Maija Dambrova Laboratory of Pharmaceutical Pharmacology Latvian Institute of Organic Synthesis Biography Publications Institution JoVE Articles Maija Dambrova has not added a biography. If you are Maija Dambrova and would like to personalize this page please email our Author Liaison for assistance. Publications HMDB 5.0: the Human Metabolome Database for 2022 Nucleic Acids Research. Jan, 2022 | Pubmed ID: 34986597 Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19 International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 35008470 Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia Medicina (Kaunas, Lithuania). Nov, 2021 | Pubmed ID: 34833429 Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes After Traumatic Brain Injury International Journal of Molecular Sciences. Oct, 2021 | Pubmed ID: 34769042 Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage Free Radical Biology & Medicine. 12, 2021 | Pubmed ID: 34728372 The Cultivation of L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants Plants (Basel, Switzerland). Sep, 2021 | Pubmed ID: 34579502 Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects Against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats Oxidative Medicine and Cellular Longevity. 2021 | Pubmed ID: 34367467 Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism International Journal of Molecular Sciences. Jun, 2021 | Pubmed ID: 34208786 Energy Substrate Metabolism and Mitochondrial Oxidative Stress in Cardiac Ischemia/reperfusion Injury Free Radical Biology & Medicine. 03, 2021 | Pubmed ID: 33484825 Genetic Inactivation of the Sigma-1 Chaperone Protein Results in Decreased Expression of the R2 Subunit of the GABA-B Receptor and Increased Susceptibility to Seizures Neurobiology of Disease. 03, 2021 | Pubmed ID: 33385516 Chemical Composition of Prunus Padus L. Flower Extract and Its Anti-inflammatory Activities in Primary Bone Marrow-derived Macrophages Journal of Ethnopharmacology. Mar, 2021 | Pubmed ID: 33307057 Total Synthesis and Evaluation of 8-deoxypumiliotoxin 193H Natural Product Research. Feb, 2021 | Pubmed ID: 31264906 Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 33520996 Fused Isoselenazolium Salts Suppress Breast Cancer Cell Growth by Dramatic Increase in Pyruvate-dependent Mitochondrial ROS Production Scientific Reports. 12, 2020 | Pubmed ID: 33299068 Mitochondrial-Protective Effects of R-Phenibut After Experimental Traumatic Brain Injury Oxidative Medicine and Cellular Longevity. 2020 | Pubmed ID: 33274011 Rats with Congenital Hydronephrosis Show Increased Susceptibility to Renal Ischemia-reperfusion Injury Physiological Reports. 11, 2020 | Pubmed ID: 33207081 Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia Journal of Cellular and Molecular Medicine. 10, 2020 | Pubmed ID: 32896106 Metformin Decreases Bacterial Trimethylamine Production and Trimethylamine N-oxide Levels in Db/db Mice Scientific Reports. 09, 2020 | Pubmed ID: 32884086 Inhibition of Sigma-1 Receptors Substantially Modulates GABA and Glutamate Transport in Presynaptic Nerve Terminals Experimental Neurology. 11, 2020 | Pubmed ID: 32795464 Low-intensity Exercise Stimulates Bioenergetics and Increases Fat Oxidation in Mitochondria of Blood Mononuclear Cells from Sedentary Adults Physiological Reports. 06, 2020 | Pubmed ID: 32562386 Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload Cardiovascular Drugs and Therapy. 12, 2020 | Pubmed ID: 32424653 Cardiac Metabolism As a Driver and Therapeutic Target of Myocardial Infarction Journal of Cellular and Molecular Medicine. 06, 2020 | Pubmed ID: 32384583 Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports Pharmacopsychiatry. Sep, 2020 | Pubmed ID: 32340063 Neuroprotective and Anti-inflammatory Activity of DAT Inhibitor R-phenylpiracetam in Experimental Models of Inflammation in Male Mice Inflammopharmacology. Oct, 2020 | Pubmed ID: 32279140 Excretion of the Polymyxin Derivative NAB739 in Murine Urine Antibiotics (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32230751 Data on Medicinal Plants in the Records of Latvian Folk Medicine from the 19th Century Data in Brief. Feb, 2020 | Pubmed ID: 31909122 Altered Mitochondrial Metabolism in the Insulin-resistant Heart Acta Physiologica (Oxford, England). 