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Journal / Bioengineering / Subretinal implantation av RPE på en bärare i…
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Bioengineering
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JoVE Journal Bioengineering
Subretinal implantation av RPE på en bärare i minigrisar
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Subretinal implantation av RPE på en bärare i minigrisar: riktlinjer för preoperativa preparat, kirurgiska tekniker och postoperativ vård

Article DOI: 10.3791/63505-v • 11:06 min • November 11th, 2022
November 11th, 2022 •
*1,2, *3, 4, 4, 4, 5,6, 5,6, 5,6, 5,6, 5,6, 5, 5, 5, 5, 7, 8, 9, 10, 11, 1, 1, 5, *8, *5
1Eye Clinic, Department of Ophthalmology, University Hospital Giessen and Marburg GmbH, 2Karl Landsteiner Institute for Retinal Research and Imaging, 3Department of Ophthalmology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, 4Institute of Macromolecular Chemistry, Czech Academy of Sciences, 5Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 6Department of Cell Biology, Faculty of Science, Charles University, 7Institute of Experimental Medicine, Czech Academy of Sciences, 8Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 9Moorfields Eye Hospitals UAE, 10Stem Cell Therapies in Neurodegenerative Diseases Lab, Research Center “Principe Felipe”, 11Eye Center Donaustadt, Department of Ophthalmology, Sigmund Freud University
* These authors contributed equally

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Den subretinala implantationen av retinalt pigmenterat epitel (RPE) är en av de mest lovande metoderna för behandling av degenerativa näthinnesjukdomar. Utförandet av prekliniska studier på storögda djurmodeller är dock fortfarande utmanande. Denna rapport presenterar riktlinjer för subretinal transplantation av RPE på en cellbärare till minigrisar.

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Bioteknik utgåva 189 Åldersrelaterad makuladegeneration retinalt pigmenterat epitel RPE storögd djurmodell minigrisar pars plana vitrektomi PPV cellbärare in vivo-kirurgi preoperativ och postoperativ vård
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