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Journal / Cancer Research / 骨肉瘤前小鼠模型对肿瘤与间充质干细胞细胞外囊泡介导通信的定义…
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JoVE Journal Cancer Research
骨肉瘤前小鼠模型对肿瘤与间充质干细胞细胞外囊泡介导通信的定义
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骨肉瘤前小鼠模型对肿瘤与间充质干细胞细胞外囊泡介导通信的定义

Article DOI: 10.3791/56932-v • 11:15 min • May 6th, 2018
May 6th, 2018 •
*1, *2, 2
1Neuro-oncology Research Group, VU Medical Center, 2Exosomes Research Group, Department of Pathology, VU Medical Center
* These authors contributed equally

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直接注射癌症衍生细胞外囊 (EVs) 导致骨髓支持肿瘤进展的重新编程;然而, 哪些细胞调解这种影响是不清楚的。在这里, 我们描述了一步一步的协议来调查 ev 介导的肿瘤间充质干细胞 (MSC) 相互作用的在体内, 揭示了一个关键的作用, 电动汽车教育的 MSCs 在转移。

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癌症研究 问题 135 原位肿瘤小鼠模型 间充质干细胞 胞外囊 肿瘤微环境 转移 骨肉瘤
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