Debra J. Skene Chronobiology, Faculty of Health & Medical Sciences University of Surrey Biography Publications Institution JoVE Articles Debra J. Skene has not added a biography. If you are Debra J. Skene and would like to personalize this page please email our Author Liaison for assistance. Publications Living Without Temporal Cues: A Case Study Frontiers in Physiology. 2020 | Pubmed ID: 32116739 Melatonin Suppression by Melanopsin-weighted Light in Patients with Bipolar I Disorder Compared to Healthy Controls Journal of Psychiatry & Neuroscience : JPN. Mar, 2020 | Pubmed ID: 32096617 Eating Behavior (Duration, Content, and Timing) Among Workers Living Under Different Levels of Urbanization Nutrients. Jan, 2020 | Pubmed ID: 32023914 Increased Plasma Melatonin in Presymptomatic Huntington Disease Sheep (Ovis Aries): Compensatory Neuroprotection in a Neurodegenerative Disease? Journal of Pineal Research. Mar, 2020 | Pubmed ID: 31742766 Effect of Acute Total Sleep Deprivation on Plasma Melatonin, Cortisol and Metabolite Rhythms in Females The European Journal of Neuroscience. Jan, 2020 | Pubmed ID: 30929284 Melatonin Suppression by Melanopsin-weighted Light in Patients with Bipolar I Disorder Compared to Healthy Controls Journal of Psychiatry & Neuroscience : JPN. 09, 2019 | Pubmed ID: 31509363 Resetting the Late Timing of 'night Owls' Has a Positive Impact on Mental Health and Performance Sleep Medicine. 08, 2019 | Pubmed ID: 31202686 Why Should We Abolish Daylight Saving Time? Journal of Biological Rhythms. 06, 2019 | Pubmed ID: 31170882 Circadian Regulation in Human White Adipose Tissue Revealed by Transcriptome and Metabolic Network Analysis Scientific Reports. 02, 2019 | Pubmed ID: 30804433 Circadian Phenotype Impacts the Brain's Resting-state Functional Connectivity, Attentional Performance, and Sleepiness Sleep. 05, 2019 | Pubmed ID: 30763951 Chronic Sleep Restriction in the Rotenone Parkinson's Disease Model in Rats Reveals Peripheral Early-phase Biomarkers Scientific Reports. 02, 2019 | Pubmed ID: 30760786 25-Hydroxyvitamin D Status, Light Exposure and Sleep Quality in UK Dwelling South Asian and Caucasian Postmenopausal Women The Journal of Steroid Biochemistry and Molecular Biology. 05, 2019 | Pubmed ID: 30710742 Effect of Single and Combined Monochromatic Light on the Human Pupillary Light Response Frontiers in Neurology. 2018 | Pubmed ID: 30555403 Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot Study Frontiers in Physiology. 2018 | Pubmed ID: 30455647 A Systems Genetics Resource and Analysis of Sleep Regulation in the Mouse PLoS Biology. 08, 2018 | Pubmed ID: 30091978 Separation of Circadian- and Behavior-driven Metabolite Rhythms in Humans Provides a Window on Peripheral Oscillators and Metabolism Proceedings of the National Academy of Sciences of the United States of America. 07, 2018 | Pubmed ID: 29991600 Erratum To: Investigation of Metabolites for Estimating Blood Deposition Time International Journal of Legal Medicine. 01, 2018 | Pubmed ID: 28840223 Investigation of Metabolites for Estimating Blood Deposition Time International Journal of Legal Medicine. Jan, 2018 | Pubmed ID: 28780758 Guidelines for Genome-Scale Analysis of Biological Rhythms Journal of Biological Rhythms. Oct, 2017 | Pubmed ID: 29098954 Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia Frontiers in Physiology. 