Marie José Goumans Department of Molecular Cell Biology Leiden University Medical Center Biography Publications Institution JoVE Articles Marie José Goumans has not added a biography. If you are Marie José Goumans and would like to personalize this page please email our Author Liaison for assistance. Publications Targeting BMP Signalling in Cardiovascular Disease and Anaemia Nature Reviews. Cardiology. Oct, 2015 | Pubmed ID: 26461965 Environmental Influences on Endothelial to Mesenchymal Transition in Developing Implanted Cardiovascular Tissue-Engineered Grafts Tissue Engineering. Part B, Reviews. Oct, 2015 | Pubmed ID: 26414174 Regional Differences in WT-1 and Tcf21 Expression During Ventricular Development: Implications for Myocardial Compaction PloS One. 2015 | Pubmed ID: 26390289 Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2015 | Pubmed ID: 26373572 Behavior of CMPCs in Unidirectional Constrained and Stress-free 3D Hydrogels Journal of Molecular and Cellular Cardiology. Aug, 2015 | Pubmed ID: 26278995 Histopathology of Aortic Complications in Bicuspid Aortic Valve Versus Marfan Syndrome: Relevance for Therapy? Heart and Vessels. Jul, 2015 | Pubmed ID: 26129868 Mononuclear Cells and Vascular Repair in HHT Frontiers in Genetics. 2015 | Pubmed ID: 25852751 Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections Journal of the American College of Cardiology. Apr, 2015 | Pubmed ID: 25835445 MAb C19 Targets a Novel Surface Marker for the Isolation of Human Cardiac Progenitor Cells from Human Heart Tissue and Differentiated HESCs Journal of Molecular and Cellular Cardiology. May, 2015 | Pubmed ID: 25820071 Functional Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes in Vitro--correlation Between Contraction Force and Electrophysiology Biomaterials. May, 2015 | Pubmed ID: 25771005 Cardiac Endothelial Cells Express Wilms' Tumor-1: Wt1 Expression in the Developing, Adult and Infarcted Heart Journal of Molecular and Cellular Cardiology. Apr, 2015 | Pubmed ID: 25681586 SLUG is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2015 | Pubmed ID: 25633317 Inhibition of TGFβ Type I Receptor Activity Facilitates Liver Regeneration Upon Acute CCl4 Intoxication in Mice Archives of Toxicology. Jan, 2015 | Pubmed ID: 25566828 Bicuspid Aortic Valve: Phosphorylation of C-Kit and Downstream Targets Are Prognostic for Future Aortopathy European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Nov, 2014 | Pubmed ID: 25161185 The MicroRNA-15 Family Inhibits the TGFβ-pathway in the Heart Cardiovascular Research. Oct, 2014 | Pubmed ID: 25103110 A Straightforward Guide to the Basic Science Behind Cardiovascular Cell-based Therapies Heart (British Cardiac Society). Aug, 2014 | Pubmed ID: 24993501 A Multistep Procedure to Prepare Pre-vascularized Cardiac Tissue Constructs Using Adult Stem Sells, Dynamic Cell Cultures, and Porous Scaffolds Frontiers in Physiology. 2014 | Pubmed ID: 24917827 Nuclear Receptor NR4A1 Promotes Breast Cancer Invasion and Metastasis by Activating TGF-β Signalling Nature Communications. 2014 | Pubmed ID: 24584437 Ascending Aorta Dilation in Association with Bicuspid Aortic Valve: a Maturation Defect of the Aortic Wall The Journal of Thoracic and Cardiovascular Surgery. Oct, 2014 | Pubmed ID: 24560417 ENDOGLIN is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-induced Angiogenesis PloS One. 2014 | Pubmed ID: 24489709 Hippo Pathway Effectors Control Cardiac Progenitor Cell Fate by Acting As Dynamic Sensors of Substrate Mechanics and Nanostructure ACS Nano. Mar, 2014 | Pubmed ID: 24483337 Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24448195 Remodeling of the Myocardium in Early Trabeculation and Cardiac Valve Formation; a Role for TGFβ2 The International Journal of Developmental Biology. 