Kristina W. Thiel Department of Obstetrics and Gynecology, Carver College of Medicine University of Iowa Biography Publications Institution JoVE Articles Kristina W. Thiel has not added a biography. If you are Kristina W. Thiel and would like to personalize this page please email our Author Liaison for assistance. Publications AptamerRunner: An Accessible Aptamer Structure Prediction and Clustering Algorithm for Visualization of Selected Aptamers BioRxiv : the Preprint Server for Biology. Nov, 2023 | Pubmed ID: 38014343 Multiplexed Live-cell Imaging for Drug Responses in Patient-derived Organoid Models of Cancer BioRxiv : the Preprint Server for Biology. Nov, 2023 | Pubmed ID: 38014133 Global Expression Analysis of Endometrial Cancer Cells in Response to Progesterone Identifies New Therapeutic Targets The Journal of Steroid Biochemistry and Molecular Biology. Nov, 2023 | Pubmed ID: 37716459 Characterization of HCI-EC-23 a Novel Estrogen- and Progesterone-responsive Endometrial Cancer Cell Line Scientific Reports. Nov, 2022 | Pubmed ID: 36396974 Sequencing and P53 Immunohistochemistry Predict Outcomes When Bevacizumab Is Added to Frontline Chemotherapy in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2022 | Pubmed ID: 35658479 Blocking Autophagy Overcomes Resistance to Dual Histone Deacetylase and Proteasome Inhibition in Gynecologic Cancer Cell Death & Disease. Jan, 2022 | Pubmed ID: 35039480 Advantages of Tyrosine Kinase Anti-Angiogenic Cediranib over Bevacizumab: Cell Cycle Abrogation and Synergy with Chemotherapy Pharmaceuticals (Basel, Switzerland). Jul, 2021 | Pubmed ID: 34358108 Successful Patient-Derived Organoid Culture of Gynecologic Cancers for Disease Modeling and Drug Sensitivity Testing Cancers. Jun, 2021 | Pubmed ID: 34200645 Targeting Wnt Signaling in Endometrial Cancer Cancers. May, 2021 | Pubmed ID: 34068065 Bacterial, Archaea, and Viral Transcripts (BAVT) Expression in Gynecological Cancers and Correlation with Regulatory Regions of the Genome Cancers. Mar, 2021 | Pubmed ID: 33807612 Creation and Validation of Models to Predict Response to Primary Treatment in Serous Ovarian Cancer Scientific Reports. Mar, 2021 | Pubmed ID: 33727600 Mutated P53 Portends Improvement in Outcomes when Bevacizumab is Combined with Chemotherapy in Advanced/recurrent Endometrial Cancer: An NRG Oncology Study Gynecologic Oncology. Apr, 2021 | Pubmed ID: 33541735 Genomic Characterization of Five Commonly Used Endometrial Cancer Cell Lines International Journal of Oncology. Dec, 2020 | Pubmed ID: 33174010 The Dawning of the Age of Personalized Medicine in Gynecologic Oncology Cancers. Oct, 2020 | Pubmed ID: 33120871 Loss of Progesterone Receptor Through Epigenetic Regulation is Associated with Poor Prognosis in Solid Tumors American Journal of Cancer Research. 2020 | Pubmed ID: 32642294 Characterization of a TP53 Somatic Variant of Unknown Function From an Ovarian Cancer Patient Using Organoid Culture and Computational Modeling Clinical Obstetrics and Gynecology. Mar, 2020 | Pubmed ID: 31876640 MTDH/AEG-1 Downregulation Using Pristimerin-loaded Nanoparticles Inhibits Fanconi Anemia Proteins and Increases Sensitivity to Platinum-based Chemotherapy Gynecologic Oncology. 11, 2019 | Pubmed ID: 31477281 An Integrated Prediction Model of Recurrence in Endometrial Endometrioid Cancers Cancer Management and Research. 