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Tail Vein Transection Bleeding Model bei vollnarkotisierter Hämophilie A Mäuse
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Tail Vein Transection Bleeding Model bei vollnarkotisierter Hämophilie A Mäuse

Article DOI: 10.3791/62952-v • 08:13 min • September 30th, 2021
September 30th, 2021 •
1,2, 1, 1, 3, 1, 4, 5, 1, 6, 1
1Global Drug Discovery, Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik

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Das verfeinerte Tail Vein Transection (TVT) Blutungsmodell bei anästhesierten Mäusen ist eine sensitive in vivo Methode zur Beurteilung hämophiler Blutungen. Dieses optimierte TVT-Blutungsmodell verwendet Blutverlust und Blutungszeit als Endpunkte, verfeinert andere Modelle und vermeidet den Tod als Endpunkt.

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Biologie Ausgabe 175 Schwanzvenentranssektionsmodell Schwanzblutung Tiermodell pharmakologische Intervention Hämophilie Faktor FVIII Knock-out-Mäuse
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