2017 | Pubmed ID: 28912724 Twenty-four-hour Rhythmicity of Circulating Metabolites: Effect of Body Mass and Type 2 Diabetes FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 12, 2017 | Pubmed ID: 28821636 Evidence for the Efficacy of Melatonin in the Treatment of Primary Adult Sleep Disorders Sleep Medicine Reviews. 08, 2017 | Pubmed ID: 28648359 Modulation of Plasma Metabolite Biomarkers of the MAPK Pathway with MEK Inhibitor RO4987655: Pharmacodynamic and Predictive Potential in Metastatic Melanoma Molecular Cancer Therapeutics. 10, 2017 | Pubmed ID: 28637716 Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness Current Alzheimer Research. 2017 | Pubmed ID: 28595523 Meal Timing Regulates the Human Circadian System Current Biology : CB. Jun, 2017 | Pubmed ID: 28578930 Metabolic Profiling of Presymptomatic Huntington's Disease Sheep Reveals Novel Biomarkers Scientific Reports. 02, 2017 | Pubmed ID: 28223686 Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures Endocrine Reviews. 12, 2016 | Pubmed ID: 27763782 Relationship Between Human Pupillary Light Reflex and Circadian System Status PloS One. 2016 | Pubmed ID: 27636197 Ancestral Sleep Current Biology : CB. Apr, 2016 | Pubmed ID: 27046809 Evaluation of MRNA Markers for Estimating Blood Deposition Time: Towards Alibi Testing from Human Forensic Stains with Rhythmic Biomarkers Forensic Science International. Genetics. Mar, 2016 | Pubmed ID: 26765251 Sex Differences in the Circadian Profiles of Melatonin and Cortisol in Plasma and Urine Matrices Under Constant Routine Conditions Chronobiology International. 2016 | Pubmed ID: 26731571 Dissecting Daily and Circadian Expression Rhythms of Clock-Controlled Genes in Human Blood Journal of Biological Rhythms. Feb, 2016 | Pubmed ID: 26527095 Bigger, Brighter, Bluer-Better? Current Light-Emitting Devices - Adverse Sleep Properties and Preventative Strategies Frontiers in Public Health. 2015 | Pubmed ID: 26528465 Diurnal Rhythms in the Human Urine Metabolome During Sleep and Total Sleep Deprivation Scientific Reports. Oct, 2015 | Pubmed ID: 26450397 Telling Biological Time from a Blood Sample: Current Capabilities and Future Potential Annals of Clinical Biochemistry. Nov, 2015 | Pubmed ID: 26169057 Natural Light Exposure, Sleep and Depression Among Day Workers and Shiftworkers at Arctic and Equatorial Latitudes PloS One. 2015 | Pubmed ID: 25874859 Increased and Mistimed Sex Hormone Production in Night Shift Workers Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Mar, 2015 | Pubmed ID: 25737330 Effect of Sleep Deprivation on the Human Metabolome Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25002497 Assessing the Suitability of MiRNA-142-5p and MiRNA-541 for Bloodstain Deposition Timing Forensic Science International. Genetics. Sep, 2014 | Pubmed ID: 24999280 Circadian Rhythm Disorders and Melatonin Production in 127 Blind Women with and Without Light Perception Journal of Biological Rhythms. Jun, 2014 | Pubmed ID: 24916394 Circadian Variation of Melatonin, Light Exposure, and Diurnal Preference in Day and Night Shift Workers of Both Sexes Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jul, 2014 | Pubmed ID: 24812038 Potential Drug Interactions with Melatonin Physiology & Behavior. May, 2014 | Pubmed ID: 24732412 Measuring and Using Light in the Melanopsin Age Trends in Neurosciences. Jan, 2014 | Pubmed ID: 24287308 Atherosclerotic Risk and Social Jetlag in Rotating Shift-workers: First Evidence from a Pilot Study Work (Reading, Mass.). Jan, 2013 | Pubmed ID: 23324695 Noisy and Individual, but Doable: Shift-work Research in Humans Progress in Brain Research. 