William S. James James Martin Stem Cell Facility, Sir William Dunn School of Pathology University of Oxford Biography Publications Institution JoVE Articles William S. James has not added a biography. If you are William S. James and would like to personalize this page please email our Author Liaison for assistance. Publications Honing the Double-Edged Sword: Improving Human IPSC-Microglia Models Frontiers in Immunology. 2020 | Pubmed ID: 33363548 TREM2 Alzheimer's Variant R47H Causes Similar Transcriptional Dysregulation to Knockout, Yet Only Subtle Functional Phenotypes in Human IPSC-derived Macrophages Alzheimer's Research & Therapy. 11, 2020 | Pubmed ID: 33198789 Interferon-stimulated Gene Products As Regulators of Central Carbon Metabolism The FEBS Journal. Nov, 2020 | Pubmed ID: 33185982 LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages Stem Cell Reports. 05, 2020 | Pubmed ID: 32359446 DdhCTP Produced by the Radical-SAM Activity of RSAD2 (viperin) Inhibits the NAD -dependent Activity of Enzymes to Modulate Metabolism FEBS Letters. May, 2020 | Pubmed ID: 32232843 Viperin, Through Its Radical-SAM Activity, Depletes Cellular Nucleotide Pools and Interferes with Mitochondrial Metabolism to Inhibit Viral Replication FEBS Letters. May, 2020 | Pubmed ID: 32061099 Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2) Chembiochem : a European Journal of Chemical Biology. 06, 2020 | Pubmed ID: 31951306 Lentiviral Gene Therapy Vector with UCOE Stably Restores Function in IPSC-derived Neutrophils of a CDG Patient Matters. 2018 | Pubmed ID: 31008103 RIPK1 is a Critical Modulator of Both Tonic and TLR-responsive Inflammatory and Cell Death Pathways in Human Macrophage Differentiation Cell Death & Disease. 09, 2018 | Pubmed ID: 30250197 Excess α-synuclein Compromises Phagocytosis in IPSC-derived Macrophages Scientific Reports. 08, 2017 | Pubmed ID: 28827786 A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response Stem Cell Reports. 06, 2017 | Pubmed ID: 28591653 LRRK2 in Peripheral and Central Nervous System Innate Immunity: Its Link to Parkinson's Disease Biochemical Society Transactions. Feb, 2017 | Pubmed ID: 28202666 CRISPR-mediated Genotypic and Phenotypic Correction of a Chronic Granulomatous Disease Mutation in Human IPS Cells Experimental Hematology. Oct, 2015 | Pubmed ID: 26101162 Physiological Characterisation of Human IPS-derived Dopaminergic Neurons PloS One. 2014 | Pubmed ID: 24586273 The Productive Entry Pathway of HIV-1 in Macrophages is Dependent on Endocytosis Through Lipid Rafts Containing CD4 PloS One. 2014 | Pubmed ID: 24465876 Differentially Expressed, Variant U1 SnRNAs Regulate Gene Expression in Human Cells Genome Research. Feb, 2013 | Pubmed ID: 23070852 Episomal Transgene Expression in Pluripotent Stem Cells Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21822889 Derivation and Characterisation of the Human Embryonic Stem Cell Line, OxF1 In Vitro Cellular & Developmental Biology. Animal. Apr, 2010 | Pubmed ID: 20333479 In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages Hazel Hall-Roberts1,2,3, Elena Di Daniel2, William S. James1, John B. Davis2, Sally A. Cowley1 1James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, 2Alzheimer’s Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine Research Building, University of Oxford, 3UK Dementia Research Institute, Cardiff University JoVE 62217 Neuroscience
In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages Hazel Hall-Roberts1,2,3, Elena Di Daniel2, William S. James1, John B. Davis2, Sally A. Cowley1 1James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, 2Alzheimer’s Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine Research Building, University of Oxford, 3UK Dementia Research Institute, Cardiff University JoVE 62217 Neuroscience
