Stefan G. Sarafianos Laboratory of Biochemical Pharmacology, Department of Pediatrics Emory University School of Medicine Biography Publications Institution JoVE Articles Stefan G. Sarafianos has not added a biography. If you are Stefan G. Sarafianos and would like to personalize this page please email our Author Liaison for assistance. Publications Novel HIV-1 Capsid-targeting Small Molecules of the PF74 Binding Site European Journal of Medicinal Chemistry. Oct, 2020 | Pubmed ID: 32814250 HIV-1 Replication Complexes Accumulate in Nuclear Speckles and Integrate into Speckle-associated Genomic Domains Nature Communications. 07, 2020 | Pubmed ID: 32665593 Effect of P-body Component Mov10 on HCV Virus Production and Infectivity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2020 | Pubmed ID: 32496609 Chemical Profiling of HIV-1 Capsid-targeting Antiviral PF74 European Journal of Medicinal Chemistry. Aug, 2020 | Pubmed ID: 32438252 Feasibility of Known RNA Polymerase Inhibitors As Anti-SARS-CoV-2 Drugs Pathogens (Basel, Switzerland). Apr, 2020 | Pubmed ID: 32357471 Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules Viruses. 04, 2020 | Pubmed ID: 32316297 7-Deaza-7-fluoro Modification Confers on 4'-cyano-nucleosides Potent Activity Against Entecavir/adefovir-resistant HBV Variants and Favorable Safety Antiviral Research. 04, 2020 | Pubmed ID: 32084506 Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches Toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H Accounts of Chemical Research. 01, 2020 | Pubmed ID: 31880912 Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals Against Hepatitis C Virus Viruses. 11, 2019 | Pubmed ID: 31717338 Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H ACS Infectious Diseases. 11, 2019 | Pubmed ID: 31577424 Conformational Changes in HIV-1 Reverse Transcriptase That Facilitate Its Maturation Structure (London, England : 1993). 10, 2019 | Pubmed ID: 31471129 Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication Viruses. 07, 2019 | Pubmed ID: 31319455 Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase Pharmaceuticals (Basel, Switzerland). Apr, 2019 | Pubmed ID: 31010004 Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket MBio. 03, 2019 | Pubmed ID: 30862755 Pharmacophore-based Design of Novel 3-hydroxypyrimidine-2,4-dione Subtypes As Inhibitors of HIV Reverse Transcriptase-associated RNase H: Tolerance of a Nonflexible Linker European Journal of Medicinal Chemistry. Mar, 2019 | Pubmed ID: 30739822 CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity Against Wild-Type and Entecavir-Resistant Hepatitis B Virus Antimicrobial Agents and Chemotherapy. 04, 2019 | Pubmed ID: 30670420 Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores ACS Infectious Diseases. 05, 2019 | Pubmed ID: 30582687 Strain-specific Effect on Biphasic DNA Binding by HIV-1 Integrase AIDS (London, England). 03, 2019 | Pubmed ID: 30475264 Small Molecule Inhibitor That Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2 Journal of Medicinal Chemistry. 02, 2019 | Pubmed ID: 30457860 Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation MBio. 10, 2018 | Pubmed ID: 30327442 The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase Cell Chemical Biology. 10, 2018 | Pubmed ID: 30174310 Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes Frontiers in Microbiology. 2018 | Pubmed ID: 30116231 Antiretroviral Potency of 4'-ethnyl-2'-fluoro-2'-deoxyadenosine, Tenofovir Alafenamide and Second-generation NNRTIs Across Diverse HIV-1 Subtypes The Journal of Antimicrobial Chemotherapy. 10, 2018 | Pubmed ID: 30053052 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones Potently and Selectively Inhibited HIV Reverse Transcriptase-associated RNase H European Journal of Medicinal Chemistry. Aug, 2018 | Pubmed ID: 30031978 6-Arylthio-3-hydroxypyrimidine-2,4-diones Potently Inhibited HIV Reverse Transcriptase-associated RNase H with Antiviral Activity European Journal of Medicinal Chemistry. Aug, 2018 | Pubmed ID: 30031976 Effect of TRNA on the Maturation of HIV-1 Reverse Transcriptase Journal of Molecular Biology. 06, 2018 | Pubmed ID: 29751015 4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a Novel HIV-1 Reverse Transcriptase Translocation Inhibitor Current Opinion in HIV and AIDS. 07, 2018 | Pubmed ID: 29697468 Multiplex Single-cell Visualization of Nucleic Acids and Protein During HIV Infection Nature Communications. 12, 2017 | Pubmed ID: 29192235 Single-Cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection Raven Shah*1, Shuiyun Lan*1, Maritza N. Puray-Chavez2, Dandan Liu2, Philip R. Tedbury1, Stefan G. Sarafianos1 1Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, 2Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine JoVE 61843 Biology
Single-Cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection Raven Shah*1, Shuiyun Lan*1, Maritza N. Puray-Chavez2, Dandan Liu2, Philip R. Tedbury1, Stefan G. Sarafianos1 1Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, 2Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine JoVE 61843 Biology
