Willi Jahnen-Dechent Helmholtz Institute for Biomedical Engineering, Biointerface Group RWTH Aachen University Biography Publications Institution JoVE Articles Willi Jahnen-Dechent has not added a biography. If you are Willi Jahnen-Dechent and would like to personalize this page please email our Author Liaison for assistance. Publications Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity Cells. 08, 2021 | Pubmed ID: 34440866 The E-modulus of the Oocyte is a Non-destructive Measure of Zona Pellucida Hardening Reproduction (Cambridge, England). 09, 2021 | Pubmed ID: 34320465 Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease Circulation. 09, 2021 | Pubmed ID: 34192892 Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 33996793 Limited Proteolysis by Acrosin Affects Sperm-binding and Mechanical Resilience of the Mouse Zona Pellucida Molecular Human Reproduction. 03, 2021 | Pubmed ID: 33779727 Fetuin-A is a HIF Target That Safeguards Tissue Integrity During Hypoxic Stress Nature Communications. 01, 2021 | Pubmed ID: 33483479 Mud in the Blood: the Role of Protein-mineral Complexes and Extracellular Vesicles in Biomineralisation and Calcification Journal of Structural Biology. 10, 2020 | Pubmed ID: 32711043 Calciprotein Particles: Mineral Behaving Badly? Current Opinion in Nephrology and Hypertension. 07, 2020 | Pubmed ID: 32404635 Rapid Calcification Propensity Testing in Blood Using a Temperature Controlled Microfluidic Polymer Chip PloS One. 2020 | Pubmed ID: 32255786 Nature's Remedy to Phosphate Woes: Calciprotein Particles Regulate Systemic Mineral Metabolism Kidney International. 04, 2020 | Pubmed ID: 32200857 Microvasculopathy and Soft Tissue Calcification in Mice Are Governed by Fetuin-A, Magnesium and Pyrophosphate PloS One. 2020 | Pubmed ID: 32074140 Lumenal Calcification and Microvasculopathy in Fetuin-A-deficient Mice Lead to Multiple Organ Morbidity PloS One. 2020 | Pubmed ID: 32074120 Apolipoprotein C3 Induces Inflammation and Organ Damage by Alternative Inflammasome Activation Nature Immunology. 01, 2020 | Pubmed ID: 31819254 The C-terminal Region of Human Plasma Fetuin-B is Dispensable for the Raised-elephant-trunk Mechanism of Inhibition of Astacin Metallopeptidases Scientific Reports. 10, 2019 | Pubmed ID: 31604990 Structure of Mammalian Plasma Fetuin-B and Its Mechanism of Selective Metallopeptidase Inhibition IUCrJ. Mar, 2019 | Pubmed ID: 30867929 Mammalian Plasma Fetuin-B is a Selective Inhibitor of Ovastacin and Meprin Metalloproteinases Scientific Reports. 01, 2019 | Pubmed ID: 30679641 Fetuin-A Protein Distribution in Mature Inflamed and Ischemic Brain Tissue PloS One. 2018 | Pubmed ID: 30412582 Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk International Journal of Nephrology. 2018 | Pubmed ID: 30245880 Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity Frontiers in Immunology. 2018 | Pubmed ID: 30233585 Targeting and Modulation of Liver Myeloid Immune Cells by Hard-Shell Microbubbles Advanced Biosystems. May, 2018 | Pubmed ID: 29876517 Histidine-rich Glycoprotein-induced Vascular Normalization Improves EPR-mediated Drug Targeting to and into Tumors Journal of Controlled Release : Official Journal of the Controlled Release Society. 07, 2018 | Pubmed ID: 29730154 Post-weaning Epiphysiolysis Causes Distal Femur Dysplasia and Foreshortened Hindlimbs in Fetuin-A-deficient Mice PloS One. 2017 | Pubmed ID: 29088242 Erratum for Maler Et Al., "Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages" MBio. 09, 2017 | Pubmed ID: 28951479 Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2017 | Pubmed ID: 28104608 Latent TGF-β Binding Protein-1 Deficiency Decreases Female Fertility Biochemical and Biophysical Research Communications. Jan, 2017 | Pubmed ID: 27956181 Recombinant Fetuin-B Protein Maintains High Fertilization Rate in Cumulus Cell-free Mouse Oocytes Molecular Human Reproduction. 