Nicholas J. Harmer Department of Biosciences University of Exeter Biography Publications Institution JoVE Articles Nicholas J. Harmer has not added a biography. If you are Nicholas J. Harmer and would like to personalize this page please email our Author Liaison for assistance. Publications Structural Insights into WcbI, a Novel Polysaccharide-biosynthesis Enzyme IUCrJ. Jan, 2014 | Pubmed ID: 25075317 A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins Antimicrobial Agents and Chemotherapy. 2014 | Pubmed ID: 24366729 Myosin-5, Kinesin-1 and Myosin-17 Cooperate in Secretion of Fungal Chitin Synthase The EMBO Journal. Jan, 2012 | Pubmed ID: 22027862 A Burkholderia Pseudomallei Macrophage Infectivity Potentiator-like Protein Has Rapamycin-inhibitable Peptidylprolyl Isomerase Activity and Pleiotropic Effects on Virulence Infection and Immunity. Nov, 2011 | Pubmed ID: 21859853 A Novel FK-506-binding-like Protein That Lacks Peptidyl-prolyl Isomerase Activity is Involved in Intracellular Infection and in Vivo Virulence of Burkholderia Pseudomallei Microbiology (Reading, England). Sep, 2011 | Pubmed ID: 21680634 The Structure of a Burkholderia Pseudomallei Immunophilin-inhibitor Complex Reveals New Approaches to Antimicrobial Development The Biochemical Journal. Aug, 2011 | Pubmed ID: 21574961 The Structure of Sedoheptulose-7-phosphate Isomerase from Burkholderia Pseudomallei Reveals a Zinc Binding Site at the Heart of the Active Site Journal of Molecular Biology. Jul, 2010 | Pubmed ID: 20447408 Evidence That Heparin Saccharides Promote FGF2 Mitogenesis Through Two Distinct Mechanisms The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18281281 Predicting Protein Function from Structure--the Roles of Short-chain Dehydrogenase/reductase Enzymes in Bordetella O-antigen Biosynthesis Journal of Molecular Biology. Nov, 2007 | Pubmed ID: 17950751 Cloning, Expression, Purification and Preliminary Crystallographic Analysis of the Short-chain Dehydrogenase Enzymes WbmF, WbmG and WbmH from Bordetella Bronchiseptica Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Aug, 2007 | Pubmed ID: 17671375 Expression and Purification of Recombinant Human Fibroblast Growth Factor Receptor in Escherichia Coli Protein Expression and Purification. Sep, 2006 | Pubmed ID: 16750394 Structural Biology and Bioinformatics in Drug Design: Opportunities and Challenges for Target Identification and Lead Discovery Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Mar, 2006 | Pubmed ID: 16524830 Multimers of the Fibroblast Growth Factor (FGF)-FGF Receptor-saccharide Complex Are Formed on Long Oligomers of Heparin The Biochemical Journal. Feb, 2006 | Pubmed ID: 16223363 Cooperative Dimerization of Fibroblast Growth Factor 1 (FGF1) Upon a Single Heparin Saccharide May Drive the Formation of 2:2:1 FGF1.FGFR2c.heparin Ternary Complexes The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16219767 1.15 A Crystal Structure of the X. Tropicalis Spred1 EVH1 Domain Suggests a Fourth Distinct Peptide-binding Mechanism Within the EVH1 Family FEBS Letters. Feb, 2005 | Pubmed ID: 15710406 Towards a Resolution of the Stoichiometry of the Fibroblast Growth Factor (FGF)-FGF Receptor-heparin Complex Journal of Molecular Biology. Jun, 2004 | Pubmed ID: 15165853 The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity Biochemistry. Jan, 2004 | Pubmed ID: 14730967 The Structural Biology of Growth Factor Receptor Activation Biophysical Chemistry. 2003 | Pubmed ID: 12646390 A Tyrosine703serine Polymorphism of CD109 Defines the Gov Platelet Alloantigens Blood. Mar, 2002 | Pubmed ID: 11861285 Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry Mirella Vivoli1, Halina R. Novak1, Jennifer A. Littlechild1, Nicholas J. Harmer1 1Department of Biosciences, University of Exeter JoVE 51809 Biology
Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry Mirella Vivoli1, Halina R. Novak1, Jennifer A. Littlechild1, Nicholas J. Harmer1 1Department of Biosciences, University of Exeter JoVE 51809 Biology