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胎儿接触产妇炎症的穆林模型,研究急性胆管炎对新生儿肠道发育的影响
JoVE 杂志
医学
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JoVE 杂志 医学
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
DOI:

08:50 min

June 24, 2020

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Chapters

  • 00:04Introduction
  • 00:52Establishment of FEMI in Pregnant Mice
  • 02:06Delivery and Care of Offspring and Intestinal Harvesting
  • 03:03Intestinal Injury Scoring
  • 04:11Quantification of Paneth and Goblet Cells
  • 06:35Results: Intestinal Injury of Newborn Mice Induced by FEMI
  • 08:22Conclusion

Summary

自动翻译

我们开发了一个胆管炎模型,以模拟胎儿接触产妇炎症(FEMI),而不会引起活体并发症,以检查FEMI对后代肠道发育的影响。这允许研究胆管炎后肠道损伤发展的机械原因。

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