01, 2017 | Pubmed ID: 27733489 Down-regulation of the Liver-derived Plasma Protein Fetuin-B Mediates Reversible Female Infertility Molecular Human Reproduction. 01, 2017 | Pubmed ID: 27733488 Letter to the Editor, Concerning: "FGF23-regulated Production of Fetuin-A (AHSG) in Osteocytes" Bone. 12, 2016 | Pubmed ID: 27260648 Association of High Fetuin-B Concentrations in Serum with Fertilization Rate in IVF: a Cross-sectional Pilot Study Human Reproduction (Oxford, England). Mar, 2016 | Pubmed ID: 26759143 Calcification Propensity and Survival Among Renal Transplant Recipients Journal of the American Society of Nephrology : JASN. Apr, 2015 | Pubmed ID: 25925688 Analysis of Ebola Virus Entry Into Macrophages The Journal of Infectious Diseases. Apr, 2015 | Pubmed ID: 25877552 Cytotoxicity of Ultrasmall Gold Nanoparticles on Planktonic and Biofilm Encapsulated Gram-Positive Staphylococci Small (Weinheim an Der Bergstrasse, Germany). Feb, 2015 | Pubmed ID: 25712910 Arterial Thrombosis is Accelerated in Mice Deficient in Histidine-rich Glycoprotein Blood. Apr, 2015 | Pubmed ID: 25691157 Cell Surface Serine Protease Matriptase-2 Suppresses Fetuin-A/AHSG-mediated Induction of Hepcidin Biological Chemistry. Jan, 2015 | Pubmed ID: 25205713 Mammalian Gamete Fusion Depends on the Inhibition of Ovastacin by Fetuin-B Biological Chemistry. Oct, 2014 | Pubmed ID: 25205729 In Vivo Nanotoxicity Testing Using the Zebrafish Embryo Assay Journal of Materials Chemistry. B, Materials for Biology and Medicine. Jun, 2013 | Pubmed ID: 24179674 Biofabrication Under Fluorocarbon: a Novel Freeform Fabrication Technique to Generate High Aspect Ratio Tissue-engineered Constructs BioResearch Open Access. Oct, 2013 | Pubmed ID: 24083093 Warfarin Induces Cardiovascular Damage in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2013 | Pubmed ID: 23990204 Hepatocyte Growth Factor-loaded Biomaterials for Mesenchymal Stem Cell Recruitment Stem Cells International. 2013 | Pubmed ID: 23861688 HRG Regulates Tumor Progression, Epithelial to Mesenchymal Transition and Metastasis Via Platelet-induced Signaling in the Pre-tumorigenic Microenvironment Angiogenesis. Oct, 2013 | Pubmed ID: 23793459 Molecularly Stabilised Ultrasmall Gold Nanoparticles: Synthesis, Characterization and Bioactivity Nanoscale. Jul, 2013 | Pubmed ID: 23743952 Differential HERG Ion Channel Activity of Ultrasmall Gold Nanoparticles Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23630249 Fetuin-B, a Liver-derived Plasma Protein is Essential for Fertilization Developmental Cell. Apr, 2013 | Pubmed ID: 23562279 Fluorescent SNAP-tag Galectin Fusion Proteins As Novel Tools in Glycobiology Current Pharmaceutical Design. 2013 | Pubmed ID: 23431989 The Role of Fetuin-A in Physiological and Pathological Mineralization Calcified Tissue International. Oct, 2013 | Pubmed ID: 23277412 Novel Insights into Osteogenesis and Matrix Remodelling Associated with Calcific Uraemic Arteriolopathy Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Apr, 2013 | Pubmed ID: 23223222 High-sensitivity Real-time Analysis of Nanoparticle Toxicity in Green Fluorescent Protein-expressing Zebrafish Small (Weinheim an Der Bergstrasse, Germany). Mar, 2013 | Pubmed ID: 23143852 Embryonic Stem Cell-derived M2-like Macrophages Delay Cutaneous Wound Healing Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Jan-Feb, 2013 | Pubmed ID: 23126541 Fetuin-a in the Developing Brain Developmental Neurobiology. May, 2013 | Pubmed ID: 23109215 Two-dimensional Polymer-based Cultures Expand Cord Blood-derived Hematopoietic Stem Cells and Support Engraftment of NSG Mice Tissue Engineering. Part C, Methods. Jan, 2013 | Pubmed ID: 22712684 Ex Vivo Expansion of Cord Blood-CD34(+) Cells Using IGFBP2 and Angptl-5 Impairs Short-term Lymphoid Repopulation in