2013 | Pubmed ID: 24623077 Quaking, an RNA-binding Protein, is a Critical Regulator of Vascular Smooth Muscle Cell Phenotype Circulation Research. Oct, 2013 | Pubmed ID: 23963726 MicroRNA-1 Enhances the Angiogenic Differentiation of Human Cardiomyocyte Progenitor Cells Journal of Molecular Medicine (Berlin, Germany). Aug, 2013 | Pubmed ID: 23625462 Extraembryonic Endoderm Cells As a Model of Endoderm Development Development, Growth & Differentiation. Apr, 2013 | Pubmed ID: 23414197 Deficiency for Endoglin in Tumor Vasculature Weakens the Endothelial Barrier to Metastatic Dissemination The Journal of Experimental Medicine. Mar, 2013 | Pubmed ID: 23401487 CD26 Inhibition Enhances Perfusion Recovery in ApoE-/-mice Current Vascular Pharmacology. Jan, 2013 | Pubmed ID: 23391419 Alteraciones De La Médula ósea Y Menor Número De Células Progenitoras Endoteliales En Pacientes De Isquemia Crítica Del Miembro PloS One. 2013 | Pubmed ID: 23383236 Reduced CD26 Expression is Associated with Improved Cardiac Function After Acute Myocardial Infarction: Insights from the REPERATOR Study Journal of Molecular and Cellular Cardiology. Dec, 2012 | Pubmed ID: 22982114 Cardiac Regeneration: Stem Cells and Beyond Current Medicinal Chemistry. 2012 | Pubmed ID: 22963568 Producción De Matriz Y Remodelación Capacidad De Células Progenitoras De Cardiomiocitos Durante La Diferenciación in Vitro Journal of Molecular and Cellular Cardiology. Jul, 2012 | Pubmed ID: 22820459 TGFβ and BMP Signaling in Cardiac Cushion Formation: Lessons from Mice and Chicken Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22656450 The Arterial and Cardiac Epicardium in Development, Disease and Repair Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22652098 Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22610569 Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22493445 Gap Junctional Coupling with Cardiomyocytes is Necessary but Not Sufficient for Cardiomyogenic Differentiation of Cocultured Human Mesenchymal Stem Cells Stem Cells (Dayton, Ohio). Jun, 2012 | Pubmed ID: 22438316 Shear Induced Collateral Artery Growth Modulated by Endoglin but Not by ALK1 Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22436015 Early Statin Treatment Prior to Primary PCI for Acute Myocardial Infarction: REPERATOR, a Randomized Placebo-controlled Pilot Trial Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions. Nov, 2012 | Pubmed ID: 22419603 TGF-β Signaling in Endothelial-to-mesenchymal Transition: the Role of Shear Stress and Primary Cilia Science Signaling. Feb, 2012 | Pubmed ID: 22355187 Human Cardiomyocyte Progenitor Cells: a Short History of Nearly Everything Journal of Cellular and Molecular Medicine. Aug, 2012 | Pubmed ID: 22260290 MicroRNA-214 Inhibits Angiogenesis by Targeting Quaking and Reducing Angiogenic Growth Factor Release Cardiovascular Research. Mar, 2012 | Pubmed ID: 22227154 Cardiomyogenic Differentiation-independent Improvement of Cardiac Function by Human Cardiomyocyte Progenitor Cell Injection in Ischaemic Mouse Hearts Journal of Cellular and Molecular Medicine. Jul, 2012 | Pubmed ID: 22003890 Alteración Depende De La Edad De Señalización De TGF-β En La Artrosis Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21638205 Letter by Sluijter Et Al Regarding Article, "Human Cardiac Stem Cell Differentiation is Regulated by a Mircrine Mechanism" Circulation. Oct, 2011 | Pubmed ID: 22025645 Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate Toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts PloS One. 2011 | Pubmed ID: 21931658 MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production Circulation Research. Sep, 2011 | Pubmed ID: 21778427 Control De Angiogénesis Por Dos únicos TGF-β Tipo I Rutas De Señalización Del Receptor Histology and Histopathology. Sep, 2011 | Pubmed ID: 21751154 Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2011 | Pubmed ID: 21720378 Forkhead Box Protein P1 As a Downstream Target of Transforming Growth Factor-β Induces Collagen Synthesis and Correlates with a More Stable Plaque Phenotype Atherosclerosis. Sep, 2011 | Pubmed ID: 21683954 Receptor De TGF-β, Señalización De Las Vías En La Angiogénesis; Objetivos Emergentes