Juanita L. Merchant Department of Internal Medicine-Gastroenterology University of Michigan Biography Publications Institution JoVE Articles Juanita L. Merchant has not added a biography. If you are Juanita L. Merchant and would like to personalize this page please email our Author Liaison for assistance. Publications Mature Enteroendocrine Cells Contributes to Basal and Pathological Stem Cell Dynamics in the Small Intestine American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2018 | Pubmed ID: 29848020 Parietal Cell Death by Cytokines Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 29713663 Indian Hedgehog Suppresses Intestinal Inflammation Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 29276751 ZBP-89 Function in Colonic Stem Cells and During Butyrate-induced Senescence Oncotarget. Nov, 2017 | Pubmed ID: 29212231 Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells Gastroenterology. 12, 2017 | Pubmed ID: 28859856 Pathophysiology of Gastric NETs: Role of Gastrin and Menin Current Gastroenterology Reports. Jul, 2017 | Pubmed ID: 28608155 A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance Gastroenterology. Jul, 2017 | Pubmed ID: 28583825 Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca Efflux Channel in the Tubulovesicle Developmental Cell. 05, 2017 | Pubmed ID: 28486130 Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions Cellular and Molecular Gastroenterology and Hepatology. Mar, 2017 | Pubmed ID: 28275687 Weight Gain in Mice on a High Caloric Diet and Chronically Treated with Omeprazole Depends on Sex and Genetic Background American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2017 | Pubmed ID: 27810953 NF-κB Mediated Transcription of DARPP-32 Prevents -induced Cell Death Gut. 05, 2017 | Pubmed ID: 27789656 SCHLAFEN 5 Expression Correlates with Intestinal Metaplasia That Progresses to Gastric Cancer Journal of Gastroenterology. Jan, 2017 | Pubmed ID: 27032393 Deletion of and Induces Hypergastrinemia and Gastric Carcinoids Gut. 06, 2017 | Pubmed ID: 26860771 Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer Cancer Research. 12, 2016 | Pubmed ID: 27758879 Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 27573785 Schlafen 4-expressing Myeloid-derived Suppressor Cells Are Induced During Murine Gastric Metaplasia The Journal of Clinical Investigation. 08, 2016 | Pubmed ID: 27427984 Invasive Mouse Gastric Adenocarcinomas Arising from Lgr5+ Stem Cells Are Dependent on Crosstalk Between the Hedgehog/GLI2 and MTOR Pathways Oncotarget. Mar, 2016 | Pubmed ID: 26859571 Increased Expression of DUOX2 Is an Epithelial Response To Mucosal Dysbiosis Required for Immune Homeostasis In Mouse Intestine Gastroenterology. Dec, 2015 | Pubmed ID: 26261005 Stress Hematopoiesis is Regulated by the Krüppel-like Transcription Factor ZBP-89 Stem Cells (Dayton, Ohio). Mar, 2014 | Pubmed ID: 24549639 Inhibition of Hedgehog Signaling in the Gastrointestinal Tract: Targeting the Cancer Microenvironment Cancer Treatment Reviews. Feb, 2014 | Pubmed ID: 24007940 Identification of a Functional TPH1 Polymorphism Associated with Irritable Bowel Syndrome Bowel Habit Subtypes The American Journal of Gastroenterology. Nov, 2013 | Pubmed ID: 24060757 Epigenetic Upregulation of Bak by ZBP-89 Inhibits the Growth of Hepatocellular Carcinoma Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 23954442 Dual Oxidases Control Release of Hydrogen Peroxide by the Gastric Epithelium to Prevent Helicobacter Felis Infection and Inflammation in Mice Gastroenterology. Nov, 2013 | Pubmed ID: 23860501 Gli1 Deletion Prevents Helicobacter-induced Gastric Metaplasia and Expansion of Myeloid Cell Subsets PloS One. 2013 | Pubmed