Joseph Loscalzo Department of Medicine Brigham and Women's Hospital and Harvard Medical School Biography Publications Institution JoVE Articles Joseph Loscalzo has not added a biography. If you are Joseph Loscalzo and would like to personalize this page please email our Author Liaison for assistance. Publications American Heart Association Cardiovascular Genome-phenome Study: Foundational Basis and Program Circulation. Jan, 2015 | Pubmed ID: 25411155 A Randomized Trial of Social Media from Circulation Circulation. Jan, 2015 | Pubmed ID: 25406308 Network-based Association of Hypoxia-responsive Genes with Cardiovascular Diseases New Journal of Physics. Oct, 2014 | Pubmed ID: 25530704 Clinical Problem-solving. A Chilly Fever The New England Journal of Medicine. Nov, 2014 | Pubmed ID: 25372092 Clinical Problem-solving. Against the Grain The New England Journal of Medicine. Oct, 2014 | Pubmed ID: 25271607 A Division of Medical Communications in an Academic Medical Center's Department of Medicine Academic Medicine : Journal of the Association of American Medical Colleges. Dec, 2014 | Pubmed ID: 25186816 Clinical Problem-solving. A Tight Predicament The New England Journal of Medicine. Sep, 2014 | Pubmed ID: 25184868 Polymorphisms in Catechol-O-methyltransferase Modify Treatment Effects of Aspirin on Risk of Cardiovascular Disease Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2014 | Pubmed ID: 25035343 Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series) Pulmonary Circulation. Jun, 2014 | Pubmed ID: 25006435 Upregulation of Steroidogenic Acute Regulatory Protein by Hypoxia Stimulates Aldosterone Synthesis in Pulmonary Artery Endothelial Cells to Promote Pulmonary Vascular Fibrosis Circulation. Jul, 2014 | Pubmed ID: 25001622 Analyzing Networks of Phenotypes in Complex Diseases: Methodology and Applications in COPD BMC Systems Biology. 2014 | Pubmed ID: 24964944 Plasma Levels of the Proinflammatory Chitin-binding Glycoprotein YKL-40, Variation in the Chitinase 3-like 1 Gene (CHI3L1), and Incident Cardiovascular Events Journal of the American Heart Association. Jun, 2014 | Pubmed ID: 24958781 DiseaseConnect: a Comprehensive Web Server for Mechanism-based Disease-disease Connections Nucleic Acids Research. Jul, 2014 | Pubmed ID: 24895436 Real-time Assessment of the Metabolic Profile of Living Cells with Genetically Encoded NADH Sensors Methods in Enzymology. 2014 | Pubmed ID: 24862275 Keshan Disease, Selenium Deficiency, and the Selenoproteome The New England Journal of Medicine. May, 2014 | Pubmed ID: 24785212 Clinical Problem-solving. Out of the Blue The New England Journal of Medicine. May, 2014 | Pubmed ID: 24785210 Complexity and Network Dynamics in Physiological Adaptation: an Integrated View Physiology & Behavior. May, 2014 | Pubmed ID: 24751342 Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24719327 Clinical Problem-solving. Wasting Away The New England Journal of Medicine. Mar, 2014 | Pubmed ID: 24597870 A Celebration of Failure Circulation. Mar, 2014 | Pubmed ID: 24589694 Clinical Problem-solving. An Unusual Case of Abdominal Pain The New England Journal of Medicine. Jan, 2014 | Pubmed ID: 24382068 Hypoxamirs and Mitochondrial Metabolism Antioxidants & Redox Signaling. Sep, 2014 | Pubmed ID: 24111795 Systems Analysis of Oxidant Stress in the Vasculature IUBMB Life. Nov, 2013 | Pubmed ID: 24265198 Clinical Problem-solving. A Curious Case of Chest Pain The New England Journal of Medicine. Nov, 2013 | Pubmed ID: 24195552 Pulmonary Hypertension: Pathophysiology and Signaling Pathways Handbook of Experimental Pharmacology. 