Para La Terapia Anti-angiogénesis Current Pharmaceutical Biotechnology. May, 2011 | Pubmed ID: 21619534 Es Necesaria Para Esfuerzo Cortante Inducida Klf2 Expresión En Células Endoteliales Embrionarias La Señalización De TGFβ/Alk5 Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21604321 In Vitro Epithelial-to-mesenchymal Transformation in Human Adult Epicardial Cells is Regulated by TGFβ-signaling and WT1 Basic Research in Cardiology. Sep, 2011 | Pubmed ID: 21516490 Human Mesenchymal Stem Cell-conditioned Medium Improves Cardiac Function Following Myocardial Infarction Stem Cell Research. May, 2011 | Pubmed ID: 21419744 La Falta De Prepara Los Cilios Primarios Inducida Por Cizallamiento Endotelial-mesenquimal De Transición Circulation Research. Apr, 2011 | Pubmed ID: 21393577 Low Oxygen Tension Positively Influences Cardiomyocyte Progenitor Cell Function Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21306557 Epithelial-to-mesenchymal Transformation Alters Electrical Conductivity of Human Epicardial Cells Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21251220 Molecular MRI of Murine Atherosclerotic Plaque Targeting NGAL: a Protein Associated with Unstable Human Plaque Characteristics Cardiovascular Research. Feb, 2011 | Pubmed ID: 21030534 MicroRNA-155 Prevents Necrotic Cell Death in Human Cardiomyocyte Progenitor Cells Via Targeting RIP1 Journal of Cellular and Molecular Medicine. Jul, 2011 | Pubmed ID: 20550618 Modulation of TGF-β/BMP-6 Expression and Increased Levels of Circulating Smooth Muscle Progenitor Cells in a Type I Diabetes Mouse Model Cardiovascular Diabetology. 2010 | Pubmed ID: 20858224 Cardiac Malformations in Pdgfralpha Mutant Embryos Are Associated with Increased Expression of WT1 and Nkx2.5 in the Second Heart Field Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2010 | Pubmed ID: 20658695 Señalización Por Miembros De La Familia TGF-beta En La Morfogénesis Vascular Y Enfermedad Trends in Cell Biology. Sep, 2010 | Pubmed ID: 20656490 Hyaluronic Acid Metabolism is Increased in Unstable Plaques European Journal of Clinical Investigation. Sep, 2010 | Pubmed ID: 20597964 Peripheral Blood Derived Cell Trafficking for Cardiac Regeneration Current Stem Cell Research & Therapy. Dec, 2010 | Pubmed ID: 20528755 IFN Gamma-dependent SOCS3 Expression Inhibits IL-6-induced STAT3 Phosphorylation and Differentially Affects IL-6 Mediated Transcriptional Responses in Endothelial Cells American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20484656 Active Wnt Signaling in Response to Cardiac Injury Basic Research in Cardiology. Sep, 2010 | Pubmed ID: 20373104 Hyperpolarization Induces Differentiation in Human Cardiomyocyte Progenitor Cells Stem Cell Reviews. Jun, 2010 | Pubmed ID: 20354915 Foetal and Adult Cardiomyocyte Progenitor Cells Have Different Developmental Potential Journal of Cellular and Molecular Medicine. Apr, 2010 | Pubmed ID: 20219011 MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-derived Cardiomyocyte Progenitor Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2010 | Pubmed ID: 20081117 Genéticos Y Farmacológicos Dirigidos Contra Como Receptor De Activina Quinasa 1 Perjudica El Crecimiento Tumoral Y La Angiogénesis The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20065063 Endothelial Cells Are Activated During Hypoxia Via Endoglin/ALK-1/SMAD1/5 Signaling in Vivo and in Vitro Biochemical and Biophysical Research Communications. Feb, 2010 | Pubmed ID: 20060813 ALK2 R206H Mutación Ligada a Fibrodisplasia Osificante Progresiva Confiere Actividad Constitutiva Al BMP Del Receptor De Tipo I Y Sensibiliza Las Células Mesenquimales Para Formación De Diferenciación Y Hueso Osteoblasto BMP-inducida Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2010 | Pubmed ID: 19929436 Impaired Recruitment of HHT-1 Mononuclear Cells to the Ischaemic Heart is Due to an Altered CXCR4/CD26 Balance Cardiovascular Research. Feb, 2010 | Pubmed ID: 19762327 Human Cardiomyocyte Progenitor Cell-derived