Scott L. Friedman Department of Medicine, Division of Liver Diseases Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Scott L. Friedman has not added a biography. If you are Scott L. Friedman and would like to personalize this page please email our Author Liaison for assistance. Publications L(59) TGF-β LAP Degradation Products Serve As a Promising Blood Biomarker for Liver Fibrogenesis in Mice Fibrogenesis & Tissue Repair. 2015 | Pubmed ID: 26379781 Induction and Contribution of Beta Platelet-derived Growth Factor Signalling by Hepatic Stellate Cells to Liver Regeneration After Partial Hepatectomy in Mice Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2015 | Pubmed ID: 26256287 Hepatic Fibrosis: Emerging Therapies Digestive Diseases (Basel, Switzerland). 2015 | Pubmed ID: 26159266 A Hepatic Stellate Cell Gene Expression Signature Associated with Outcomes in Hepatitis C Cirrhosis and Hepatocellular Carcinoma After Curative Resection Gut. Jun, 2015 | Pubmed ID: 26045137 Modulation of Cardiac Fibrosis by Krüppel-like Factor 6 Through Transcriptional Control of Thrombospondin 4 in Cardiomyocytes Cardiovascular Research. Sep, 2015 | Pubmed ID: 25987545 Emerging and Disease-specific Mechanisms of Hepatic Stellate Cell Activation Seminars in Liver Disease. May, 2015 | Pubmed ID: 25974897 Granulocyte Macrophage Colony-stimulating Factor is Required for Aortic Dissection/intramural Haematoma Nature Communications. 2015 | Pubmed ID: 25923510 Hepatic Fibrosis: Concept to Treatment Journal of Hepatology. Apr, 2015 | Pubmed ID: 25920084 Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis Gastroenterology. Aug, 2015 | Pubmed ID: 25865049 Preserved Expression of MRNA Coding Von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C Molecular Medicine (Cambridge, Mass.). 2015 | Pubmed ID: 25860876 Epithelial Xbp1 is Required for Cellular Proliferation and Differentiation During Mammary Gland Development Molecular and Cellular Biology. May, 2015 | Pubmed ID: 25713103 Pathobiology of Liver Fibrosis: a Translational Success Story Gut. May, 2015 | Pubmed ID: 25681399 β-PDGF Receptor Expressed by Hepatic Stellate Cells Regulates Fibrosis in Murine Liver Injury, but Not Carcinogenesis Journal of Hepatology. Jul, 2015 | Pubmed ID: 25678385 Principles on the Path to a Hepatologist's Enlightenment Hepatology (Baltimore, Md.). Jul, 2015 | Pubmed ID: 25645892 Strategies and Endpoints of Antifibrotic Drug Trials: Summary and Recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014 Hepatology (Baltimore, Md.). Aug, 2015 | Pubmed ID: 25626988 Challenges and Opportunities in Drug and Biomarker Development for Nonalcoholic Steatohepatitis: Findings and Recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop Hepatology (Baltimore, Md.). Apr, 2015 | Pubmed ID: 25557690 Alcohol and Inflammatory Responses: Summary of the 2013 Alcohol and Immunology Research Interest Group (AIRIG) Meeting Alcohol (Fayetteville, N.Y.). Feb, 2015 | Pubmed ID: 25468277 Inhibition of the CXCL12/CXCR4 Chemokine Axis with AMD3100, a CXCR4 Small Molecule Inhibitor, Worsens Murine Hepatic Injury Hepatology Research : the Official Journal of the Japan Society of Hepatology. Jul, 2015 | Pubmed ID: 25163538 A Genomic and Clinical Prognostic Index for Hepatitis C-related Early-stage Cirrhosis That Predicts Clinical Deterioration Gut. Aug, 2015 | Pubmed ID: 25143343 The Past 10 Years of Gastroenterology and Hepatology-reflections and Predictions Nature Reviews. Gastroenterology & Hepatology. Nov, 2014 | Pubmed ID: 25291429 IL-17A Enhances the Expression of Profibrotic Genes Through Upregulation of the TGF-β Receptor on Hepatic Stellate Cells in a JNK-dependent Manner Journal of Immunology (Baltimore, Md. : 1950). Oct, 2014 | Pubmed ID: 25210118 Focusing on the Past, Present, and Future of Hepatology Journal of Hepatology. Dec, 2014 | Pubmed ID: 25195549 Final and Future Frontiers Journal of Hepatology. Nov, 2014 | Pubmed ID: 25149111 Tracking HCC Pathogenesis but Not the Tumor Cells After Biopsy Journal of Hepatology. Sep, 2014 | Pubmed ID: 24915611 LAP Degradation Product Reflects Plasma Kallikrein-dependent TGF-β Activation in Patients with Hepatic Fibrosis SpringerPlus. 