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Een High Throughput, multiplexverzending en Gerichte Proteomic CSF Assay te kwantificeren neurodegeneratieve Biomarkers en apolipoproteïne E isovormen Status
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Een High Throughput, multiplexverzending en Gerichte Proteomic CSF Assay te kwantificeren neurodegeneratieve Biomarkers en apolipoproteïne E isovormen Status

Article DOI: 10.3791/54541-v • 07:08 min • October 20th, 2016
October 20th, 2016 •
*1, *1, 1, 1, 2, 3, 4, 5, 1
1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London
* These authors contributed equally

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We beschrijven een high-throughput, multiplex en gerichte proteomische cerebrospinale vloeistof (CSF) test ontwikkeld met potentieel voor klinische toepassing. De test kan kwantificeren potentiële markers en risicofactoren voor neurodegeneratie zoals de apolipoproteïne E varianten (E2, E3 en E4), en de allelische expressie te meten.

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Geneeskunde CSF gerichte proteomics Multiple Reaction Monitoring apolipoproteïne E isovorm dementie biomarker tandem-massaspectrometrie multiplex
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