Martin McMahon Diller Cancer Research Building University of California, San Francisco Biography Publications Institution JoVE Articles Martin McMahon has not added a biography. If you are Martin McMahon and would like to personalize this page please email our Author Liaison for assistance. Publications BRAFV600E Cooperates with PI3'-Kinase Signaling, Independent of AKT, to Regulate Melanoma Cell Proliferation Molecular Cancer Research : MCR. Jan, 2014 | Pubmed ID: 24425783 Abnormal Ras Signaling in Costello Syndrome (CS) Negatively Regulates Enamel Formation Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24057668 Differential AKT Dependency Displayed by Mouse Models of BRAFV600E-initiated Melanoma The Journal of Clinical Investigation. Dec, 2013 | Pubmed ID: 24200692 Hematopoietic Expression of Oncogenic BRAF Promotes Aberrant Growth of Monocyte-lineage Cells Resistant to PLX4720 Molecular Cancer Research : MCR. Dec, 2013 | Pubmed ID: 24152792 Phenformin Enhances the Therapeutic Benefit of BRAF(V600E) Inhibition in Melanoma Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24145418 Mutationally Activated PIK3CA(H1047R) Cooperates with BRAF(V600E) to Promote Lung Cancer Progression Cancer Research. Nov, 2013 | Pubmed ID: 24019382 Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-driven Lung Tumors Cancer Discovery. Nov, 2013 | Pubmed ID: 23965987 Modelling Vemurafenib Resistance in Melanoma Reveals a Strategy to Forestall Drug Resistance Nature. Feb, 2013 | Pubmed ID: 23302800 Elucidating Distinct Roles for NF1 in Melanomagenesis Cancer Discovery. Mar, 2013 | Pubmed ID: 23171796 Oncogene-dependent Control of MiRNA Biogenesis and Metastatic Progression in a Model of Undifferentiated Pleomorphic Sarcoma The Journal of Pathology. Jan, 2013 | Pubmed ID: 22951975 An Ultraviolet-radiation-independent Pathway to Melanoma Carcinogenesis in the Red Hair/fair Skin Background Nature. Nov, 2012 | Pubmed ID: 23123854 The Intermediate-activity (L597V)BRAF Mutant Acts As an Epistatic Modifier of Oncogenic RAS by Enhancing Signaling Through the RAF/MEK/ERK Pathway Genes & Development. Sep, 2012 | Pubmed ID: 22892241 Activation Du Gène B-Raf Coopère Avec Perte PTEN à L'expression De C-Myc En Voiture Dans Le Cancer De La Prostate Avancé Cancer Research. Sep, 2012 | Pubmed ID: 22836754 Analysis of MRNA Profiles After MEK1/2 Inhibition in Human Pancreatic Cancer Cell Lines Reveals Pathways Involved in Drug Sensitivity Molecular Cancer Research : MCR. Dec, 2012 | Pubmed ID: 22833572 Regulated Temporal-spatial Astrocyte Precursor Cell Proliferation Involves BRAF Signalling in Mammalian Spinal Cord Development (Cambridge, England). Jul, 2012 | Pubmed ID: 22675209 A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma Cancer Discovery. Aug, 2012 | Pubmed ID: 22628411 Cooperative Interactions of BRAFV600E Kinase and CDKN2A Locus Deficiency in Pediatric Malignant Astrocytoma As a Basis for Rational Therapy Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22586120 Abrogation of BRAFV600E-induced Senescence by PI3K Pathway Activation Contributes to Melanomagenesis Genes & Development. May, 2012 | Pubmed ID: 22549727 E-cadherin Regulates the Behavior and Fate of Epithelial Stem Cells and Their Progeny in the Mouse Incisor Developmental Biology. Jun, 2012 | Pubmed ID: 22537490 MEK1/2 Inhibition Elicits Regression of Autochthonous Lung Tumors Induced by KRASG12D or BRAFV600E Cancer Research. Jun, 2012 | Pubmed ID: 22511580 β-catenin Signaling Controls Metastasis in Braf-activated Pten-deficient Melanomas Cancer Cell. Dec, 2011 | Pubmed ID: 22172720 Control of Mitotic Spindle Angle by the RAS-regulated ERK1/2 Pathway Determines Lung Tube Shape Science (New York, N.Y.). Jul, 2011 | Pubmed ID: 21764747 Mutationally Activated BRAF(V600E) Elicits Papillary Thyroid Cancer in the Adult Mouse Cancer Research. Jun, 2011 | Pubmed ID: 21512141 Costello and Cardio-facio-cutaneous Syndromes: Moving Toward Clinical Trials in RASopathies American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. May, 2011 | Pubmed ID: 21495172 Parsing out the Complexity of RAF Inhibitor Resistance Pigment Cell & Melanoma Research. Apr, 2011 | Pubmed ID: 21392366 RAF Translocations Expand Cancer Targets Nature Medicine. Jul, 2010 | Pubmed ID: 20613748 Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver Science Translational Medicine. Jan, 2010 | Pubmed ID: 20371474 Characterization of Melanoma Cells Capable of Propagating Tumors from a Single Cell