Vivo Journal of Tissue Engineering and Regenerative Medicine. Dec, 2013 | Pubmed ID: 22653714 Accelerated Growth Plate Mineralization and Foreshortened Proximal Limb Bones in Fetuin-A Knockout Mice PloS One. 2012 | Pubmed ID: 23091616 Nanoparticle-based Test Measures Overall Propensity for Calcification in Serum Journal of the American Society of Nephrology : JASN. Oct, 2012 | Pubmed ID: 22956818 Vitamin K-antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype PloS One. 2012 | Pubmed ID: 22952653 Fetuin-A Function in Systemic Mineral Metabolism Trends in Cardiovascular Medicine. Nov, 2012 | Pubmed ID: 22902178 Context Dependent Role of the CD36--thrombospondin--histidine-rich Glycoprotein Axis in Tumor Angiogenesis and Growth PloS One. 2012 | Pubmed ID: 22808089 Cord Blood-hematopoietic Stem Cell Expansion in 3D Fibrin Scaffolds with Stromal Support Biomaterials. Oct, 2012 | Pubmed ID: 22800538 Clearance of Fetuin-A--containing Calciprotein Particles is Mediated by Scavenger Receptor-A Circulation Research. Aug, 2012 | Pubmed ID: 22753077 Cytotoxicity of Gold Nanoparticles Methods in Enzymology. 2012 | Pubmed ID: 22568908 A Fluorescent Method to Determine Vitamin K-dependent Gamma-glutamyl Carboxylase Activity Analytical Biochemistry. Feb, 2012 | Pubmed ID: 22210513 Effect of Vitamin K2 Supplementation on Functional Vitamin K Deficiency in Hemodialysis Patients: a Randomized Trial American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. Feb, 2012 | Pubmed ID: 22169620 Compatibility of Different Polymers for Cord Blood-derived Hematopoietic Progenitor Cells Journal of Materials Science. Materials in Medicine. Jan, 2012 | Pubmed ID: 22071984 A Red Herring in Vascular Calcification: 'nanobacteria' Are Protein-mineral Complexes Involved in Biomineralization Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Nov, 2011 | Pubmed ID: 21965584 Exposure to Uremic Serum Induces a Procalcific Phenotype in Human Mesenchymal Stem Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2011 | Pubmed ID: 21680902 Fetuin-A Regulation of Calcified Matrix Metabolism Circulation Research. Jun, 2011 | Pubmed ID: 21659653 Impact of Sirolimus, Tacrolimus and Mycophenolate Mofetil on Osteoclastogenesis--implications for Post-transplantation Bone Disease Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Dec, 2011 | Pubmed ID: 21622987 肝的蛋白胎球蛋白 A,在致命的全身性炎症中占有的保护作用。 PloS One. 2011 | Pubmed ID: 21347455 Enhanced Platelet Activation Mediates the Accelerated Angiogenic Switch in Mice Lacking Histidine-rich Glycoprotein PloS One. 2011 | Pubmed ID: 21264222 Fetuin-A is a Mineral Carrier Protein: Small Angle Neutron Scattering Provides New Insight on Fetuin-A Controlled Calcification Inhibition Biophysical Journal. Dec, 2010 | Pubmed ID: 21156141 Fetuin-A and Cystatin C Are Endogenous Inhibitors of Human Meprin Metalloproteases Biochemistry. Oct, 2010 | Pubmed ID: 20806899 Serological Cardiovascular and Mortality Risk Predictors in Dialysis Patients Receiving Sevelamer: a Prospective Study Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Aug, 2010 | Pubmed ID: 20172849 外围管理的胎球蛋白抑制大鼠早期缺血性脑损伤。 Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2010 | Pubmed ID: 19953099 Secretion of Fibrinolytic Enzymes Facilitates Human Mesenchymal Stem Cell Invasion into Fibrin Clots Cells, Tissues, Organs. 2010 | Pubmed ID: 19390164 Sevelamer and the Bone-vascular Axis in Chronic Kidney Disease: Bone Turnover, Inflammation, and Calcification Regulation Kidney International. Supplement. Dec, 2009 | Pubmed ID: 19946324 The Physiologic Development of Fetuin-a Serum Concentrations in Children Pediatric Research. Dec, 2009 | Pubmed ID: 19690510 Gold Nanoparticles of Diameter 1.4 Nm Trigger Necrosis by Oxidative Stress and Mitochondrial Damage Small (Weinheim an Der Bergstrasse, Germany). Sep, 2009 | Pubmed ID: 19642089 Fetuin-A Protects Against Atherosclerotic Calcification in CKD Journal of the American Society of Nephrology : JASN. Jun, 2009 | Pubmed ID: 19389852 类型 3 Cystatins ;fetuins,激肽和富组氨酸糖蛋白。 Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273244 A Shielding Topology Stabilizes the Early Stage Protein-mineral Complexes of Fetuin-A and Calcium Phosphate: a Time-resolved Small-angle X-ray Study Chembiochem : a European Journal of Chemical Biology. Mar, 2009 | Pubmed ID: 19222044 Function Follows Form: Shape Complementarity and Nanoparticle Toxicity Nanomedicine (London, England). Oct, 2008 | Pubmed ID: 18817462 Histidine-rich Glycoprotein Protects from Systemic Candida Infection PLoS Pathogens. Aug, 2008 | Pubmed ID: 18797515 Hierarchical Role of Fetuin-A and Acidic Serum Proteins in the Formation and Stabilization of Calcium Phosphate Particles The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18364352 Mineral Chaperones: a Role for Fetuin-A and Osteopontin in the Inhibition and Regression of Pathologic Calcification Journal of Molecular Medicine (Berlin, Germany). Apr, 2008 | Pubmed ID: 18080808 Assessment of Stem Cell/biomaterial Combinations for Stem Cell-based Tissue Engineering Biomaterials. Jan, 2008 | Pubmed ID: 17935776 Size-dependent Cytotoxicity of Gold Nanoparticles Small (Weinheim an Der Bergstrasse, Germany). Nov, 2007 | Pubmed ID: 17963284 Vascular Calcification and Fetuin-A Deficiency in Chronic Kidney Disease Trends in Cardiovascular Medicine. May, 2007 | Pubmed ID: 17482094 Fetuin-A (AHSG) Prevents Extraosseous Calcification Induced by Uraemia and Phosphate Challenge in Mice Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jun, 2007 | Pubmed ID: 17389622 Proteolytic Processing by Matrix Metalloproteinases and Phosphorylation by Protein Kinase CK2 of Fetuin-A, the Major Globulin of Fetal Calf Serum Biochimie. Mar, 2007 | Pubmed ID: 17110014 CCAAT Enhancer Binding Protein Beta and Hepatocyte Nuclear Factor 3beta Are Necessary and Sufficient to Mediate Dexamethasone-induced Up-regulation of Alpha2HS-glycoprotein/fetuin-A Gene Expression Journal of Molecular Endocrinology. Apr, 2006 | Pubmed ID: 16595698 The Effect of Surface Modification of a Porous TiO2/perlite Composite on the Ingrowth of Bone Tissue in Vivo Biomaterials. Mar, 2006 | Pubmed ID: 16139880 Myocardial Stiffness, Cardiac Remodeling, and Diastolic Dysfunction in Calcification-prone Fetuin-A-deficient Mice Journal of the American Society of Nephrology : JASN. Nov, 2005 | Pubmed ID: 16177000 Fetuin-A, a Hepatocyte-specific Protein That Binds Plasmodium Berghei Thrombospondin-related Adhesive Protein: a Potential Role in Infectivity Infection and Immunity. Sep, 2005 | Pubmed ID: 16113307 Multifunctional Roles for Serum Protein Fetuin-a in Inhibition of Human Vascular Smooth Muscle Cell Calcification Journal of the American Society of Nephrology : JASN. Oct, 2005 | Pubmed ID: 16093453 Role of Calcification Inhibitors in the Pathogenesis of Vascular Calcification in Chronic Kidney Disease (CKD) Kidney International. Jun, 2005 | Pubmed ID: 15882271 Do Not Be Misguided by Guidelines: the Calcium X Phosphate Product Can Be a Trojan Horse Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Apr, 2005 | Pubmed ID: 15728269 The Serum Glycoprotein Fetuin-A Promotes Lewis Lung Carcinoma Tumorigenesis Via Adhesive-dependent and Adhesive-independent Mechanisms Cancer Research. Jan, 2005 | Pubmed ID: 15695392 In Vitro Behavior of a Porous TiO2/perlite Composite and Its Surface Modification with Fibronectin Biomaterials. Jun, 2005 | Pubmed ID: 15603777 Human Vascular Smooth Muscle Cells Undergo Vesicle-mediated Calcification in Response to Changes in Extracellular Calcium and Phosphate Concentrations: a Potential Mechanism for Accelerated Vascular Calcification in ESRD Journal of the American Society of Nephrology : JASN. Nov, 