2013 | Pubmed ID: 24092335 SDF-1α in Glycan Nanoparticles Exhibits Full Activity and Reduces Pulmonary Hypertension in Rats Biomacromolecules. Nov, 2013 | Pubmed ID: 24059347 Clinical Problem-solving. A Patient with Syncope The New England Journal of Medicine. Sep, 2013 | Pubmed ID: 24004124 Methoxistasis: Integrating the Roles of Homocysteine and Folic Acid in Cardiovascular Pathobiology Nutrients. Aug, 2013 | Pubmed ID: 23955381 The Identification of Nitric Oxide As Endothelium-derived Relaxing Factor Circulation Research. Jul, 2013 | Pubmed ID: 23833290 Clinical Problem-solving. A Patient with Migrating Polyarthralgias The New England Journal of Medicine. Jul, 2013 | Pubmed ID: 23822780 Tumor Necrosis Factor-α-mediated Suppression of Dual-specificity Phosphatase 4: Crosstalk Between NFκB and MAPK Regulates Endothelial Cell Survival Molecular and Cellular Biochemistry. Oct, 2013 | Pubmed ID: 23812841 Effectiveness of Spironolactone Plus Ambrisentan for Treatment of Pulmonary Arterial Hypertension (from the [ARIES] Study 1 and 2 Trials) The American Journal of Cardiology. Sep, 2013 | Pubmed ID: 23751938 Clinical Problem-solving. Waiting for the Other Foot to Drop The New England Journal of Medicine. Jun, 2013 | Pubmed ID: 23738548 Hypoxia: a Master Regulator of MicroRNA Biogenesis and Activity Free Radical Biology & Medicine. Sep, 2013 | Pubmed ID: 23712003 Editor's Note Circulation. Apr, 2013 | Pubmed ID: 23662311 Clinical Problem-solving. In the Thick of It The New England Journal of Medicine. May, 2013 | Pubmed ID: 23635054 Gut Microbiota, the Genome, and Diet in Atherogenesis The New England Journal of Medicine. Apr, 2013 | Pubmed ID: 23614591 Ever at the Mercy of Well-intentioned Regulations: Their Adverse Consequences and Unproven Benefits Circulation. Mar, 2013 | Pubmed ID: 23509030 Venous Thrombosis in the Nephrotic Syndrome The New England Journal of Medicine. Mar, 2013 | Pubmed ID: 23465106 Selenistasis: Epistatic Effects of Selenium on Cardiovascular Phenotype Nutrients. Feb, 2013 | Pubmed ID: 23434902 From Clinical Observation to Mechanism--Heyde's Syndrome The New England Journal of Medicine. Feb, 2013 | Pubmed ID: 23388020 Clinical Problem-solving. The Search is On The New England Journal of Medicine. Feb, 2013 | Pubmed ID: 23388008 Alteration of Relation of Atherogenic Lipoprotein Cholesterol to Apolipoprotein B by Intensive Statin Therapy in Patients with Acute Coronary Syndrome (from the Limiting UNdertreatment of Lipids in ACS With Rosuvastatin [LUNAR] Trial) The American Journal of Cardiology. Feb, 2013 | Pubmed ID: 23237107 Plasma Aldosterone Levels Are Elevated in Patients with Pulmonary Arterial Hypertension in the Absence of Left Ventricular Heart Failure: a Pilot Study European Journal of Heart Failure. Mar, 2013 | Pubmed ID: 23111998 S-nitrosothiols and the S-nitrosoproteome of the Cardiovascular System Antioxidants & Redox Signaling. Jan, 2013 | Pubmed ID: 22770551 Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification Journal of the American Heart Association. Dec, 2012 | Pubmed ID: 23316327 Increasing Glucose 6-phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose PloS One. 2012 | Pubmed ID: 23185302 From Clinical Observation to Mechanism--Heyde's Syndrome The New England Journal of Medicine. Nov, 2012 | Pubmed ID: 23150964 Holding Our Breath: The Emerging and Anticipated Roles of MicroRNA in Pulmonary Hypertension Pulmonary Circulation. Jul, 2012 | Pubmed ID: 23130098 Clinical Problem-solving. A Complex Cause of Pleuritic Chest Pain The New England Journal of Medicine. Nov, 2012 | Pubmed ID: 23113486 Both Selenium Deficiency and Modest Selenium Supplementation Lead to Myocardial Fibrosis in Mice Via Effects on Redox-methylation Balance Molecular Nutrition & Food Research. Dec, 2012 | Pubmed ID: 23097236 Cardiomyogenesis