ID: 23520544 ZBP-89 Regulates Expression of Tryptophan Hydroxylase I and Mucosal Defense Against Salmonella Typhimurium in Mice Gastroenterology. Jun, 2013 | Pubmed ID: 23395646 Inflammation and Gli2 Suppress Gastrin Gene Expression in a Murine Model of Antral Hyperplasia PloS One. 2012 | Pubmed ID: 23110168 Butyrate Increases IL-23 Production by Stimulated Dendritic Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2012 | Pubmed ID: 23086919 Transgenic Expression of Interferon-γ in Mouse Stomach Leads to Inflammation, Metaplasia, and Dysplasia The American Journal of Pathology. Dec, 2012 | Pubmed ID: 23036899 Conditional Deletion of Menin Results in Antral G Cell Hyperplasia and Hypergastrinemia American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2012 | Pubmed ID: 22766853 IFNγ Contributes to the Development of Gastric Epithelial Cell Metaplasia in Huntingtin Interacting Protein 1 Related (Hip1r)-deficient Mice Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2012 | Pubmed ID: 22525425 A High-fat Diet Regulates Gastrin and Acid Secretion Through Primary Cilia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2012 | Pubmed ID: 22516298 Plasma Shh Levels Reduced in Pancreatic Cancer Patients Pancreas. Oct, 2012 | Pubmed ID: 22513293 The Same Pocket in Menin Binds Both MLL and JUND but Has Opposite Effects on Transcription Nature. Feb, 2012 | Pubmed ID: 22327296 Interaction Between ZBP-89 and P53 Mutants and Its Contribution to Effects of HDACi on Hepatocellular Carcinoma Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22214764 Hedgehog Signalling in Gut Development, Physiology and Cancer The Journal of Physiology. Feb, 2012 | Pubmed ID: 22144577 Menin and JunD Regulate Gastrin Gene Expression Through Proximal DNA Elements American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2011 | Pubmed ID: 21852362 Gastric Tuft Cells Express DCLK1 and Are Expanded in Hyperplasia Histochemistry and Cell Biology. Aug, 2011 | Pubmed ID: 21688022 ZBP-89 Enhances Bak Expression and Causes Apoptosis in Hepatocellular Carcinoma Cells Biochimica Et Biophysica Acta. Jan, 2011 | Pubmed ID: 20850481 Histamine 3 Receptor Activation Mediates Inhibition of Acid Secretion During Helicobacter-induced Gastritis World Journal of Gastrointestinal Pathophysiology. Dec, 2010 | Pubmed ID: 21607157 Helicobacter Pylori Induction of the Gastrin Promoter Through GC-rich DNA Elements Helicobacter. Oct, 2010 | Pubmed ID: 21083750 Hedgehog Signaling in Gastric Physiology and Cancer Progress in Molecular Biology and Translational Science. 2010 | Pubmed ID: 21075343 Bone Morphogenetic Protein Signaling Regulates Gastric Epithelial Cell Development and Proliferation in Mice Gastroenterology. Dec, 2010 | Pubmed ID: 20826155 Intracellular Calcium Release and Protein Kinase C Activation Stimulate Sonic Hedgehog Gene Expression During Gastric Acid Secretion Gastroenterology. Dec, 2010 | Pubmed ID: 20816837 Hedgehog Signaling and Gastrointestinal Cancer Biochimica Et Biophysica Acta. Jul, 2010 | Pubmed ID: 20307590 Hedgehog is an Anti-inflammatory Epithelial Signal for the Intestinal Lamina Propria Gastroenterology. Jun, 2010 | Pubmed ID: 20206176 Underrepresentation of Underrepresented Minorities in Academic Medicine: the Need to Enhance the Pipeline and the Pipe Gastroenterology. Jan, 2010 | Pubmed ID: 19944787 Interleukin-1beta Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog Gastroenterology. Feb, 2010 | Pubmed ID: 19883649 Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning Gastroenterology. Aug, 2009 | Pubmed ID: 19445942 ZBP-89 Reduces the Cell Death Threshold in Hepatocellular Carcinoma Cells by Increasing Caspase-6 and S Phase Cell