Patrick H. Maxwell Department of Biological Sciences Rensselaer Polytechnic Institute Biography Publications Institution JoVE Articles Patrick H. Maxwell has not added a biography. If you are Patrick H. Maxwell and would like to personalize this page please email our Author Liaison for assistance. Publications Extension of Saccharomyces Paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species Genetics. Aug, 2014 | Pubmed ID: 25106655 HIF-1 Reduces Ischaemia-reperfusion Injury in the Heart by Targeting the Mitochondrial Permeability Transition Pore Cardiovascular Research. Oct, 2014 | Pubmed ID: 25063991 The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24371136 Renal Cell Carcinoma: Translational Aspects of Metabolism and Therapeutic Consequences Kidney International. Oct, 2013 | Pubmed ID: 23823604 The Hypoxia Factor Hif-1α Controls Neural Crest Chemotaxis and Epithelial to Mesenchymal Transition The Journal of Cell Biology. May, 2013 | Pubmed ID: 23712262 Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination Circulation Research. Jun, 2013 | Pubmed ID: 23564640 Epistatic Role of the MYH9/APOL1 Region on Familial Hematuria Genes PloS One. 2013 | Pubmed ID: 23516419 Incidence of End-stage Renal Disease in the Turkish-Cypriot Population of Northern Cyprus: a Population Based Study PloS One. 2013 | Pubmed ID: 23349874 C3 Glomerulonephritis and CFHR5 Nephropathy Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Feb, 2013 | Pubmed ID: 23125424 What Happens to Clinical Training Fellows? A Retrospective Study of the 20 Years Outcome of a Medical Research Council UK Cohort BMJ Open. 2012 | Pubmed ID: 22936819 Increasing Evidence That Genetic Variation in Complement Factor H Related 5 (CFHR5) Causes Disease: a Commentary on 'Atypical Haemolytic Uremic Syndrome and Genetic Aberrations in the Complement Factor-H-related 5 Gene' Journal of Human Genetics. Aug, 2012 | Pubmed ID: 22739721 Von Hippel-Lindau Protein in the RPE is Essential for Normal Ocular Growth and Vascular Development Development (Cambridge, England). Jul, 2012 | Pubmed ID: 22627278 Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy The American Journal of Pathology. Apr, 2012 | Pubmed ID: 22342523 The ERA-EDTA Working Group on Inherited Kidney Disorders Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jan, 2012 | Pubmed ID: 22287704 Tumor Strengths and Frailties: Aspiring to Prevent Colon Cancer Nature Medicine. Jan, 2012 | Pubmed ID: 22227665 Human CHCHD4 Mitochondrial Proteins Regulate Cellular Oxygen Consumption Rate and Metabolism and Provide a Critical Role in Hypoxia Signaling and Tumor Progression The Journal of Clinical Investigation. Feb, 2012 | Pubmed ID: 22214851 Retrotransposition is Associated with Genome Instability During Chronological Aging Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22021441 Renal Cyst Formation in Fh1-deficient Mice is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling Cancer Cell. Oct, 2011 | Pubmed ID: 22014577 Hypoxia-inducible Transcription Factors Stabilization in the Thick Ascending Limb Protects Against Ischemic Acute Kidney Injury Journal of the American Society of Nephrology : JASN. Nov, 2011 | Pubmed ID: 21921145 Dimethyloxalyglycine Stimulates the Early Stages of Gastrointestinal Repair Processes Through VEGF-dependent Mechanisms Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2011 | Pubmed ID: 21876537 Seeing the Smoking Gun: a Sensitive and Specific Method to Visualize Loss of the Tumour Suppressor, Fumarate Hydratase, in Human Tissues The Journal of Pathology. Sep, 2011 | Pubmed ID: 21792933 Inactivation of the Von Hippel-Lindau Tumour Suppressor Gene Induces Neuromedin U Expression in Renal Cancer Cells Molecular Cancer. 