in the Aging and Failing Human Heart Circulation. Oct, 2012 | Pubmed ID: 22955965 Network Medicine Approaches to the Genetics of Complex Diseases Discovery Medicine. Aug, 2012 | Pubmed ID: 22935211 Clinical Problem-solving. Breathtaking Journey The New England Journal of Medicine. Aug, 2012 | Pubmed ID: 22853017 Tracking Chromatid Segregation to Identify Human Cardiac Stem Cells That Regenerate Extensively the Infarcted Myocardium Circulation Research. Sep, 2012 | Pubmed ID: 22851539 The Emerging Paradigm of Network Medicine in the Study of Human Disease Circulation Research. Jul, 2012 | Pubmed ID: 22821909 Aldosterone Inactivates the Endothelin-B Receptor Via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension Circulation. Aug, 2012 | Pubmed ID: 22787113 Clinical Problem-solving. At a Loss The New England Journal of Medicine. Jul, 2012 | Pubmed ID: 22762321 Homocysteine and Cardiovascular Risk: the Perils of Reductionism in a Complex System Clinical Chemistry. Dec, 2012 | Pubmed ID: 22623744 Systems Pharmacology, Pharmacogenetics, and Clinical Trial Design in Network Medicine Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Jul-Aug, 2012 | Pubmed ID: 22581565 Clinical Problem-solving. Whistling in the Dark The New England Journal of Medicine. May, 2012 | Pubmed ID: 22551132 Regenerative Pulmonary Medicine: Potential and Promise, Pitfalls and Challenges European Journal of Clinical Investigation. Aug, 2012 | Pubmed ID: 22435680 Irreproducible Experimental Results: Causes, (mis)interpretations, and Consequences Circulation. Mar, 2012 | Pubmed ID: 22412087 Deciphering the Molecular Basis of Human Cardiovascular Disease Through Network Biology Current Opinion in Cardiology. May, 2012 | Pubmed ID: 22382498 Clinical Problem-solving. A Startling Decline The New England Journal of Medicine. Mar, 2012 | Pubmed ID: 22375976 MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach Circulation. Mar, 2012 | Pubmed ID: 22371328 Comparison of Lipid-modifying Efficacy of Rosuvastatin Versus Atorvastatin in Patients with Acute Coronary Syndrome (from the LUNAR Study) The American Journal of Cardiology. May, 2012 | Pubmed ID: 22360820 Clinical Problem-solving. Worth a Second Look The New England Journal of Medicine. Feb, 2012 | Pubmed ID: 22296081 Personalized Cardiovascular Medicine and Drug Development: Time for a New Paradigm Circulation. Jan, 2012 | Pubmed ID: 22294708 Homocysteine Induces Cardiomyocyte Dysfunction and Apoptosis Through P38 MAPK-mediated Increase in Oxidant Stress Journal of Molecular and Cellular Cardiology. Mar, 2012 | Pubmed ID: 22227328 Clinical Problem-solving. Breathless The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22216845 Redox Regulation of Mitochondrial Function Antioxidants & Redox Signaling. Jun, 2012 | Pubmed ID: 22146081 High-resolution Imaging of Selenium in Kidneys: a Localized Selenium Pool Associated with Glutathione Peroxidase 3 Antioxidants & Redox Signaling. Feb, 2012 | Pubmed ID: 21854231 Pulmonary Vascular Disease Related to Hemodynamic Stress in the Pulmonary Circulation Comprehensive Physiology. Jan, 2011 | Pubmed ID: 23737167 Physiological Stress Increases Renal Injury in ENOS-knockout Mice Hypertension Research : Official Journal of the Japanese Society of Hypertension. Dec, 2011 | Pubmed ID: 22170389 Clinical Problem-solving. A Bird's-eye View of Fever The New England Journal of Medicine. Nov, 2011 | Pubmed ID: 22047564 Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection Cell Metabolism. Oct, 2011 | Pubmed ID: 21982715 Systems Biology and the Future of Medicine Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Nov-Dec, 2011 | Pubmed ID: 21928407 Bone Morphogenetic Protein-2 