2014 | Pubmed ID: 24877031 NRBF2 Regulates Autophagy and Prevents Liver Injury by Modulating Atg14L-linked Phosphatidylinositol-3 Kinase III Activity Nature Communications. 2014 | Pubmed ID: 24849286 Hepatic Fibrosis and the Microenvironment: Fertile Soil for Hepatocellular Carcinoma Development Gene Expression. 2014 | Pubmed ID: 24801168 Association of Genetic Variants with Rapid Fibrosis: Progression After Liver Transplantation for Hepatitis C Transplantation. May, 2014 | Pubmed ID: 24770613 Reversal, Maintenance or Progression: What Happens to the Liver After a Virologic Cure of Hepatitis C? Antiviral Research. Jul, 2014 | Pubmed ID: 24726738 Transporting Pharmacogenomics into Clinical Practice Journal of Hepatology. Jul, 2014 | Pubmed ID: 24703955 Central Role of Conventional Dendritic Cells in Regulation of Bone Marrow Release and Survival of Neutrophils Journal of Immunology (Baltimore, Md. : 1950). Apr, 2014 | Pubmed ID: 24591364 Replacing a Crystal Ball with a Calculator in Predicting Liver Disease Outcomes Journal of Hepatology. May, 2014 | Pubmed ID: 24486331 "There Are Decades Where Nothing Happens; and There Are Weeks Where Decades Happen"--Vladimir Ilyich Lenin Journal of Hepatology. Mar, 2014 | Pubmed ID: 24333649 Contributions of Metabolic Dysregulation and Inflammation to Nonalcoholic Steatohepatitis, Hepatic Fibrosis, and Cancer Current Opinion in Oncology. Jan, 2014 | Pubmed ID: 24275855 Focus Journal of Hepatology. Jan, 2014 | Pubmed ID: 24121095 β-Catenin Signaling in Hepatocellular Cancer: Implications in Inflammation, Fibrosis, and Proliferation Cancer Letters. Feb, 2014 | Pubmed ID: 24071572 Hepatic Stellate Cells and Liver Fibrosis Comprehensive Physiology. Oct, 2013 | Pubmed ID: 24265236 Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-induced Liver Disease PloS One. 2013 | Pubmed ID: 24130706 Genetic Characteristics of the Human Hepatic Stellate Cell Line LX-2 PloS One. 2013 | Pubmed ID: 24116068 Focus Journal of Hepatology. Nov, 2013 | Pubmed ID: 23958934 A Candidate Gene Study for the Association of Host Single Nucleotide Polymorphisms with Liver Cirrhosis Risk in Chinese Hepatitis B Patients Genetic Testing and Molecular Biomarkers. Sep, 2013 | Pubmed ID: 23844940 Genome-wide Transcriptome Analysis Identifies Novel Gene Signatures Implicated in Human Chronic Liver Disease American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2013 | Pubmed ID: 23812039 CXCL12 Induces Hepatic Stellate Cell Contraction Through a Calcium-independent Pathway American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2013 | Pubmed ID: 23812037 Functions of Autophagy in Normal and Diseased Liver Autophagy. Aug, 2013 | Pubmed ID: 23774882 Focus Journal of Hepatology. Sep, 2013 | Pubmed ID: 23770255 Focus Journal of Hepatology. Jul, 2013 | Pubmed ID: 23583274 Preface to BBA Issue Devoted to Fibrosis Biochimica Et Biophysica Acta. Jul, 2013 | Pubmed ID: 23507143 Endoplasmic Reticulum Stress Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy Journal of Hepatology. Jul, 2013 | Pubmed ID: 23485523 Focus Journal of Hepatology. May, 2013 | Pubmed ID: 23376365 Post-transcriptional Activation of PPAR Alpha by KLF6 in Hepatic Steatosis Journal of Hepatology. May, 2013 | Pubmed ID: 23353867 Hepatitis Outreach Network: a Practical Strategy for Hepatitis Screening with Linkage to Care in Foreign-born Communities Journal of Hepatology. May, 2013 | Pubmed ID: 23333446 Prognostic Gene Expression Signature for Patients with Hepatitis C-related Early-stage Cirrhosis Gastroenterology. May, 2013 | Pubmed ID: 23333348 Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma Gastroenterology. Mar, 2013 | Pubmed ID: 23313965 Therapy for Fibrotic Diseases: Nearing the Starting Line Science Translational Medicine. Jan, 2013 | Pubmed ID: 23303606 Free Fatty Acids Repress Small Heterodimer Partner (SHP) Activation and Adiponectin Counteracts Bile Acid-induced Liver Injury in Superobese Patients with Nonalcoholic Steatohepatitis Hepatology (Baltimore, Md.). Apr, 2013 | Pubmed ID: 23299969 Liver Fibrosis in 2012: Convergent Pathways That Cause Hepatic Fibrosis in NASH Nature Reviews. Gastroenterology & Hepatology. Feb, 2013 | Pubmed ID: 23296246 A Histone Deacetylase Inhibitor, Largazole, Decreases Liver Fibrosis and Angiogenesis by Inhibiting Transforming Growth Factor-β and Vascular Endothelial Growth Factor Signalling Liver International : Official Journal of the International Association for the Study of the Liver. Apr, 2013 | Pubmed ID: 23279742 Cellular Basis of Hepatic Fibrosis and Its Role in Inflammation and Cancer Frontiers in Bioscience (Scholar Edition). 2013 | Pubmed ID: 23277047 Focus Journal of Hepatology. Mar, 2013 | Pubmed ID: 23247068 The Expression Patterns and Clinical Significance of MicroRNAs in Liver Diseases and Hepatocellular Carcinoma Current Pharmaceutical Design. 2013 | Pubmed ID: 23092345 Focus Journal of Hepatology. Jan, 2013 | Pubmed ID: 23085646 Vascular Injury Triggers Krüppel-like Factor 6 Mobilization and Cooperation with Specificity Protein 1 to Promote Endothelial Activation Through Upregulation of the Activin Receptor-like Kinase 1 Gene Circulation Research. Jan, 2013 | Pubmed ID: 23048070 Reduced Hepatic Stellate Cell Expression of Kruppel-like Factor 6 Tumor Suppressor Isoforms Amplifies Fibrosis During Acute and Chronic Rodent Liver Injury Hepatology (Baltimore, Md.). Feb, 2013 | Pubmed ID: 22961688 A Novel Murine Model to Deplete Hepatic Stellate Cells Uncovers Their Role in Amplifying Liver Damage in Mice Hepatology (Baltimore, Md.). Jan, 2013 | Pubmed ID: 22961591 Antifibrotic Activity of Sorafenib in Experimental Hepatic Fibrosis: Refinement of Inhibitory Targets, Dosing, and Window of Efficacy in Vivo Digestive Diseases and Sciences. Jan, 2013 | Pubmed ID: 22918681 Autophagy and Mesenchymal Cell Fibrogenesis Biochimica Et Biophysica Acta. Jul, 2012 | Pubmed ID: 23142802 Protect Thee from the Sins of Thy Fathers? Nature Medicine. Sep, 2012 | Pubmed ID: 22961157 Focus Journal of Hepatology. Nov, 2012 | Pubmed ID: 22922569 Hepatocyte Growth Factor Enhances Alternative Splicing of the Kruppel-like Factor 6 (KLF6) Tumor Suppressor to Promote Growth Through SRSF1 Molecular Cancer Research : MCR. Sep, 2012 | Pubmed ID: 22859706 High Mobility Group Box 1 Activates Toll Like Receptor 4 Signaling in Hepatic Stellate Cells Life Sciences. Sep, 2012 | Pubmed ID: 22841886 Wnt-pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2012 | Pubmed ID: 22811581 The Role of Chemokines in Acute Liver Injury Frontiers in Physiology. 2012 | Pubmed ID: 22723782 Focus Journal of Hepatology. Sep, 2012 | Pubmed ID: 22691572 Autophagy Fuels Tissue Fibrogenesis Autophagy. May, 2012 | Pubmed ID: 22617442 CD11b(+) Gr1(+) Bone Marrow Cells Ameliorate Liver Fibrosis by Producing Interleukin-10 in Mice Hepatology (Baltimore, Md.). Nov, 2012 | Pubmed ID: 22544759 Enhanced Hepatocarcinogenesis in Mouse Models and Human Hepatocellular Carcinoma by Coordinate KLF6 Depletion and Increased Messenger RNA Splicing Hepatology (Baltimore, Md.). Oct, 2012 | Pubmed ID: 22535637 Focus. Metchnikoff, Macrophages and the Metabolic Syndrome Journal of Hepatology. Jul, 2012 | Pubmed ID: 22522383 Anti-fibrotic Activity and Enhanced Interleukin-6 Production by Hepatic Stellate Cells in Response to Imatinib Mesylate Liver International : Official Journal of the International Association for the Study of the Liver. Jul, 2012 | Pubmed ID: 22507133 Fibrosis-dependent