John J. Tentler Medicine University of Colorado Denver Anschutz Medical Campus Biography Publications Institution JoVE Articles John J. Tentler has not added a biography. If you are John J. Tentler and would like to personalize this page please email our Author Liaison for assistance. Publications Antitumor Activity of the Aurora a Selective Kinase Inhibitor, Alisertib, Against Preclinical Models of Colorectal Cancer Oncotarget. Jul, 2016 | Pubmed ID: 27385211 An Integrated Bioinformatics Analysis to Dissect Kinase Dependency in Triple Negative Breast Cancer BMC Genomics. 2015 | Pubmed ID: 26681397 Antitumor Activity of a Potent MEK Inhibitor, TAK-733, Against Colorectal Cancer Cell Lines and Patient Derived Xenografts Oncotarget. Oct, 2015 | Pubmed ID: 26439693 Combined Inhibition of MEK and Aurora A Kinase in KRAS/PIK3CA Double-mutant Colorectal Cancer Models Frontiers in Pharmacology. 2015 | Pubmed ID: 26136684 P53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer Molecular Cancer Therapeutics. May, 2015 | Pubmed ID: 25758253 Antitumor Activity of the MEK Inhibitor TAK-733 Against Melanoma Cell Lines and Patient-derived Tumor Explants Molecular Cancer Therapeutics. Feb, 2015 | Pubmed ID: 25376610 Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer PloS One. 2014 | Pubmed ID: 25401499 Triple-negative Breast Cancer: Bridging the Gap from Cancer Genomics to Predictive Biomarkers Therapeutic Advances in Medical Oncology. May, 2014 | Pubmed ID: 24790649 Overcoming IGF1R/IR Resistance Through Inhibition of MEK Signaling in Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 24045180 Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23757356 MERTK Receptor Tyrosine Kinase is a Therapeutic Target in Melanoma The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23585477 Association of the Epithelial-to-mesenchymal Transition Phenotype with Responsiveness to the P21-activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models Frontiers in Pharmacology. 2013 | Pubmed ID: 23543898 Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2013 | Pubmed ID: 23358974 CtBP1 is Expressed in Melanoma and Represses the Transcription of P16INK4a and Brca1 The Journal of Investigative Dermatology. May, 2013 | Pubmed ID: 23303449 Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2013 | Pubmed ID: 23136197 ATM and MET Kinases Are Synthetic Lethal with Nongenotoxic Activation of P53 Nature Chemical Biology. Jul, 2012 | Pubmed ID: 22660439 Patient-derived Tumour Xenografts As Models for Oncology Drug Development Nature Reviews. Clinical Oncology. Jun, 2012 | Pubmed ID: 22508028 Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-mutant Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012 | Pubmed ID: 22173548 Mapping of ESE-1 Subdomains Required to Initiate Mammary Epithelial Cell Transformation Via a Cytoplasmic Mechanism Molecular Cancer. 2011 | Pubmed ID: 21871131 The Insulin-like Growth Factor I Receptor/insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2010 | Pubmed ID: 20943761 Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras-mutated Colorectal Cancer Molecular Cancer Therapeutics. Dec, 2010 | Pubmed ID: 20923857 Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2010 | Pubmed ID: 20530704 Assessment of the in Vivo Antitumor Effects of ENMD-2076, a Novel Multitargeted Kinase Inhibitor, Against Primary and Cell Line-derived Human Colorectal Cancer Xenograft Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2010 | Pubmed ID: 20406842 Targeting Vascular Endothelial Growth Factor Receptor-1 and -3 with Cediranib (AZD2171): Effects on Migration and Invasion of Gastrointestinal Cancer Cell Lines Molecular Cancer Therapeutics. Sep, 2009 | Pubmed ID: 19755510 Vorinostat and Bortezomib Exert Synergistic Antiproliferative and Proapoptotic Effects in Colon Cancer Cell Models Molecular Cancer Therapeutics. Feb, 2009 | Pubmed ID: 19174560 Structural and Functional Analysis of the Differential Effects of C-Jun and V-Jun on Prolactin Gene Expression Molecular Endocrinology (Baltimore, Md.). Oct, 2004 | Pubmed ID: 15231872 ESX Induces Transformation and Functional Epithelial to Mesenchymal Transition in MCF-12A Mammary Epithelial Cells Oncogene. Mar, 2004 | Pubmed ID: 14767472 The Epithelial-specific ETS Transcription Factor ESX/ESE-1/Elf-3 Modulates Breast Cancer-associated Gene Expression DNA and Cell Biology. Feb, 2003 | Pubmed ID: 12713734 Selective Repression of Rat Prolactin Gene by Stable Expression of Dominant-negative Ets in GH4 Pituitary Cells Endocrine. Feb-Mar, 2003 | Pubmed ID: 12668863 विकास और एक Preclinical रोगी व्युत्पन्न ट्यूमर उपन्यास विरोधी कैंसर उपचार की जांच के लिए Xenograft मॉडल का रखरखाव Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Cancer Research
विकास और एक Preclinical रोगी व्युत्पन्न ट्यूमर उपन्यास विरोधी कैंसर उपचार की जांच के लिए Xenograft मॉडल का रखरखाव Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Cancer Research