03, 2020 | Pubmed ID: 31840389 Medicinal Plants and Their Uses Recorded in the Archives of Latvian Folklore from the 19th Century Journal of Ethnopharmacology. Mar, 2020 | Pubmed ID: 31707047 Pharmacological Approaches to Tackle NCLs Biochimica Et Biophysica Acta. Molecular Basis of Disease. 09, 2020 | Pubmed ID: 31521819 Skull Fractures Induce Neuroinflammation and Worsen Outcomes After Closed Head Injury in Mice Journal of Neurotrauma. 01, 2020 | Pubmed ID: 31441378 Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity Frontiers in Endocrinology. 2019 | Pubmed ID: 31920980 Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from DC Root Extract Nutrients. Nov, 2019 | Pubmed ID: 31752295 Data on Analysis of MK-801 Bioavailability in Mouse Plasma and Brain Tissue by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry Data in Brief. Dec, 2019 | Pubmed ID: 31692721 Cardioprotective Effects of Idebenone Do Not Involve ROS Scavenging: Evidence for Mitochondrial Complex I Bypass in Ischemia/reperfusion Injury Journal of Molecular and Cellular Cardiology. 10, 2019 | Pubmed ID: 31445917 Effects of the N-methyl-d-aspartate Receptor Antagonist, MK-801, on Spatial Memory and Influence of the Route of Administration Behavioural Brain Research. 10, 2019 | Pubmed ID: 31276703 Allosteric Modulators of Sigma-1 Receptor: A Review Frontiers in Pharmacology. 2019 | Pubmed ID: 30941035 Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism Nutrients. Mar, 2019 | Pubmed ID: 30857217 Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia Shock (Augusta, Ga.). 12, 2019 | Pubmed ID: 30640252 Development of Local Strontium Ranelate Delivery Systems and Long Term in Vitro Drug Release Studies in Osteogenic Medium Scientific Reports. 11, 2018 | Pubmed ID: 30425295 Efficacy of Proanthocyanidins from Root Extract in Reducing Viability While Preserving Oral Commensal Materials (Basel, Switzerland). Aug, 2018 | Pubmed ID: 30135370 Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris" The Journal of Clinical Endocrinology and Metabolism. 11, 2018 | Pubmed ID: 30124877 Plasma Acylcarnitine Concentrations Reflect the Acylcarnitine Profile in Cardiac Tissues Scientific Reports. 12, 2017 | Pubmed ID: 29235526 Denosumab-induced Hypophosphataemia in a Case of Normocalcaemic Primary Hyperparathyroidism Internal Medicine Journal. 08, 2017 | Pubmed ID: 28782221 Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice BioFactors (Oxford, England). Sep, 2017 | Pubmed ID: 28759135 S-phenylpiracetam, a Selective DAT Inhibitor, Reduces Body Weight Gain Without Influencing Locomotor Activity Pharmacology, Biochemistry, and Behavior. 09, 2017 | Pubmed ID: 28743458 The Activity of Selective Sigma-1 Receptor Ligands in Seizure Models in Vivo Behavioural Brain Research. 06, 2017 | Pubmed ID: 28389336 Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB Basic & Clinical Pharmacology & Toxicology. Aug, 2017 | Pubmed ID: 28244203 Trimethylamine N-oxide Impairs Pyruvate and Fatty Acid Oxidation in Cardiac Mitochondria Toxicology Letters. Feb, 2017 | Pubmed ID: 28049038 Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium Due to Competition for OCTN2-mediated Transport Basic & Clinical Pharmacology & Toxicology. May, 2017 | Pubmed ID: 27983775 Response to Comment by Sergei V. Jargin: "Meldonium (Mildronate): Primum Nоn Nocere" Pharmacological Research. Dec, 2016 | Pubmed ID: 27725311 The Unusual Pharmacokinetics of Meldonium: Implications for Doping Pharmacological Research. Sep, 2016 | Pubmed ID: 27262679 Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria The Biochemical Journal. 