Mechanisms of Hepatocarcinogenesis Hepatology (Baltimore, Md.). Aug, 2012 | Pubmed ID: 22378017 Combination Therapy for Hepatocellular Carcinoma: Additive Preclinical Efficacy of the HDAC Inhibitor Panobinostat with Sorafenib Journal of Hepatology. Jun, 2012 | Pubmed ID: 22322234 A Silent Partner No Longer – Sinusoidal Endothelial Cells in Liver Homeostasis and Disease Journal of Hepatology. May, 2012 | Pubmed ID: 22322233 Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues Gastroenterology. Apr, 2012 | Pubmed ID: 22240484 Genomics and Proteomics in Liver Fibrosis and Cirrhosis Fibrogenesis & Tissue Repair. 2012 | Pubmed ID: 22214245 Glucokinase Links Krüppel-like Factor 6 to the Regulation of Hepatic Insulin Sensitivity in Nonalcoholic Fatty Liver Disease Hepatology (Baltimore, Md.). Apr, 2012 | Pubmed ID: 22095588 Focus. An Emerging Conceptual Scaffold for NASH Journal of Hepatology. Mar, 2012 | Pubmed ID: 22075260 Discoidin Domain Receptor 2 Deficiency Predisposes Hepatic Tissue to Colon Carcinoma Metastasis Gut. Oct, 2012 | Pubmed ID: 22071959 Focus Journal of Hepatology. Jan, 2012 | Pubmed ID: 21906568 Dendritic Cell Regulation of Carbon Tetrachloride-induced Murine Liver Fibrosis Regression Hepatology (Baltimore, Md.). Jan, 2012 | Pubmed ID: 21898476 Current Status of Novel Antifibrotic Therapies in Patients with Chronic Liver Disease Therapeutic Advances in Gastroenterology. Nov, 2011 | Pubmed ID: 22043231 Loss of Discoidin Domain Receptor 2 Promotes Hepatic Fibrosis After Chronic Carbon Tetrachloride Through Altered Paracrine Interactions Between Hepatic Stellate Cells and Liver-associated Macrophages The American Journal of Pathology. Dec, 2011 | Pubmed ID: 22019896 Human Hepatic Stellate Cell Line (LX-2) Exhibits Characteristics of Bone Marrow-derived Mesenchymal Stem Cells Experimental and Molecular Pathology. Dec, 2011 | Pubmed ID: 21930125 A Polymorphism That Delays Fibrosis in Hepatitis C Promotes Alternative Splicing of AZIN1, Reducing Fibrogenesis Hepatology (Baltimore, Md.). Dec, 2011 | Pubmed ID: 21837750 Nature, Natural and NAFLD Journal of Hepatology. Nov, 2011 | Pubmed ID: 21767508 Gene-expression Signature of Vascular Invasion in Hepatocellular Carcinoma Journal of Hepatology. Dec, 2011 | Pubmed ID: 21703203 Focus Journal of Hepatology. Sep, 2011 | Pubmed ID: 21621571 [Polymorphism of Ornithine Decarboxylase Antizyme Inhibitor 1 Gene is Associated with Liver Cirrhosis in Chinese Hepatitis B Patients] Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology. Mar, 2011 | Pubmed ID: 21586232 Carcinogen-induced Hepatic Tumors in KLF6+/- Mice Recapitulate Aggressive Human Hepatocellular Carcinoma Associated with P53 Pathway Deregulation Hepatology (Baltimore, Md.). Aug, 2011 | Pubmed ID: 21563203 Scraping Fibrosis: Expressway to the Core of Fibrosis Nature Medicine. May, 2011 | Pubmed ID: 21546973 Mechanisms of Hepatic Fibrogenesis Best Practice & Research. Clinical Gastroenterology. Apr, 2011 | Pubmed ID: 21497738 Focus Journal of Hepatology. Jul, 2011 | Pubmed ID: 21396971 Mechanismen Der Leberfibrose Experimenteller Fasciola Hepatica Infektion Zugeordnet: Rollen Der Fas2 Proteinase Und Hepatische Stellate Zelle Aktivierung The Journal of Parasitology. Feb, 2011 | Pubmed ID: 21348611 MicroRNA-basierte Klassifizierung Der Hepatozellulären Karzinom Und Onkogene Rolle Der MiR-517a Gastroenterology. May, 2011 | Pubmed ID: 21324318 Reactive Oxygen Species and NADPH Oxidase 4 Induced by Transforming Growth Factor β1 Are the Therapeutic Targets of Polyenylphosphatidylcholine in the Suppression of Human Hepatic Stellate Cell Activation Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Jun, 2011 | Pubmed ID: 21318733 SPARC Downregulation Attenuates the Profibrogenic Response of Hepatic Stellate Cells Induced by TGF-β1 and PDGF American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2011 | Pubmed ID: 21311029 Impaired Dermal Wound Healing in Discoidin Domain Receptor 2-deficient Mice Associated with Defective Extracellular Matrix Remodeling Fibrogenesis & Tissue Repair. 