Cycle Arrest Cancer Letters. Sep, 2009 | Pubmed ID: 19362768 Sonic Hedgehog in Gastric Physiology and Neoplastic Transformation: Friend or Foe? Current Opinion in Endocrinology, Diabetes, and Obesity. Feb, 2009 | Pubmed ID: 19104239 Induction of Follistatin Precedes Gastric Transformation in Gastrin Deficient Mice Biochemical and Biophysical Research Communications. Nov, 2008 | Pubmed ID: 18804092 Somatostatin Stimulates Menin Gene Expression by Inhibiting Protein Kinase A American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2008 | Pubmed ID: 18755809 Hip1r is Expressed in Gastric Parietal Cells and is Required for Tubulovesicle Formation and Cell Survival in Mice The Journal of Clinical Investigation. Jul, 2008 | Pubmed ID: 18535670 Regulated Expression of the Human Gastrin Gene in Mice Regulatory Peptides. Nov, 2008 | Pubmed ID: 18456349 What Lurks Beneath: IL-11, Via Stat3, Promotes Inflammation-associated Gastric Tumorigenesis The Journal of Clinical Investigation. May, 2008 | Pubmed ID: 18431518 Prospective Identification of a Multilineage Progenitor in Murine Stomach Epithelium Gastroenterology. Dec, 2007 | Pubmed ID: 18054570 A Role for CITED2, a CBP/p300 Interacting Protein, in Colon Cancer Cell Invasion FEBS Letters. Dec, 2007 | Pubmed ID: 18054336 Sumoylation-dependent Control of Homotypic and Heterotypic Synergy by the Kruppel-type Zinc Finger Protein ZBP-89 The Journal of Biological Chemistry. Dec, 2007 | Pubmed ID: 17940278 Reduced Pepsin A Processing of Sonic Hedgehog in Parietal Cells Precedes Gastric Atrophy and Transformation The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17872943 H Pylori Infection Causes Chronic Pancreatitis in Mongolian Gerbils World Journal of Gastroenterology. Aug, 2007 | Pubmed ID: 17663507 ATM Phosphorylates ZBP-89 at Ser202 to Potentiate P21waf1 Induction by Butyrate Biochemical and Biophysical Research Communications. Aug, 2007 | Pubmed ID: 17560543 Tales from the Crypts: Regulatory Peptides and Cytokines in Gastrointestinal Homeostasis and Disease The Journal of Clinical Investigation. Jan, 2007 | Pubmed ID: 17200701 Intestinal Overexpression of ZNF148 Suppresses ApcMin/+ Neoplasia Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2006 | Pubmed ID: 17019648 Recruitment of Ataxia-telangiectasia Mutated to the P21(waf1) Promoter by ZBP-89 Plays a Role in Mucosal Protection Gastroenterology. Sep, 2006 | Pubmed ID: 16952553 P53 Mutants Suppress ZBP-89 Function Anticancer Research. May-Jun, 2006 | Pubmed ID: 16827139 Inhibition of Growth Hormone Receptor Gene Expression by Saturated Fatty Acids: Role of Kruppel-like Zinc Finger Factor, ZBP-89 Molecular Endocrinology (Baltimore, Md.). Nov, 2006 | Pubmed ID: 16825291 An Isoform of ZBP-89 Predisposes the Colon to Colitis Nucleic Acids Research. 2006 | Pubmed ID: 16517939 Helicobacter Pylori-secreted Factors Inhibit Dendritic Cell IL-12 Secretion: a Mechanism of Ineffective Host Defense American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2006 | Pubmed ID: 16469828 Parietal Cell Hyperstimulation and Autoimmune Gastritis in Cholera Toxin Transgenic Mice American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2006 | Pubmed ID: 16399875 Somatostatin Inhibits Dendritic Cell Responsiveness to Helicobacter Pylori Regulatory Peptides. Mar, 2006 | Pubmed ID: 16375983 Helicobacter Pylori Outer Membrane Protein 18 (Hp1125) Induces Dendritic Cell Maturation and Function Helicobacter. Oct, 2005 | Pubmed ID: 16181353 Inflammation, Atrophy, Gastric Cancer: Connecting the Molecular Dots Gastroenterology. Sep, 2005 | Pubmed ID: 16143144 Interferon Gamma Induction of Gastric Mucous Neck Cell Hypertrophy Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2005 | Pubmed ID: 15765119 Chronic Gastritis in the Hypochlorhydric Gastrin-deficient Mouse Progresses to Adenocarcinoma Oncogene. Mar, 2005 | Pubmed ID: 15735748 Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15691835 Modulating the Cytokine Response to Treat Helicobacter Gastritis Biochemical Pharmacology. Feb, 2005 | Pubmed ID: 15652228 The Epstein-Barr Virus Protein BMRF1 Activates Gastrin Transcription Journal of Virology. Jan, 2005 | Pubmed ID: 15613302 Helicobacter-induced Intestinal Metaplasia in the Stomach Correlates with Elk-1 and Serum Response Factor Induction of Villin The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15576363 Kinetic Profiles of P300 Occupancy in Vivo Predict Common Features of Promoter Structure and Coactivator Recruitment Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15286281 Inflammation and Cancer III. Somatostatin and the Innate Immune System American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2004 | Pubmed ID: 15068961 Transcription Factor ZBP-89 is Required for STAT1 Constitutive Expression Nucleic Acids Research. Dec, 2003 | Pubmed ID: 14654702 Treatment of Helicobacter Gastritis with IL-4 Requires Somatostatin Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003 | Pubmed ID: 14555768 ZBP-89 Mediates Butyrate Regulation of Gene Expression The Journal of Nutrition. 07, 2003 | Pubmed ID: 12840224 Acinetobacter Lwoffii Infection and Gastritis Microbes and Infection. Jun, 2003 | Pubmed ID: 12787741 Mutation of P53 in Recurrent Hepatocellular Carcinoma and Its Association with the Expression of ZBP-89 The American Journal of Pathology. Jun, 2003 | Pubmed ID: 12759240 A Model for Integrative Study of Human Gastric Acid Secretion Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2003 | Pubmed ID: 12433865 Regulation of Epithelial Cell Growth by ZBP-89: Potential Relevance in Pancreatic Cancer International Journal of Gastrointestinal Cancer. 2002 | Pubmed ID: 12622418 Genetic or Chemical Hypochlorhydria is Associated with Inflammation That Modulates Parietal and G-cell Populations in Mice Gastroenterology. Jan, 2002 | Pubmed ID: 11781287 VacA Pores As Portable Portals for Urea The Journal of Clinical Investigation. Sep, 2001 | Pubmed ID: 11560948 ZBP-89 Promotes Growth Arrest Through Stabilization of P53 Molecular and Cellular Biology. Jul, 2001 | Pubmed ID: 11416144 An OmpA-like Protein from Acinetobacter Spp. Stimulates Gastrin and Interleukin-8 Promoters Infection and Immunity. Jun, 2000 | Pubmed ID: 10816525 Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse Zhen Wang1,4, Ramon Ocadiz-Ruiz1, Sinju Sundaresan1, Lin Ding1, Michael Hayes1, Nirakar Sahoo3, Haoxing Xu1,2, Juanita L. Merchant1,2,5 1Department of Internal Medicine-Gastroenterology, University of Michigan, 2Department of Molecular and Integrative Physiology, University of Michigan, 3Department of Molecular, Cellular and Developmental Biology, University of Michigan, 4Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 5Division of Gastroenterology, University of Arizona College of Medicine JoVE 57629 Biology
Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse Zhen Wang1,4, Ramon Ocadiz-Ruiz1, Sinju Sundaresan1, Lin Ding1, Michael Hayes1, Nirakar Sahoo3, Haoxing Xu1,2, Juanita L. Merchant1,2,5 1Department of Internal Medicine-Gastroenterology, University of Michigan, 2Department of Molecular and Integrative Physiology, University of Michigan, 3Department of Molecular, Cellular and Developmental Biology, University of Michigan, 4Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 5Division of Gastroenterology, University of Arizona College of Medicine JoVE 57629 Biology