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Centromere-Associated Protein-E Gene Editing Using the CRISPR/Cas9 System

June 23rd, 2023
1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 3,4, 1,2
1Department of Cell Biology and Genetics, The School of Basic Medical Sciences, Fujian Medical University, 2Key Laboratory of Stem Cell Engineering and Regenerative Medicine, Fujian Province University, 3College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, 4Medical Research Center, Fujian Maternity and Child Health Hospital

Summary
Automatic Translation

이 논문은 CRISPR/Cas9 시스템과 세 가지 표현형 기반 스크리닝 전략을 사용하여 중심체 관련 단백질-E(CENP-E) 녹아웃 세포의 구축을 보고합니다. 당사는 CENP-E 녹아웃 세포주를 활용하여 약물 개발 및 생물학 연구에 유용한 CENP-E 억제제의 특이성과 독성을 검증하기 위한 새로운 접근법을 확립했습니다.

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