Janis Kuka Laboratory of Pharmaceutical Pharmacology Latvian Institute of Organic Synthesis Biography Publications Institution JoVE Articles Janis Kuka has not added a biography. If you are Janis Kuka and would like to personalize this page please email our Author Liaison for assistance. Publications Imitation of β-lactam Binding Enables Broad-spectrum Metallo-β-lactamase Inhibitors Nature Chemistry. Jan, 2022 | Pubmed ID: 34903857 Antibacterial Activity of Apramycin at Acidic PH Warrants Wide Therapeutic Window in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis EBioMedicine. Nov, 2021 | Pubmed ID: 34740109 Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage Free Radical Biology & Medicine. 12, 2021 | Pubmed ID: 34728372 Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects Against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats Oxidative Medicine and Cellular Longevity. 2021 | Pubmed ID: 34367467 -Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs ACS Medicinal Chemistry Letters. Nov, 2020 | Pubmed ID: 33214822 Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia Journal of Cellular and Molecular Medicine. 10, 2020 | Pubmed ID: 32896106 Metformin Decreases Bacterial Trimethylamine Production and Trimethylamine N-oxide Levels in Db/db Mice Scientific Reports. 09, 2020 | Pubmed ID: 32884086 Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload Cardiovascular Drugs and Therapy. 12, 2020 | Pubmed ID: 32424653 Excretion of the Polymyxin Derivative NAB739 in Murine Urine Antibiotics (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32230751 Skull Fractures Induce Neuroinflammation and Worsen Outcomes After Closed Head Injury in Mice Journal of Neurotrauma. 01, 2020 | Pubmed ID: 31441378 Plasma Acylcarnitine Concentrations Reflect the Acylcarnitine Profile in Cardiac Tissues Scientific Reports. 12, 2017 | Pubmed ID: 29235526 Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice BioFactors (Oxford, England). Sep, 2017 | Pubmed ID: 28759135 Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB Basic & Clinical Pharmacology & Toxicology. Aug, 2017 | Pubmed ID: 28244203 Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria The Biochemical Journal. 05, 2016 | Pubmed ID: 26936967 Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity Pharmacological Research. 11, 2016 | Pubmed ID: 26850121 Decreased Acylcarnitine Content Improves Insulin Sensitivity in Experimental Mice Models of Insulin Resistance Pharmacological Research. 11, 2016 | Pubmed ID: 26621248 Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella Pneumoniae The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26187464 Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis Vascular Pharmacology. Sep, 2015 | Pubmed ID: 25989106 Suppression of Intestinal Microbiota-dependent Production of Pro-atherogenic Trimethylamine N-oxide by Shifting L-carnitine Microbial Degradation Life Sciences. Nov, 2014 | Pubmed ID: 25301199 Expression and Purification of Active, Stabilized Trimethyllysine Hydroxylase Protein Expression and Purification. 12, 2014 | Pubmed ID: 25220864 Long-chain Acylcarnitine Content Determines the Pattern of Energy Metabolism in Cardiac Mitochondria Molecular and Cellular Biochemistry. Oct, 2014 | Pubmed ID: 24878991 Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size Pharmacological Research. Jul, 2014 | Pubmed ID: 24836867 Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats Magnesium Research. Jan-Mar, 2014 | Pubmed ID: 24827813 The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State Metabolism: Clinical and Experimental. Jan, 2014 | Pubmed ID: 24140100 Activated Peroxisomal Fatty Acid Metabolism Improves Cardiac Recovery in Ischemia-reperfusion Naunyn-Schmiedeberg's Archives of Pharmacology. Jun, 2013 | Pubmed ID: 23525500 Troubleshooting Digital Macro Photography for Image Acquisition and the Analysis of Biological Samples Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2013 | Pubmed ID: 23202591 A Short-term High-dose Administration of Sodium Pivalate Impairs Pyruvate Metabolism Without Affecting Cardiac Function Cardiovascular Toxicology. Dec, 2012 | Pubmed ID: 22539084 The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012 | Pubmed ID: 21903968 Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats Pharmacological Reports : PR. 2011 | Pubmed ID: 21857086 Mildronate Treatment Alters γ-butyrobetaine and L-carnitine Concentrations in Healthy Volunteers The Journal of Pharmacy and Pharmacology. Sep, 2011 | Pubmed ID: 21827492 Inhibition of Carnitine Acetyltransferase by Mildronate, a Regulator of Energy Metabolism Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2009 | Pubmed ID: 19912061 Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats Basic & Clinical Pharmacology & Toxicology. Dec, 2009 | Pubmed ID: 19663820 Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats British Journal of Pharmacology. Aug, 2009 | Pubmed ID: 19594753 Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart Cardiovascular Drugs and Therapy. Aug, 2009 | Pubmed ID: 19536647 Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart Life Sciences. Oct, 2008 | Pubmed ID: 18801379 Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine
Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine