Jörg Rahnenführer Department of Statistics Technical University of Dortmund Biography Publications Institution JoVE Articles Jörg Rahnenführer has not added a biography. If you are Jörg Rahnenführer and would like to personalize this page please email our Author Liaison for assistance. Publications From Smoking Guns to Footprints: Mining for Critical Events of Toxicity Pathways in Transcriptome Data Archives of Toxicology. May, 2015 | Pubmed ID: 25851820 Prognostic Impact of COX-2 in Non-small Cell Lung Cancer: a Comprehensive Compartment-specific Evaluation of Tumor and Stromal Cell Expression Cancer Letters. Jan, 2015 | Pubmed ID: 25449785 Clinical Outcome of Patients with Lymph Node-positive Prostate Cancer Following Radical Prostatectomy and Extended Sentinel Lymph Node Dissection Urologia Internationalis. 2015 | Pubmed ID: 25170747 Loss of Circadian Clock Gene Expression is Associated with Tumor Progression in Breast Cancer Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 25485508 EDI3 Links Choline Metabolism to Integrin Expression, Cell Adhesion and Spreading Cell Adhesion & Migration. 2014 | Pubmed ID: 25482527 Toxicogenomics Directory of Chemically Exposed Human Hepatocytes Archives of Toxicology. Dec, 2014 | Pubmed ID: 25399406 Prognostic Influence of Pre-operative C-reactive Protein in Node-negative Breast Cancer Patients PloS One. 2014 | Pubmed ID: 25340395 Robust Selection of Cancer Survival Signatures from High-throughput Genomic Data Using Two-fold Subsampling PloS One. 2014 | Pubmed ID: 25295525 The Lung-specific Proteome Defined by Integration of Transcriptomics and Antibody-based Profiling FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2014 | Pubmed ID: 25169055 From Transient Transcriptome Responses to Disturbed Neurodevelopment: Role of Histone Acetylation and Methylation As Epigenetic Switch Between Reversible and Irreversible Drug Effects Archives of Toxicology. Jul, 2014 | Pubmed ID: 24935251 Molecular Biological Determinations of Meningioma Progression and Recurrence PloS One. 2014 | Pubmed ID: 24722350 Design Principles of Concentration-dependent Transcriptome Deviations in Drug-exposed Differentiating Stem Cells Chemical Research in Toxicology. Mar, 2014 | Pubmed ID: 24383497 Interferon-inducible Guanylate Binding Protein (GBP2) is Associated with Better Prognosis in Breast Cancer and Indicates an Efficient T Cell Response Breast Cancer (Tokyo, Japan). Jul, 2014 | Pubmed ID: 23001506 Detection of Patient Subgroups with Differential Expression in Omics Data: a Comprehensive Comparison of Univariate Measures PloS One. 2013 | Pubmed ID: 24278130 Test Systems of Developmental Toxicity: State-of-the Art and Future Perspectives Archives of Toxicology. Dec, 2013 | Pubmed ID: 24190503 The Prognostic Relevance of Tumour-infiltrating Plasma Cells and Immunoglobulin Kappa C Indicates an Important Role of the Humoral Immune Response in Non-small Cell Lung Cancer Cancer Letters. Jun, 2013 | Pubmed ID: 23370224 D-score: a Search Engine Independent MD-score Proteomics. Mar, 2013 | Pubmed ID: 23307401 Human Embryonic Stem Cell-derived Test Systems for Developmental Neurotoxicity: a Transcriptomics Approach Archives of Toxicology. Jan, 2013 | Pubmed ID: 23179753 Biomarker Discovery in Non-small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2013 | Pubmed ID: 23032747 Expression of Aurora Kinase A is Associated with Metastasis-free Survival in Node-negative Breast Cancer Patients BMC Cancer. 2012 | Pubmed ID: 23186136 No Longer Confidential: Estimating the Confidence of Individual Regression Predictions PloS One. 2012 | Pubmed ID: 23166592 Cumulative Disease Progression Models for Cross-sectional Data: a Review and Comparison Biometrical Journal. Biometrische Zeitschrift. Sep, 2012 | Pubmed ID: 22886685 Optimal Strategies for Sequential Validation of Significant Features from High-dimensional Genomic Data Journal of Toxicology and Environmental Health. Part A. 2012 | Pubmed ID: 22686304 A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C As a Compatible Prognostic Marker in Human Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012 | Pubmed ID: 22351685 Glycerophospholipid Profile in Oncogene-induced Senescence Biochimica Et Biophysica Acta. Sep, 2012 | Pubmed ID: 22178194 Survival Models with Preclustered Gene Groups As Covariates BMC Bioinformatics. 