Jonathan A. R. Worrall School of Life Sciences University of Essex Biography Publications Institution JoVE Articles Jonathan A. R. Worrall has not added a biography. If you are Jonathan A. R. Worrall and would like to personalize this page please email our Author Liaison for assistance. Publications Iron Oxidation in Escherichia Coli Bacterioferritin Ferroxidase Centre, a Site Designed to React Rapidly with H2O2 but Slowly with O2 Angewandte Chemie (International Ed. in English). Jan, 2021 | Pubmed ID: 33482043 Using Cryo-EM to Understand Antimycobacterial Resistance in the Catalase-peroxidase (KatG) from Mycobacterium Tuberculosis Structure (London, England : 1993). Jan, 2021 | Pubmed ID: 33444527 Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe =O Formation Angewandte Chemie (International Ed. in English). 11, 2020 | Pubmed ID: 32780931 A Subtle Structural Change in the Distal Haem Pocket Has a Remarkable Effect on Tuning Hydrogen Peroxide Reactivity in Dye Decolourising Peroxidases from Streptomyces Lividans Dalton Transactions (Cambridge, England : 2003). Feb, 2020 | Pubmed ID: 31942590 Comparison of the Structural Dynamic and Mitochondrial Electron-transfer Properties of the Proapoptotic Human Cytochrome C Variants, G41S, Y48H and A51V Journal of Inorganic Biochemistry. 02, 2020 | Pubmed ID: 31760234 Successful Sample Preparation for Serial Crystallography Experiments Journal of Applied Crystallography. Dec, 2019 | Pubmed ID: 31798361 High-throughput Structures of Protein-ligand Complexes at Room Temperature Using Serial Femtosecond Crystallography IUCrJ. Nov, 2019 | Pubmed ID: 31709063 Dose-resolved Serial Synchrotron and XFEL Structures of Radiation-sensitive Metalloproteins IUCrJ. Jul, 2019 | Pubmed ID: 31316799 A Histidine Residue and a Tetranuclear Cuprous-thiolate Cluster Dominate the Copper Loading Landscape of a Copper Storage Protein from Streptomyces Lividans Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2019 | Pubmed ID: 31111982 An Aromatic Dyad Motif in Dye Decolourising Peroxidases Has Implications for Free Radical Formation and Catalysis Chemistry (Weinheim an Der Bergstrasse, Germany). Apr, 2019 | Pubmed ID: 30945782 Naturally Occurring Disease-Related Mutations in the 40-57 Ω-Loop of Human Cytochrome C Control Triggering of the Alkaline Isomerization Biochemistry. 07, 2018 | Pubmed ID: 29949346 A Cytosolic Copper Storage Protein Provides a Second Level of Copper Tolerance in Streptomyces Lividans Metallomics : Integrated Biometal Science. 01, 2018 | Pubmed ID: 29292456 Heightened Dynamics of the Oxidized Y48H Variant of Human Cytochrome C Increases Its Peroxidatic Activity Biochemistry. 11, 2017 | Pubmed ID: 29083920 Kinetic Characterisation of a Dye Decolourising Peroxidase from Streptomyces Lividans: New Insight into the Mechanism of Anthraquinone Dye Decolourisation Dalton Transactions (Cambridge, England : 2003). Jul, 2017 | Pubmed ID: 28695933 Photoreduction and Validation of Haem-ligand Intermediate States in Protein Crystals by Single-crystal Spectroscopy and Diffraction IUCrJ. May, 2017 | Pubmed ID: 28512573 Tyrosine or Tryptophan? Modifying a Metalloradical Catalytic Site by Removal of the Cys-Tyr Cross-Link in the Galactose 6-Oxidase Homologue GlxA Angewandte Chemie (International Ed. in English). 06, 2017 | Pubmed ID: 28464409 Near-complete Backbone Resonance Assignments of Acid-denatured Human Cytochrome C in Dimethylsulfoxide: a Prelude to Studying Interactions with Phospholipids Biomolecular NMR Assignments. Oct, 2017 | Pubmed ID: 28260216 Active-site Maturation and Activity of the Copper-radical Oxidase GlxA Are Governed by a Tryptophan Residue The Biochemical Journal. 