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Monitoring van on-target signaalreacties bij larvale zebravissen - Z-REX ontmaskert precieze mechanismen van elektrofiele geneesmiddelen en metabolieten
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Monitoring van on-target signaalreacties bij larvale zebravissen - Z-REX ontmaskert precieze mechanismen van elektrofiele geneesmiddelen en metabolieten

Article DOI: 10.3791/64846-v • 05:28 min • June 2nd, 2023
June 2nd, 2023 •
1, 1, 2, 3, 4, 1
1Swiss Federal Institute of Technology Lausanne (EPFL), 2Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 3Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, 4University of Lausanne (UNIL)

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Zebravis gericht op reactieve elektrofielen en oxidanten (Z-REX) is een op chemische biologie gebaseerde methode voor het onderzoek van reactieve signalering van kleine moleculen. Deze techniek kan worden toegepast op levende vissen van verschillende ontwikkelingsstadia. Hier koppelen we standaardtests in zebravissen aan Z-REX voor signaalrouteanalyse.

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Biologie Nummer 196
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