James R. Woodgett Samuel Lunenfeld Research Institute Mount Sinai Hospital Biography Publications Institution JoVE Articles James R. Woodgett has not added a biography. If you are James R. Woodgett and would like to personalize this page please email our Author Liaison for assistance. Publications Towards the Preparation of Radiolabeled 1-aryl-3-benzyl Ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) Fixation Bioorganic & Medicinal Chemistry Letters. Jan, 2012 | Pubmed ID: 22321216 Genetic Inactivation of GSK3α Rescues Spine Deficits in Disc1-L100P Mutant Mice Schizophrenia Research. Jun, 2011 | Pubmed ID: 21498050 Selective Loss of Glycogen Synthase Kinase-3α in Birds Reveals Distinct Roles for GSK-3 Isozymes in Tau Phosphorylation FEBS Letters. Apr, 2011 | Pubmed ID: 21419127 Tissue-specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation PloS One. 2011 | Pubmed ID: 21253590 Genetic and Pharmacological Evidence for Schizophrenia-related Disc1 Interaction with GSK-3 Synapse (New York, N.Y.). Mar, 2011 | Pubmed ID: 20687111 Does GSK-3 Provide a Shortcut for PI3K Activation of Wnt Signalling? F1000 Biology Reports. 2010 | Pubmed ID: 21283602 Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20841359 Role of Phosphoinositide 3-kinase {alpha}, Protein Kinase C, and L-type Ca2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility Hypertension. Sep, 2010 | Pubmed ID: 20696985 When Pathways Collide: Collaboration and Connivance Among Signalling Proteins in Development Nature Reviews. Molecular Cell Biology. Jun, 2010 | Pubmed ID: 20461097 Glycogen Synthase Kinase-3beta Regulates Post-myocardial Infarction Remodeling and Stress-induced Cardiomyocyte Proliferation in Vivo Circulation Research. May, 2010 | Pubmed ID: 20360256 Abnormalities in Brain Structure and Behavior in GSK-3alpha Mutant Mice Molecular Brain. 2009 | Pubmed ID: 19925672 GSK-3 is a Master Regulator of Neural Progenitor Homeostasis Nature Neuroscience. Nov, 2009 | Pubmed ID: 19801986 Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression Cancer Research. Jun, 2009 | Pubmed ID: 19491266 IL-17 Receptor Signaling Inhibits C/EBPbeta by Sequential Phosphorylation of the Regulatory 2 Domain Science Signaling. Feb, 2009 | Pubmed ID: 19244213 Exploring Pluripotency with Chemical Genetics Cell Stem Cell. Feb, 2009 | Pubmed ID: 19200796 Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19064989 Utility of Metformin in Breast Cancer Treatment, is Neoangiogenesis a Risk Factor? Breast Cancer Research and Treatment. Mar, 2009 | Pubmed ID: 18438706 Deletion of GSK-3beta in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation The Journal of Clinical Investigation. Nov, 2008 | Pubmed ID: 18830417 GSK-3beta in Mouse Fibroblasts Controls Wound Healing and Fibrosis Through an Endothelin-1-dependent Mechanism The Journal of Clinical Investigation. Oct, 2008 | Pubmed ID: 18802478 Targeting Glycogen Synthase Kinase-3 (GSK-3) in the Treatment of Type 2 Diabetes Expert Opinion on Therapeutic Targets. Oct, 2008 | Pubmed ID: 18781825 Tissue-specific Role of Glycogen Synthase Kinase 3beta in Glucose Homeostasis and Insulin Action Molecular and Cellular Biology. Oct, 2008 | Pubmed ID: 18694957 Phosphorylation of GSK-3beta by CGMP-dependent Protein Kinase II Promotes Hypertrophic Differentiation of Murine Chondrocytes The Journal of Clinical Investigation. Jul, 2008 | Pubmed ID: 18551195 Glycogen Synthase Kinase-3beta Heterozygote Knockout Mice As a Model of Findings in Postmortem Schizophrenia Brain or As a Model of Behaviors Mimicking Lithium Action: Negative Results Behavioural Pharmacology. May, 2008 | Pubmed ID: 18469539 Homozygous Deletion of Glycogen Synthase Kinase 3beta Bypasses