2011 | Pubmed ID: 21288331 Dendritic Cells in Alcoholic Liver Injury and Fibrosis Alcoholism, Clinical and Experimental Research. May, 2011 | Pubmed ID: 21284665 Inhibition of PDGF, TGF-β, and Abl Signaling and Reduction of Liver Fibrosis by the Small Molecule Bcr-Abl Tyrosine Kinase Antagonist Nilotinib Journal of Hepatology. Sep, 2011 | Pubmed ID: 21251937 Focus Journal of Hepatology. May, 2011 | Pubmed ID: 21232564 Platelets Arrive at the Scene of Fibrosis……studies Journal of Hepatology. May, 2011 | Pubmed ID: 21167890 Pathogenesis of Liver Fibrosis Annual Review of Pathology. 2011 | Pubmed ID: 21073339 Verlust Von Matrix-Metalloproteasen-2 Verstärkt Murinen Toxin-induzierten Leberfibrose Durch Heraufregulierung Kollagen Ich Ausdruck Digestive Diseases and Sciences. Feb, 2011 | Pubmed ID: 20563750 Fibrosis in the Liver: Acute Protection and Chronic Disease Progress in Molecular Biology and Translational Science. 2010 | Pubmed ID: 21074733 E3 Ubiquitin Ligase Synoviolin is Involved in Liver Fibrogenesis PloS One. 2010 | Pubmed ID: 21049091 Toll-like Receptor 4 Signaling in Liver Injury and Hepatic Fibrogenesis Fibrogenesis & Tissue Repair. 2010 | Pubmed ID: 20964825 Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Plays a Key Role in Stellate Cell Activation and Liver Fibrogenesis in Vivo Gastroenterology. Oct, 2010 | Pubmed ID: 20685364 Acute Liver Failure is Associated with Elevated Liver Stiffness and Hepatic Stellate Cell Activation Hepatology (Baltimore, Md.). Sep, 2010 | Pubmed ID: 20684020 KLF6 Gene and Early Melanoma Development in a Collagen I-rich Extracellular Environment Journal of the National Cancer Institute. Aug, 2010 | Pubmed ID: 20660366 Characterization of the Human Activin-A Receptor Type II-like Kinase 1 (ACVRL1) Promoter and Its Regulation by Sp1 BMC Molecular Biology. 2010 | Pubmed ID: 20587022 Evolving Challenges in Hepatic Fibrosis Nature Reviews. Gastroenterology & Hepatology. Aug, 2010 | Pubmed ID: 20585339 Klf6/copeb is Required for Hepatic Outgrowth in Zebrafish and for Hepatocyte Specification in Mouse ES Cells Developmental Biology. Aug, 2010 | Pubmed ID: 20430021 Obesity, Inflammatory Signaling, and Hepatocellular Carcinoma-an Enlarging Link Cancer Cell. Feb, 2010 | Pubmed ID: 20159605 Downregulation of Hepatic Stellate Cell Activation by Retinol and Palmitate Mediated by Adipose Differentiation-related Protein (ADRP) Journal of Cellular Physiology. Jun, 2010 | Pubmed ID: 20143336 Tumor Suppressor Activity of KLF6 Mediated by Downregulation of the PTTG1 Oncogene FEBS Letters. Mar, 2010 | Pubmed ID: 20116377 A DDX5 S480A Polymorphism is Associated with Increased Transcription of Fibrogenic Genes in Hepatic Stellate Cells The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 20022962 Kupffer Cell Activation by Ambient Air Particulate Matter Exposure May Exacerbate Non-alcoholic Fatty Liver Disease Journal of Immunotoxicology. Dec, 2009 | Pubmed ID: 19908945 Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma Cancer Research. Sep, 2009 | Pubmed ID: 19723656 Therapeutic Targeting of the PDGF and TGF-beta-signaling Pathways in Hepatic Stellate Cells by PTK787/ZK22258 Laboratory Investigation; a Journal of Technical Methods and Pathology. Oct, 2009 | Pubmed ID: 19668241 Ras Pathway Activation in Hepatocellular Carcinoma and Anti-tumoral Effect of Combined Sorafenib and Rapamycin in Vivo Journal of Hepatology. Oct, 2009 | Pubmed ID: 19665249 Multiple Variants in Toll-like Receptor 4 Gene Modulate Risk of Liver Fibrosis in Caucasians with Chronic Hepatitis C Infection Journal of Hepatology. Oct, 2009 | Pubmed ID: 19586676 Detection of Intracellular ADAMTS13, a Secreted Zinc-metalloprotease, Via Flow