Darius J. R. Lane Molecular Pharmacology and Pathology Program, Department of Pathology & Bosch Institute University of Sydney Biography Publications Institution JoVE Articles Darius J. R. Lane has not added a biography. If you are Darius J. R. Lane and would like to personalize this page please email our Author Liaison for assistance. Publications The Metastasis Suppressor, N-myc Downstream-regulated Gene 1 (NDRG1), Inhibits Stress-induced Autophagy in Cancer Cells The Journal of Biological Chemistry. Apr, 2014 | Pubmed ID: 24532803 Expanding Horizons in Iron Chelation and the Treatment of Cancer: Role of Iron in the Regulation of ER Stress and the Epithelial-mesenchymal Transition Biochimica Et Biophysica Acta. Jan, 2014 | Pubmed ID: 24472573 Molecular Functions of the Iron-regulated Metastasis Suppressor, NDRG1, and Its Potential As a Molecular Target for Cancer Therapy Biochimica Et Biophysica Acta. Jan, 2014 | Pubmed ID: 24269900 Anti-plasmodial Activity of Aroylhydrazone and Thiosemicarbazone Iron Chelators: Effect on Erythrocyte Membrane Integrity, Parasite Development and the Intracellular Labile Iron Pool Journal of Inorganic Biochemistry. Dec, 2013 | Pubmed ID: 24028863 Biochemistry of Cardiomyopathy in the Mitochondrial Disease Friedreich's Ataxia The Biochemical Journal. Aug, 2013 | Pubmed ID: 23849057 Hepcidin, Show Some Self-control! How the Hormone of Iron Metabolism Regulates Its Own Expression The Biochemical Journal. Jun, 2013 | Pubmed ID: 23662810 Transferrin Iron Uptake is Stimulated by Ascorbate Via an Intracellular Reductive Mechanism Biochimica Et Biophysica Acta. Jun, 2013 | Pubmed ID: 23481043 N-myc Downstream Regulated 1 (NDRG1) is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) During Cellular Stress Caused by Iron Depletion PloS One. 2013 | Pubmed ID: 23437357 Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action Antioxidants & Redox Signaling. Jun, 2013 | Pubmed ID: 23199217 The Glutamate Aspartate Transporter (GLAST) Mediates L-glutamate-stimulated Ascorbate-release Via Swelling-activated Anion Channels in Cultured Neonatal Rodent Astrocytes Cell Biochemistry and Biophysics. Mar, 2013 | Pubmed ID: 22886112 Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-dithiol-iron Complexes: Long-lived NO That is Trafficked by Interacting Proteins The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22262835 Mitochondrial Mayhem: the Mitochondrion As a Modulator of Iron Metabolism and Its Role in Disease Antioxidants & Redox Signaling. Dec, 2011 | Pubmed ID: 21545274 Two Routes of Iron Accumulation in Astrocytes: Ascorbate-dependent Ferrous Iron Uptake Via the Divalent Metal Transporter (DMT1) Plus an Independent Route for Ferric Iron The Biochemical Journal. Nov, 2010 | Pubmed ID: 20819077 Mitochondrial Iron Trafficking and the Integration of Iron Metabolism Between the Mitochondrion and Cytosol Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20495089 A Role for Na+/H+ Exchangers and Intracellular PH in Regulating Vitamin C-driven Electron Transport Across the Plasma Membrane The Biochemical Journal. Jun, 2010 | Pubmed ID: 20307259 Voltage-dependent Anion-selective Channel (VDAC) in the Plasma Membrane FEBS Letters. May, 2010 | Pubmed ID: 20184885 Frataxin, a Molecule of Mystery: Trading Stability for Function in Its Iron-binding Site The Biochemical Journal. Mar, 2010 | Pubmed ID: 20141512 Ascorbate and Plasma Membrane Electron Transport--enzymes Vs Efflux Free Radical Biology & Medicine. Sep, 2009 | Pubmed ID: 19501649 Transplasma Membrane Electron Transport Comes in Two Flavors BioFactors (Oxford, England). 2008 | Pubmed ID: 19734120 Non-transferrin Iron Reduction and Uptake Are Regulated by Transmembrane Ascorbate Cycling in K562 Cells The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18347019 A Highly Sensitive Colorimetric Microplate Ferrocyanide Assay Applied to Ascorbate-stimulated Transplasma Membrane Ferricyanide Reduction and Mitochondrial Succinate Oxidation Analytical Biochemistry. Feb, 2008 | Pubmed ID: 17949676 Voltage-dependent Anion-selective Channel 1 (VDAC1)--a Mitochondrial Protein, Rediscovered As a Novel Enzyme in the Plasma Membrane The International Journal of Biochemistry & Cell Biology. Feb, 2005 | Pubmed ID: 15474974 VDAC1 is a Transplasma Membrane NADH-ferricyanide Reductase The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14573604 A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells Darius J. R. Lane1, Alfons Lawen2 1Molecular Pharmacology and Pathology Program, Department of Pathology & Bosch Institute, University of Sydney, 2Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University JoVE 51322 Biology
A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells Darius J. R. Lane1, Alfons Lawen2 1Molecular Pharmacology and Pathology Program, Department of Pathology & Bosch Institute, University of Sydney, 2Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University JoVE 51322 Biology