Cardiomyocytes Display a Maturated Electrical Phenotype Journal of Molecular and Cellular Cardiology. Jan, 2010 | Pubmed ID: 19460390 Improvement of Cardiac Efficacy and Safety Models in Drug Discovery by the Use of Stem Cell-derived Cardiomyocytes Expert Opinion on Drug Discovery. Apr, 2009 | Pubmed ID: 23485039 A New Direction for Cardiac Regeneration Therapy: Application of Synergistically Acting Epicardium-derived Cells and Cardiomyocyte Progenitor Cells Circulation. Heart Failure. Nov, 2009 | Pubmed ID: 19919990 VEGF Y Los Inhibidores De La Kinasa Del Receptor De TGFbeta Tipo I Sinérgicamente Promover La Formación De Vasos Sanguíneos Mediante La Inducción De La Expresión De La Integrina-alfa5 Journal of Cell Science. Sep, 2009 | Pubmed ID: 19706683 Increase in ALK1/ALK5 Ratio As a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice Journal of Immunology (Baltimore, Md. : 1950). Jun, 2009 | Pubmed ID: 19494318 Human Cardiomyocyte Progenitor Cell Transplantation Preserves Long-term Function of the Infarcted Mouse Myocardium Cardiovascular Research. Aug, 2009 | Pubmed ID: 19429921 Formación De Vasos Pobres En Embriones De Knock-in Los Ratones Que Expresaban ALK5 Con Mutación De Bucle L45 Defectuoso En Smad Activación Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2009 | Pubmed ID: 19398960 A New in Vitro Model for Stem Cell Differentiation and Interaction Stem Cell Research. Mar, 2009 | Pubmed ID: 19383416 Cell Therapy for Myocardial Regeneration Current Molecular Medicine. Apr, 2009 | Pubmed ID: 19355911 Human Cardiomyocyte Progenitor Cells Differentiate into Functional Mature Cardiomyocytes: an in Vitro Model for Studying Human Cardiac Physiology and Pathophysiology Nature Protocols. 2009 | Pubmed ID: 19197267 Stem Cells from In- or Outside of the Heart: Isolation, Characterization, and Potential for Myocardial Tissue Regeneration Pediatric Cardiology. Jul, 2009 | Pubmed ID: 19184178 TGF-beta En La Disfunción Y Biología Vascular Cell Research. Jan, 2009 | Pubmed ID: 19114994 Increased Expression of the Transforming Growth Factor-beta Signaling Pathway, Endoglin, and Early Growth Response-1 in Stable Plaques Stroke; a Journal of Cerebral Circulation. Feb, 2009 | Pubmed ID: 19074480 ¿Transformar El Factor De Crecimiento Beta-inducida Endotelial-a-mesenquimal Transición: Un Interruptor Fibrosis Cardiaca? Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345316 Endoglina En La Angiogénesis Y Enfermedades Vasculares Angiogenesis. 2008 | Pubmed ID: 18283546 Balance Between Angiopoietin-1 and Angiopoietin-2 is in Favor of Angiopoietin-2 in Atherosclerotic Plaques with High Microvessel Density Journal of Vascular Research. 2008 | Pubmed ID: 18182823 Toll-like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction Circulation Research. Feb, 2008 | Pubmed ID: 18007026 TGF-beta1 Induces Efficient Differentiation of Human Cardiomyocyte Progenitor Cells into Functional Cardiomyocytes in Vitro Stem Cell Research. Nov, 2007 | Pubmed ID: 19383394 Compensatoria Señalización Inducida En La Vasculatura De Saco Vitelino Por Eliminación De TGFbeta Receptores En Ratones Journal of Cell Science. Dec, 2007 | Pubmed ID: 18029401 Isolation and Expansion of Resident Cardiac Progenitor Cells Expert Review of Cardiovascular Therapy. Jan, 2007 | Pubmed ID: 17187455 Endoglina Tiene Un Papel Crucial En La Reparación Vascular Mediada Por Células De La Sangre Circulation. Nov, 2006 | Pubmed ID: 17088457 Controlling Cardiomyocyte Survival Novartis Foundation Symposium. 2006 | Pubmed ID: 17019805 Smad7 Y Proteína Fosfatasa 1alpha Son Determinantes Críticos En La Duración Del TGF-beta/ALK1 Señalización En Células Endoteliales BMC Cell Biology. 