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使用诱导型成骨细胞谱系特异性 Stat3 敲除小鼠研究正畸牙齿移动过程中的牙槽骨重塑

小鼠正畸牙齿移动（OTM）模型

鼠肺泡骨标本采集

Yuanqi Liu*^1,2,3,4,5, Siyuan Sun*^1,2,3,4,5, Ziyi Jiang*⁶, Xinyi Gong^2,3,4,5, Yiling Yang^2,3,4,5, Yanfei Zhu^2,3,4,5, Hongyuan Xu^2,3,4,5, Anting Jin^2,3,4,5, Xiangru Huang^2,3,4,5, Xin Gao^2,3,4,5, Tingwei Lu^2,3,4,5, Jingyi Liu^2,3,4,5, Xinyu Wang^2,3,4,5, Qinggang Dai^3,4,5,7, Lingyong Jiang^2,3,4,5

¹Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine, ²College of Stomatology,Shanghai Jiao Tong University, ³National Center for Stomatology, ⁴National Clinical Research Center for Oral Diseases, ⁵Shanghai Key Laboratory of Stomatology, ⁶Shanghai Starriver Bilingual School, ⁷The 2nd Dental Center, Ninth People’s Hospital, Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine

Summary

本研究提供了一种使用诱导型成骨细胞谱系特异性 Stat3 敲除小鼠研究正畸力下骨重塑的方案，并描述了分析正畸牙齿移动过程中牙槽骨重塑的方法，从而揭示了骨骼机械生物学。

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