Alfons Lawen Department of Biochemistry and Molecular Biology, School of Biomedical Sciences Monash University Biography Publications Institution JoVE Articles Alfons Lawen has not added a biography. If you are Alfons Lawen and would like to personalize this page please email our Author Liaison for assistance. Publications Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action Antioxidants & Redox Signaling. Jun, 2013 | Pubmed ID: 23199217 The Glutamate Aspartate Transporter (GLAST) Mediates L-glutamate-stimulated Ascorbate-release Via Swelling-activated Anion Channels in Cultured Neonatal Rodent Astrocytes Cell Biochemistry and Biophysics. Mar, 2013 | Pubmed ID: 22886112 Characterization of the N-methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase Chemistry & Biology. Apr, 2011 | Pubmed ID: 21513883 Two Routes of Iron Accumulation in Astrocytes: Ascorbate-dependent Ferrous Iron Uptake Via the Divalent Metal Transporter (DMT1) Plus an Independent Route for Ferric Iron The Biochemical Journal. Nov, 2010 | Pubmed ID: 20819077 Neurones Express Glutamine Synthetase when Deprived of Glutamine or Interaction with Astrocytes Journal of Neurochemistry. Sep, 2010 | Pubmed ID: 20557426 A Role for Na+/H+ Exchangers and Intracellular PH in Regulating Vitamin C-driven Electron Transport Across the Plasma Membrane The Biochemical Journal. Jun, 2010 | Pubmed ID: 20307259 Voltage-dependent Anion-selective Channel (VDAC) in the Plasma Membrane FEBS Letters. May, 2010 | Pubmed ID: 20184885 Inhibition of Abeta Aggregation and Neurotoxicity by the 39-kDa Receptor-associated Protein Journal of Neurochemistry. Mar, 2010 | Pubmed ID: 20002523 Ascorbate and Plasma Membrane Electron Transport--enzymes Vs Efflux Free Radical Biology & Medicine. Sep, 2009 | Pubmed ID: 19501649 Targeting Mitochondrial Permeability in Cancer Drug Development Molecular Nutrition & Food Research. Jan, 2009 | Pubmed ID: 19035550 Transplasma Membrane Electron Transport Comes in Two Flavors BioFactors (Oxford, England). 2008 | Pubmed ID: 19734120 Non-transferrin Iron Reduction and Uptake Are Regulated by Transmembrane Ascorbate Cycling in K562 Cells The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18347019 A Highly Sensitive Colorimetric Microplate Ferrocyanide Assay Applied to Ascorbate-stimulated Transplasma Membrane Ferricyanide Reduction and Mitochondrial Succinate Oxidation Analytical Biochemistry. Feb, 2008 | Pubmed ID: 17949676 Another Piece of the Puzzle of Apoptotic Cytochrome C Release Molecular Microbiology. Nov, 2007 | Pubmed ID: 17887962 Mitocans: Mitochondrial Targeted Anti-cancer Drugs As Improved Therapies and Related Patent Documents Recent Patents on Anti-cancer Drug Discovery. Nov, 2006 | Pubmed ID: 18221044 An Improved Purification Procedure for Cyclosporin Synthetase Protein Expression and Purification. Feb, 2006 | Pubmed ID: 16139518 Voltage-dependent Anion-selective Channel 1 (VDAC1)--a Mitochondrial Protein, Rediscovered As a Novel Enzyme in the Plasma Membrane The International Journal of Biochemistry & Cell Biology. Feb, 2005 | Pubmed ID: 15474974 Plasma Membrane NADH-oxidoreductase in Cells Carrying Mitochondrial DNA G11778A Mutation and in Cells Devoid of Mitochondrial DNA (rho0) BioFactors (Oxford, England). 2004 | Pubmed ID: 15706055 Characterization of VDAC1 As a Plasma Membrane NADH-oxidoreductase BioFactors (Oxford, England). 2004 | Pubmed ID: 15630200 VDAC1 is a Transplasma Membrane NADH-ferricyanide Reductase The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14573604 Non-ribosomal Peptide Synthetases As Technological Platforms for the Synthesis of Highly Modified Peptide Bioeffectors--Cyclosporin Synthetase As a Complex Example Biotechnology Annual Review. 2003 | Pubmed ID: 14650927 Bioethics Needs a Distinct Voice if It is to Aid Science Nature. Oct, 2003 | Pubmed ID: 14574381 Novel Effects on Memory Observed Following Unilateral Intracranial Administration of Okadaic Acid, Cyclosporin A, FK506 and [MeVal4]CyA Brain Research. Oct, 2003 | Pubmed ID: 14519526 Apoptosis-an Introduction BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Sep, 2003 | Pubmed ID: 12938178 Involvement of Reactive Oxygen Species in Capsaicinoid-induced Apoptosis in Transformed Cells Free Radical Research. Jun, 2003 | Pubmed ID: 12868488 New Functions of an Old Protein: the Eukaryotic Porin or Voltage Dependent Anion Selective Channel (VDAC) The Italian Journal of Biochemistry. Mar, 2003 | Pubmed ID: 12833633 Photoaffinity Labeling of the N-methyltransferase Domains of Cyclosporin Synthetase Photochemistry and Photobiology. Feb, 2003 | Pubmed ID: 12785050 Transplasma Membrane Electron Transport: Enzymes Involved and Biological Function Redox Report : Communications in Free Radical Research. 2003 | Pubmed ID: 12631439 Mapping and Molecular Modeling of S-adenosyl-L-methionine Binding Sites in N-methyltransferase Domains of the Multifunctional Polypeptide Cyclosporin Synthetase The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12399454 Cyclosporin A, FK506 and Rapamycin Produce Multiple, Temporally Distinct, Effects on Memory Following Single-trial, Passive Avoidance Training in the Chick Brain Research. Feb, 2002 | Pubmed ID: 11821011 A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells Darius J. R. Lane1, Alfons Lawen2 1Molecular Pharmacology and Pathology Program, Department of Pathology & Bosch Institute, University of Sydney, 2Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University JoVE 51322 Biology
A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells Darius J. R. Lane1, Alfons Lawen2 1Molecular Pharmacology and Pathology Program, Department of Pathology & Bosch Institute, University of Sydney, 2Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University JoVE 51322 Biology