Hiroshi Handa Department of Chemical Biology Tokyo Medical University Biography Publications Institution JoVE Articles Hiroshi Handa has not added a biography. If you are Hiroshi Handa and would like to personalize this page please email our Author Liaison for assistance. Publications Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology Cancers. Jan, 2022 | Pubmed ID: 35053527 PLZF and Its Fusion Proteins Are Pomalidomide-dependent CRBN Neosubstrates Communications Biology. 11, 2021 | Pubmed ID: 34764413 Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1 Cancers. Jun, 2021 | Pubmed ID: 34209885 Exploiting Ubiquitin Ligase Cereblon As a Target for Small-molecule Compounds in Medicine and Chemical Biology Cell Chemical Biology. 07, 2021 | Pubmed ID: 34033753 BRCA1 Degradation in Response to Mitochondrial Damage in Breast Cancer Cells Scientific Reports. 04, 2021 | Pubmed ID: 33888730 Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses Due to IMiD-induced PD-L1 Upregulation on Myeloma Cells Molecular Cancer Therapeutics. 07, 2021 | Pubmed ID: 33879556 Illuminating ALS Motor Neurons With Optogenetics in Zebrafish Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 33816488 Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 33777938 Small-molecule HDAC and Akt Inhibitors Suppress Tumor Growth and Enhance Immunotherapy in Multiple Myeloma Journal of Experimental & Clinical Cancer Research : CR. Mar, 2021 | Pubmed ID: 33757580 Multi-phaseted Problems of TDP-43 in Selective Neuronal Vulnerability in ALS Cellular and Molecular Life Sciences : CMLS. May, 2021 | Pubmed ID: 33709256 Adenine Nucleotide Translocase 2, a Putative Target Protein for 2-carba Cyclic Phosphatidic Acid in Microglial Cells Cellular Signalling. 06, 2021 | Pubmed ID: 33592249 Do Not Curse the Darkness of the Spinal Cord, Light TDP-43 Neural Regeneration Research. May, 2021 | Pubmed ID: 33229745 Short-chain Fatty Acids Bind to Apoptosis-associated Speck-like Protein to Activate Inflammasome Complex to Prevent Salmonella Infection PLoS Biology. 09, 2020 | Pubmed ID: 32991574 ARID2 is a Pomalidomide-dependent CRL4 Substrate in Multiple Myeloma Cells Nature Chemical Biology. 11, 2020 | Pubmed ID: 32958952 L-Arginine Prevents Cereblon-mediated Ubiquitination of Glucokinase and Stimulates Glucose-6-phosphate Production in Pancreatic β-cells Communications Biology. 09, 2020 | Pubmed ID: 32901087 -Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer Cancers. Aug, 2020 | Pubmed ID: 32878320 Hypnotic Effect of Thalidomide is Independent of Teratogenic Ubiquitin/proteasome Pathway Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32848052 Molecular Mechanisms of Thalidomide and Its Derivatives Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 2020 | Pubmed ID: 32522938 Induction of Adaptive Immune Responses Against Antigens Incorporated Within the Capsid of Simian Virus 40 The Journal of General Virology. 08, 2020 | Pubmed ID: 32501197 UGGT1 Retains Proinsulin in the Endoplasmic Reticulum in an Arginine Dependent Manner Biochemical and Biophysical Research Communications. 06, 2020 | Pubmed ID: 32423812 Molecular Mechanisms of the Teratogenic Effects of Thalidomide Pharmaceuticals (Basel, Switzerland). May, 2020 | Pubmed ID: 32414180 Aromatase is a Novel Neosubstrate of Cereblon Responsible for Immunomodulatory Drug-induced Thrombocytopenia Blood. 06, 2020 | Pubmed ID: 32219443 Annexin A1 Accounts for an Anti-inflammatory Binding Target of Sesamin Metabolites NPJ Science of Food. 2020 | Pubmed ID: 32133417 Genome-wide Screening Reveals a Role for Subcellular Localization of CRBN in the Anti-myeloma Activity of Pomalidomide Scientific Reports. 03, 2020 | Pubmed ID: 32132601 Optogenetic Modulation of TDP-43 Oligomerization Accelerates ALS-related Pathologies in the Spinal Motor Neurons Nature Communications. 02, 2020 | Pubmed ID: 32081878 Successful Management of Acquired Factor V Inhibitor by Monitoring Factor V Activity, Antigen, and Inhibitor Values During Immunosuppressive Therapy Acta Haematologica. 2020 | Pubmed ID: 31563916 [Cereblon As a Primary Target of IMiDs] [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology. 2019 | Pubmed ID: 31597822 P63 is a Cereblon Substrate Involved in Thalidomide Teratogenicity Nature Chemical Biology. 11, 2019 | Pubmed ID: 31591562 Estradiol Accelerates Liver Regeneration Through Estrogen Receptor α Clinical and Experimental Gastroenterology. 2019 | Pubmed ID: 31413616 Molecular Mechanisms of Cereblon-based Drugs Pharmacology & Therapeutics. 10, 2019 | Pubmed ID: 31202702 Arginine Induces IGF-1 Secretion from the Endoplasmic Reticulum Biochemical and Biophysical Research Communications. 