Stephen C Cunnane Research Center on Aging and Department of Physiology and Biophysics Université de Sherbrooke Biography Publications Institution JoVE Articles Stephen C Cunnane has not added a biography. If you are Stephen C Cunnane and would like to personalize this page please email our Author Liaison for assistance. Publications Ageing and ApoE Change DHA Homeostasis: Relevance to Age-related Cognitive Decline The Proceedings of the Nutrition Society. Oct, 2013 | Pubmed ID: 24103099 Brain Docosahexaenoic Acid [DHA] Incorporation and Blood Flow Are Increased in Chronic Alcoholics: A Positron Emission Tomography Study Corrected for Cerebral Atrophy PloS One. 2013 | Pubmed ID: 24098376 Long-term Calorie Restriction Has Minimal Impact on Brain Metabolite and Fatty Acid Profiles in Aged Rats on a Western-style Diet Neurochemistry International. Nov, 2013 | Pubmed ID: 23974047 Relationship Between Diet and Plasma Long-chain N-3 PUFAs in Older People: Impact of Apolipoprotein E Genotype Journal of Lipid Research. Sep, 2013 | Pubmed ID: 23801662 Daily Flaxseed Consumption Improves Glycemic Control in Obese Men and Women with Pre-diabetes: a Randomized Study Nutrition Research (New York, N.Y.). May, 2013 | Pubmed ID: 23684438 Thyroid Function and Cognition in the Euthyroid Elderly: A Case-control Study Embedded in Quebec Longitudinal Study - NuAge Psychoneuroendocrinology. Mar, 2013 | Pubmed ID: 23507188 Stimulation of Mild, Sustained Ketonemia by Medium-chain Triacylglycerols in Healthy Humans: Estimated Potential Contribution to Brain Energy Metabolism Nutrition (Burbank, Los Angeles County, Calif.). Apr, 2013 | Pubmed ID: 23274095 Dietary Oils and FADS1-FADS2 Genetic Variants Modulate [13C]α-linolenic Acid Metabolism and Plasma Fatty Acid Composition The American Journal of Clinical Nutrition. Jan, 2013 | Pubmed ID: 23221573 Docosahexaenoic Acid Homeostasis, Brain Aging and Alzheimer's Disease: Can We Reconcile the Evidence? Prostaglandins, Leukotrienes, and Essential Fatty Acids. Jan, 2013 | Pubmed ID: 22575581 The Ketogenic Diet Increases Brain Glucose and Ketone Uptake in Aged Rats: a Dual Tracer PET and Volumetric MRI Study Brain Research. Dec, 2012 | Pubmed ID: 23063891 Plasma Long-chain Omega-3 Fatty Acids and Atrophy of the Medial Temporal Lobe Neurology. Aug, 2012 | Pubmed ID: 22855869 N-3 PUFA Status Affects Expression of Genes Involved in Neuroenergetics Differently in the Fronto-parietal Cortex Compared to the CA1 Area of the Hippocampus: Effect of Rest and Neuronal Activation in the Rat Prostaglandins, Leukotrienes, and Essential Fatty Acids. Jun, 2012 | Pubmed ID: 22579067 Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2012 | Pubmed ID: 22466064 Mild Experimental Ketosis Increases Brain Uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a Dual-tracer PET Imaging Study in Rats Nutritional Neuroscience. Mar, 2011 | Pubmed ID: 21605500 N-3 Fatty Acids and Cardiovascular Events The New England Journal of Medicine. Mar, 2011 | Pubmed ID: 21366485 Plasma Incorporation, Apparent Retroconversion and β-oxidation of 13C-docosahexaenoic Acid in the Elderly Nutrition & Metabolism. 