05, 2016 | Pubmed ID: 26936967 Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity Pharmacological Research. 11, 2016 | Pubmed ID: 26850121 Decreased Acylcarnitine Content Improves Insulin Sensitivity in Experimental Mice Models of Insulin Resistance Pharmacological Research. 11, 2016 | Pubmed ID: 26621248 The Neuroprotective Effects of R-phenibut After Focal Cerebral Ischemia Pharmacological Research. 11, 2016 | Pubmed ID: 26621244 R-phenibut Binds to the α2-δ Subunit of Voltage-dependent Calcium Channels and Exerts Gabapentin-like Anti-nociceptive Effects Pharmacology, Biochemistry, and Behavior. Oct, 2015 | Pubmed ID: 26234470 Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella Pneumoniae The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26187464 Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis Vascular Pharmacology. Sep, 2015 | Pubmed ID: 25989106 Determination of Trimethylamine-N-oxide in Combination with L-carnitine and γ-butyrobetaine in Human Plasma by UPLC/MS/MS Biomedical Chromatography : BMC. Nov, 2015 | Pubmed ID: 25873316 Acute Anti-hyperglycaemic Effects of an Unripe Apple Preparation Containing Phlorizin in Healthy Volunteers: a Preliminary Study Journal of the Science of Food and Agriculture. Feb, 2015 | Pubmed ID: 24917557 Suppression of Intestinal Microbiota-dependent Production of Pro-atherogenic Trimethylamine N-oxide by Shifting L-carnitine Microbial Degradation Life Sciences. Nov, 2014 | Pubmed ID: 25301199 A Cross-sectional Survey of Urinary Iodine Status in Latvia Medicina (Kaunas, Lithuania). 2014 | Pubmed ID: 25172607 Long-chain Acylcarnitine Content Determines the Pattern of Energy Metabolism in Cardiac Mitochondria Molecular and Cellular Biochemistry. Oct, 2014 | Pubmed ID: 24878991 Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size Pharmacological Research. Jul, 2014 | Pubmed ID: 24836867 Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats Magnesium Research. Jan-Mar, 2014 | Pubmed ID: 24827813 Libiguins A and B: Novel Phragmalin Limonoids Isolated from Neobeguea Mahafalensis Causing Profound Enhancement of Sexual Activity Planta Medica. Mar, 2014 | Pubmed ID: 24549927 Mildronate, the Inhibitor of L-carnitine Transport, Induces Brain Mitochondrial Uncoupling and Protects Against Anoxia-reoxygenation European Journal of Pharmacology. Jan, 2014 | Pubmed ID: 24333219 The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State Metabolism: Clinical and Experimental. Jan, 2014 | Pubmed ID: 24140100 Meldonium Decreases the Diet-increased Plasma Levels of Trimethylamine N-oxide, a Metabolite Associated with Atherosclerosis Journal of Clinical Pharmacology. Oct, 2013 | Pubmed ID: 23893520 Elevated Vascular γ-butyrobetaine Levels Attenuate the Development of High Glucose-induced Endothelial Dysfunction Clinical and Experimental Pharmacology & Physiology. Aug, 2013 | Pubmed ID: 23710938 Synthesis and Biological Evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide Stereoisomers As Novel Positive Allosteric Modulators of Sigma-1 Receptor Bioorganic & Medicinal Chemistry. May, 2013 | Pubmed ID: 23582449 Activated Peroxisomal Fatty Acid Metabolism Improves Cardiac Recovery in Ischemia-reperfusion Naunyn-Schmiedeberg's Archives of Pharmacology. Jun, 2013 | Pubmed ID: 23525500 Association of Reduced Glyoxalase 1 Activity and Painful Peripheral Diabetic Neuropathy in Type 1 and 2 Diabetes Mellitus Patients Journal of Diabetes and Its Complications. May-Jun, 2013 | Pubmed ID: 23351995 Troubleshooting Digital Macro Photography for Image Acquisition and the Analysis of Biological Samples Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2013 | Pubmed ID: 23202591 Glyoxalase 1 and Glyoxalase 2 Activities in Blood and Neuronal Tissue Samples from Experimental Animal Models of Obesity and Type 2 Diabetes Mellitus The Journal of Physiological Sciences : JPS. Nov, 2012 | Pubmed ID: 22893478 High L-carnitine Concentrations