Activates NADPH Oxidase to Increase Endoplasmic Reticulum Stress and Human Coronary Artery Smooth Muscle Cell Calcification Biochemical and Biophysical Research Communications. Sep, 2011 | Pubmed ID: 21907184 Tissue-specific Adult Stem Cells in the Human Lung Nature Medicine. Sep, 2011 | Pubmed ID: 21900912 Internal Medicine Residency Redesign: Proposal of the Internal Medicine Working Group The American Journal of Medicine. Sep, 2011 | Pubmed ID: 21854887 Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation The Journal of Biological Chemistry. Oct, 2011 | Pubmed ID: 21852236 Lipid Metabolism by Gut Microbes and Atherosclerosis Circulation Research. Jul, 2011 | Pubmed ID: 21737814 Clinical Problem-solving. A Sleeping Giant The New England Journal of Medicine. Jul, 2011 | Pubmed ID: 21732839 Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease Circulation. May, 2011 | Pubmed ID: 21576679 Hyperhomocysteinemia from Trimethylation of Hepatic Phosphatidylethanolamine During Cholesterol Cholelithogenesis in Inbred Mice Hepatology (Baltimore, Md.). Aug, 2011 | Pubmed ID: 21567442 Evidence for Human Lung Stem Cells The New England Journal of Medicine. May, 2011 | Pubmed ID: 21561345 Systems Biology and Personalized Medicine: a Network Approach to Human Disease Proceedings of the American Thoracic Society. May, 2011 | Pubmed ID: 21543801 Clinical Problem-solving. A Sweet Source of Abdominal Pain The New England Journal of Medicine. May, 2011 | Pubmed ID: 21542747 Glutathione Peroxidase-3 Deficiency Promotes Platelet-dependent Thrombosis in Vivo Circulation. May, 2011 | Pubmed ID: 21518981 Can Scientific Quality Be Quantified? Circulation. Mar, 2011 | Pubmed ID: 21382902 Clinical Problem-solving. Lying Low The New England Journal of Medicine. Mar, 2011 | Pubmed ID: 21366479 The Perils of Combination Antithrombotic Therapy and Potential Resolutions Stroke; a Journal of Cerebral Circulation. Feb, 2011 | Pubmed ID: 21263146 The Perils of Combination Antithrombotic Therapy and Potential Resolutions Circulation. Jan, 2011 | Pubmed ID: 21263004 Building a Departmental Quality Program: a Patient-based and Provider-led Approach Academic Medicine : Journal of the Association of American Medical Colleges. Mar, 2011 | Pubmed ID: 21248609 Clinical Problem-solving. A Crazy Cause of Dyspnea The New England Journal of Medicine. Jan, 2011 | Pubmed ID: 21208111 Both Maximal Expression of Selenoproteins and Selenoprotein Deficiency Can Promote Development of Type 2 Diabetes-like Phenotype in Mice Antioxidants & Redox Signaling. Jun, 2011 | Pubmed ID: 21194350 Network Medicine: a Network-based Approach to Human Disease Nature Reviews. Genetics. Jan, 2011 | Pubmed ID: 21164525 Glutathione Peroxidase-1 in Health and Disease: from Molecular Mechanisms to Therapeutic Opportunities Antioxidants & Redox Signaling. Oct, 2011 | Pubmed ID: 21087145 Reciprocal Regulation of 11β-hydroxysteroid Dehydrogenase 1 and Glucocorticoid Receptor Expression by Dexamethasone Inhibits Human Coronary Artery Smooth Muscle Cell Proliferation in Vitro Molecular and Cellular Biochemistry. Jan, 2011 | Pubmed ID: 20922465 Vascular Nitric Oxide: Formation and Function Journal of Blood Medicine. Aug, 2010 | Pubmed ID: 21572574 Clinical Problem-solving. Bitter Pills The New England Journal of Medicine. Nov, 2010 | Pubmed ID: 21047229 The Cellular Response to Hypoxia: Tuning the System with MicroRNAs The Journal of Clinical Investigation. Nov, 2010 | Pubmed ID: 20972325 Clinical Problem-solving. A Heavy Heart The New England Journal of Medicine. Oct, 2010 | Pubmed ID: 20925549 Strategic Plan for Lung Vascular Research: An NHLBI-ORDR Workshop Report American Journal of Respiratory and Critical Care Medicine. Dec, 2010 | Pubmed ID: 20833821 Clinical Problem-solving. Hard to Conceive The New England Journal of Medicine. Sep, 2010 | Pubmed ID: 20818907 Clinical Problem-solving. A Rash Hypothesis The New England Journal of Medicine. Jul, 2010 | Pubmed ID: 20592300 Nanoglycan Complex Formulation Extends VEGF Retention Time in the Lung Biomacromolecules. Jul, 2010 | Pubmed ID: 20575564 New Section in Circulation: Implications of Contemporary Clinical Trials Circulation. Jun, 2010 | Pubmed ID: 20530021 The Critical Roles of Platelet Activation and Reduced NO Bioavailability in Fatal Pulmonary Arterial Hypertension in a Murine Hemolysis Model Blood. Sep, 2010 | Pubmed ID: 20511540 Genetics and Beyond--the Transcriptome of Human Monocytes and Disease Susceptibility PloS One. 2010 | Pubmed ID: 20502693 Clinical Problem-solving. The Beat Goes On The New England Journal of Medicine. May, 2010 | Pubmed ID: 20445184 Evaluation of a Redesign Initiative in an Internal-medicine Residency The New England Journal of Medicine. Apr, 2010 | Pubmed ID: 20375407 MicroRNA-210: a Unique and Pleiotropic Hypoxamir Cell Cycle (Georgetown, Tex.). Mar, 2010 | Pubmed ID: 20237418 Glutathione Peroxidase-1 Modulates Lipopolysaccharide-induced Adhesion Molecule Expression in Endothelial Cells by Altering CD14 Expression FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2010 | Pubmed ID: 20219985 Clinical Problem-solving. Stalking the Diagnosis The New England Journal of Medicine. Mar, 2010 | Pubmed ID: 20200388 Antioxidant Enzyme Deficiencies and Vascular Disease Expert Review of Endocrinology & Metabolism. Jan, 2010 | Pubmed ID: 20190873 Clinical Problem-solving. Painful Purple Toes The New England Journal of Medicine. Jan, 2010 | Pubmed ID: 20054049 High Glucose Inhibits Glucose-6-phosphate Dehydrogenase, Leading to Increased Oxidative Stress and Beta-cell Apoptosis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2010 | Pubmed ID: 20032314 The Effect of Salt on Renal Damage in ENOS-deficient Mice Hypertension Research : Official Journal of the Japanese Society of Hypertension. Feb, 2010 | Pubmed ID: 19960018 Serum Selenium and Prognosis in Cardiovascular Disease: Results from the AtheroGene Study Atherosclerosis. Mar, 2010 | Pubmed ID: 19836749 Glucose-6-phosphate Dehydrogenase-deficient Mice Have Increased Renal Oxidative Stress and Increased Albuminuria FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2010 | Pubmed ID: 19805580 Clinical Problem-solving. A Bloody Mystery The New England Journal of Medicine. Nov, 2009 | Pubmed ID: 19890132 Homocysteine-mediated Thrombosis and Angiostasis in Vascular Pathobiology The Journal of Clinical Investigation. Nov, 2009 | Pubmed ID: 19841539 MicroRNA-210 Controls Mitochondrial Metabolism During Hypoxia by Repressing the Iron-sulfur Cluster Assembly Proteins ISCU1/2 Cell Metabolism. Oct, 2009 | Pubmed ID: 19808020 Glutathione Peroxidase Deficiency Exacerbates Ischemia-reperfusion Injury in Male but Not Female Myocardium: Insights into Antioxidant Compensatory Mechanisms American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2009 | Pubmed ID: 19801492 Clinical Problem-solving. The Writing on the Wall The New England Journal of Medicine. Oct, 2009 | Pubmed ID: 19797286 Oxidative Risk for Atherothrombotic Cardiovascular Disease Free Radical Biology & Medicine. Dec, 2009 | Pubmed ID: 19751821 The Effect of L-arginine and Creatine on Vascular Function and Homocysteine Metabolism Vascular Medicine (London, England). Aug, 2009 | Pubmed ID: 19651674 Clinical Problem-solving. A Fragile Balance The New England Journal of Medicine. Jul, 2009 | Pubmed ID: 19571286 Quo Vadis: Whither Homocysteine Research? Cardiovascular Toxicology. Jun, 