Grant A. Ramm QIMR Berghofer Medical Research Institute Biography Publications Institution JoVE Articles Grant A. Ramm has not added a biography. If you are Grant A. Ramm and would like to personalize this page please email our Author Liaison for assistance. Publications Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease The American Journal of Pathology. Sep, 2017 | Pubmed ID: 28935574 Extracellular Vesicles for Personalized Therapy Decision Support in Advanced Metastatic Cancers and Its Potential Impact for Prostate Cancer The Prostate. Oct, 2017 | Pubmed ID: 28856701 Serum Ferritin Concentration Predicts Hepatic Fibrosis Better Than Hepatic Iron Concentration in Human HFE-Haemochromatosis Liver International : Official Journal of the International Association for the Study of the Liver. Sep, 2017 | Pubmed ID: 28231420 Reply Hepatology (Baltimore, Md.). Mar, 2017 | Pubmed ID: 28010035 GNPAT P.D519G is Independently Associated with Markedly Increased Iron Stores in HFE P.C282Y Homozygotes Blood Cells, Molecules & Diseases. Mar, 2017 | Pubmed ID: 27936396 Diagnosing Schistosomiasis-induced Liver Morbidity: Implications for Global Control International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases. Jan, 2017 | Pubmed ID: 27816660 Filling the Gap on Caveolin-1 in Liver Carcinogenesis Trends in Cancer. Dec, 2016 | Pubmed ID: 28741517 Function and Regulation of MicroRNAs and Their Potential As Biomarkers in Paediatric Liver Disease International Journal of Molecular Sciences. Oct, 2016 | Pubmed ID: 27801781 Caveolin-1 Function in Liver Physiology and Disease Trends in Molecular Medicine. Oct, 2016 | Pubmed ID: 27633517 Transient Liver Elastography in Unsedated Control Children: Impact of Age and Intercurrent Illness Journal of Paediatrics and Child Health. Jun, 2016 | Pubmed ID: 27203205 Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury The American Journal of Pathology. Jul, 2016 | Pubmed ID: 27181403 Mechanism of Pancreatic and Liver Malformations in Human Fetuses with Short-rib Polydactyly Syndrome Birth Defects Research. Part A, Clinical and Molecular Teratology. Jul, 2016 | Pubmed ID: 26970085 Value of the 8-oxodG/dG Ratio in Chronic Liver Inflammation of Patients with Hepatocellular Carcinoma Redox Biology. Aug, 2016 | Pubmed ID: 26890046 Reply Hepatology (Baltimore, Md.). Jun, 2016 | Pubmed ID: 26845080 Characterising Granuloma Regression and Liver Recovery in a Murine Model of Schistosomiasis Japonica International Journal for Parasitology. Apr, 2016 | Pubmed ID: 26812024 The Role of Liver Progenitor Cells During Liver Regeneration, Fibrogenesis, and Carcinogenesis American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2016 | Pubmed ID: 26608186 Reply Hepatology (Baltimore, Md.). Jun, 2016 | Pubmed ID: 26417986 Should HFE P.C282Y Homozygotes with Moderately Elevated Serum Ferritin Be Treated? A Randomised Controlled Trial Comparing Iron Reduction with Sham Treatment (Mi-iron) BMJ Open. Aug, 2015 | Pubmed ID: 26270952 The Development of Hepatic Stellate Cells in Normal and Abnormal Human Fetuses - an Immunohistochemical Study Physiological Reports. Aug, 2015 | Pubmed ID: 26265759 Aspartate Aminotransferase to Platelet Ratio and Fibrosis-4 As Biomarkers in Biopsy-validated Pediatric Cystic Fibrosis Liver Disease Hepatology (Baltimore, Md.). Nov, 2015 | Pubmed ID: 26223427 Transcriptional Profiling of Chronic Clinical Hepatic Schistosomiasis Japonica Indicates Reduced Metabolism and Immune Responses Parasitology. Oct, 2015 | Pubmed ID: 26216487 Case Report: Fetal Bilateral Diaphragmatic Agenesis, Ectopic Liver and Abnormal Pancreas Fetal and Pediatric Pathology. 