2019 | Pubmed ID: 31239780 Molecular Characterization of Non-responders to Chemotherapy in Serous Ovarian Cancer International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30866519 A Prediction Model for Preoperative Risk Assessment in Endometrial Cancer Utilizing Clinical and Molecular Variables International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30857319 Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function P53 Mutations Disease Markers. 2018 | Pubmed ID: 30647797 AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with P53 Mutations Cancers. May, 2018 | Pubmed ID: 29783721 Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer Nature Nanotechnology. 01, 2018 | Pubmed ID: 29203914 Role of Metadherin in Estrogen-regulated Gene Expression International Journal of Molecular Medicine. Aug, 2017 | Pubmed ID: 28627585 High Stathmin Expression is a Marker for Poor Clinical Outcome in Endometrial Cancer: An NRG Oncology Group/gynecologic Oncology Group Study Gynecologic Oncology. Aug, 2017 | Pubmed ID: 28532857 Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. May, 2017 | Pubmed ID: 28375929 Prediction of Chemo-response in Serous Ovarian Cancer Molecular Cancer. Oct, 2016 | Pubmed ID: 27756408 Stratification of Endometrioid Endometrial Cancer Patients into Risk Levels Using Somatic Mutations Gynecologic Oncology. Jul, 2016 | Pubmed ID: 27181389 Inverse Relationship Between Progesterone Receptor and Myc in Endometrial Cancer PloS One. 2016 | Pubmed ID: 26859414 Downregulation of FOXO1 MRNA Levels Predicts Treatment Failure in Patients with Endometrial Pathology Conservatively Managed with Progestin-containing Intrauterine Devices Gynecologic Oncology. Jan, 2016 | Pubmed ID: 26524723 NEDD4 Ubiquitin Ligase is a Putative Oncogene in Endometrial Cancer That Activates IGF-1R/PI3K/Akt Signaling Gynecologic Oncology. Oct, 2015 | Pubmed ID: 26193427 MiR-888: A Novel Cancer-Testis Antigen That Targets the Progesterone Receptor in Endometrial Cancer Translational Oncology. Apr, 2015 | Pubmed ID: 25926074 Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility Via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25787082 TP53 Oncomorphic Mutations Predict Resistance to Platinum‑ and Taxane‑based Standard Chemotherapy in Patients Diagnosed with Advanced Serous Ovarian Carcinoma International Journal of Oncology. Feb, 2015 | Pubmed ID: 25385265 Cell-internalization SELEX: Method for Identifying Cell-internalizing RNA Aptamers for Delivering SiRNAs to Target Cells Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25319652 Systematic Dissection of the Mechanisms Underlying Progesterone Receptor Downregulation in Endometrial Cancer Oncotarget. Oct, 2014 | Pubmed ID: 25229191 Past, Present, and Future of Hormonal Therapy in Recurrent Endometrial Cancer International Journal of Women's Health. 2014 | Pubmed ID: 24833920 Comprehensive Profiling of EGFR/HER Receptors for Personalized Treatment of Gynecologic Cancers Molecular Diagnosis & Therapy. Apr, 2014 | Pubmed ID: 24403167 Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells Current Pharmaceutical Design. 2014 | Pubmed ID: 23888956 Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant P53 Obstetrics and Gynecology International. 2013 | Pubmed ID: 24381593 The Estrogen Receptor Joins Other Cancer Biomarkers As a Predictor of Outcome Obstetrics and Gynecology International. 2013 | Pubmed ID: 24223042 The Epidermal Growth Factor Receptor and Its Ligands in Cardiovascular Disease International Journal of Molecular Sciences. Oct, 2013 | Pubmed ID: 24132149 The Consequence of Oncomorphic TP53 Mutations in Ovarian Cancer International Journal of Molecular Sciences. Sep, 2013 | Pubmed ID: 24065105 Drug Resistance Mediated by AEG-1/MTDH/LYRIC Advances in Cancer Research. 