2009 | Pubmed ID: 19484390 Pilot Trials in Clinical Research: of What Value Are They? Circulation. Apr, 2009 | Pubmed ID: 19349331 Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses The Journal of Biological Chemistry. May, 2009 | Pubmed ID: 19254950 Balancing Role of Nitric Oxide in Complement-mediated Activation of Platelets from MCd59a and MCd59b Double-knockout Mice American Journal of Hematology. Apr, 2009 | Pubmed ID: 19229985 Regulation of the Extracellular Antioxidant Selenoprotein Plasma Glutathione Peroxidase (GPx-3) in Mammalian Cells Molecular and Cellular Biochemistry. Jul, 2009 | Pubmed ID: 19219623 Aldosterone Increases Oxidant Stress to Impair Guanylyl Cyclase Activity by Cysteinyl Thiol Oxidation in Vascular Smooth Muscle Cells The Journal of Biological Chemistry. Mar, 2009 | Pubmed ID: 19141618 Sleep and Cardiovascular Disease: an Overview Progress in Cardiovascular Diseases. Jan-Feb, 2009 | Pubmed ID: 19110129 The Treatment of Hyperhomocysteinemia Annual Review of Medicine. 2009 | Pubmed ID: 18729731 Oxidative Mechanisms and Atherothrombotic Cardiovascular Disease Drug Discovery Today. Therapeutic Strategies. Mar, 2008 | Pubmed ID: 21048889 Paraoxonase and Coronary Heart Disease Risk: Language Misleads, Linkage Misinforms, Function Clarifies Circulation. Cardiovascular Genetics. Dec, 2008 | Pubmed ID: 20031548 A Statement on Ethics from the HEART Group JACC. Cardiovascular Imaging. May, 2008 | Pubmed ID: 19356460 Selenium Supplementation Improves Antioxidant Capacity in Vitro and in Vivo in Patients with Coronary Artery Disease The SElenium Therapy in Coronary Artery Disease Patients (SETCAP) Study American Heart Journal. Dec, 2008 | Pubmed ID: 19033020 Membrane Redox State and Apoptosis: Death by Peroxide Cell Metabolism. Sep, 2008 | Pubmed ID: 18762018 Hepatocellular Carcinoma with Intracavitary Cardiac Involvement: a Case Report and Review of the Literature The American Journal of Cardiology. Sep, 2008 | Pubmed ID: 18721529 Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-stage Renal Disease: a Proof of Principle Clinical Chemistry. Sep, 2008 | Pubmed ID: 18676588 Inflammation, Endothelial Injury, and Persistent Pulmonary Hypertension in Heterozygous BMPR2-mutant Mice American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2008 | Pubmed ID: 18552156 Role of Oxidative Stress and Nitric Oxide in Atherothrombosis Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 18508590 Lipid Levels After Acute Coronary Syndromes Journal of the American College of Cardiology. Apr, 2008 | Pubmed ID: 18402897 Task Force 7: Training in Cardiovascular Research Journal of the American College of Cardiology. Jan, 2008 | Pubmed ID: 18206756 Redox Regulation in the Extracellular Environment Circulation Journal : Official Journal of the Japanese Circulation Society. Jan, 2008 | Pubmed ID: 18159092 Role of Promoter Polymorphisms in the Plasma Glutathione Peroxidase (GPx-3) Gene As a Risk Factor for Cerebral Venous Thrombosis Stroke; a Journal of Cerebral Circulation. Feb, 2008 | Pubmed ID: 18096833 Pathogenic Mechanisms of Pulmonary Arterial Hypertension Journal of Molecular and Cellular Cardiology. Jan, 2008 | Pubmed ID: 17950310 Should Hyperhomocysteinemia Be Treated in Patients with Atherosclerotic Disease? Current Atherosclerosis Reports. Nov, 2007 | Pubmed ID: 18001620 Association Studies in an Era of Too Much Information: Clinical Analysis of New Biomarker and Genetic Data Circulation. Oct, 2007 | Pubmed ID: 17965399 Frontiers in Nephrology: Targeting Inflammation Using Novel Nitric Oxide Donors Journal of the American Society of Nephrology : JASN. Nov, 2007 | Pubmed ID: 17942956 The Frequency of Anticardiolipin Antibodies