Cytometry Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Aug, 2009 | Pubmed ID: 19526483 Hepatic Fibrosis Current Opinion in Gastroenterology. May, 2009 | Pubmed ID: 19396960 Antifibrotic Effects of CXCL9 and Its Receptor CXCR3 in Livers of Mice and Humans Gastroenterology. Jul, 2009 | Pubmed ID: 19344719 Resveratrol Amplifies Profibrogenic Effects of Free Fatty Acids on Human Hepatic Stellate Cells Hepatology Research : the Official Journal of the Japan Society of Hepatology. Jun, 2009 | Pubmed ID: 19207580 Detection of Novel Biomarkers of Liver Cirrhosis by Proteomic Analysis Hepatology (Baltimore, Md.). Apr, 2009 | Pubmed ID: 19177598 PTK787/ZK22258 Attenuates Stellate Cell Activation and Hepatic Fibrosis in Vivo by Inhibiting VEGF Signaling Laboratory Investigation; a Journal of Technical Methods and Pathology. Feb, 2009 | Pubmed ID: 19114984 Functional Role of the KLF6 Tumour Suppressor Gene in Gastric Cancer European Journal of Cancer (Oxford, England : 1990). Mar, 2009 | Pubmed ID: 19101139 Commentary: Gastroenterology and Hepatology: an Evolving Marriage, Not an Imminent Divorce The American Journal of Gastroenterology. Jan, 2009 | Pubmed ID: 19098841 Functional Linkage of Cirrhosis-predictive Single Nucleotide Polymorphisms of Toll-like Receptor 4 to Hepatic Stellate Cell Responses Hepatology (Baltimore, Md.). Mar, 2009 | Pubmed ID: 19085953 TGF-beta Regulates the Expression of Transcription Factor KLF6 and Its Splice Variants and Promotes Co-operative Transactivation of Common Target Genes Through a Smad3-Sp1-KLF6 Interaction The Biochemical Journal. Apr, 2009 | Pubmed ID: 19076057 P38-MAPK - Und Caspase-3-vermittelter Superoxid Induziert Apoptose Der Ratte Hepatische Stellate Zellen: Umkehrung Von Retinsäure Journal of Cellular Physiology. Jan, 2009 | Pubmed ID: 18792915 Advances in Antifibrotic Therapy Expert Review of Gastroenterology & Hepatology. Dec, 2008 | Pubmed ID: 19090740 Preface. Hepatic Fibrosis: Pathogenesis, Diagnosis, and Emerging Therapies Clinics in Liver Disease. Nov, 2008 | Pubmed ID: 18984462 Pivotal Role of MTOR Signaling in Hepatocellular Carcinoma Gastroenterology. Dec, 2008 | Pubmed ID: 18929564 Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma The New England Journal of Medicine. Nov, 2008 | Pubmed ID: 18923165 Activation of Hepatic Stellate Cells After Phagocytosis of Lymphocytes: A Novel Pathway of Fibrogenesis Hepatology (Baltimore, Md.). Sep, 2008 | Pubmed ID: 18726940 Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma Cancer Research. Aug, 2008 | Pubmed ID: 18701503 Increased Alternative Splicing of the KLF6 Tumour Suppressor Gene Correlates with Prognosis and Tumour Grade in Patients with Pancreatic Cancer European Journal of Cancer (Oxford, England : 1990). Sep, 2008 | Pubmed ID: 18691883 Future Trends in Hepatology: Challenges and Opportunities Hepatology (Baltimore, Md.). Aug, 2008 | Pubmed ID: 18666245 Hepatic Fibrosis -- Overview Toxicology. Dec, 2008 | Pubmed ID: 18662740 KLF6-SV1 Overexpression Accelerates Human and Mouse Prostate Cancer Progression and Metastasis The Journal of Clinical Investigation. Aug, 2008 | Pubmed ID: 18596922 The Kruppel-like Factor 6 Genotype is Associated with Fibrosis in Nonalcoholic Fatty Liver Disease Gastroenterology. Jul, 2008 | Pubmed ID: 18515091 Mechanisms of Hepatic Fibrogenesis Gastroenterology. May, 2008 | Pubmed ID: 18471545 Ras Promotes Growth by Alternative Splicing-mediated Inactivation of the KLF6 Tumor Suppressor in Hepatocellular Carcinoma Gastroenterology. May, 2008 | Pubmed ID: 18471523 The Movement of Aquatic Mercury Through Terrestrial Food Webs Science (New York, N.Y.). Apr, 2008 | Pubmed ID: 18420925 Targeting SiRNA to Arrest Fibrosis Nature Biotechnology. Apr, 2008 | Pubmed ID: 18392021 Cannabinoids Provoke Alcoholic Steatosis Through a Conspiracy of Neighbors Cell Metabolism. Mar, 2008 | Pubmed ID: 18316020 Experimental