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JoVE Journal Medicine
Initiatie van gemetastaseerd borstcarcinoom door Targeting van de Ductaal Epitheel met adenovirus-Cre
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Initiatie van gemetastaseerd borstcarcinoom door Targeting van de Ductaal Epitheel met adenovirus-Cre: A Novel transgeen muismodel van de Breast Cancer

Article DOI: 10.3791/51171-v • 07:14 min • March 26th, 2014
March 26th, 2014 •
*1, *1, 1, 1, 1, 1, 1, 2, 3, 4,5,6, 1
1Tumor Microenvironment and Metastasis Program, Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics, Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center, University of Pennsylvania, 6Center for Advanced Medicine, University of Pennsylvania
* These authors contributed equally

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Activering van latente mutaties met adenovirus-Cre in de borstklier ductale systeem een ​​klinisch relevante metastatische borstkanker. Opneming van een YFP promotor maakt het volgen van distale metastatische tumorcellen. Dit model is nuttig om latente metastase, anti-tumor immuniteit, en voor het ontwerpen van nieuwe immunotherapieën behandeling van borstkanker bestuderen.

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Geneeskunde Transgene muizen borstkanker metastase intraductale injectie latente mutaties adenovirus-Cre
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