Neeleema Seetaloo Living Systems Institute, Department of Biosciences University of Exeter Biography Publications Institution JoVE Articles Neeleema Seetaloo Neeleema is a PhD student at the University of Exeter, working with Dr Jonathan J. Phillips on developing millisecond hydrogen/deuterium-exchange mass spectrometry methods and techniques at high structural and temporal resolution for the study of intrinsically disordered proteins, such as alpha-synuclein. In particular, her work focuses on the molecular conformational changes that occur in the monomeric form of alpha-synuclein as it experiences different physiological conditions which vary in pH and ionic strength. Prior to her PhD, she completed an MSc in Molecular Biology and Biotechnology at Queen’s University Belfast and a BA in Natural Sciences at the University of Cambridge. Publications HDfleX: Software for Flexible High Structural Resolution of Hydrogen/Deuterium-Exchange Mass Spectrometry Data Analytical Chemistry. 03, 2022 | Pubmed ID: 35263087 Extent of N-terminus Exposure of Monomeric Alpha-synuclein Determines Its Aggregation Propensity Nature Communications. 06, 2020 | Pubmed ID: 32499486 Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions Neeleema Seetaloo1, Jonathan J. Phillips1 1Living Systems Institute, Department of Biosciences, University of Exeter JoVE 64050 Neuroscience
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions Neeleema Seetaloo1, Jonathan J. Phillips1 1Living Systems Institute, Department of Biosciences, University of Exeter JoVE 64050 Neuroscience