Do Not Prevent Late Diabetic Complications in Type 1 and 2 Diabetic Patients Nutrition Research (New York, N.Y.). May, 2012 | Pubmed ID: 22652370 The Sensorimotor and Cognitive Deficits in Rats Following 90- and 120-min Transient Occlusion of the Middle Cerebral Artery Journal of Neuroscience Methods. Jul, 2012 | Pubmed ID: 22640751 A Short-term High-dose Administration of Sodium Pivalate Impairs Pyruvate Metabolism Without Affecting Cardiac Function Cardiovascular Toxicology. Dec, 2012 | Pubmed ID: 22539084 The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012 | Pubmed ID: 21903968 Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats Pharmacological Reports : PR. 2011 | Pubmed ID: 21857086 Mildronate Treatment Alters γ-butyrobetaine and L-carnitine Concentrations in Healthy Volunteers The Journal of Pharmacy and Pharmacology. Sep, 2011 | Pubmed ID: 21827492 Investigation into Stereoselective Pharmacological Activity of Phenotropil Basic & Clinical Pharmacology & Toxicology. Nov, 2011 | Pubmed ID: 21689376 Mildronate Treatment Improves Functional Recovery Following Middle Cerebral Artery Occlusion in Rats Behavioural Brain Research. Sep, 2011 | Pubmed ID: 21420440 Anti-diabetic Effects of Mildronate Alone or in Combination with Metformin in Obese Zucker Rats European Journal of Pharmacology. May, 2011 | Pubmed ID: 21371472 Flow Cytometric Analysis of Glyoxalase-1 Expression in Human Leukocytes Cell Biochemistry and Function. Mar, 2011 | Pubmed ID: 21370249 Mildronate Exerts Acute Anticonvulsant and Antihypnotic Effects Behavioural Pharmacology. Sep, 2010 | Pubmed ID: 20661137 The Anti-inflammatory and Antinociceptive Effects of NF-kappaB Inhibitory Guanidine Derivative ME10092 International Immunopharmacology. Apr, 2010 | Pubmed ID: 20074673 Inhibition of Carnitine Acetyltransferase by Mildronate, a Regulator of Energy Metabolism Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2009 | Pubmed ID: 19912061 Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats Basic & Clinical Pharmacology & Toxicology. Dec, 2009 | Pubmed ID: 19663820 Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats British Journal of Pharmacology. Aug, 2009 | Pubmed ID: 19594753 Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart Cardiovascular Drugs and Therapy. Aug, 2009 | Pubmed ID: 19536647 Quantitative Analysis of Phenibut in Rat Brain Tissue Extracts by Liquid Chromatography-tandem Mass Spectrometry Biomedical Chromatography : BMC. Dec, 2008 | Pubmed ID: 19034959 Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart Life Sciences. Oct, 2008 | Pubmed ID: 18801379 Effect of Inhibiting Carnitine Biosynthesis on Male Rat Sexual Performance Physiology & Behavior. Oct, 2008 | Pubmed ID: 18640137 Comparative Pharmacological Activity of Optical Isomers of Phenibut European Journal of Pharmacology. Mar, 2008 | Pubmed ID: 18275958 Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction Journal of Cardiovascular Pharmacology. Dec, 2006 | Pubmed ID: 17204911 The Differential Influences of Melanocortins on Nociception in the Formalin and Tail Flick Tests Pharmacology, Biochemistry, and Behavior. Oct, 2006 | Pubmed ID: 16970983 Investigations on the Pharmacology of the Cardioprotective Guanidine ME10092 Journal of Cardiovascular Pharmacology. Aug, 2004 | Pubmed ID: 15243298 The Methylester of Gamma-butyrobetaine, but Not Gamma-butyrobetaine Itself, Induces Muscarinic Receptor-dependent Vasodilatation Naunyn-Schmiedeberg's Archives of Pharmacology. May, 2004 | Pubmed ID: 15060760 Mildronate: Cardioprotective Action Through Carnitine-lowering Effect Trends in Cardiovascular Medicine. Aug, 2002 | Pubmed ID: 12242052 Cardioprotective Effects of N-hydroxyguanidine PR5 in Myocardial Ischaemia and Reperfusion in Rats British Journal of Pharmacology. Nov, 1999 | Pubmed ID: 10556947 Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine
Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine