Nicholas O. Fischer Physical and Life Sciences Directorate Lawrence Livermore National Laboratory Biography Publications Institution JoVE Articles Nicholas O. Fischer has not added a biography. If you are Nicholas O. Fischer and would like to personalize this page please email our Author Liaison for assistance. Publications A Survey of Preclinical Studies Evaluating Nanoparticle-Based Vaccines Against Non-Viral Sexually Transmitted Infections Frontiers in Pharmacology. 2021 | Pubmed ID: 34899322 Probing Function in 3D Neuronal Cultures: A Survey of 3D Multielectrode Array Advances Current Opinion in Pharmacology. 10, 2021 | Pubmed ID: 34481335 Induction of Protection in Mice Against a Respiratory Challenge by a Vaccine Formulated with the Major Outer Membrane Protein in Nanolipoprotein Particles Vaccines. Jul, 2021 | Pubmed ID: 34358171 Intranasal Nanoparticle Vaccination Elicits a Persistent, Polyfunctional CD4 T Cell Response in the Murine Lung Specific for a Highly Conserved Influenza Virus Antigen That Is Sufficient To Mediate Protection from Influenza Virus Challenge Journal of Virology. 07, 2021 | Pubmed ID: 34076479 Characterization of Spore Proteins Using a Nanoscaffold Vaccine Platform Frontiers in Immunology. 2020 | Pubmed ID: 32714323 Functional and Transcriptional Characterization of Complex Neuronal Co-cultures Scientific Reports. 07, 2020 | Pubmed ID: 32620908 Modeling the Temporal Network Dynamics of Neuronal Cultures PLoS Computational Biology. 05, 2020 | Pubmed ID: 32453727 HIV Influences Microtubule Associated Protein-2: Potential Marker of HIV-associated Neurocognitive Disorders AIDS (London, England). 06, 2020 | Pubmed ID: 32073448 Cationic HDL Mimetics Enhance in Vivo Delivery of Self-replicating MRNA Nanomedicine : Nanotechnology, Biology, and Medicine. 02, 2020 | Pubmed ID: 31982617 A Flexible 3-dimensional Microelectrode Array for in Vitro Brain Models Lab on a Chip. 03, 2020 | Pubmed ID: 31976505 A Reconfigurable In Vitro Model for Studying the Blood-Brain Barrier Annals of Biomedical Engineering. Feb, 2020 | Pubmed ID: 31741228 Optimizing Cell Encapsulation Condition in ECM-Collagen I Hydrogels to Support 3D Neuronal Cultures Journal of Neuroscience Methods. 01, 2020 | Pubmed ID: 31626846 Tissue-specific Extracellular Matrix Accelerates the Formation of Neural Networks and Communities in a Neuron-glia Co-culture on a Multi-electrode Array Scientific Reports. 03, 2019 | Pubmed ID: 30858401 Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses Journal of Immunology (Baltimore, Md. : 1950). 01, 2019 | Pubmed ID: 30541879 Evaluation of in Vitro Neuronal Platforms As Surrogates for in Vivo Whole Brain Systems Scientific Reports. Jul, 2018 | Pubmed ID: 30018409 Lipid Composition Dictates Serum Stability of Reconstituted High-density Lipoproteins: Implications for in Vivo Applications Nanoscale. Apr, 2018 | Pubmed ID: 29564446 Small-angle X-ray and Neutron Scattering Demonstrates That Cell-free Expression Produces Properly Formed Disc-shaped Nanolipoprotein Particles Protein Science : a Publication of the Protein Society. 03, 2018 | Pubmed ID: 29266475 Cell-free Production of a Functional Oligomeric Form of a Major Outer-membrane Protein (MOMP) for Vaccine Development The Journal of Biological Chemistry. 09, 2017 | Pubmed ID: 28739800 Enhancement of Antigen-specific CD4 and CD8 T Cell Responses Using a Self-assembled Biologic Nanolipoprotein Particle Vaccine Vaccine. 03, 2017 | Pubmed ID: 28214044 Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake ACS Applied Materials & Interfaces. Aug, 2016 | Pubmed ID: 27411034 Fluorescence Correlation Spectroscopy at Micromolar Concentrations Without Optical Nanoconfinement The Journal of Physical Chemistry. B. Aug, 2014 | Pubmed ID: 25060197 Nanoparticles and Antigen Delivery: Understanding the Benefits and Drawbacks of Different Delivery Platforms Nanomedicine (London, England). Apr, 2014 | Pubmed ID: 24787434 Enhancing the Efficacy of Innate Immune Agonists: Could Nanolipoprotein Particles Hold the Key? Nanomedicine (London, England). Mar, 2014 | Pubmed ID: 24746187 Evaluation of Nanolipoprotein Particles (NLPs) As an in Vivo Delivery Platform PloS One. 2014 | Pubmed ID: 24675794 Quantifying Interactions of a Membrane Protein Embedded in a Lipid Nanodisc Using Fluorescence Correlation Spectroscopy Biophysical Journal. Jan, 2014 | Pubmed ID: 24461026 The Use of Nanolipoprotein Particles to Enhance the Immunostimulatory Properties of Innate Immune Agonists Against Lethal Influenza Challenge Biomaterials. Dec, 2013 | Pubmed ID: 24075406 Colocalized Delivery of Adjuvant and Antigen Using Nanolipoprotein Particles Enhances the Immune Response to Recombinant Antigens Journal of the American Chemical Society. Feb, 2013 | Pubmed ID: 23331082 Enhanced Cellulose Degradation Using Cellulase-nanosphere Complexes PloS One. 2012 | Pubmed ID: 22870287 Identification and Optimization of DNA Aptamer Binding Regions Using DNA Microarrays Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21370059 Isolation, Characterization, and Stability of Discretely-sized Nanolipoprotein Particles Assembled with Apolipophorin-III PloS One. Jul, 2010 | Pubmed ID: 20657844 Kinetic Analysis of His-tagged Protein Binding to Nickel-chelating Nanolipoprotein Particles Bioconjugate Chemistry. Jul, 2010 | Pubmed ID: 20586461 Conjugation to Nickel-chelating Nanolipoprotein Particles Increases the Potency and Efficacy of Subunit Vaccines to Prevent West Nile Encephalitis Bioconjugate Chemistry. Jun, 2010 | Pubmed ID: 20509624 Hydrogen Production by a Hyperthermophilic Membrane-bound Hydrogenase in Water-soluble Nanolipoprotein Particles Journal of the American Chemical Society. Jun, 2009 | Pubmed ID: 19449869 Immobilization of His-tagged Proteins on Nickel-chelating Nanolipoprotein Particles Bioconjugate Chemistry. Mar, 2009 | Pubmed ID: 19239247 Biodetection에 대 한 중원소 Subwavelength 광학 구성품입니다 ACS Nano. Feb, 2008 | Pubmed ID: 19206625 Sensitive and Selective Viral DNA Detection Assay Via Microbead-based Rolling Circle Amplification Bioorganic & Medicinal Chemistry Letters. Nov, 2008 | Pubmed ID: 18694640 Massively Parallel Interrogation of Aptamer Sequence, Structure and Function PloS One. Jul, 2008 | Pubmed ID: 18628955 Single Microbead SELEX for Efficient SsDNA Aptamer Generation Against Botulinum Neurotoxin Chemical Communications (Cambridge, England). Apr, 2008 | Pubmed ID: 18401506 Protein Detection Via Direct Enzymatic Amplification of Short DNA Aptamers Analytical Biochemistry. Feb, 2008 | Pubmed ID: 17980857 Aptasensors for Biosecurity Applications Current Opinion in Chemical Biology. Jun, 2007 | Pubmed ID: 17548236 Heightened Sense for Sensing: Recent Advances in Pathogen Immunoassay Sensing Platforms The Analyst. Mar, 2007 | Pubmed ID: 17325749 백신 개발을 위한 Chlamydia muridarum 의 재조합 주요 외막 단백질에 무세포 규모 생산 및 보조제 추가 Sean F. Gilmore*1, Wei He*1, Angela C. Evans1, Delia F. Tifrea2, Sukumar Pal2, Brent Segelke1, Sandra K. G. Peters1, B. Dillon Vannest1, Nicholas O. Fischer1, Amy Rasley1, Luis M. de la Maza2, Matthew A. Coleman1,3 1Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, 2Department of Pathology and Laboratory Medicine, University of California, 3School of Medicine, Radiation Oncology, University of California Davis JoVE 63028 Immunology and Infection
백신 개발을 위한 Chlamydia muridarum 의 재조합 주요 외막 단백질에 무세포 규모 생산 및 보조제 추가 Sean F. Gilmore*1, Wei He*1, Angela C. Evans1, Delia F. Tifrea2, Sukumar Pal2, Brent Segelke1, Sandra K. G. Peters1, B. Dillon Vannest1, Nicholas O. Fischer1, Amy Rasley1, Luis M. de la Maza2, Matthew A. Coleman1,3 1Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, 2Department of Pathology and Laboratory Medicine, University of California, 3School of Medicine, Radiation Oncology, University of California Davis JoVE 63028 Immunology and Infection