2011 | Pubmed ID: 21791076 Familial C3 Glomerulopathy Associated with CFHR5 Mutations: Clinical Characteristics of 91 Patients in 16 Pedigrees Clinical Journal of the American Society of Nephrology : CJASN. Jun, 2011 | Pubmed ID: 21566112 Developmentally Arrested Structures Preceding Cerebellar Tumors in Von Hippel-Lindau Disease Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Aug, 2011 | Pubmed ID: 21499240 Copy Number Profiling in Von Hippel-Lindau Disease Renal Cell Carcinoma Genes, Chromosomes & Cancer. Jul, 2011 | Pubmed ID: 21456047 Dysregulation of the HIF Pathway Due to VHL Mutation Causing Severe Erythrocytosis and Pulmonary Arterial Hypertension Blood. Mar, 2011 | Pubmed ID: 21454469 Cardiopulmonary Function in Two Human Disorders of the Hypoxia-inducible Factor (HIF) Pathway: Von Hippel-Lindau Disease and HIF-2alpha Gain-of-function Mutation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2011 | Pubmed ID: 21389259 Prolyl Hydroxylase 3 (PHD3) is Essential for Hypoxic Regulation of Neutrophilic Inflammation in Humans and Mice The Journal of Clinical Investigation. Mar, 2011 | Pubmed ID: 21317538 Expression Profiling in Progressive Stages of Fumarate-hydratase Deficiency: the Contribution of Metabolic Changes to Tumorigenesis Cancer Research. Nov, 2010 | Pubmed ID: 20978192 Hypoxia and Upregulation of Hypoxia-inducible Factor 1{alpha} Stimulate Venous Thrombus Recanalization Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2010 | Pubmed ID: 20930171 VHL Inactivation Induces HEF1 and Aurora Kinase A Journal of the American Society of Nephrology : JASN. Dec, 2010 | Pubmed ID: 20864688 Differentiation in Neuroblastoma: Diffusion-limited Hypoxia Induces Neuro-endocrine Secretory Protein 55 and Other Markers of a Chromaffin Phenotype PloS One. 2010 | Pubmed ID: 20862257 Identification of a Mutation in Complement Factor H-related Protein 5 in Patients of Cypriot Origin with Glomerulonephritis Lancet. Sep, 2010 | Pubmed ID: 20800271 Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function Gastroenterology. Dec, 2010 | Pubmed ID: 20600011 HLA Has Strongest Association with IgA Nephropathy in Genome-wide Analysis Journal of the American Society of Nephrology : JASN. Oct, 2010 | Pubmed ID: 20595679 HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia PloS One. 2010 | Pubmed ID: 20559438 Genetic Loci Influencing Kidney Function and Chronic Kidney Disease Nature Genetics. May, 2010 | Pubmed ID: 20383145 Variation in IGHMBP2 is Not Associated with IgA Nephropathy in Independent Studies of UK Caucasian and Chinese Han Patients Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. May, 2010 | Pubmed ID: 20031928 The Role of HIF in Immunity The International Journal of Biochemistry & Cell Biology. Apr, 2010 | Pubmed ID: 19840863 Erythropoietin Administration in Humans Causes a Marked and Prolonged Reduction in Circulating Hepcidin Haematologica. Mar, 2010 | Pubmed ID: 19833632 Prolyl Hydroxylase Domain Inhibitors: a Route to HIF Activation and Neuroprotection Antioxidants & Redox Signaling. Apr, 2010 | Pubmed ID: 19737089 Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-inducible Factors PloS One. 2009 | Pubmed ID: 19924283 Genome-wide Association Study Identifies Variants in TMPRSS6 Associated with Hemoglobin Levels Nature Genetics. Nov, 2009 | Pubmed ID: 19820698 Novel Insights into the Role of the Tumor Suppressor Von Hippel Lindau in Cellular Differentiation, Ciliary Biology, and Cyst Repression Journal of Molecular Medicine (Berlin, Germany). Sep, 2009 | Pubmed ID: 19629420 Rrm3 Protects the Saccharomyces Cerevisiae Genome from Instability at Nascent Sites of Retrotransposition Genetics. Jul, 2009 | Pubmed ID: 19414561 Oxygen Availability SHIFts the Cell Cycle Cell Cycle (Georgetown, Tex.). May, 2009 | Pubmed ID: 19377302 Plasma Hepcidin Levels Are Elevated but Responsive to Erythropoietin Therapy in Renal Disease Kidney International. May, 2009 | Pubmed ID: 19212416 Identification of Novel VHL Regulated Genes by Transcriptomic Analysis of RCC10 Renal Carcinoma Cells Advances in Enzyme Regulation. 