Models of Hepatocellular Carcinoma Journal of Hepatology. May, 2008 | Pubmed ID: 18314222 Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver Physiological Reviews. Jan, 2008 | Pubmed ID: 18195085 Insulin-like Growth Factor-i Regulates Kruppel-like Factor-6 Gene Expression in a P53-dependent Manner Endocrinology. Apr, 2008 | Pubmed ID: 18174288 Regression of Fibrosis After Chronic Stimulation of Cannabinoid CB2 Receptor in Cirrhotic Rats The Journal of Pharmacology and Experimental Therapeutics. Feb, 2008 | Pubmed ID: 18029545 Liver Fibrosis: from Mechanisms to Treatment Gastroentérologie Clinique Et Biologique. Oct, 2007 | Pubmed ID: 18166858 A Deer in the Headlights: BAMBI Meets Liver Fibrosis Nature Medicine. Nov, 2007 | Pubmed ID: 17987019 Hepatic Fibrogenesis Seminars in Liver Disease. Nov, 2007 | Pubmed ID: 17979077 Antiangiogenic Treatment with Sunitinib Ameliorates Inflammatory Infiltrate, Fibrosis, and Portal Pressure in Cirrhotic Rats Hepatology (Baltimore, Md.). Dec, 2007 | Pubmed ID: 17935226 KLF6 Allelic Loss is Associated with Tumor Recurrence and Markedly Decreased Survival in Head and Neck Squamous Cell Carcinoma International Journal of Cancer. Journal International Du Cancer. Nov, 2007 | Pubmed ID: 17621627 Immunopathogenesis of Hepatitis C Virus Infection and Hepatic Fibrosis: New Insights into Antifibrotic Therapy in Chronic Hepatitis C Hepatology Research : the Official Journal of the Japan Society of Hepatology. Aug, 2007 | Pubmed ID: 17517074 Functional Inactivation of the KLF6 Tumor Suppressor Gene by Loss of Heterozygosity and Increased Alternative Splicing in Glioblastoma International Journal of Cancer. Journal International Du Cancer. Sep, 2007 | Pubmed ID: 17514651 Reversibility of Hepatic Fibrosis and Cirrhosis--is It All Hype? Nature Clinical Practice. Gastroenterology & Hepatology. May, 2007 | Pubmed ID: 17476207 Genomics and Signaling Pathways in Hepatocellular Carcinoma Seminars in Liver Disease. Feb, 2007 | Pubmed ID: 17295177 Downregulation of KLF6 is an Early Event in Hepatocarcinogenesis, and Stimulates Proliferation While Reducing Differentiation Journal of Hepatology. Apr, 2007 | Pubmed ID: 17196295 Hepatic Fibrosis 2006: Report of the Third AASLD Single Topic Conference Hepatology (Baltimore, Md.). Jan, 2007 | Pubmed ID: 17187439 Adenovirus-mediated Expression of BMP-7 Suppresses the Development of Liver Fibrosis in Rats Gut. May, 2007 | Pubmed ID: 17127702 Reefer Madness? Assessing the Effects of Cannabinoids with a Less Jaundiced Eye Journal of Hepatology. Jan, 2007 | Pubmed ID: 17107732 Beneficial Effect of Glatiramer Acetate (Copaxone) on Immune Modulation of Experimental Hepatic Fibrosis American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2007 | Pubmed ID: 17038628 Targeted and Regulable Expression of Transgenes in Hepatic Stellate Cells and Myofibroblasts in Culture and in Vivo Using an Adenoviral Cre/loxP System to Antagonise Hepatic Fibrosis Gut. Mar, 2007 | Pubmed ID: 16956920 Diagnosis of Hepatic Fibrosis in Patients with Chronic Hepatitis C Clinics in Liver Disease. Nov, 2006 | Pubmed ID: 17164119 KLF6 Degradation After Apoptotic DNA Damage FEBS Letters. Dec, 2006 | Pubmed ID: 17113081 A Molecular Signature to Discriminate Dysplastic Nodules from Early Hepatocellular Carcinoma in HCV Cirrhosis Gastroenterology. Dec, 2006 | Pubmed ID: 17087938 Molecular Diagnosis of Chronic Liver Disease and Hepatocellular Carcinoma: the Potential of Gene Expression Profiling Seminars in Liver Disease. Nov, 2006 | Pubmed ID: 17051451 Transcriptional Regulation of Stellate Cell Activation Journal of Gastroenterology and Hepatology. Oct, 2006 | Pubmed ID: 16958680 Stellate Cell Apoptosis by a Soluble Mediator from Immortalized Human Hepatocytes Apoptosis : an International Journal on Programmed Cell Death. Aug, 2006 | Pubmed ID: 16830231 Adenosine A(2A) Receptors Play a Role