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Journal / Bioengineering / Opprettelse av et kneledd på en brikke for…
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Bioengineering
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JoVE Journal Bioengineering
Opprettelse av et kneledd på en brikke for modellering av leddsykdommer og testing av medisiner
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Opprettelse av et kneledd på en brikke for modellering av leddsykdommer og testing av medisiner

Article DOI: 10.3791/64186-v • 12:44 min • January 27th, 2023
January 27th, 2023 •
1,2, 1,3, 1, 1, 1, 1, 1, 1, 4, 5, 4,6, 1,8, 1,7, 1,2,7
1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong

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Vi tilbyr detaljerte metoder for å generere fire typer vev fra humane mesenkymale stamceller, som brukes til å rekapitulere brusk, bein, fettpute og synovium i det menneskelige kneleddet. Disse fire vevene er integrert i en tilpasset bioreaktor og koblet sammen gjennom mikrofluidikk, og genererer dermed et kneledd på en brikke.

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Bioengineering slitasjegikt vev chip sykdomsmodifiserende slitasjegikt narkotika mikrofysiologiske systemet
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