2009 | Pubmed ID: 19162062 Xenon Preconditioning Protects Against Renal Ischemic-reperfusion Injury Via HIF-1alpha Activation Journal of the American Society of Nephrology : JASN. Apr, 2009 | Pubmed ID: 19144758 Regulation of Renal Epithelial Tight Junctions by the Von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and is Independent of E-cadherin Molecular Biology of the Cell. Feb, 2009 | Pubmed ID: 19073886 Deletion of the Von Hippel-Lindau Gene in Pancreatic Beta Cells Impairs Glucose Homeostasis in Mice The Journal of Clinical Investigation. Jan, 2009 | Pubmed ID: 19065050 Variations Within Oxygen-regulated Gene Expression in Humans Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2009 | Pubmed ID: 19008490 The A20 Gene Protects Kidneys from Ischaemia/reperfusion Injury by Suppressing Pro-inflammatory Activation Journal of Molecular Medicine (Berlin, Germany). Dec, 2008 | Pubmed ID: 18813897 Progression of Epididymal Maldevelopment into Hamartoma-like Neoplasia in VHL Disease Neoplasia (New York, N.Y.). Oct, 2008 | Pubmed ID: 18813354 Incorporation of Y'-Ty1 CDNA Destabilizes Telomeres in Saccharomyces Cerevisiae Telomerase-negative Mutants Genetics. Aug, 2008 | Pubmed ID: 18660531 Autosomal Dominant Erythrocytosis and Pulmonary Arterial Hypertension Associated with an Activating HIF2 Alpha Mutation Blood. Aug, 2008 | Pubmed ID: 18650473 Developmental and Tissue-specific Accumulation Pattern for the Drosophila Melanogaster TART ORF1 Protein Gene. May, 2008 | Pubmed ID: 18406546 Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice Molecular and Cellular Biology. May, 2008 | Pubmed ID: 18332118 The Von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress Molecular and Cellular Biology. Apr, 2008 | Pubmed ID: 18285459 Role of Gas6 in Erythropoiesis and Anemia in Mice The Journal of Clinical Investigation. Feb, 2008 | Pubmed ID: 18188450 Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-reperfusion Injury Journal of the American Society of Nephrology : JASN. Jan, 2008 | Pubmed ID: 18178798 Expression of Hypoxia-inducible Factors in Normal Human Lung Development Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. May-Jun, 2008 | Pubmed ID: 17990921 Retrosequence Formation Restructures the Yeast Genome Genes & Development. Dec, 2007 | Pubmed ID: 18079177 Inadvertent Postdialysis Anticoagulation Due to Heparin Line Locks Hemodialysis International. International Symposium on Home Hemodialysis. Oct, 2007 | Pubmed ID: 17922740 Erythropoietin Gene Expression in Renal Carcinoma is Considerably More Frequent Than Paraneoplastic Polycythemia International Journal of Cancer. Journal International Du Cancer. Dec, 2007 | Pubmed ID: 17640059 Host Factors That Control Long Terminal Repeat Retrotransposons in Saccharomyces Cerevisiae: Implications for Regulation of Mammalian Retroviruses Eukaryotic Cell. Jul, 2007 | Pubmed ID: 17496126 Reactivation of Snail Genes in Renal Fibrosis and Carcinomas: a Process of Reversed Embryogenesis? Cell Cycle (Georgetown, Tex.). Mar, 2007 | Pubmed ID: 17374993 Genetic Insights into the Hypoxia-inducible Factor (HIF) Pathway Advances in Enzyme Regulation. 2007 | Pubmed ID: 17335877 Lack of Endothelial Cell Survivin Causes Embryonic Defects in Angiogenesis, Cardiogenesis, and Neural Tube Closure Blood. Jun, 2007 | Pubmed ID: 17299096 Snail Activation Disrupts Tissue Homeostasis and Induces Fibrosis in the Adult Kidney The EMBO Journal. Nov, 2006 | Pubmed ID: 17093497 Identification of Multiple Transcription Initiation, Polyadenylation, and Splice Sites in the Drosophila Melanogaster TART Family of Telomeric Retrotransposons Nucleic Acids Research. 