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Journal / Genetics / 研究线粒体功能障碍的 体外…
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Genetics

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JoVE Journal Genetics
研究线粒体功能障碍的 体外 方法：一种Cybrid模型
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研究线粒体功能障碍的 体外 方法：一种Cybrid模型

Article DOI: 10.3791/63452-v • 06:05 min • March 9th, 2022
March 9th, 2022 •
*1, *1, 1, 1
1Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta
* These authors contributed equally

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透软骨圆柱体是通过将线粒体 DNA （mtDNA） 耗尽的细胞 （rho0 细胞） 与来自线粒体疾病患者的细胞形成体（去核细胞）融合而获得的杂交细胞。它们可以确定疾病的核或线粒体起源，评估生化活性，并确认mtDNA相关变异的致病作用。

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遗传学，第181期，
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