2015 | Pubmed ID: 26030091 An Ex Vivo Model for Studying Hepatic Schistosomiasis and the Effect of Released Protein from Dying Eggs PLoS Neglected Tropical Diseases. May, 2015 | Pubmed ID: 25965781 Type 2 Diabetes Mellitus: Limitations of Conventional Therapies and Intervention with Nucleic Acid-based Therapeutics Chemical Reviews. Jun, 2015 | Pubmed ID: 25918949 Reply: To PMID 25605615 Hepatology (Baltimore, Md.). Dec, 2015 | Pubmed ID: 25914125 Reduced Mortality Due to Phlebotomy in Moderately Iron-loaded HFE Haemochromatosis? The Need for Clinical Trials Journal of Hepatology. Jul, 2015 | Pubmed ID: 25839407 Circulating MicroRNAs As Noninvasive Diagnostic Biomarkers of Liver Disease in Children with Cystic Fibrosis Journal of Pediatric Gastroenterology and Nutrition. Feb, 2015 | Pubmed ID: 25625579 Exome Sequencing in HFE C282Y Homozygous Men with Extreme Phenotypes Identifies a GNPAT Variant Associated with Severe Iron Overload Hepatology (Baltimore, Md.). Aug, 2015 | Pubmed ID: 25605615 Analysis of the Intrahepatic Ductular Reaction and Progenitor Cell Responses in Hepatitis C Virus Recurrence After Liver Transplantation Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Dec, 2014 | Pubmed ID: 25241637 TWEAK and LTβ Signaling During Chronic Liver Disease Frontiers in Immunology. 2014 | Pubmed ID: 24592262 Role of TWEAK in Coregulating Liver Progenitor Cell and Fibrogenic Responses Hepatology (Baltimore, Md.). Mar, 2014 | Pubmed ID: 24038142 Ductular Reaction in Hereditary Hemochromatosis: the Link Between Hepatocyte Senescence and Fibrosis Progression Hepatology (Baltimore, Md.). Mar, 2014 | Pubmed ID: 24037895 Transforming Growth Factor-β and Toll-like Receptor-4 Polymorphisms Are Not Associated with Fibrosis in Haemochromatosis World Journal of Gastroenterology. Dec, 2013 | Pubmed ID: 24409064 Iron and Hepatic Carcinogenesis Critical Reviews in Oncogenesis. 2013 | Pubmed ID: 23879586 Schistosomajaponicum Eggs Induce a Proinflammatory, Anti-Fibrogenic Phenotype in Hepatic Stellate Cells PloS One. 2013 | Pubmed ID: 23840855 Spatial and Temporal Transcriptomics of Schistosoma Japonicum-induced Hepatic Granuloma Formation Reveals Novel Roles for Neutrophils Journal of Leukocyte Biology. Aug, 2013 | Pubmed ID: 23709687 Role of Resident Liver Cells in the Pathogenesis of Schistosomiasis Trends in Parasitology. Dec, 2012 | Pubmed ID: 23099112 Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis The American Journal of Pathology. Oct, 2012 | Pubmed ID: 22858058 A Membrane Vesicle-based Dual Vaccine Against Melanoma and Lewis Lung Carcinoma Biomaterials. Sep, 2012 | Pubmed ID: 22681975 Clinical Cofactors and Hepatic Fibrosis in Hereditary Hemochromatosis: the Role of Diabetes Mellitus Hepatology (Baltimore, Md.). Sep, 2012 | Pubmed ID: 22422567 Abnormal WT1 Expression in Human Fetuses with Bilateral Renal Agenesis and Cardiac Malformations Birth Defects Research. Part A, Clinical and Molecular Teratology. Feb, 2012 | Pubmed ID: 22246978 Transcriptional Basis for Hepatic Fibrosis in Cystic Fibrosis-associated Liver