Senescence Allowing Ras Transformation of Primary Murine Fibroblasts Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18367674 Rationally Designed PKA Inhibitors for Positron Emission Tomography: Synthesis and Cerebral Biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide Bioorganic & Medicinal Chemistry. May, 2008 | Pubmed ID: 18346896 Genetic Deficiency of Glycogen Synthase Kinase-3beta Corrects Diabetes in Mouse Models of Insulin Resistance PLoS Biology. Feb, 2008 | Pubmed ID: 18288891 Frequent Accumulation of Nuclear E-cadherin and Alterations in the Wnt Signaling Pathway in Esophageal Squamous Cell Carcinomas Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2008 | Pubmed ID: 18084253 Glycogen Synthase Kinase 3alpha-specific Regulation of Murine Hepatic Glycogen Metabolism Cell Metabolism. Oct, 2007 | Pubmed ID: 17908561 GSK-3beta Controls Osteogenesis Through Regulating Runx2 Activity PloS One. 2007 | Pubmed ID: 17786208 Glycogen Synthase Kinase-3beta Induces Neuronal Cell Death Via Direct Phosphorylation of Mixed Lineage Kinase 3 The Journal of Biological Chemistry. Oct, 2007 | Pubmed ID: 17711861 Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-mesenchymal Transitions Cells, Tissues, Organs. 2007 | Pubmed ID: 17587811 Systematic Discovery of in Vivo Phosphorylation Networks Cell. Jun, 2007 | Pubmed ID: 17570479 Functional Redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines Developmental Cell. Jun, 2007 | Pubmed ID: 17543867 CD4+ and CD8+ T Cell Survival is Regulated Differentially by Protein Kinase Ctheta, C-Rel, and Protein Kinase B Journal of Immunology (Baltimore, Md. : 1950). Mar, 2007 | Pubmed ID: 17312138 Glycogen Synthase Kinase 3, Circadian Rhythms, and Bipolar Disorder: a Molecular Link in the Therapeutic Action of Lithium Journal of Circadian Rhythms. 2007 | Pubmed ID: 17295926 Essential Roles for GSK-3s and GSK-3-primed Substrates in Neurotrophin-induced and Hippocampal Axon Growth Neuron. Dec, 2006 | Pubmed ID: 17178402 Glycogen Synthase Kinase-3--an Overview of an Over-achieving Protein Kinase Current Drug Targets. Nov, 2006 | Pubmed ID: 17100578 Functional Distinctions of Protein Kinase B/Akt Isoforms Defined by Their Influence on Cell Migration Trends in Cell Biology. Sep, 2006 | Pubmed ID: 16870447 Role of the Phox Homology Domain and Phosphorylation in Activation of Serum and Glucocorticoid-regulated Kinase-3 The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16790420 IFN-gamma Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins Immunity. May, 2006 | Pubmed ID: 16713974 Serum and Glucocorticoid-regulated Protein Kinases: Variations on a Theme Journal of Cellular Biochemistry. Aug, 2006 | Pubmed ID: 16619268 Expression of Wnt-signaling Pathway Proteins in Intraductal Papillary Mucinous Neoplasms of the Pancreas: a Tissue Microarray Analysis Human Pathology. Feb, 2006 | Pubmed ID: 16426922 NF-kappaB Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis in Vivo Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148125 Modulating Autoimmunity: Pick Your PI3 Kinase Nature Medicine. Sep, 2005 | Pubmed ID: 16145571 GSK3: an In-Toll-erant Protein Kinase? Nature Immunology. Aug, 2005 | Pubmed ID: 16034428 Chronic Activation of Protein Kinase Bbeta/Akt2 Leads to Multinucleation and Cell Fusion in Human Epithelial Kidney Cells: Events Associated with Tumorigenesis Oncogene. Aug, 2005 | Pubmed ID: 16007218 Differential Gene Expression Profile Reveals Deregulation of Pregnancy Specific Beta1 Glycoprotein 9 Early During Colorectal Carcinogenesis BMC Cancer. 2005 | Pubmed ID: 15982419 Problems with Co-funding in Canada Science (New York, N.Y.). Jun, 2005 | Pubmed ID: 15976286 CpG Island Microarray Probe Sequences Derived from a Physical Library Are Representative of CpG Islands Annotated on the Human Genome Nucleic Acids Research. 