2011 | Pubmed ID: 21272363 Increased Postprandial Nonesterified Fatty Acid Appearance and Oxidation in Type 2 Diabetes is Not Fully Established in Offspring of Diabetic Subjects PloS One. 2010 | Pubmed ID: 20532041 Image-derived Input Function in Dynamic Human PET/CT: Methodology and Validation with 11C-acetate and 18F-fluorothioheptadecanoic Acid in Muscle and 18F-fluorodeoxyglucose in Brain European Journal of Nuclear Medicine and Molecular Imaging. Aug, 2010 | Pubmed ID: 20437239 Bezafibrate Mildly Stimulates Ketogenesis and Fatty Acid Metabolism in Hypertriglyceridemic Subjects The Journal of Pharmacology and Experimental Therapeutics. Jul, 2010 | Pubmed ID: 20404010 Maternal Dietary Fat Determines Metabolic Profile and the Magnitude of Endocannabinoid Inhibition of the Stress Response in Neonatal Rat Offspring Endocrinology. Apr, 2010 | Pubmed ID: 20160134 N-3 Fatty Acid Intake from Marine Food Products Among Quebecers: Comparison to Worldwide Recommendations Public Health Nutrition. Jan, 2010 | Pubmed ID: 19433004 Plasma N-3 Fatty Acid Response to an N-3 Fatty Acid Supplement is Modulated by ApoE Epsilon4 but Not by the Common PPAR-alpha L162V Polymorphism in Men The British Journal of Nutrition. Oct, 2009 | Pubmed ID: 19828088 Alpha-Linolenic Acid Supplementation and Conversion to N-3 Long-chain Polyunsaturated Fatty Acids in Humans Prostaglandins, Leukotrienes, and Essential Fatty Acids. Feb-Mar, 2009 | Pubmed ID: 19269799 Towards Establishing Dietary Reference Intakes for Eicosapentaenoic and Docosahexaenoic Acids The Journal of Nutrition. Apr, 2009 | Pubmed ID: 19244379 Eicosapentaenoic Acid Decreases Postprandial Beta-hydroxybutyrate and Free Fatty Acid Responses in Healthy Young and Elderly Nutrition (Burbank, Los Angeles County, Calif.). Mar, 2009 | Pubmed ID: 19036560 Ketones and Brain Function: Possible Link to Polyunsaturated Fatty Acids and Availability of a New Brain PET Tracer, 11C-acetoacetate Epilepsia. Nov, 2008 | Pubmed ID: 19049595 Heterogeneity in Randomized Controlled Trials of Long Chain (fish) Omega-3 Fatty Acids in Restenosis, Secondary Prevention and Ventricular Arrhythmias Journal of the American College of Nutrition. Jun, 2008 | Pubmed ID: 18838524 Plasma Omega-3 Fatty Acid Response to a Fish Oil Supplement in the Healthy Elderly Lipids. Nov, 2008 | Pubmed ID: 18795357 Conjugated Linoleic Acids: Why the Discrepancy Between Animal and Human Studies? Nutrition Reviews. Jul, 2008 | Pubmed ID: 18667017 Flaxseed and Cardiovascular Risk Factors: Results from a Double Blind, Randomized, Controlled Clinical Trial Journal of the American College of Nutrition. Feb, 2008 | Pubmed ID: 18460483 [11C] Acetoacetate Utilization by Breast and Prostate Tumors: a PET and Biodistribution Study in Mice Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jul-Aug, 2008 | Pubmed ID: 18454299 An Emerging Risk Factor for Obesity: Does Disequilibrium of Polyunsaturated Fatty Acid Metabolism Contribute to Excessive Adipose Tissue Development? The British Journal of Nutrition. Sep, 2008 | Pubmed ID: 18307824 Fish-oil Supplementation in Patients with Implantable Cardioverter Defibrillators: a Meta-analysis CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Jan, 2008 | Pubmed ID: 18195289 Flaxseed on Cardiovascular Disease Markers in Healthy Menopausal Women: a Randomized, Double-blind, Placebo-controlled Trial Nutrition (Burbank, Los Angeles County, Calif.). Jan, 2008 | Pubmed ID: 17981439 Unresolved Issues in the Link Between Docosahexaenoic Acid and Alzheimer's Disease Prostaglandins, Leukotrienes, and Essential Fatty Acids. Nov-Dec, 2007 | Pubmed ID: 18036804 Extremely Limited Synthesis of Long Chain Polyunsaturates in Adults: Implications for Their Dietary Essentiality and Use As Supplements Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme. Aug, 2007 | Pubmed ID: 17622276 Docosahexaenoic Acid and Shore-based Diets in Hominin Encephalization: a Rebuttal American Journal of Human Biology : the Official Journal of the Human Biology Council. Jul-Aug, 2007 | Pubmed ID: 17546620 Automated Synthesis of 11C-acetoacetic Acid, a Key Alternate Brain Fuel to Glucose Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine. Aug, 2007 | Pubmed ID: 17544283 Biosynthetic Production of Universally (13)C-labelled Polyunsaturated Fatty Acids As Reference Materials for Natural Health Product Research Analytical and Bioanalytical Chemistry. Sep, 2007 | Pubmed ID: 17486321 Docosahexaenoic Acid and Human Brain Evolution: Missing the Forest for the Trees--comments by Cunnane The British Journal of Nutrition. May, 2007 | Pubmed ID: 17408531 Alpha-Linolenic Acid and Fish Oil N-3 Fatty Acids and Cardiovascular Disease Risk The American Journal of Clinical Nutrition. Mar, 2007 | Pubmed ID: 17344517 Comparison of Composition and Absorption of Sugarcane Policosanols The British Journal of Nutrition. Feb, 2007 | Pubmed ID: 17298709 Markedly Raised Intake of Saturated and Monounsaturated Fatty Acids in Rats on a High-fat Ketogenic Diet Does Not Inhibit Carbon Recycling of 13C-alpha-linolenate Lipids. Oct, 2006 | Pubmed ID: 17180881 Omega-3 Fatty Acids, Energy Substrates, and Brain Function During Aging Prostaglandins, Leukotrienes, and Essential Fatty Acids. Sep, 2006 | Pubmed ID: 16829066 [Survival of the Fattest: the Key to Human Brain Evolution] Médecine Sciences : M/S. Jun-Jul, 2006 | Pubmed ID: 16828044 Suckling Rats Actively Recycle Carbon from Alpha-linolenate into Newly Synthesized Lipids Even During Extreme Dietary Deficiency of N-3 Polyunsaturates Pediatric Research. Jan, 2006 | Pubmed ID: 16326997 Breath Acetone Predicts Plasma Ketone Bodies in Children with Epilepsy on a Ketogenic Diet Nutrition (Burbank, Los Angeles County, Calif.). Jan, 2006 | Pubmed ID: 16183255 Despite Transient Ketosis, the Classic High-fat Ketogenic Diet Induces Marked Changes in Fatty Acid Metabolism in Rats Metabolism: Clinical and Experimental. Sep, 2005 | Pubmed ID: 16125522 Origins and Evolution of the Western Diet: Implications of Iodine and Seafood Intakes for the Human Brain The American Journal of Clinical Nutrition. Aug, 2005 | Pubmed ID: 16087997 Effects of a Diet High in Plant Sterols, Vegetable Proteins, and Viscous Fibers (dietary Portfolio) on Circulating Sterol Levels and Red Cell Fragility in Hypercholesterolemic Subjects Lipids. Feb, 2005 | Pubmed ID: 15884765 Dietary 18:3omega3 Influences Immune Function and the Tissue Fatty Acid Response to Antigens and Adjuvant Immunology Letters. Aug, 2004 | Pubmed ID: 15325802 Claims to Identify Detrimental Effects of the Ketogenic Diet (KD) on Cognitive Function in Rats Pediatric Research. Oct, 2004 | Pubmed ID: 15319466 Lovastatin Exacerbates Atypical Absence Seizures with