Kathrin Plath Department of Biological Chemistry David Geffen School of Medicine Biography Publications Institution JoVE Articles Kathrin Plath has not added a biography. If you are Kathrin Plath and would like to personalize this page please email our Author Liaison for assistance. Publications The Role of Xist in X-Chromosome Dosage Compensation Trends in Cell Biology. Jun, 2018 | Pubmed ID: 29910081 Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence Stem Cell Reports. May, 2018 | Pubmed ID: 29742391 X Chromosome Dosage Influences DNA Methylation Dynamics During Reprogramming to Mouse IPSCs Stem Cell Reports. May, 2018 | Pubmed ID: 29681539 High-Throughput Screening of a Luciferase Reporter of Gene Silencing on the Inactive X Chromosome Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29671264 Analysis of Cardiomyocyte Clonal Expansion During Mouse Heart Development and Injury Nature Communications. 02, 2018 | Pubmed ID: 29467410 Regulation of X-chromosome Dosage Compensation in Human: Mechanisms and Model Systems Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Nov, 2017 | Pubmed ID: 28947660 Cbx3 Maintains Lineage Specificity During Neural Differentiation Genes & Development. 02, 2017 | Pubmed ID: 28270516 Cooperative Binding of Transcription Factors Orchestrates Reprogramming Cell. 01, 2017 | Pubmed ID: 28111071 Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation Cell Stem Cell. 01, 2017 | Pubmed ID: 27989770 Human Embryonic Stem Cells Do Not Change Their X Inactivation Status During Differentiation Cell Reports. 01, 2017 | Pubmed ID: 27989715 Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State Cell Stem Cell. 10, 2016 | Pubmed ID: 27618217 Transcriptome Encyclopedia of Early Human Development Cell. May, 2016 | Pubmed ID: 27153491 The "lnc" Between 3D Chromatin Structure and X Chromosome Inactivation Seminars in Cell & Developmental Biology. 08, 2016 | Pubmed ID: 27062886 X Chromosome Reactivation in Reprogramming and in Development Current Opinion in Cell Biology. Dec, 2015 | Pubmed ID: 26540406 A High-throughput Screen of Inactive X Chromosome Reactivation Identifies the Enhancement of DNA Demethylation by 5-aza-2'-dC Upon Inhibition of Ribonucleotide Reductase Epigenetics & Chromatin. 2015 | Pubmed ID: 26468331 The Xist LncRNA Interacts Directly with SHARP to Silence Transcription Through HDAC3 Nature. May, 2015 | Pubmed ID: 25915022 X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency Cell. Dec, 2014 | Pubmed ID: 25525883 The Mbd1-Atf7ip-Setdb1 Pathway Contributes to the Maintenance of X Chromosome Inactivation Epigenetics & Chromatin. 2014 | Pubmed ID: 25028596 A Mechanistic Link Between Gene Regulation and Genome Architecture in Mammalian Development Current Opinion in Genetics & Development. Aug, 2014 | Pubmed ID: 24998386 The Xist LncRNA Exploits Three-dimensional Genome Architecture to Spread Across the X Chromosome Science (New York, N.Y.). Aug, 2013 | Pubmed ID: 23828888 Stage-specific Regulation of Reprogramming to Induced Pluripotent Stem Cells by Wnt Signaling and T Cell Factor Proteins Cell Reports. Jun, 2013 | Pubmed ID: 23791530 Proteomic and Genomic Approaches Reveal Critical Functions of H3K9 Methylation and Heterochromatin Protein-1γ in Reprogramming to Pluripotency Nature Cell Biology. Jul, 2013 | Pubmed ID: 23748610 The Pluripotency Factor-bound Intron 1 of Xist is Dispensable for X Chromosome Inactivation and Reactivation in Vitro and in Vivo Cell Reports. Mar, 2013 | Pubmed ID: 23523354 Epigenetics of Reprogramming to