Cancer Research. Jan, 2010 | Pubmed ID: 20048081 Proceedings from the 2009 Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back American Journal of Medical Genetics. Part A. Jan, 2010 | Pubmed ID: 20014119 Down-regulation of Cdx2 in Colorectal Carcinoma Cells by the Raf-MEK-ERK 1/2 Pathway Cellular Signalling. Dec, 2009 | Pubmed ID: 19686845 Meeting Report: Consensus from the First and Second Global Workshops in Melanoma November 19-20, 2008 Pigment Cell & Melanoma Research. Oct, 2009 | Pubmed ID: 19659612 Braf(V600E) Cooperates with Pten Loss to Induce Metastatic Melanoma Nature Genetics. May, 2009 | Pubmed ID: 19282848 Oncogenic BRAF(V600E) Inhibits BIM Expression to Promote Melanoma Cell Survival Pigment Cell & Melanoma Research. Oct, 2008 | Pubmed ID: 18715233 Meeting Report: Fourth International Congress of the Society for Melanoma Research Pigment Cell & Melanoma Research. Feb, 2008 | Pubmed ID: 18353140 A Model of Intussusceptive Angiogenesis Novartis Foundation Symposium. 2007 | Pubmed ID: 18300412 A New Mouse Model to Explore the Initiation, Progression, and Therapy of BRAFV600E-induced Lung Tumors Genes & Development. Feb, 2007 | Pubmed ID: 17299132 Diverse Toll-like Receptors Utilize Tpl2 to Activate Extracellular Signal-regulated Kinase (ERK) in Hemopoietic Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16484370 Constitutive Activation of Akt by Flt3 Internal Tandem Duplications is Necessary for Increased Survival, Proliferation, and Myeloid Transformation Cancer Research. Nov, 2005 | Pubmed ID: 16266983 The Epidermal Growth Factor Receptor Gene Family As a Target for Therapeutic Intervention in Numerous Cancers: What's Genetics Got to Do with It? Expert Opinion on Therapeutic Targets. Oct, 2005 | Pubmed ID: 16185155 Pharmacologic Inhibition of RAF-->MEK-->ERK Signaling Elicits Pancreatic Cancer Cell Cycle Arrest Through Induced Expression of P27Kip1 Cancer Research. Jun, 2005 | Pubmed ID: 15930308 Analysis of Genomic DNA Alterations and MRNA Expression Patterns in a Panel of Human Pancreatic Cancer Cell Lines Genes, Chromosomes & Cancer. Sep, 2005 | Pubmed ID: 15929091 Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines Cell Cycle (Georgetown, Tex.). Jun, 2005 | Pubmed ID: 15917660 Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor Molecular and Cellular Biology. Jan, 2005 | Pubmed ID: 15601844 Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT Molecular and Cellular Biology. Dec, 2004 | Pubmed ID: 15572689 Effects of a Conditionally Active V-ErbB and an EGF-R Inhibitor on Transformation of NIH-3T3 Cells and Abrogation of Cytokine Dependency of Hematopoietic Cells Oncogene. Oct, 2004 | Pubmed ID: 15361836 Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15128735 Inactivation of Icmt Inhibits Transformation by Oncogenic K-Ras and B-Raf The Journal of Clinical Investigation. Feb, 2004 | Pubmed ID: 14966563 DeltaRaf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry Molecular and Cellular Biology. Dec, 2003 | Pubmed ID: 14645540 Hedgehog is an Early and Late Mediator of Pancreatic Cancer Tumorigenesis Nature. Oct, 2003 | Pubmed ID: 14520413 Ras-induced Serine Phosphorylation of the Focal Adhesion Protein Paxillin is Mediated by the Raf-->MEK-->ERK Pathway Experimental Cell Research. Jul, 2003 | Pubmed ID: 12837288 Inhibition of the Raf/MEK/ERK Pathway Up-regulates Expression of the Coxsackievirus and Adenovirus Receptor in Cancer Cells Cancer Research. May, 2003 | Pubmed ID: 12727824 Effects of the RAF/MEK/ERK and PI3K/AKT Signal Transduction Pathways on the Abrogation of Cytokine-dependence and Prevention of Apoptosis in Hematopoietic Cells Oncogene. Apr, 2003 | Pubmed ID: 12717425 De Novo Infection and Serial Transmission of Kaposi's Sarcoma-associated Herpesvirus in Cultured Endothelial Cells Journal of Virology. Mar, 2002 | Pubmed ID: 11836422 Induction of Tubulogenesis in Telomerase-immortalized Human Microvascular Endothelial Cells by Glioblastoma Cells Experimental Cell Research. Feb, 2002 | Pubmed ID: 11795943 Le plus rapide de l'Ouest dans la ville: une touche contemporaine sur l'analyse classique western blot Jillian M. Silva1, Martin McMahon1 1Diller Cancer Research Building, University of California, San Francisco JoVE 51149 Biology
Le plus rapide de l'Ouest dans la ville: une touche contemporaine sur l'analyse classique western blot Jillian M. Silva1, Martin McMahon1 1Diller Cancer Research Building, University of California, San Francisco JoVE 51149 Biology