and Genetic Mutations Associated with Hypercoagulability Among Patients with Wegener's Granulomatosis with and Without History of a Thrombotic Event The Journal of Rheumatology. Dec, 2007 | Pubmed ID: 17918782 Homocysteine and Glutathione Peroxidase-1 Antioxidants & Redox Signaling. Nov, 2007 | Pubmed ID: 17822368 Human Alpha B-crystallin Mutation Causes Oxido-reductive Stress and Protein Aggregation Cardiomyopathy in Mice Cell. Aug, 2007 | Pubmed ID: 17693254 Usefulness of the Aldosterone Synthase Gene Polymorphism C-344-T to Predict Cardiac Remodeling in African-Americans Versus Non-African-Americans with Chronic Systolic Heart Failure The American Journal of Cardiology. Jul, 2007 | Pubmed ID: 17631084 Human Disease Classification in the Postgenomic Era: a Complex Systems Approach to Human Pathobiology Molecular Systems Biology. 2007 | Pubmed ID: 17625512 Regulation of the Protein Disulfide Proteome by Mitochondria in Mammalian Cells Proceedings of the National Academy of Sciences of the United States of America. Jun, 2007 | Pubmed ID: 17581874 Entrepreneurship in the Medical Academy: Possibilities and Challenges in Commercialization of Research Discoveries Circulation. Mar, 2007 | Pubmed ID: 17389277 Effect of FXIII on Monocyte and Fibroblast Function Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2007 | Pubmed ID: 17310105 Aldosterone Impairs Vascular Reactivity by Decreasing Glucose-6-phosphate Dehydrogenase Activity Nature Medicine. Feb, 2007 | Pubmed ID: 17273168 Promoter Polymorphisms in the Plasma Glutathione Peroxidase (GPx-3) Gene: a Novel Risk Factor for Arterial Ischemic Stroke Among Young Adults and Children Stroke; a Journal of Cerebral Circulation. Jan, 2007 | Pubmed ID: 17122425 Predictors of Improved Left Ventricular Systolic Function in an Urban Cardiomyopathy Program The American Journal of Cardiology. Dec, 2006 | Pubmed ID: 17145222 Vascular Calcification: Pathobiological Mechanisms and Clinical Implications Circulation Research. Nov, 2006 | Pubmed ID: 17095733 Homocysteine Clinics in Laboratory Medicine. Sep, 2006 | Pubmed ID: 16938586 Different Effects of Angiotensin Receptor Blockade on End-organ Damage in Salt-dependent and Salt-independent Hypertension Circulation. Aug, 2006 | Pubmed ID: 16923758 The NIH Budget and the Future of Biomedical Research The New England Journal of Medicine. Apr, 2006 | Pubmed ID: 16625006 Pulmonary Arterial Hypertension Annals of Medicine. 2006 | Pubmed ID: 16581695 Joseph Loscalzo, MD, PhD: a Conversation with the Editor. Interview by William Clifford Roberts The American Journal of Cardiology. Apr, 2006 | Pubmed ID: 16563929 Nitric Oxide and Posttranslational Modification of the Vascular Proteome: S-nitrosation of Reactive Thiols Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2006 | Pubmed ID: 16543494 Homocysteine Trials--clear Outcomes for Complex Reasons The New England Journal of Medicine. Apr, 2006 | Pubmed ID: 16531615 Evaluation of the Pro-angiogenic Effect of Factor XIII in Heterotopic Mouse Heart Allografts and FXIII-deficient Mice Thrombosis and Haemostasis. Mar, 2006 | Pubmed ID: 16525585 Glucose-6-phosphate Dehydrogenase Deficiency Decreases Vascular Superoxide and Atherosclerotic Lesions in Apolipoprotein E(-/-) Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2006 | Pubmed ID: 16439706 Impaired Angiogenesis in Glutathione Peroxidase-1-deficient Mice is Associated with Endothelial Progenitor Cell Dysfunction Circulation Research. Feb, 2006 | Pubmed ID: 16373599 Aminoglycosides Decrease Glutathione Peroxidase-1 Activity by Interfering with Selenocysteine Incorporation The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16354666 Identification of Cholesteryl Esters