Calif.). Nov, 2015 | Pubmed ID: 26344758 Structural Plasticity of the Coiled-coil Domain of Rotavirus NSP4 Journal of Virology. Dec, 2014 | Pubmed ID: 25231315 Human Enteroids As an Ex-vivo Model of Host-pathogen Interactions in the Gastrointestinal Tract Experimental Biology and Medicine (Maywood, N.J.). Sep, 2014 | Pubmed ID: 24719375 A Novel Form of Rotavirus NSP2 and Phosphorylation-dependent NSP2-NSP5 Interactions Are Associated with Viroplasm Assembly Journal of Virology. Jan, 2014 | Pubmed ID: 24198401 Human Enteroids: Preclinical Models of Non-inflammatory Diarrhea Stem Cell Research & Therapy. 2013 | Pubmed ID: 24564938 Activation of the Endoplasmic Reticulum Calcium Sensor STIM1 and Store-operated Calcium Entry by Rotavirus Requires NSP4 Viroporin Activity Journal of Virology. Dec, 2013 | Pubmed ID: 24109210 Autophagy Hijacked Through Viroporin-activated Calcium/calmodulin-dependent Kinase Kinase-β Signaling is Required for Rotavirus Replication Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23184977 Rotavirus Non-structural Proteins: Structure and Function Current Opinion in Virology. Aug, 2012 | Pubmed ID: 22789743 Genetic Divergence of Rotavirus Nonstructural Protein 4 Results in Distinct Serogroup-specific Viroporin Activity and Intracellular Punctate Structure Morphologies Journal of Virology. May, 2012 | Pubmed ID: 22357281 Hepatitis B Virus Regulatory HBx Protein Binding to DDB1 is Required but is Not Sufficient for Maximal HBV Replication Virology. Apr, 2012 | Pubmed ID: 22342275 Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity MBio. Nov, 2010 | Pubmed ID: 21151776 Rotavirus Vaccines and Pathogenesis: 2008 Current Opinion in Gastroenterology. Jan, 2009 | Pubmed ID: 19114772 Integrins Alpha1beta1 and Alpha2beta1 Are Receptors for the Rotavirus Enterotoxin Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18587047 Epitope Mapping and Use of Epitope-specific Antisera to Characterize the VP5* Binding Site in Rotavirus SA11 NSP4 Virology. Mar, 2008 | Pubmed ID: 18164740 Rotavirus Viremia and Extraintestinal Viral Infection in the Neonatal Rat Model Journal of Virology. May, 2006 | Pubmed ID: 16641274 Sequence Analysis of the VP4, VP6, VP7, and NSP4 Gene Products of the Bovine Rotavirus WC3 Virus Genes. Mar, 2002 | Pubmed ID: 12018701 Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions (Video) | JoVE J. Thomas Gebert1, Francesca J. Scribano1, Kristen A. Engevik1, Joseph M. Hyser1 1Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine JoVE 66132 Immunology and Infection
Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions (Video) | JoVE J. Thomas Gebert1, Francesca J. Scribano1, Kristen A. Engevik1, Joseph M. Hyser1 1Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine JoVE 66132 Immunology and Infection
