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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Article DOI: 10.3791/54541-v • 07:08 min • October 20th, 2016
October 20th, 2016 •
*1, *1, 1, 1, 2, 3, 4, 5, 1
1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London
* These authors contributed equally

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Summary
Automatic Translation

We describe a high-throughput, multiplex, and targeted proteomic cerebrospinal fluid (CSF) assay developed with potential for clinical translation. The test can quantitate potential markers and risk factors for neurodegeneration, such as the apolipoprotein E variants (E2, E3 and E4), and measure their allelic expression.

Tags

High Throughput Multiplexed Targeted Proteomic CSF Assay Neurodegenerative Biomarkers Apolipoprotein E Isoforms Status Diagnosis Treatment Monitoring Diagnostic Purposes Neurodegenerative Diseases Prognostic Information Rapid Simple Sample Preparation Highly Specific Cost Effective Clinical Lab Therapy Clinical Trials Novel Therapies Neurodegeneration Other Diseases Tissues Urine Kidney Disorders Plasma Cardiomyopathy Cells Pluripotency Synthetic Peptides
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