2013 | Pubmed ID: 23889990 Catch It Before It Kills: Progesterone, Obesity, and the Prevention of Endometrial Cancer Discovery Medicine. Sep, 2012 | Pubmed ID: 23021376 An Exploratory Study of the Variables Impacting Preterm Birth Rates in New Mexico BMC Pregnancy and Childbirth. Jun, 2012 | Pubmed ID: 22720802 Endometrial Cancer Obstetrics and Gynecology Clinics of North America. Jun, 2012 | Pubmed ID: 22640714 Delivery of Chemo-sensitizing SiRNAs to HER2+-breast Cancer Cells Using RNA Aptamers Nucleic Acids Research. Jul, 2012 | Pubmed ID: 22467215 Endometrial Cancer: Reviving Progesterone Therapy in the Molecular Age Discovery Medicine. Sep, 2011 | Pubmed ID: 21955848 Knockdown of MTDH Sensitizes Endometrial Cancer Cells to Cell Death Induction by Death Receptor Ligand TRAIL and HDAC Inhibitor LBH589 Co-treatment PloS One. 2011 | Pubmed ID: 21687633 Progesterone: the Ultimate Endometrial Tumor Suppressor Trends in Endocrinology and Metabolism: TEM. Apr, 2011 | Pubmed ID: 21353793 Effects of Bevacizumab in Mouse Model of Endometrial Cancer: Defining the Molecular Basis for Resistance Oncology Reports. Mar, 2011 | Pubmed ID: 21240464 Systemic Administration of Optimized Aptamer-siRNA Chimeras Promotes Regression of PSMA-expressing Tumors Nature Biotechnology. Sep, 2009 | Pubmed ID: 19701187 Therapeutic Applications of DNA and RNA Aptamers Oligonucleotides. Sep, 2009 | Pubmed ID: 19653880 Author Spotlight: Developing Multiplexed Kinetic Assays for Organoid-Based Drug Response Analysis Kaitriana E. Colling*1,2, Emily L. Symons*1, Lorenzo Buroni*3, Hiruni K. Sumanasiri1, Jessica Andrew-Udoh1, Emily Witt1,4, Haley A. Losh1, Abigail M. Morrison1, Kimberly K. Leslie5, Christopher J. Dunnill6, Johann S. de Bono3, Kristina W. Thiel1,7 1Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, 2Cancer Biology Graduate Program, Carver College of Medicine, University of Iowa, 3The Institute of Cancer Research: and the Royal Marsden NHS Foundation Trust, 4Department of Radiation Oncology, Carver College of Medicine, University of Iowa, 5Division of Molecular Medicine, Departments of Internal Medicine and Obstetrics and Gynecology, University of New Mexico Comprehensive Cancer Center, University of New Mexico Health Sciences Center, 6Agilent Technologies, 7Holden Comprehensive Cancer Center, University of Iowa JoVE 66072 Cancer Research
Author Spotlight: Developing Multiplexed Kinetic Assays for Organoid-Based Drug Response Analysis Kaitriana E. Colling*1,2, Emily L. Symons*1, Lorenzo Buroni*3, Hiruni K. Sumanasiri1, Jessica Andrew-Udoh1, Emily Witt1,4, Haley A. Losh1, Abigail M. Morrison1, Kimberly K. Leslie5, Christopher J. Dunnill6, Johann S. de Bono3, Kristina W. Thiel1,7 1Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, 2Cancer Biology Graduate Program, Carver College of Medicine, University of Iowa, 3The Institute of Cancer Research: and the Royal Marsden NHS Foundation Trust, 4Department of Radiation Oncology, Carver College of Medicine, University of Iowa, 5Division of Molecular Medicine, Departments of Internal Medicine and Obstetrics and Gynecology, University of New Mexico Comprehensive Cancer Center, University of New Mexico Health Sciences Center, 6Agilent Technologies, 7Holden Comprehensive Cancer Center, University of Iowa JoVE 66072 Cancer Research