Ruslan Rust Institute for Regenerative Medicine University of Zurich Biography Publications Institution JoVE Articles Ruslan Rust I am currently working as a Group Leader at the Institute for Regenerative Medicine of the University of Zurich, Switzerland and focus on basic and translational research in vascular and neurobiology. I received my PhD at the ETH Zurich, Switzerland in 2019 defending the thesis entitled “Vascular Repair after Ischemia” supervised by Prof. Dr. M.E. Schwab. During the PhD, I became interested in translational stroke research and developing regenerative therapies in preclinical rodent models. From 2019, I joined the group of Prof. Dr. R.M. Nitsch and Dr. C. Tackenberg in the Institute for Regenerative Medicine (IREM) at the University of Zurich, Switzerland. In this project, I focused on developing next-generation stem cell-based therapies following stroke. I am currently member of the Society for Neuroscience (SFN) and European Society for Clinical Investigation (ESCI). I received several fellowships and awards including the selection as a Young Scientist for the 70th Lindau Nobel Laureate Meeting 2020 by the Lindau Nobel committee and a full doctoral fellowship by the German Academic Scholarship Foundation, Germany’s largest and most prestigious scholarship foundation. Our current research focuses on overcoming limitations in cell therapies following brain injury using state-of-the-art genetic, molecular, and computational tools. We have recently generated a scalable neural cell source from induced pluripotent stem cells (iPSCs) under xeno-free conditions that can be continuously tracked in vivo. These cells will be genetically engineered with a brain-shuttle system to facilitate systemic delivery across the brain barriers. To circumvent immune rejection, transplants will co-express distinct immunosuppressive molecules together with safety checkpoints. Efficacy of these advanced cell therapies will be evaluated through an experimental pipeline comprising i.a. in vivo imaging, deep learning-based behavioral profiling, and spatially resolved transcriptomics. The generated findings will be valuable to advance cell therapy for brain injury further towards clinical applications in the foreseeable future. Publications APOE2, E3, and E4 Differentially Modulate Cellular Homeostasis, Cholesterol Metabolism, and Inflammatory Response in Isogenic IPSC-derived Astrocytes Stem Cell Reports. Jan, 2022 | Pubmed ID: 34919811 Slow Development of Bladder Malfunction Parallels Spinal Cord Fiber Sprouting and Interneurons' Loss After Spinal Cord Transection Experimental Neurology. 02, 2022 | Pubmed ID: 34826427 'Scary' Pericytes: the Fibrotic Scar in Brain and Spinal Cord Lesions Trends in Neurosciences. Jan, 2022 | Pubmed ID: 34774344 Isolation and Culture of Adult Hippocampal Precursor Cells As Free-Floating Neurospheres Methods in Molecular Biology (Clifton, N.J.). Month, 2022 | Pubmed ID: 34557999 Astrocytes for Brain Repair: More Than Just a Neuron's Sidekick Brain Pathology (Zurich, Switzerland). 09, 2021 | Pubmed ID: 34196052 IPS-derived Pericytes for Neurovascular Regeneration European Journal of Clinical Investigation. 09, 2021 | Pubmed ID: 34050924 Towards Blood Biomarkers for Stroke Patients Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 04, 2021 | Pubmed ID: 33563080 Characterization of the Blood Brain Barrier Disruption in the Photothrombotic Stroke Model Frontiers in Physiology. Month, 2020 | Pubmed ID: 33262704 Author Correction: Mast Cells Increase Adult Neural Precursor Proliferation and Differentiation but This Potential is Not Realized in Vivo Under Physiological Conditions Scientific Reports. Nov, 2020 | Pubmed ID: 33168937 Distinct Changes in All Major Components of the Neurovascular Unit Across Different Neuropathological Stages of Alzheimer's Disease Brain Pathology (Zurich, Switzerland). 11, 2020 | Pubmed ID: 32866303 A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain Frontiers in Neuroscience. Month, 2020 | Pubmed ID: 32265643 Insights into the Dual Role of Angiogenesis Following Stroke Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 06, 2020 | Pubmed ID: 32065073 Anti-Nogo-A Antibodies Prevent Vascular Leakage and Act As Pro-angiogenic Factors Following Stroke Scientific Reports. 12, 2019 | Pubmed ID: 31882970 Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair Trends in Neurosciences. 09, 2019 | Pubmed ID: 31285047 Nogo-A Targeted Therapy Promotes Vascular Repair and Functional Recovery Following Stroke Proceedings of the National Academy of Sciences of the United States of America. 07, 2019 | Pubmed ID: 31235580 A Revised View on Growth and Remodeling in the Retinal Vasculature Scientific Reports. 03, 2019 | Pubmed ID: 30824785 Pro- and Antiangiogenic Therapies: Current Status and Clinical Implications FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 01, 2019 | Pubmed ID: 30085886 Inflammation After Stroke: A Local Rather Than Systemic Response? Trends in Neurosciences. 12, 2018 | Pubmed ID: 30327142 Loss of Nogo-A, Encoded by the Schizophrenia Risk Gene Rtn4, Reduces MGlu3 Expression and Causes Hyperexcitability in Hippocampal CA3 Circuits PloS One. Month, 2018 | Pubmed ID: 30040841 Stroke Promotes Systemic Endothelial Inflammation and Atherosclerosis Trends in Molecular Medicine. 07, 2018 | Pubmed ID: 29747910 Mast Cells Increase Adult Neural Precursor Proliferation and Differentiation but This Potential is Not Realized in Vivo Under Physiological Conditions Scientific Reports. 12, 2017 | Pubmed ID: 29259265 השתלה תוך-מוחית ומעקב ביולומינסנציה In Vivo של תאי אב עצביים אנושיים במוח העכבר Rebecca Z. Weber1,2, Chantal Bodenmann1, Daniela Uhr1, Kathrin J. Zürcher1, Debora Wanner1, Melanie Generali1, Roger M. Nitsch1, Ruslan Rust*1,2, Christian Tackenberg*1,2 1Institute for Regenerative Medicine, University of Zurich, 2Neuroscience Center Zurich, University of Zurich and ETH Zurich JoVE 63102 Neuroscience
השתלה תוך-מוחית ומעקב ביולומינסנציה In Vivo של תאי אב עצביים אנושיים במוח העכבר Rebecca Z. Weber1,2, Chantal Bodenmann1, Daniela Uhr1, Kathrin J. Zürcher1, Debora Wanner1, Melanie Generali1, Roger M. Nitsch1, Ruslan Rust*1,2, Christian Tackenberg*1,2 1Institute for Regenerative Medicine, University of Zurich, 2Neuroscience Center Zurich, University of Zurich and ETH Zurich JoVE 63102 Neuroscience