2011 | Pubmed ID: 22177110 Clonal Cytogenetic Progression Within Intratumorally Heterogeneous Meningiomas Predicts Tumor Recurrence International Journal of Oncology. Dec, 2011 | Pubmed ID: 21922133 Probabilistic Consensus Scoring Improves Tandem Mass Spectrometry Peptide Identification Journal of Proteome Research. Aug, 2011 | Pubmed ID: 21644507 Ep-CAM RNA Expression Predicts Metastasis-free Survival in Three Cohorts of Untreated Node-negative Breast Cancer Breast Cancer Research and Treatment. Feb, 2011 | Pubmed ID: 20352488 Polymorphisms in the IGF1 Signalling Pathway Including the Myostatin Gene Are Associated with Left Ventricular Mass in Male Athletes British Journal of Sports Medicine. Jan, 2011 | Pubmed ID: 19136503 Changes in Cortical Cytoskeletal and Extracellular Matrix Gene Expression in Prostate Cancer Are Related to Oncogenic ERG Deregulation BMC Cancer. 2010 | Pubmed ID: 20860828 Modelling Nonstationary Gene Regulatory Processes Advances in Bioinformatics. 2010 | Pubmed ID: 20721277 Role of Thioredoxin Reductase 1 and Thioredoxin Interacting Protein in Prognosis of Breast Cancer Breast Cancer Research : BCR. 2010 | Pubmed ID: 20584310 YLoc--an Interpretable Web Server for Predicting Subcellular Localization Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20507917 Comparison of Scores for Bimodality of Gene Expression Distributions and Genome-wide Evaluation of the Prognostic Relevance of High-scoring Genes BMC Bioinformatics. 2010 | Pubmed ID: 20500820 Peek a Peak: a Glance at Statistics for Quantitative Label-free Proteomics Expert Review of Proteomics. Apr, 2010 | Pubmed ID: 20377391 ERBB2 and TOP2A in Breast Cancer: a Comprehensive Analysis of Gene Amplification, RNA Levels, and Protein Expression and Their Influence on Prognosis and Prediction Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2010 | Pubmed ID: 20371687 Going from Where to Why--interpretable Prediction of Protein Subcellular Localization Bioinformatics (Oxford, England). May, 2010 | Pubmed ID: 20299325 Arabidopsis Female Gametophyte Gene Expression Map Reveals Similarities Between Plant and Animal Gametes Current Biology : CB. Mar, 2010 | Pubmed ID: 20226671 Analysis of Compound Synergy in High-throughput Cellular Screens by Population-based Lifetime Modeling PloS One. 2010 | Pubmed ID: 20111714 ERBB2 Induces an Antiapoptotic Expression Pattern of Bcl-2 Family Members in Node-negative Breast Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2010 | Pubmed ID: 20068093 Predicting Drug Susceptibility of Non-small Cell Lung Cancers Based on Genetic Lesions The Journal of Clinical Investigation. Jun, 2009 | Pubmed ID: 19451690 P15 Promoter Methylation - a Novel Prognostic Marker in Glioblastoma Patients International Journal of Oncology. Jun, 2009 | Pubmed ID: 19424593 Retention Time Alignment Algorithms for LC/MS Data Must Consider Non-linear Shifts Bioinformatics (Oxford, England). Mar, 2009 | Pubmed ID: 19176558 Classification with High-dimensional Genetic Data: Assigning Patients and Genetic Features to Known Classes Biometrical Journal. Biometrische Zeitschrift. Dec, 2008 | Pubmed ID: 19067340 Rtreemix: an R Package for Estimating Evolutionary Pathways and Genetic Progression Scores Bioinformatics (Oxford, England). Oct, 2008 | Pubmed ID: 18718947 Protein Phosphatase and TRAIL Receptor Genes As New Candidate Tumor Genes on Chromosome 8p in Prostate Cancer Cancer Genomics & Proteomics. Mar-Apr, 2008 | Pubmed ID: 18460741 Stability Analysis of Mixtures of Mutagenetic Trees BMC Bioinformatics. 2008 | Pubmed ID: 18366778 Correspondence of Tumor Localization with Tumor Recurrence and Cytogenetic Progression in Meningiomas Neurosurgery. Jan, 2008 | Pubmed ID: 18300892 Conformational Analysis of Alternative Protein Structures Bioinformatics (Oxford, England). Dec, 2007 | Pubmed ID: 17933849 Application of Oncogenetic Trees Mixtures As a Biostatistical Model of the Clonal Cytogenetic Evolution of Meningiomas International Journal of Cancer. Journal International Du Cancer. Oct, 2007 | Pubmed ID: 17557299 GOTax: Investigating Biological Processes and Biochemical Activities Along the Taxonomic Tree Genome Biology. 