2012 | Pubmed ID: 22877677 Identification of Human Plasma Metabolites Exhibiting Time-of-day Variation Using an Untargeted Liquid Chromatography-mass Spectrometry Metabolomic Approach Chronobiology International. Aug, 2012 | Pubmed ID: 22823870 Diurnal Rhythms in Blood Cell Populations and the Effect of Acute Sleep Deprivation in Healthy Young Men Sleep. Jul, 2012 | Pubmed ID: 22754039 Daily Rhythms of Plasma Melatonin, but Not Plasma Leptin or Leptin MRNA, Vary Between Lean, Obese and Type 2 Diabetic Men PloS One. 2012 | Pubmed ID: 22623983 Mood, Alertness, and Performance in Response to Sleep Deprivation and Recovery Sleep in Experienced Shiftworkers Versus Non-shiftworkers Chronobiology International. Jun, 2012 | Pubmed ID: 22621349 Human Nonvisual Responses to Simultaneous Presentation of Blue and Red Monochromatic Light Journal of Biological Rhythms. Feb, 2012 | Pubmed ID: 22306975 Heart Rate Variability and Endothelial Function After Sleep Deprivation and Recovery Sleep Among Male Shift and Non-shift Workers Scandinavian Journal of Work, Environment & Health. Mar, 2012 | Pubmed ID: 21953310 Rhythmic Diurnal Gene Expression in Human Adipose Tissue from Individuals Who Are Lean, Overweight, and Type 2 Diabetic Diabetes. May, 2011 | Pubmed ID: 21411511 The Physiological Period Length of the Human Circadian Clock in Vivo is Directly Proportional to Period in Human Fibroblasts PloS One. Oct, 2010 | Pubmed ID: 21042402 Predicting Human Nocturnal Nonvisual Responses to Monochromatic and Polychromatic Light with a Melanopsin Photosensitivity Function Chronobiology International. Oct, 2010 | Pubmed ID: 20969522 Effect of Total Sleep Deprivation on Postprandial Metabolic and Insulin Responses in Shift Workers and Non-shift Workers The Journal of Endocrinology. Aug, 2010 | Pubmed ID: 20479040 Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder Sleep. May, 2010 | Pubmed ID: 20469812 Daily Light Exposure Profiles in Older Non-resident Extreme Morning and Evening Types Journal of Sleep Research. Dec, 2009 | Pubmed ID: 19691475 Blue-light Phase Shifts PER3 Gene Expression in Human Leukocytes Chronobiology International. May, 2009 | Pubmed ID: 19444755 Age-related Changes in Acute and Phase-advancing Responses to Monochromatic Light Journal of Biological Rhythms. Feb, 2009 | Pubmed ID: 19227580 Clinical Update: Melatonin and Sleep Disorders Clinical Medicine (London, England). Aug, 2008 | Pubmed ID: 18724603 Benzodiazepine-induced Reduction in Activity Mirrors Decrements in Cognitive and Psychomotor Performance Human Psychopharmacology. Oct, 2008 | Pubmed ID: 18570226 Differences in Sleep, Light, and Circadian Phase in Offshore 18:00-06:00 H and 19:00-07:00 H Shift Workers Chronobiology International. Apr, 2008 | Pubmed ID: 18484362 Alertness, Mood and Performance Rhythm Disturbances Associated with Circadian Sleep Disorders in the Blind Journal of Sleep Research. Jun, 2008 | Pubmed ID: 18482109 Light-induced Melatonin Suppression in Humans with Polychromatic and Monochromatic Light Chronobiology International. 2007 | Pubmed ID: 18075803 Visual Impairment and Circadian Rhythm Disorders Dialogues in Clinical Neuroscience. 2007 | Pubmed ID: 17969867 Circadian Rhythm Sleep Disorders in the Blind and Their Treatment with Melatonin Sleep Medicine. Sep, 2007 | Pubmed ID: 17420154 PER3 Polymorphism Predicts Sleep Structure and Waking Performance Current Biology : CB. Apr, 2007 | Pubmed ID: 17346965 Age-related Change in the Association Between a Polymorphism in the PER3 Gene and Preferred Timing of Sleep and Waking Activities Journal of Sleep Research. Mar, 2007 | Pubmed ID: 17309758 A Silent Polymorphism in the PER1 Gene Associates with Extreme Diurnal Preference in Humans Journal of Human Genetics. 