in the Pathogenesis of Hepatic Cirrhosis British Journal of Pharmacology. Aug, 2006 | Pubmed ID: 16783407 Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2006 | Pubmed ID: 16778100 Anti-fibrotic Activity of NK Cells in Experimental Liver Injury Through Killing of Activated HSC Journal of Hepatology. Jul, 2006 | Pubmed ID: 16515819 Phagocytosis of Apoptotic Bodies by Hepatic Stellate Cells Induces NADPH Oxidase and is Associated with Liver Fibrosis in Vivo Hepatology (Baltimore, Md.). Mar, 2006 | Pubmed ID: 16496318 Reversal of Hepatic Fibrosis -- Fact or Fantasy? Hepatology (Baltimore, Md.). Feb, 2006 | Pubmed ID: 16447275 Developmental Regulation of Yolk Sac Hematopoiesis by Kruppel-like Factor 6 Blood. Feb, 2006 | Pubmed ID: 16234353 BMP-7 Opposes TGF-beta1-mediated Collagen Induction in Mouse Pulmonary Myofibroblasts Through Id2 American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2006 | Pubmed ID: 16126788 Sex Steroids Have Differential Effects on Growth and Gene Expression in Primary Human Prostatic Epithelial Cell Cultures Derived from the Peripheral Versus Transition Zones Carcinogenesis. Feb, 2006 | Pubmed ID: 16123118 Regulation of Kruppel-like Factor 6 Tumor Suppressor Activity by Acetylation Cancer Research. Oct, 2005 | Pubmed ID: 16230382 Enhanced Oral Tolerance in Transgenic Mice with Hepatocyte Secretion of IL-10 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148101 Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread Cancer Research. Jul, 2005 | Pubmed ID: 15994951 Krüppel-like Factor-6 Promotes Preadipocyte Differentiation Through Histone Deacetylase 3-dependent Repression of DLK1 The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15917248 Prevention of Rat Hepatocarcinogenesis by Acyclic Retinoid is Accompanied by Reduction in Emergence of Both TGF-alpha-expressing Oval-like Cells and Activated Hepatic Stellate Cells Nutrition and Cancer. 2005 | Pubmed ID: 15860442 Interleukin-6 Protects Hepatocytes from CCl4-mediated Necrosis and Apoptosis in Mice by Reducing MMP-2 Expression Journal of Hepatology. Apr, 2005 | Pubmed ID: 15763341 A Germline DNA Polymorphism Enhances Alternative Splicing of the KLF6 Tumor Suppressor Gene and is Associated with Increased Prostate Cancer Risk Cancer Research. Feb, 2005 | Pubmed ID: 15735005 Precision-cut Liver Slices As a New Model to Study Toxicity-induced Hepatic Stellate Cell Activation in a Physiologic Milieu Toxicological Sciences : an Official Journal of the Society of Toxicology. May, 2005 | Pubmed ID: 15728706 Mac the Knife? Macrophages- the Double-edged Sword of Hepatic Fibrosis The Journal of Clinical Investigation. Jan, 2005 | Pubmed ID: 15630440 Mechanisms of Disease: Mechanisms of Hepatic Fibrosis and Therapeutic Implications Nature Clinical Practice. Gastroenterology & Hepatology. Dec, 2004 | Pubmed ID: 16265071 Lhx2-/- Mice Develop Liver Fibrosis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15536133 Das Michael Li1,2, Ravi R. Pathak5, Esther Lopez-Rivera3, Scott L. Friedman1, Julio A. Aguirre-Ghiso4, Andrew G. Sikora5 1Department of Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, 2Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, 3Division of Nephrology, Columbia University College of Physicians and Surgeons, 4Departments of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, 5Bobby R. Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine Medicine
Das Michael Li1,2, Ravi R. Pathak5, Esther Lopez-Rivera3, Scott L. Friedman1, Julio A. Aguirre-Ghiso4, Andrew G. Sikora5 1Department of Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, 2Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, 3Division of Nephrology, Columbia University College of Physicians and Surgeons, 4Departments of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, 5Bobby R. Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine Medicine