in Human Carotid Atherosclerosis by Ex Vivo Image-guided Proton MRS Journal of Lipid Research. Feb, 2006 | Pubmed ID: 16317172 Elevated Levels of Homocysteine Compromise Blood-brain Barrier Integrity in Mice Blood. Jan, 2006 | Pubmed ID: 16189268 Mechanism of Disease: Pulmonary Hypertension Discovery Medicine. Feb, 2005 | Pubmed ID: 20704929 Clinical Trials in Cardiovascular Medicine in an Era of Marginal Benefit, Bias, and Hyperbole Circulation. Nov, 2005 | Pubmed ID: 16286598 Cyclooxygenase Inhibition and Cardiovascular Risk Circulation. Aug, 2005 | Pubmed ID: 16061757 Increased Susceptibility to Pulmonary Hypertension in Heterozygous BMPR2-mutant Mice Circulation. Jul, 2005 | Pubmed ID: 16027259 Glucose-6 Phosphate Dehydrogenase Deficiency Decreases the Vascular Response to Angiotensin II Circulation. Jul, 2005 | Pubmed ID: 15998684 Genetic Determinants of Vascular Oxidant Stress and Endothelial Dysfunction Congestive Heart Failure (Greenwich, Conn.). Mar-Apr, 2005 | Pubmed ID: 15860972 Endogenous Mechanisms of Inhibition of Platelet Function Microcirculation (New York, N.Y. : 1994). Apr-May, 2005 | Pubmed ID: 15814434 Adenosine-dependent Induction of Glutathione Peroxidase 1 in Human Primary Endothelial Cells and Protection Against Oxidative Stress Circulation Research. Apr, 2005 | Pubmed ID: 15802613 Oxidative Enzymopathies and Vascular Disease Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2005 | Pubmed ID: 15790928 Discovering the Full Spectrum of Cardiovascular Disease: Minority Health Summit 2003: Report of the Basic Science Writing Group Circulation. Mar, 2005 | Pubmed ID: 15769753 Homocysteine Down-regulates Cellular Glutathione Peroxidase (GPx1) by Decreasing Translation The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15734734 Molecular Mechanisms Underlying the Proangiogenic Effect of Factor XIII Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2005 | Pubmed ID: 15618543 S-nitrosoprotein Formation and Localization in Endothelial Cells Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15618409 Coronary Calcium Screening and the American Heart Association News Embargo Circulation. Dec, 2004 | Pubmed ID: 15583087 Ethics and Professionalism: Can There Be Consensus? An Editorial Comment on the Report of the ACCF/AHA Consensus Conference on Professionalism and Ethics Circulation. Oct, 2004 | Pubmed ID: 15492327 Pulmonary Arterial Hypertension The New England Journal of Medicine. Oct, 2004 | Pubmed ID: 15483284 L-arginine and Atherothrombosis The Journal of Nutrition. Oct, 2004 | Pubmed ID: 15465788 Nitric Oxide Insufficiency and Atherothrombosis Histochemistry and Cell Biology. Oct, 2004 | Pubmed ID: 15338226 Atherosclerotic Vascular Disease Conference: Writing Group III: Pathophysiology Circulation. Jun, 2004 | Pubmed ID: 15173044 Atherosclerotic Vascular Disease Conference: Executive Summary: Atherosclerotic Vascular Disease Conference Proceeding for Healthcare Professionals from a Special Writing Group of the American Heart Association Circulation. Jun, 2004 | Pubmed ID: 15173041 Fremstilling og karakterisering af SDF-1α-Chitosan-dextransulfat Nanopartikler Andrew R. Bader1, Tina Li1, Weiping Wang2, Daniel S. Kohane2, Joseph Loscalzo1, Ying-Yi Zhang1 1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 2Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care, Boston Children's Hospital Chemistry
Fremstilling og karakterisering af SDF-1α-Chitosan-dextransulfat Nanopartikler Andrew R. Bader1, Tina Li1, Weiping Wang2, Daniel S. Kohane2, Joseph Loscalzo1, Ying-Yi Zhang1 1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 2Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care, Boston Children's Hospital Chemistry