Steven Webb Department of Applied Mathematics Liverpool John Moores University Biography Publications Institution JoVE Articles Steven Webb has not added a biography. If you are Steven Webb and would like to personalize this page please email our Author Liaison for assistance. Publications A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in the ICU Critical Care Medicine. Jun, 2016 | Pubmed ID: 26968024 Cost of Surviving Sepsis: a Novel Model of Recovery from Sepsis in Drosophila Melanogaster Intensive Care Medicine Experimental. Dec, 2016 | Pubmed ID: 26791145 Targeted Gene Exchange in Plant Cells Mediated by a Zinc Finger Nuclease Double Cut Plant Biotechnology Journal. Apr, 2016 | Pubmed ID: 26426390 Timescale Analysis of a Mathematical Model of Acetaminophen Metabolism and Toxicity Journal of Theoretical Biology. Dec, 2015 | Pubmed ID: 26348886 A Multicenter Randomized Trial of Continuous Versus Intermittent β-Lactam Infusion in Severe Sepsis American Journal of Respiratory and Critical Care Medicine. Dec, 2015 | Pubmed ID: 26200166 Putting Critical Care Medicine on Trial Critical Care Medicine. Aug, 2015 | Pubmed ID: 26181113 Early Mobilization and Recovery in Mechanically Ventilated Patients in the ICU: a Bi-national, Multi-centre, Prospective Cohort Study Critical Care (London, England). 2015 | Pubmed ID: 25715872 Increased Hospital Costs Associated with Red Blood Cell Transfusion Transfusion. May, 2015 | Pubmed ID: 25488623 Failure to Upregulate Cell Surface PD-1 is Associated with Dysregulated Stimulation of T Cells by TGN1412-like CD28 Superagonist MAbs. 2014 | Pubmed ID: 25517314 Expert Consensus and Recommendations on Safety Criteria for Active Mobilization of Mechanically Ventilated Critically Ill Adults Critical Care (London, England). 2014 | Pubmed ID: 25475522 Goal-directed Resuscitation for Patients with Early Septic Shock The New England Journal of Medicine. Oct, 2014 | Pubmed ID: 25272316 A Multicentre Feasibility Study Evaluating Stress Ulcer Prophylaxis Using Hospital-based Registry Data Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Sep, 2014 | Pubmed ID: 25161016 Combined Mathematical Modelling and Experimentation to Predict Polymersome Uptake by Oral Cancer Cells Nanomedicine : Nanotechnology, Biology, and Medicine. Feb, 2014 | Pubmed ID: 24036098 A Cellular Automaton Model Examining the Effects of Oxygen, Hydrogen Ions and Lactate on Early Tumour Growth Journal of Mathematical Biology. Oct, 2014 | Pubmed ID: 23982261 Intensive Care Unit Mobility Practices in Australia and New Zealand: a Point Prevalence Study Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Dec, 2013 | Pubmed ID: 24289506 The Authors Reply Critical Care Medicine. Oct, 2013 | Pubmed ID: 24060791 Theoretical Predictions of Lactate and Hydrogen Ion Distributions in Tumours PloS One. 2013 | Pubmed ID: 23991029 Harmonizing International Trials of Early Goal-directed Resuscitation for Severe Sepsis and Septic Shock: Methodology of ProCESS, ARISE, and ProMISe Intensive Care Medicine. Oct, 2013 | Pubmed ID: 23958738 Trait Stacking Via Targeted Genome Editing Plant Biotechnology Journal. Dec, 2013 | Pubmed ID: 23953646 Patient Comfort in the Intensive Care Unit: a Multicentre, Binational Point Prevalence Study of Analgesia, Sedation and Delirium Management Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Sep, 2013 | Pubmed ID: 23944208 A Protocol for a Multicentre Randomised Controlled Trial of Continuous Beta-lactam Infusion Compared with Intermittent Beta-lactam Dosing in Critically Ill Patients with Severe Sepsis: the BLING II Study Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Sep, 2013 | Pubmed ID: 23944203 Transport of Gabapentin by LAT1 (SLC7A5) Biochemical Pharmacology. Jun, 2013 | Pubmed ID: 23567998 Reply to Soman Et Al Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jul, 2013 | Pubmed ID: 23547166 Acid-mediated Tumour Cell Invasion: a Discrete Modelling Approach Using the Extended Potts Model Clinical & Experimental Metastasis. Aug, 2013 | Pubmed ID: 23543037 A Flexible Mathematical Model Platform for Studying Branching Networks: Experimentally Validated Using the Model Actinomycete, Streptomyces Coelicolor PloS One. 2013 | Pubmed ID: 23441147 Sustaining Australian Research Through Clinical Trials and Investigator Networks The Medical Journal of Australia. Feb, 2013 | Pubmed ID: 23418682 Viral Pneumonitis is Increased in Obese Patients During the First Wave of Pandemic A(H1N1) 2009 Virus PloS One. 2013 | Pubmed ID: 23418448 The Role of Spatial Population Structure on the Evolution of Parasites with Acquired Immunity and Demography Journal of Theoretical Biology. May, 2013 | Pubmed ID: 23376644 Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 