2006 | Pubmed ID: 16571110 TGF-beta Type II Receptor-deficient Thymocytes Develop Normally but Demonstrate Increased CD8+ Proliferation in Vivo Blood. Dec, 2005 | Pubmed ID: 16131565 Involvement of Furin-like Proprotein Convertases in the Arterial Response to Injury Cardiovascular Research. Oct, 2005 | Pubmed ID: 15963479 The Role of Stem Cells in Cardiac Regeneration Journal of Cellular and Molecular Medicine. Jan-Mar, 2005 | Pubmed ID: 15784162 Gene Expression Profiling Demonstrates That TGF-beta1 Signals Exclusively Through Receptor Complexes Involving Alk5 and Identifies Targets of TGF-beta Signaling Physiological Genomics. May, 2005 | Pubmed ID: 15769904 Paracrina Defectuoso Señalización Por TGFbeta En Saco Vitelino Vasculatura De Ratones Mutantes Endoglina: Un Paradigma Para Telangiectasia Hemorrágico Hereditaria Development (Cambridge, England). Dec, 2004 | Pubmed ID: 15548578 Endoglina Promueve La Proliferación De Células Endoteliales Y TGF-beta/ALK1 Transduction De La Señal The EMBO Journal. Oct, 2004 | Pubmed ID: 15385967 Human Stem Cells Shape the Future of Cardiac Regeneration Research International Journal of Cardiology. Jun, 2004 | Pubmed ID: 15336839 A Gain of Function Mutation in the Activation Loop of Platelet-derived Growth Factor Beta-receptor Deregulates Its Kinase Activity The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15284236 Synergy and Antagonism Between Notch and BMP Receptor Signaling Pathways in Endothelial Cells The EMBO Journal. Feb, 2004 | Pubmed ID: 14739937 Controlar El Destino De La Célula Por Receptores De Proteínas Morfogenéticas óseas Molecular and Cellular Endocrinology. Dec, 2003 | Pubmed ID: 14656483 Como Receptor De Activina Quinasa (ALK) 1 Es Un Mediador Antagónico De Señalización Lateral De TGFbeta/ALK5 Molecular Cell. Oct, 2003 | Pubmed ID: 14580334 Controlling the Angiogenic Switch: a Balance Between Two Distinct TGF-b Receptor Signaling Pathways Trends in Cardiovascular Medicine. Oct, 2003 | Pubmed ID: 14522471 Células Madre Hematopoyéticas De TGF-beta Deficiente Señalización Tienen Auto Renovación Normal Y Capacidad Regenerativa En Vivo a Pesar De La Creciente Capacidad Proliferativa in Vitro Blood. Nov, 2003 | Pubmed ID: 12842983 Distribución De Smad2 Fosforilada Identifica Los Tejidos Diana De Ligandos TGF Beta En Desarrollo Del Ratón Gene Expression Patterns : GEP. Jun, 2003 | Pubmed ID: 12799085 Expression and Activation of the BMP-signaling Components in Human Fracture Nonunions The Journal of Bone and Joint Surgery. American Volume. Nov, 2002 | Pubmed ID: 12429748 Estimulación De La Expresión De Id1 Por Proteínas Morfogenéticas De Hueso Es Suficiente Y Necesario Para La Activación De Inducida Por La Proteína Morfogenética ósea De Células Endoteliales Circulation. Oct, 2002 | Pubmed ID: 12390958 Sobreexpresión De Smad7 Da Lugar a Severas Alteraciones Patológicas En Múltiples Tejidos Epiteliales The EMBO Journal. Jun, 2002 | Pubmed ID: 12032071 Transformando La Transducción De La Señal De Factor De Crecimiento Beta Journal of Leukocyte Biology. May, 2002 | Pubmed ID: 11994497 Equilibrar El Estado De La Activación Del Endotelio Con Dos Distintas TGF-beta Tipo I Receptores The EMBO Journal. Apr, 2002 | Pubmed ID: 11927558 Regulación De La Proliferación Celular Por Proteínas Smad Journal of Cellular Physiology. Apr, 2002 | Pubmed ID: 11920677 El cultivo de ratón cardíaca válvulas en el sistema de cultivo tisular miniatura Boudewijn P.T. Kruithof1, Samuel C. Lieber2, Marianna Kruithof-de Julio3, Vincian Gaussin4, Marie José Goumans1 1Department of Molecular Cell Biology, Leiden University Medical Center, 2Department of Engineering Technology, New Jersey Institute of Technology, 3Department of Urology, Leiden University Medical Center, 4Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School Bioengineering
El cultivo de ratón cardíaca válvulas en el sistema de cultivo tisular miniatura Boudewijn P.T. Kruithof1, Samuel C. Lieber2, Marianna Kruithof-de Julio3, Vincian Gaussin4, Marie José Goumans1 1Department of Molecular Cell Biology, Leiden University Medical Center, 2Department of Engineering Technology, New Jersey Institute of Technology, 3Department of Urology, Leiden University Medical Center, 4Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School Bioengineering