Only Minimal Effects on Brain Sterols Journal of Lipid Research. Nov, 2004 | Pubmed ID: 15314096 Metabolism of Polyunsaturated Fatty Acids and Ketogenesis: an Emerging Connection Prostaglandins, Leukotrienes, and Essential Fatty Acids. Mar, 2004 | Pubmed ID: 14769482 Intramuscular Injection of Antigens and Adjuvant Preferentially Decreases 18:2n-6 and 18:3n-3 in Pig Neck Muscle Lipids. Dec, 2003 | Pubmed ID: 14870924 Dietary Alpha-linolenic Acid Increases the N-3 PUFA Content of Sow's Milk and the Tissues of the Suckling Piglet Lipids. Oct, 2003 | Pubmed ID: 14669969 Problems with Essential Fatty Acids: Time for a New Paradigm? Progress in Lipid Research. Nov, 2003 | Pubmed ID: 14559071 Survival of the Fattest: Fat Babies Were the Key to Evolution of the Large Human Brain Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. Sep, 2003 | Pubmed ID: 14527626 Why is Carbon from Some Polyunsaturates Extensively Recycled into Lipid Synthesis? Lipids. Apr, 2003 | Pubmed ID: 12848297 Whole-body Utilization of N-3 PUFA in N-6 PUFA-deficient Rats Lipids. Feb, 2003 | Pubmed ID: 12733752 Whole-body Beta-oxidation of 18:2omega6 and 18:3omega3 in the Pig Varies Markedly with Weaning Strategy and Dietary 18:3omega3 Journal of Lipid Research. Feb, 2003 | Pubmed ID: 12576513 Alpha-linolenic Acid, Linoleic Acid, Coronary Artery Disease, and Overall Mortality The American Journal of Clinical Nutrition. Feb, 2003 | Pubmed ID: 12540417 Effects of High- and Low-isoflavone Soyfoods on Blood Lipids, Oxidized LDL, Homocysteine, and Blood Pressure in Hyperlipidemic Men and Women The American Journal of Clinical Nutrition. Aug, 2002 | Pubmed ID: 12145008 Breath Acetone is a Reliable Indicator of Ketosis in Adults Consuming Ketogenic Meals The American Journal of Clinical Nutrition. Jul, 2002 | Pubmed ID: 12081817 Soluble Fiber Intake at a Dose Approved by the US Food and Drug Administration for a Claim of Health Benefits: Serum Lipid Risk Factors for Cardiovascular Disease Assessed in a Randomized Controlled Crossover Trial The American Journal of Clinical Nutrition. May, 2002 | Pubmed ID: 11976156 Brain-specific Lipids from Marine, Lacustrine, or Terrestrial Food Resources: Potential Impact on Early African Homo Sapiens Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. Apr, 2002 | Pubmed ID: 11923081 Brain Sterols in the AY-9944 Rat Model of Atypical Absence Seizures Epilepsia. Jan, 2002 | Pubmed ID: 11879380 Arachidonate Metabolism in Neonates Pediatric Research. Mar, 2002 | Pubmed ID: 11861928 Breath Acetone As a Measure of Systemic Ketosis Assessed in a Rat Model of the Ketogenic Diet Clinical Chemistry. Jan, 2002 | Pubmed ID: 11751546 Rat Bölgesel Beyin Enerji Yüzeyleri Alımına Kantitatif Tedbir için A Çift Tracer PET-MR Protokolü Maggie Roy1, Scott Nugent1, Sébastien Tremblay2, Maxime Descoteaux3, Jean-François Beaudoin2, Luc Tremblay2, Roger Lecomte2,4, Stephen C Cunnane1 1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke Neuroscience
Rat Bölgesel Beyin Enerji Yüzeyleri Alımına Kantitatif Tedbir için A Çift Tracer PET-MR Protokolü Maggie Roy1, Scott Nugent1, Sébastien Tremblay2, Maxime Descoteaux3, Jean-François Beaudoin2, Luc Tremblay2, Roger Lecomte2,4, Stephen C Cunnane1 1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke Neuroscience