2005 | Pubmed ID: 15911630 Recent Advances in the Protein Kinase B Signaling Pathway Current Opinion in Cell Biology. Apr, 2005 | Pubmed ID: 15780591 Phosphoinositide-dependent Phosphorylation of PDK1 Regulates Nuclear Translocation Molecular and Cellular Biology. Mar, 2005 | Pubmed ID: 15743829 Glycogen Synthase Kinase 3beta is a Negative Regulator of Growth Factor-induced Activation of the C-Jun N-terminal Kinase The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15466414 Proteomic, Functional, and Domain-based Analysis of in Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization Current Biology : CB. Aug, 2004 | Pubmed ID: 15324660 Glycogen Synthase Kinase-3beta Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2004 | Pubmed ID: 15282284 Lithium Antagonizes Dopamine-dependent Behaviors Mediated by an AKT/glycogen Synthase Kinase 3 Signaling Cascade Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15044694 Unravelling the Activation Mechanisms of Protein Kinase B/Akt FEBS Letters. Jul, 2003 | Pubmed ID: 12829245 JNK1 Activity Lowers the Cellular Production of H2O2 and Modulates the Growth Arrest Response to Scavenging of H2O2 by Catalase Experimental Cell Research. Apr, 2003 | Pubmed ID: 12681294 GSK-3: Tricks of the Trade for a Multi-tasking Kinase Journal of Cell Science. Apr, 2003 | Pubmed ID: 12615961 Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12458207 Negative Regulation of Phosphatidylinositol 3-kinase and Akt Signalling Pathway by PKC Cellular Signalling. Jan, 2003 | Pubmed ID: 12401518 Open Heart Surgery of PI-3 Kinase Signaling Cell Cycle (Georgetown, Tex.). Nov-Dec, 2002 | Pubmed ID: 12548014 A Molecular Compendium of Genes Expressed in Multiple Myeloma Blood. Sep, 2002 | Pubmed ID: 12200383 Multiple Phosphoinositide 3-kinase-dependent Steps in Activation of Protein Kinase B Molecular and Cellular Biology. Sep, 2002 | Pubmed ID: 12167717 CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly The Journal of Experimental Medicine. Aug, 2002 | Pubmed ID: 12163562 Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-mediated Phosphorylation and Inactivation by Lysophosphatidic Acid Through a Protein Kinase C-dependent Intracellular Pathway Molecular and Cellular Biology. Apr, 2002 | Pubmed ID: 11884598 Role of Glycogen Synthase Kinase-3 in Cancer: Regulation by Wnts and Other Signaling Pathways Advances in Cancer Research. 2002 | Pubmed ID: 11883528 The Active Form of Glycogen Synthase Kinase-3beta is Associated with Granulovacuolar Degeneration in Neurons in Alzheimer's Disease Acta Neuropathologica. Feb, 2002 | Pubmed ID: 11810173 DREAM is a Critical Transcriptional Repressor for Pain Modulation Cell. Jan, 2002 | Pubmed ID: 11792319 सामाजिक सहभागिता व्यवहार के मूल्यांकन Oksana Kaidanovich-Beilin1, Tatiana Lipina1, Igor Vukobradovic2, John Roder1,3,4,5, James R. Woodgett1,3 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 2Toronto Centre for Phenogenomics, Mount Sinai Hospital, 3Department of Medical Biophysics, University of Toronto, 4Department of Psychology, University of Toronto, 5Department of Psychiatry, University of Toronto JoVE 2473 Neuroscience
सामाजिक सहभागिता व्यवहार के मूल्यांकन Oksana Kaidanovich-Beilin1, Tatiana Lipina1, Igor Vukobradovic2, John Roder1,3,4,5, James R. Woodgett1,3 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 2Toronto Centre for Phenogenomics, Mount Sinai Hospital, 3Department of Medical Biophysics, University of Toronto, 4Department of Psychology, University of Toronto, 5Department of Psychiatry, University of Toronto JoVE 2473 Neuroscience