Induced Pluripotency Cell. Mar, 2013 | Pubmed ID: 23498940 Pluripotency in 3D: Genome Organization in Pluripotent Cells Current Opinion in Cell Biology. Dec, 2012 | Pubmed ID: 23199754 Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function Cell Reports. Nov, 2012 | Pubmed ID: 23177621 Stem Cells in the Land of the Rising Sun: ISSCR 2012 Cell Stem Cell. Nov, 2012 | Pubmed ID: 23122288 Pluripotency Re-centered Around Esrrb The EMBO Journal. Nov, 2012 | Pubmed ID: 23064149 Characterization and Therapeutic Potential of Induced Pluripotent Stem Cell-derived Cardiovascular Progenitor Cells PloS One. 2012 | Pubmed ID: 23056209 Concise Review: Pluripotency and the Transcriptional Inactivation of the Female Mammalian X Chromosome Stem Cells (Dayton, Ohio). Jan, 2012 | Pubmed ID: 21997775 Mediator Coordinates PIC Assembly with Recruitment of CHD1 Genes & Development. Oct, 2011 | Pubmed ID: 21979373 Small RNAs Loom Large During Reprogramming Cell Stem Cell. Jun, 2011 | Pubmed ID: 21624799 Progress in Understanding Reprogramming to the Induced Pluripotent State Nature Reviews. Genetics. Apr, 2011 | Pubmed ID: 21415849 Reprogramming to Pluripotency: Stepwise Resetting of the Epigenetic Landscape Cell Research. Mar, 2011 | Pubmed ID: 21321600 Mechanistic Insights into Reprogramming to Induced Pluripotency Journal of Cellular Physiology. Apr, 2011 | Pubmed ID: 20945378 Female Human IPSCs Retain an Inactive X Chromosome Cell Stem Cell. Sep, 2010 | Pubmed ID: 20727844 Molecular Analyses of Human Induced Pluripotent Stem Cells and Embryonic Stem Cells Cell Stem Cell. Aug, 2010 | Pubmed ID: 20682452 Genome-wide Dynamics of Replication Timing Revealed by in Vitro Models of Mouse Embryogenesis Genome Research. Feb, 2010 | Pubmed ID: 19952138 Signed Weighted Gene Co-expression Network Analysis of Transcriptional Regulation in Murine Embryonic Stem Cells BMC Genomics. Jul, 2009 | Pubmed ID: 19619308 Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures Cell Stem Cell. Jul, 2009 | Pubmed ID: 19570518 Directed Differentiation of Human-induced Pluripotent Stem Cells Generates Active Motor Neurons Stem Cells (Dayton, Ohio). Apr, 2009 | Pubmed ID: 19350680 Post-translational Regulation of Oct4 Transcriptional Activity PloS One. 2009 | Pubmed ID: 19221599 Epigenetic Reprogramming and Induced Pluripotency Development (Cambridge, England). Feb, 2009 | Pubmed ID: 19168672 Role of the Murine Reprogramming Factors in the Induction of Pluripotency Cell. Jan, 2009 | Pubmed ID: 19167336 Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages Stem Cells (Dayton, Ohio). Jun, 2008 | Pubmed ID: 18450826 Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue David Jelinek1,2, Aimee Flores1,3, Melanie Uebelhoer1, Vincent Pasque2, Kathrin Plath2,3, M. Luisa Iruela-Arispe1,3, Heather R. Christofk2,3, William E. Lowry1,3, Hilary A. Coller1,2,3 1Department of Molecular, Cell and Developmental Biology, UCLA, 2Department of Biological Chemistry, David Geffen School of Medicine, 3Molecular Biology Institute Interdepartmental Program, UCLA JoVE 57760 Biochemistry
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue David Jelinek1,2, Aimee Flores1,3, Melanie Uebelhoer1, Vincent Pasque2, Kathrin Plath2,3, M. Luisa Iruela-Arispe1,3, Heather R. Christofk2,3, William E. Lowry1,3, Hilary A. Coller1,2,3 1Department of Molecular, Cell and Developmental Biology, UCLA, 2Department of Biological Chemistry, David Geffen School of Medicine, 3Molecular Biology Institute Interdepartmental Program, UCLA JoVE 57760 Biochemistry