07, 2019 | Pubmed ID: 31101333 Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation IScience. May, 2019 | Pubmed ID: 31055217 Magnetically Promoted Rapid Immunofluorescence Staining for Frozen Tissue Sections The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 08, 2019 | Pubmed ID: 30958084 Application of High-performance Magnetic Nanobeads to Biological Sensing Devices Analytical and Bioanalytical Chemistry. Mar, 2019 | Pubmed ID: 30627798 Function and Structural Regulation of the Carbon Monoxide (CO)-responsive Membrane Protein PGRMC1 Journal of Clinical Biochemistry and Nutrition. Jul, 2018 | Pubmed ID: 30087538 Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera Clinical Chemistry. 10, 2018 | Pubmed ID: 30021922 NQO1 Inhibits the TLR-dependent Production of Selective Cytokines by Promoting IκB-ζ Degradation The Journal of Experimental Medicine. 08, 2018 | Pubmed ID: 29934320 Role of Exosomes As a Proinflammatory Mediator in the Development of EBV-associated Lymphoma Blood. 06, 2018 | Pubmed ID: 29685921 Structural Basis of Thalidomide Enantiomer Binding to Cereblon Scientific Reports. 01, 2018 | Pubmed ID: 29358579 Effect of Ruxolitinib Therapy on the Quality-of-life of Japanese Patients with Myelofibrosis Current Medical Research and Opinion. 03, 2018 | Pubmed ID: 29224367 Evaluation of the Dose and Efficacy of Ruxolitinib in Japanese Patients with Myelofibrosis International Journal of Hematology. Jan, 2018 | Pubmed ID: 28986762 Recent Topics in IMiDs and Cereblon [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology. 2017 | Pubmed ID: 28978850 The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK Marine Drugs. Aug, 2017 | Pubmed ID: 28783126 Cystathionine β-synthase and PGRMC1 As CO Sensors Free Radical Biology & Medicine. 10, 2016 | Pubmed ID: 27565814 Cereblon and Its Downstream Substrates As Molecular Targets of Immunomodulatory Drugs International Journal of Hematology. Sep, 2016 | Pubmed ID: 27460676 A Novel Cereblon Modulator Recruits GSPT1 to the CRL4(CRBN) Ubiquitin Ligase Nature. 07, 2016 | Pubmed ID: 27338790 Discovery of the Target for Immunomodulatory Drugs (IMiDs) [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology. 05, 2016 | Pubmed ID: 27263779 Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase Via the Thalidomide Receptor Cereblon Molecular Cell. Mar, 2016 | Pubmed ID: 26990986 Haem-dependent Dimerization of PGRMC1/Sigma-2 Receptor Facilitates Cancer Proliferation and Chemoresistance Nature Communications. Mar, 2016 | Pubmed ID: 26988023 Chemical Proteomics Reveals Ferrochelatase As a Common Off-target of Kinase Inhibitors ACS Chemical Biology. 05, 2016 | Pubmed ID: 26863403 Macrolides Sensitize EGFR-TKI-induced Non-apoptotic Cell Death Via Blocking Autophagy Flux in Pancreatic Cancer Cell Lines International Journal of Oncology. Jan, 2016 | Pubmed ID: 26718641 SV40 VP1 Major Capsid Protein in Its Self-assembled Form Allows VP1 Pentamers to Coat Various Types of Artificial Beads Regardless of Their Sizes and Shapes Biotechnology Reports (Amsterdam, Netherlands). Mar, 2015 | Pubmed ID: 28435806 Correction for Cao Et Al., Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex Molecular and Cellular Biology. Dec, 2015 | Pubmed ID: 26518638 CTCF Regulates NELF, DSIF and P-TEFb Recruitment During Transcription Transcription. 2015 | Pubmed ID: 26399478 Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex Molecular and Cellular Biology. Oct, 2015 | Pubmed ID: 26217014 Myeloid Disease: Another Action of a Thalidomide Derivative Nature. Jul, 2015 | Pubmed ID: 26131932 Structure of the Human Cereblon-DDB1-lenalidomide Complex Reveals Basis for Responsiveness to Thalidomide Analogs Nature Structural & Molecular Biology. Sep, 2014 | Pubmed ID: 25108355 DSIF and NELF Interact with Integrator to Specify the Correct Post-transcriptional Fate of SnRNA Genes Nature Communications. Jun, 2014 | Pubmed ID: 24968874 얼룩말 물고기 애벌레의 척추 모터 뉴런에서 TDP-43의 광유전학 적 단계 전환 Kazuhide Asakawa1, Hiroshi Handa1, Koichi Kawakami2,3 1Department of Chemical Biology, Tokyo Medical University, 2Division of Molecular and Developmental Biology, National Institute of Genetics, 3Department of Genetics, Graduate University for Advanced Studies (SOKENDAI) JoVE 62932 Neuroscience
얼룩말 물고기 애벌레의 척추 모터 뉴런에서 TDP-43의 광유전학 적 단계 전환 Kazuhide Asakawa1, Hiroshi Handa1, Koichi Kawakami2,3 1Department of Chemical Biology, Tokyo Medical University, 2Division of Molecular and Developmental Biology, National Institute of Genetics, 3Department of Genetics, Graduate University for Advanced Studies (SOKENDAI) JoVE 62932 Neuroscience