2004 | Pubmed ID: 15504939 Alpha2HS-glycoprotein, an Antagonist of Transforming Growth Factor Beta in Vivo, Inhibits Intestinal Tumor Progression Cancer Research. Sep, 2004 | Pubmed ID: 15374947 Alpha 2-HS Glycoprotein (fetuin-A) Modulates Murine Skin Tumorigenesis International Journal of Oncology. Aug, 2004 | Pubmed ID: 15254728 Functional Expression of HGF and HGF Receptor/c-met in Adult Human Mesenchymal Stem Cells Suggests a Role in Cell Mobilization, Tissue Repair, and Wound Healing Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 15153617 Tissue Distribution and Activity Testing Suggest a Similar but Not Identical Function of Fetuin-B and Fetuin-A The Biochemical Journal. Nov, 2003 | Pubmed ID: 12943536 The Serum Protein Alpha 2-Heremans-Schmid Glycoprotein/fetuin-A is a Systemically Acting Inhibitor of Ectopic Calcification The Journal of Clinical Investigation. Aug, 2003 | Pubmed ID: 12897203 Modulation of Angiogenic Functions in Human Macrophages by Biomaterials Biomaterials. Sep, 2003 | Pubmed ID: 12809767 Deficiencies of Calcium-regulatory Proteins in Dialysis Patients: a Novel Concept of Cardiovascular Calcification in Uremia Kidney International. Supplement. May, 2003 | Pubmed ID: 12694317 Association of Low Fetuin-A (AHSG) Concentrations in Serum with Cardiovascular Mortality in Patients on Dialysis: a Cross-sectional Study Lancet. Mar, 2003 | Pubmed ID: 12642050 Structural Basis of Calcification Inhibition by Alpha 2-HS Glycoprotein/fetuin-A. Formation of Colloidal Calciprotein Particles The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12556469 Fine Mapping of the H-kininogen Binding Site in Plasma Prekallikrein Apple Domain 2 International Immunopharmacology. Dec, 2002 | Pubmed ID: 12489801 Novel Insights into Uremic Vascular Calcification: Role of Matrix Gla Protein and Alpha-2-Heremans Schmid Glycoprotein/fetuin Blood Purification. 2002 | Pubmed ID: 12207096 Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene Diabetes. Aug, 2002 | Pubmed ID: 12145157 Alpha 2-HS Glycoprotein/fetuin, a Transforming Growth Factor-beta/bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11901155 Systemic Inhibition of Spontaneous Calcification by the Serum Protein Alpha 2-HS Glycoprotein/fetuin Zeitschrift Fur Kardiologie. 2001 | Pubmed ID: 11374033 一种半自动且可重现的基于生物学的体外定量钙沉积的方法 Armand M. G. Jaminon*1, Nikolas Rapp*1, Asim C. Akbulut1, Robert Dzhanaev2, Chris P. Reutelingsperger1, Willi Jahnen-Dechent2, Leon J. Schurgers1,3 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 2Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 3Institute of Experimental Medicine and Systems Biology, RWTH Aachen University JoVE 64029 Biochemistry 混合μCT-FMT成像和图像分析 Felix Gremse*1, Dennis Doleschel*1, Sara Zafarnia1, Anne Babler2, Willi Jahnen-Dechent2, Twan Lammers1,3, Wiltrud Lederle1, Fabian Kiessling1 1Experimental Molecular Imaging, RWTH Aachen University, 2Institute for Biomedical Engineering - Biointerface Laboratory, RWTH Aachen University, 3Utrecht Institute for Pharmaceutical Sciences, Utrecht University Bioengineering
一种半自动且可重现的基于生物学的体外定量钙沉积的方法 Armand M. G. Jaminon*1, Nikolas Rapp*1, Asim C. Akbulut1, Robert Dzhanaev2, Chris P. Reutelingsperger1, Willi Jahnen-Dechent2, Leon J. Schurgers1,3 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 2Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 3Institute of Experimental Medicine and Systems Biology, RWTH Aachen University JoVE 64029 Biochemistry
混合μCT-FMT成像和图像分析 Felix Gremse*1, Dennis Doleschel*1, Sara Zafarnia1, Anne Babler2, Willi Jahnen-Dechent2, Twan Lammers1,3, Wiltrud Lederle1, Fabian Kiessling1 1Experimental Molecular Imaging, RWTH Aachen University, 2Institute for Biomedical Engineering - Biointerface Laboratory, RWTH Aachen University, 3Utrecht Institute for Pharmaceutical Sciences, Utrecht University Bioengineering