Disease Journal of Pediatric Gastroenterology and Nutrition. Mar, 2012 | Pubmed ID: 22157922 Possible Role of WT1 in a Human Fetus with Evolving Bronchial Atresia, Pulmonary Malformation and Renal Agenesis Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2012 | Pubmed ID: 21985433 Anti-chemokine Therapy for the Treatment of Hepatic Fibrosis: an Attractive Approach Hepatology (Baltimore, Md.). Jul, 2011 | Pubmed ID: 21710472 Differential Expression of Chemokine and Matrix Re-modelling Genes is Associated with Contrasting Schistosome-induced Hepatopathology in Murine Models PLoS Neglected Tropical Diseases. Jun, 2011 | Pubmed ID: 21666794 Cystic Fibrosis-cirrhosis, Portal Hypertension, and Liver Biopsy: Reply Hepatology (Baltimore, Md.). Mar, 2011 | Pubmed ID: 21374683 High Parasite Burdens Cause Liver Damage in Mice Following Plasmodium Berghei ANKA Infection Independently of CD8(+) T Cell-mediated Immune Pathology Infection and Immunity. May, 2011 | Pubmed ID: 21343349 Importance of Hepatic Fibrosis in Cystic Fibrosis and the Predictive Value of Liver Biopsy Hepatology (Baltimore, Md.). Jan, 2011 | Pubmed ID: 21254170 Paediatric Cholestatic Liver Disease: Diagnosis, Assessment of Disease Progression and Mechanisms of Fibrogenesis World Journal of Gastrointestinal Pathophysiology. Jun, 2010 | Pubmed ID: 21607144 Iron Homeostasis, Hepatocellular Injury, and Fibrogenesis in Hemochromatosis: the Role of Inflammation in a Noninflammatory Liver Disease Seminars in Liver Disease. Aug, 2010 | Pubmed ID: 20665379 Co-ordinated Gene Expression in the Liver and Spleen During Schistosoma Japonicum Infection Regulates Cell Migration PLoS Neglected Tropical Diseases. May, 2010 | Pubmed ID: 20502518 Temporal Expression of Chemokines Dictates the Hepatic Inflammatory Infiltrate in a Murine Model of Schistosomiasis PLoS Neglected Tropical Diseases. Feb, 2010 | Pubmed ID: 20161726 Neutrophil Depletion Blocks Early Collagen Degradation in Repairing Cholestatic Rat Livers The American Journal of Pathology. Mar, 2010 | Pubmed ID: 20110408 Chemokine (C-C Motif) Receptors in Fibrogenesis and Hepatic Regeneration Following Acute and Chronic Liver Disease Hepatology (Baltimore, Md.). Nov, 2009 | Pubmed ID: 19877298 Identification of Ferritin Receptors: Their Role in Iron Homeostasis, Hepatic Injury, and Inflammation Gastroenterology. Nov, 2009 | Pubmed ID: 19789086 Ferritin Functions As a Proinflammatory Cytokine Via Iron-independent Protein Kinase C Zeta/nuclear Factor KappaB-regulated Signaling in Rat Hepatic Stellate Cells Hepatology (Baltimore, Md.). Mar, 2009 | Pubmed ID: 19241483 Serum Hyaluronic Acid with Serum Ferritin Accurately Predicts Cirrhosis and Reduces the Need for Liver Biopsy in C282Y Hemochromatosis Hepatology (Baltimore, Md.). Feb, 2009 | Pubmed ID: 19177571 Fibrogenesis in Pediatric Cholestatic Liver Disease: Role of Taurocholate and Hepatocyte-derived Monocyte Chemotaxis Protein-1 in Hepatic Stellate Cell Recruitment Hepatology (Baltimore, Md.). Feb, 2009 | Pubmed ID: 19115220 Lymphotoxin-beta Receptor Signaling Regulates Hepatic Stellate Cell Function and Wound Healing in a Murine Model of Chronic Liver Injury Hepatology (Baltimore, Md.). Jan, 2009 | Pubmed ID: 19111021 Assessment of Hepatic Steatosis: Comparison of Quantitative and Semiquantitative Methods in 108 Liver Biopsies Liver International : Official Journal of the International Association for the Study of the Liver. Apr, 2009 | Pubmed ID: 19018987 How Much Iron is Too Much? Expert Review of Gastroenterology & Hepatology. Jun, 2008 | Pubmed ID: 19072377 Hereditary Hemochromatosis in the Post-HFE Era Hepatology (Baltimore, Md.). Sep, 2008 | Pubmed ID: 18752323 Hepatic Macrophages Promote the Neutrophil-dependent Resolution of Fibrosis in Repairing Cholestatic Rat Livers Surgery. May, 2008 | Pubmed ID: 18436015 Environmental and Genetic Modifiers of the Progression to Fibrosis and Cirrhosis in Hemochromatosis Blood. May, 2008 | Pubmed ID: 18316631 The Function of Serotonin Within the Liver Journal of Hepatology. Apr, 2008 | Pubmed ID: 18280000 Effect of Phorbol Ester and Platelet-derived Growth Factor on Protein Kinase C in Rat Hepatic Stellate Cells Liver International : Official Journal of the International Association for the Study of the Liver. Oct, 2007 | Pubmed ID: 17845534 Role of Iron in Hepatic Fibrosis: One Piece in the Puzzle World Journal of Gastroenterology. Sep, 2007 | Pubmed ID: 17729396 A Novel Mutation in Ferroportin Implicated in Iron Overload Journal of Hepatology. May, 2007 | Pubmed ID: 17383046 Attenuated Liver Progenitor (oval) Cell and Fibrogenic Responses to the Choline Deficient, Ethionine Supplemented Diet in the BALB/c Inbred Strain of Mice Journal of Hepatology. Jan, 2007 | Pubmed ID: 17112626 The Clinical Relevance of Compound Heterozygosity for the C282Y and H63D Substitutions in Hemochromatosis Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Nov, 2006 | Pubmed ID: 16979952 A Role for Serotonin (5-HT) in Hepatic Stellate Cell Function and Liver Fibrosis The American Journal of Pathology. Sep, 2006 | Pubmed ID: 16936262 A Contributory Role for Activated Hepatic Stellate Cells in the Dynamics of Schistosoma Japonicum Egg-induced Fibrosis International Journal for Parasitology. Aug, 2006 | Pubmed ID: 16806222 Screening for Hemochromatosis in Asymptomatic Subjects with or Without a Family History Archives of Internal Medicine. Feb, 2006 | Pubmed ID: 16476869 Outcome After Portoenterostomy in Biliary Atresia: Pivotal Role of Degree of Liver Fibrosis and Intensity of Stellate Cell Activation Journal of Pediatric Gastroenterology and Nutrition. Jan, 2006 | Pubmed ID: 16385261 Hepatotoxicity of Iron Overload: Mechanisms of Iron-induced Hepatic Fibrogenesis Seminars in Liver Disease. Nov, 2005 | Pubmed ID: 16315137 Lymphotoxin-beta Production Following Bile Duct Ligation: Possible Role for Kupffer Cells Journal of Gastroenterology and Hepatology. Nov, 2005 | Pubmed ID: 16246198 Repair After Cholestatic Liver Injury Correlates with Neutrophil Infiltration and Matrix Metalloproteinase 8 Activity Surgery. Aug, 2005 | Pubmed ID: 16153442 Is HFE Involved in Increased Hepcidin Expression and Hypoferremia in Inflammation and Anemia of Chronic Disease? Hepatology (Baltimore, Md.). Apr, 2005 | Pubmed ID: 15791616 Hemojuvelin (HJV)-associated Hemochromatosis: Analysis of HJV and HFE Mutations and Iron Overload in Three Families Haematologica. Feb, 2005 | Pubmed ID: 15710580 Serum Markers of Hepatic Fibrogenesis in Cystic Fibrosis Liver Disease Journal of Hepatology. Oct, 2004 | Pubmed ID: 15464237 Endogenous Ursodeoxycholic Acid and Cholic Acid in Liver Disease Due to Cystic Fibrosis Hepatology (Baltimore, Md.). Jun, 2004 | Pubmed