2006 | Pubmed ID: 17020919 Statin-induced Expression of CD59 on Vascular Endothelium in Hypoxia: a Potential Mechanism for the Anti-inflammatory Actions of Statins in Rheumatoid Arthritis Arthritis Research & Therapy. 2006 | Pubmed ID: 16859540 Low Oxygen Stimulates the Intellect. Symposium on Hypoxia and Development, Physiology and Disease EMBO Reports. Jul, 2006 | Pubmed ID: 16799463 Formation of Primary Cilia in the Renal Epithelium is Regulated by the Von Hippel-Lindau Tumor Suppressor Protein Journal of the American Society of Nephrology : JASN. Jul, 2006 | Pubmed ID: 16775032 Mutation of Von Hippel-Lindau Tumour Suppressor and Human Cardiopulmonary Physiology PLoS Medicine. Jul, 2006 | Pubmed ID: 16768548 HIF Prolyl Hydroxylases in the Rat; Organ Distribution and Changes in Expression Following Hypoxia and Coronary Artery Ligation Journal of Molecular and Cellular Cardiology. Jul, 2006 | Pubmed ID: 16765982 Venular Basement Membranes Contain Specific Matrix Protein Low Expression Regions That Act As Exit Points for Emigrating Neutrophils The Journal of Experimental Medicine. Jun, 2006 | Pubmed ID: 16754715 Regulation of E-cadherin Expression by VHL and Hypoxia-inducible Factor Cancer Research. Apr, 2006 | Pubmed ID: 16585181 Correction of Severe Anaemia Using Immuno-regulated Gene Therapy is Achieved by Restoring the Early Erythroblast Compartment British Journal of Haematology. Mar, 2006 | Pubmed ID: 16445835 Association of MEGSIN 2093C-2180T Haplotype at the 3' Untranslated Region with Disease Severity and Progression of IgA Nephropathy Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jun, 2006 | Pubmed ID: 16431886 A Family with Erythrocytosis Establishes a Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16407130 Genetic Studies of IgA Nephropathy Nephron. Experimental Nephrology. 2006 | Pubmed ID: 16282702 Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia Cancer Research. Dec, 2005 | Pubmed ID: 16357161 Effects of VHL Deficiency on Endolymphatic Duct and Sac Cancer Research. Dec, 2005 | Pubmed ID: 16322231 HIF, a Missing Link Between Metabolism and Cancer Nature Medicine. Oct, 2005 | Pubmed ID: 16211034 Hypoxia-inducible Factor As a Physiological Regulator Experimental Physiology. Nov, 2005 | Pubmed ID: 16157658 The HIF Pathway in Cancer Seminars in Cell & Developmental Biology. Aug-Oct, 2005 | Pubmed ID: 16144689 Genetic Evidence for a Tumor Suppressor Role of HIF-2alpha Cancer Cell. Aug, 2005 | Pubmed ID: 16098466 A Common Pathway for Genetic Events Leading to Pheochromocytoma Cancer Cell. Aug, 2005 | Pubmed ID: 16098460 Manipulation of Oxygen Tensions for in Vitro Cell Culture Using a Hypoxic Workstation Expert Review of Proteomics. Jun, 2005 | Pubmed ID: 16000078 Contrasting Properties of Hypoxia-inducible Factor 1 (HIF-1) and HIF-2 in Von Hippel-Lindau-associated Renal Cell Carcinoma Molecular and Cellular Biology. Jul, 2005 | Pubmed ID: 15964822 Is It Rejection? Be on the Lookout for 'decoys' Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Sep, 2005 | Pubmed ID: 15919691 Distinct Novel Mutations Affecting the Same Base in the NIPA1 Gene Cause Autosomal Dominant Hereditary Spastic Paraplegia in Two Chinese Families Human Mutation. Feb, 2005 | Pubmed ID: 15643603 The Prolyl Hydroxylase Enzymes That Act As Oxygen Sensors Regulating Destruction of Hypoxia-inducible Factor Alpha Advances in Enzyme Regulation. 