02, 2017 | Pubmed ID: 28093470 Increased Dynamics in the 40-57 Ω-loop of the G41S Variant of Human Cytochrome C Promote Its Pro-apoptotic Conformation Scientific Reports. Jul, 2016 | Pubmed ID: 27461282 Heterogeneity in the Histidine-brace Copper Coordination Sphere in Auxiliary Activity Family 10 (AA10) Lytic Polysaccharide Monooxygenases The Journal of Biological Chemistry. Jun, 2016 | Pubmed ID: 27129229 The DyP-type Peroxidase DtpA is a Tat-substrate Required for GlxA Maturation and Morphogenesis in Streptomyces Open Biology. Jan, 2016 | Pubmed ID: 26740586 Copper and Nickel Bind Via Two Distinct Kinetic Mechanisms to a CsoR Metalloregulator Dalton Transactions (Cambridge, England : 2003). Dec, 2015 | Pubmed ID: 26536457 Structural Insights into Conformational Switching in the Copper Metalloregulator CsoR from Streptomyces Lividans Acta Crystallographica. Section D, Biological Crystallography. Sep, 2015 | Pubmed ID: 26327377 GlxA is a New Structural Member of the Radical Copper Oxidase Family and is Required for Glycan Deposition at Hyphal Tips and Morphogenesis of Streptomyces Lividans The Biochemical Journal. Aug, 2015 | Pubmed ID: 26205496 Backbone Resonance Assignments of Ferric Human Cytochrome C and the Pro-apoptotic G41S Mutant in the Ferric and Ferrous States Biomolecular NMR Assignments. Oct, 2015 | Pubmed ID: 26123826 Copper Trafficking in the CsoR Regulon of Streptomyces Lividans Metallomics : Integrated Biometal Science. Jan, 2015 | Pubmed ID: 25409712 Structural and Mechanistic Insights into an Extracytoplasmic Copper Trafficking Pathway in Streptomyces Lividans The Biochemical Journal. May, 2014 | Pubmed ID: 24548299 Conformational and Thermodynamic Hallmarks of DNA Operator Site Specificity in the Copper Sensitive Operon Repressor from Streptomyces Lividans Nucleic Acids Research. Jan, 2014 | Pubmed ID: 24121681 The Hydrogen-peroxide-induced Radical Behaviour in Human Cytochrome C-phospholipid Complexes: Implications for the Enhanced Pro-apoptotic Activity of the G41S Mutant The Biochemical Journal. Dec, 2013 | Pubmed ID: 24099549 The Role of the Cys-X-X-X-Cys Motif on the Kinetics of Cupric Ion Loading to the Streptomyces Lividans Sco Protein Dalton Transactions (Cambridge, England : 2003). Aug, 2013 | Pubmed ID: 23759834 Morphological Development and Cytochrome C Oxidase Activity in Streptomyces Lividans Are Dependent on the Action of a Copper Bound Sco Protein Open Biology. Jan, 2013 | Pubmed ID: 23345541 Response to Copper Stress in Streptomyces Lividans Extends Beyond Genes Under Direct Control of a Copper-sensitive Operon Repressor Protein (CsoR) The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22451651 Ferric Haem Forms of Mycobacterium Tuberculosis Catalase-peroxidase Probed by EPR Spectroscopy: Their Stability and Interplay with PH Biochimie. Jun, 2012 | Pubmed ID: 22381358 An Investigation into a Cardiolipin Acyl Chain Insertion Site in Cytochrome C Biochimica Et Biophysica Acta. May, 2012 | Pubmed ID: 22365930 The Role of a Disulfide Bridge in the Stability and Folding Kinetics of Arabidopsis Thaliana Cytochrome C(6A) Biochimica Et Biophysica Acta. Feb, 2012 | Pubmed ID: 22085909 Structural and Kinetic Studies of Imidazole Binding to Two Members of the Cytochrome C (6) Family Reveal an Important Role for a Conserved Heme Pocket Residue Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Apr, 2011 | Pubmed ID: 21267610 Thermodynamic Analysis of Jun-Fos Coiled Coil Peptide Antagonists The FEBS Journal. Feb, 2011 | Pubmed ID: 21199371 Copper Mining in Streptomyces: Enzymes, Natural Products and Development Natural Product Reports. May, 2010 | Pubmed ID: 20372697 Cytochrome C6A: Discovery, Structure and Properties Responsible for Its Low Haem Redox Potential Biochemical Society Transactions. Dec, 2008 | Pubmed ID: 19021519 Fixed Target Serial Data Collection at Diamond Light Source Sam Horrell1, Danny Axford1, Nicholas E. Devenish1, Ali Ebrahim1, Michael A. Hough2, Darren A. Sherrell1,3, Selina L. S. Storm1,4, Ivo Tews5, Jonathan A. R. Worrall2, Robin L. Owen1 1Diamond Light Source, Harwell Science and Innovation Campus, 2School of Life Sciences, University of Essex, 3X-ray Science Division, Argonne National Laboratory, 4European Molecular Biology Laboratory, Hamburg Outstation c/o DESY, 5Biological Sciences, Institute for Life Sciences, University of Southampton JoVE 62200 Biochemistry
Fixed Target Serial Data Collection at Diamond Light Source Sam Horrell1, Danny Axford1, Nicholas E. Devenish1, Ali Ebrahim1, Michael A. Hough2, Darren A. Sherrell1,3, Selina L. S. Storm1,4, Ivo Tews5, Jonathan A. R. Worrall2, Robin L. Owen1 1Diamond Light Source, Harwell Science and Innovation Campus, 2School of Life Sciences, University of Essex, 3X-ray Science Division, Argonne National Laboratory, 4European Molecular Biology Laboratory, Hamburg Outstation c/o DESY, 5Biological Sciences, Institute for Life Sciences, University of Southampton JoVE 62200 Biochemistry