ID: 15185309 Signals for Hepatic Figrogenesis in Pediatric Cholestatic Liver Disease: Review and Hypothesis Comparative Hepatology. Jan, 2004 | Pubmed ID: 14960157 Quantitative Analysis of the Expression of ACAT Genes in Human Tissues by Real-time PCR Journal of Lipid Research. Apr, 2004 | Pubmed ID: 14729857 Effect of Protein Kinase C Activation and Inhibition on Rat Hepatic Stellate Cell Activation Digestive Diseases and Sciences. Apr, 2003 | Pubmed ID: 12741473 Identification and Characterization of the Hepatic Stellate Cell Transferrin Receptor The American Journal of Pathology. May, 2003 | Pubmed ID: 12707050 Evidence for a Sub-morphological Inflammatory Process in the Liver in Haemochromatosis Journal of Hepatology. Apr, 2003 | Pubmed ID: 12663233 Disrupted Hepcidin Regulation in HFE-associated Haemochromatosis and the Liver As a Regulator of Body Iron Homoeostasis Lancet (London, England). Feb, 2003 | Pubmed ID: 12606179 Aldehydic Products of Lipid Peroxidation Do Not Directly Activate Rat Hepatic Stellate Cells Journal of Gastroenterology and Hepatology. Jul, 2002 | Pubmed ID: 12121509 The Role of Hepatic Stellate Cells and Transforming Growth Factor-beta(1) in Cystic Fibrosis Liver Disease The American Journal of Pathology. May, 2002 | Pubmed ID: 12000722 مورين الكولين تعاني من نقص، تستكمل اثيونيني (الرفيق) النظام الغذائي النموذجي لإصابة الكبد المزمنة Jully Gogoi-Tiwari1, Julia Köhn-Gaone1, Corey Giles2, Dirk Schmidt-Arras3, Francis D. Gratte1,4, Caryn L. Elsegood1, Geoffrey W. McCaughan5,6,7, Grant A. Ramm8,9, John K. Olynyk10,11, Janina E.E. Tirnitz-Parker1,12 1School of Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, 2School of Public Health & Curtin Health Innovation Research Institute, Curtin University, 3Institute of Biochemistry, Christian-Albrechts-University, 4School of Veterinary and Life Sciences, Murdoch University, 5Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, 6Royal Prince Alfred Hospital, 7A.W. Morrow Gastroenterology and Liver Centre, 8QIMR Berghofer Medical Research Institute, 9Faculty of Medicine and Biomedical Sciences, The University of Queensland, 10Fiona Stanley and Fremantle Hospitals, 11School of Medical and Health Sciences, Edith Cowan University, 12School of Medicine and Pharmacology, University of Western Australia JoVE 56138 Biology
مورين الكولين تعاني من نقص، تستكمل اثيونيني (الرفيق) النظام الغذائي النموذجي لإصابة الكبد المزمنة Jully Gogoi-Tiwari1, Julia Köhn-Gaone1, Corey Giles2, Dirk Schmidt-Arras3, Francis D. Gratte1,4, Caryn L. Elsegood1, Geoffrey W. McCaughan5,6,7, Grant A. Ramm8,9, John K. Olynyk10,11, Janina E.E. Tirnitz-Parker1,12 1School of Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, 2School of Public Health & Curtin Health Innovation Research Institute, Curtin University, 3Institute of Biochemistry, Christian-Albrechts-University, 4School of Veterinary and Life Sciences, Murdoch University, 5Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, 6Royal Prince Alfred Hospital, 7A.W. Morrow Gastroenterology and Liver Centre, 8QIMR Berghofer Medical Research Institute, 9Faculty of Medicine and Biomedical Sciences, The University of Queensland, 10Fiona Stanley and Fremantle Hospitals, 11School of Medical and Health Sciences, Edith Cowan University, 12School of Medicine and Pharmacology, University of Western Australia JoVE 56138 Biology