2006 | Pubmed ID: 17051316 Human Circadian Rhythms: Physiological and Therapeutic Relevance of Light and Melatonin Annals of Clinical Biochemistry. Sep, 2006 | Pubmed ID: 17022876 Mice Convert Melatonin to 6-sulphatoxymelatonin General and Comparative Endocrinology. Jul, 2006 | Pubmed ID: 16564048 Alerting Effects of Light Are Sensitive to Very Short Wavelengths Neuroscience Letters. May, 2006 | Pubmed ID: 16490309 Circadian Variation in Endothelial Function is Attenuated in Postmenopausal Women Maturitas. Jun, 2006 | Pubmed ID: 16466869 A Single-nucleotide Polymorphism in the 5'-untranslated Region of the HPER2 Gene is Associated with Diurnal Preference Journal of Sleep Research. Sep, 2005 | Pubmed ID: 16120104 Light-induced Melatonin Suppression: Age-related Reduction in Response to Short Wavelength Light Experimental Gerontology. Mar, 2005 | Pubmed ID: 15763401 Melatonin As a Chronobiotic Sleep Medicine Reviews. Feb, 2005 | Pubmed ID: 15649736 The Effects of Low-dose 0.5-mg Melatonin on the Free-running Circadian Rhythms of Blind Subjects Journal of Biological Rhythms. Oct, 2003 | Pubmed ID: 14582858 A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference Sleep. Jun, 2003 | Pubmed ID: 12841365 Phase Advancing Human Circadian Rhythms with Short Wavelength Light Neuroscience Letters. May, 2003 | Pubmed ID: 12727312 Optimization of Light and Melatonin to Phase-shift Human Circadian Rhythms Journal of Neuroendocrinology. Apr, 2003 | Pubmed ID: 12622847 Melatonin Rhythmicity: Effect of Age and Alzheimer's Disease Experimental Gerontology. Jan-Feb, 2003 | Pubmed ID: 12543278 The 3111 Clock Gene Polymorphism is Not Associated with Sleep and Circadian Rhythmicity in Phenotypically Characterized Human Subjects Journal of Sleep Research. Dec, 2002 | Pubmed ID: 12464098 An Action Spectrum for Melatonin Suppression: Evidence for a Novel Non-rod, Non-cone Photoreceptor System in Humans The Journal of Physiology. Aug, 2001 | Pubmed ID: 11507175 Use of Melatonin in the Treatment of Phase Shift and Sleep Disorders Advances in Experimental Medicine and Biology. 1999 | Pubmed ID: 10721041 Effects of Light on Human Circadian Rhythms Reproduction, Nutrition, Development. May-Jun, 1999 | Pubmed ID: 10420432 Melatonin in Circadian Sleep Disorders in the Blind Biological Signals and Receptors. Jan-Apr, 1999 | Pubmed ID: 10085469 Use of Melatonin in Circadian Rhythm Disorders and Following Phase Shifts Acta Neurobiologiae Experimentalis. 1996 | Pubmed ID: 8787196 Human Circadian Phenotyping and Diurnal Performance Testing in the Real World Elise R. Facer-Childs1,2,3, Benita Middleton1, Andrew P. Bagshaw2, Debra J. Skene1 1Chronobiology, Faculty of Health & Medical Sciences, University of Surrey, 2Centre for Human Brain Health, University of Birmingham, 3Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University JoVE 60448 Behavior
Human Circadian Phenotyping and Diurnal Performance Testing in the Real World Elise R. Facer-Childs1,2,3, Benita Middleton1, Andrew P. Bagshaw2, Debra J. Skene1 1Chronobiology, Faculty of Health & Medical Sciences, University of Surrey, 2Centre for Human Brain Health, University of Birmingham, 3Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University JoVE 60448 Behavior