2007 | Pubmed ID: 17346342 Factor Interaction Analysis for Chromosome 8 and DNA Methylation Alterations Highlights Innate Immune Response Suppression and Cytoskeletal Changes in Prostate Cancer Molecular Cancer. 2007 | Pubmed ID: 17280610 Hyperdiploidy Defines a Distinct Cytogenetic Entity of Meningiomas Journal of Neuro-oncology. Jun, 2007 | Pubmed ID: 17225936 Model Selection for Mixtures of Mutagenetic Trees Statistical Applications in Genetics and Molecular Biology. 2006 | Pubmed ID: 17049028 A New Measure for Functional Similarity of Gene Products Based on Gene Ontology BMC Bioinformatics. 2006 | Pubmed ID: 16776819 Improved Scoring of Functional Groups from Gene Expression Data by Decorrelating GO Graph Structure Bioinformatics (Oxford, England). Jul, 2006 | Pubmed ID: 16606683 Patients with High-grade Gliomas Harboring Deletions of Chromosomes 9p and 10q Benefit from Temozolomide Treatment Neoplasia (New York, N.Y.). Oct, 2005 | Pubmed ID: 16242071 Computational Methods for the Design of Effective Therapies Against Drug Resistant HIV Strains Bioinformatics (Oxford, England). Nov, 2005 | Pubmed ID: 16144807 Learning Multiple Evolutionary Pathways from Cross-sectional Data Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. Jul-Aug, 2005 | Pubmed ID: 16108705 Confirmation of Human Protein Interaction Data by Human Expression Data BMC Bioinformatics. 2005 | Pubmed ID: 15877815 Estimating HIV Evolutionary Pathways and the Genetic Barrier to Drug Resistance The Journal of Infectious Diseases. Jun, 2005 | Pubmed ID: 15871130 Retinal Properties and Potential of the Adult Mammalian Ciliary Epithelium Stem Cells Vision Research. Jun, 2005 | Pubmed ID: 15792841 Estimating Cancer Survival and Clinical Outcome Based on Genetic Tumor Progression Scores Bioinformatics (Oxford, England). May, 2005 | Pubmed ID: 15705654 Mtreemix: a Software Package for Learning and Using Mixture Models of Mutagenetic Trees Bioinformatics (Oxford, England). May, 2005 | Pubmed ID: 15657098 Calculating the Statistical Significance of Changes in Pathway Activity from Gene Expression Data Statistical Applications in Genetics and Molecular Biology. 2004 | Pubmed ID: 16646794 Cellular and Molecular Characterization of Early and Late Retinal Stem Cells/progenitors: Differential Regulation of Proliferation and Context Dependent Role of Notch Signaling Journal of Neurobiology. Dec, 2004 | Pubmed ID: 15452852 Automated Clustering of Ensembles of Alternative Models in Protein Structure Databases Protein Engineering, Design & Selection : PEDS. Jun, 2004 | Pubmed ID: 15319469 Identification of C-Kit Receptor As a Regulator of Adult Neural Stem Cells in the Mammalian Eye: Interactions with Notch Signaling Developmental Biology. Sep, 2004 | Pubmed ID: 15302600 Hybrid Clustering for Microarray Image Analysis Combining Intensity and Shape Features BMC Bioinformatics. Apr, 2004 | Pubmed ID: 15117421 Unsupervised Technique for Robust Target Separation and Analysis of DNA Microarray Spots Through Adaptive Pixel Clustering Bioinformatics (Oxford, England). May, 2002 | Pubmed ID: 12050071 Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation Vaibhav Shinde*1, Stefanie Klima*2, Perumal Srinivasan Sureshkumar1, Kesavan Meganathan1, Smita Jagtap1, Eugen Rempel3, Jörg Rahnenführer3, Jan Georg Hengstler4, Tanja Waldmann2, Jürgen Hescheler1, Marcel Leist*2, Agapios Sachinidis*1 1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund JoVE 52333 Developmental Biology
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation Vaibhav Shinde*1, Stefanie Klima*2, Perumal Srinivasan Sureshkumar1, Kesavan Meganathan1, Smita Jagtap1, Eugen Rempel3, Jörg Rahnenführer3, Jan Georg Hengstler4, Tanja Waldmann2, Jürgen Hescheler1, Marcel Leist*2, Agapios Sachinidis*1 1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund JoVE 52333 Developmental Biology