2004 | Pubmed ID: 15581484 Ty1 Mobilizes Subtelomeric Y' Elements in Telomerase-negative Saccharomyces Cerevisiae Survivors Molecular and Cellular Biology. Nov, 2004 | Pubmed ID: 15509791 Persistent Induction of HIF-1alpha and -2alpha in Cardiomyocytes and Stromal Cells of Ischemic Myocardium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2004 | Pubmed ID: 15247145 Family-based Association Study Showing That Immunoglobulin A Nephropathy is Associated with the Polymorphisms 2093C and 2180T in the 3' Untranslated Region of the Megsin Gene Journal of the American Society of Nephrology : JASN. Jul, 2004 | Pubmed ID: 15213261 HIF-1's Relationship to Oxygen: Simple Yet Sophisticated Cell Cycle (Georgetown, Tex.). Feb, 2004 | Pubmed ID: 14712080 HIF and Oxygen Sensing; As Important to Life As the Air We Breathe? Annals of Medicine. 2003 | Pubmed ID: 12822740 Heterozygous Deficiency of Hypoxia-inducible Factor-2alpha Protects Mice Against Pulmonary Hypertension and Right Ventricular Dysfunction During Prolonged Hypoxia The Journal of Clinical Investigation. May, 2003 | Pubmed ID: 12750401 Evidence for Hypoxia-induced Neuronal-to-chromaffin Metaplasia in Neuroblastoma FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2003 | Pubmed ID: 12665472 Widespread Hypoxia-inducible Expression of HIF-2alpha in Distinct Cell Populations of Different Organs FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2003 | Pubmed ID: 12490539 Disruption of Oxygen Homeostasis Underlies Congenital Chuvash Polycythemia Nature Genetics. Dec, 2002 | Pubmed ID: 12415268 Long-term Reversal of Chronic Anemia Using a Hypoxia-regulated Erythropoietin Gene Therapy Blood. Oct, 2002 | Pubmed ID: 12239150 Delivery of Erythropoietin by Encapsulated Myoblasts in a Genetic Model of Severe Anemia Kidney International. Oct, 2002 | Pubmed ID: 12234311 Oxygen Homeostasis and Cancer: Insights from a Rare Disease Clinical Medicine (London, England). Jul-Aug, 2002 | Pubmed ID: 12195866 Peptide Blockade of HIFalpha Degradation Modulates Cellular Metabolism and Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002 | Pubmed ID: 12149454 HIF Activation Identifies Early Lesions in VHL Kidneys: Evidence for Site-specific Tumor Suppressor Function in the Nephron Cancer Cell. Jun, 2002 | Pubmed ID: 12124175 Regulation of the HIF Pathway: Enzymatic Hydroxylation of a Conserved Prolyl Residue in Hypoxia-inducible Factor Alpha Subunits Governs Capture by the PVHL E3 Ubiquitin Ligase Complex Advances in Enzyme Regulation. 2002 | Pubmed ID: 12123724 Expression of Hypoxia-inducible Factor-1alpha and -2alpha in Hypoxic and Ischemic Rat Kidneys Journal of the American Society of Nephrology : JASN. Jul, 2002 | Pubmed ID: 12089367 Structural Basis for the Recognition of Hydroxyproline in HIF-1 Alpha by PVHL Nature. Jun, 2002 | Pubmed ID: 12050673 The Use of Dioxygen by HIF Prolyl Hydroxylase (PHD1) Bioorganic & Medicinal Chemistry Letters. Jun, 2002 | Pubmed ID: 12039559 Expression of Hypoxia-inducible Factors in Human Renal Cancer: Relationship to Angiogenesis and to the Von Hippel-Lindau Gene Mutation Cancer Research. May, 2002 | Pubmed ID: 12019178 Oxygen Sensors and Angiogenesis Seminars in Cell & Developmental Biology. Feb, 2002 | Pubmed ID: 11969369 Hypoxia-induced, Perinecrotic Expression of Endothelial Per-ARNT-Sim Domain Protein-1/hypoxia-inducible Factor-2alpha Correlates with Tumor Progression, Vascularization, and Focal Macrophage Infiltration in Bladder Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2002 | Pubmed ID: 11839666 الجمع بين الفرز المغناطيسي للخلايا الأم والاختبارات تذبذب لتحليل الجينوم عدم الاستقرار خلال الإنقسامية شيخوخة الخلايا في Melissa N. Patterson1, Patrick H. Maxwell1 1Department of Biological Sciences, Rensselaer Polytechnic Institute JoVE 51850 Biology
الجمع بين الفرز المغناطيسي للخلايا الأم والاختبارات تذبذب لتحليل الجينوم عدم الاستقرار خلال الإنقسامية شيخوخة الخلايا في Melissa N. Patterson1, Patrick H. Maxwell1 1Department of Biological Sciences, Rensselaer Polytechnic Institute JoVE 51850 Biology