Intensive Care Medicine. Feb, 2013 | Pubmed ID: 23361625 Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012 Critical Care Medicine. Feb, 2013 | Pubmed ID: 23353941 Regulation of Tumour Intracellular PH: a Mathematical Model Examining the Interplay Between H+ and Lactate Journal of Theoretical Biology. Apr, 2013 | Pubmed ID: 23340437 A Theoretical Study of the Role of Spatial Population Structure in the Evolution of Parasite Virulence Theoretical Population Biology. Mar, 2013 | Pubmed ID: 23274478 Continuous Infusion of Beta-lactam Antibiotics in Severe Sepsis: a Multicenter Double-blind, Randomized Controlled Trial Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jan, 2013 | Pubmed ID: 23074313 Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care The New England Journal of Medicine. Nov, 2012 | Pubmed ID: 23075127 End Points for Phase II Trials in Intensive Care: Recommendations from the Australian and New Zealand Clinical Trials Group Consensus Panel Meeting Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Sep, 2012 | Pubmed ID: 22963216 Safety and Immunogenicity of Bacterial and Tobacco Plant Cell Line Derived Recombinant Native and Mutant Escherichia Coli Heat-labile Toxin in Chickens Avian Pathology : Journal of the W.V.P.A. Oct, 2012 | Pubmed ID: 22928883 Accuracy of International Classification of Diseases, 10th Revision Codes for Identifying Severe Sepsis in Patients Admitted from the Emergency Department Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Jun, 2012 | Pubmed ID: 22697618 Comparison of Physician Prediction with 2 Prognostic Scoring Systems in Predicting 2-year Mortality After Intensive Care Admission: a Linked-data Cohort Study Journal of Critical Care. Aug, 2012 | Pubmed ID: 22341729 Critical Care Services and the H1N1 (2009) Influenza Epidemic in Australia and New Zealand in 2010: the Impact of the Second Winter Epidemic Critical Care (London, England). 2011 | Pubmed ID: 21658233 Chemotaxis: a Feedback-based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour PLoS Biology. May, 2011 | Pubmed ID: 21610858 Acute Kidney Injury in Patients with Influenza A (H1N1) 2009 Intensive Care Medicine. May, 2011 | Pubmed ID: 21394631 Emerging Modelling Methodologies in Medicine and Biology, Introduction to the Special Issue Theory in Biosciences = Theorie in Den Biowissenschaften. Mar, 2011 | Pubmed ID: 20798999 A Survey of Antibiotic Prescribing Practices in Australian and New Zealand Intensive Care Units Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Sep, 2010 | Pubmed ID: 21261573 The Second Winter of Influenza A (H1N1) 2009 in Australian and New Zealand Intensive Care Units Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Dec, 2010 | Pubmed ID: 21143079 Extracorporeal Life Support. ECMO Patients Overestimated BMJ (Clinical Research Ed.). 2010 | Pubmed ID: 21118885 Use of the Parameterised Finite Element Method to Robustly and Efficiently Evolve the Edge of a Moving Cell Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2010 | Pubmed ID: 20959932 The Practical Experience of Managing the H1N1 2009 Influenza Pandemic in Australian and New Zealand Intensive Care Units Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Jun, 2010 | Pubmed ID: 20513221 Enhanced Diagnosis of Pandemic (H1N1) 2009 Influenza Infection Using Molecular and Serological Testing in Intensive Care Unit Patients with Suspected Influenza Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jul, 2010 | Pubmed ID: 20482372 Acute Kidney Injury and 2009 H1N1 Influenza-related Critical Illness Contributions to Nephrology. 2010 | Pubmed ID: 20427982 Comparison of Adult Patients Hospitalised with Pandemic (H1N1) 2009 Influenza and Seasonal Influenza During the "PROTECT" Phase of the Pandemic Response The Medical Journal of Australia. Mar, 2010 | Pubmed ID: 20230358 Venous Thromboembolism Prophylaxis in the Critically Ill: a Point Prevalence Survey of Current Practice in Australian and New Zealand Intensive Care Units Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Mar, 2010 | Pubmed ID: 20196708 All Health Professionals Should Receive the 2009 H1N1 Influenza Vaccine Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Mar, 2010 | Pubmed ID: 20196706 Early Observational Research and Registries During the 2009-2010 Influenza A Pandemic Critical Care Medicine. Apr, 2010 | Pubmed ID: 20101176 Critical Care Services and 2009 H1N1 Influenza in Australia and New Zealand The New England Journal of Medicine. Nov, 2009 | Pubmed ID: 19815860 Pandemic (H1N1) 2009 Influenza ("swine Flu") in Australian and New Zealand Intensive Care Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Sep, 2009 | Pubmed ID: 19737115 Landmark Survival As an End-point for Trials in Critically Ill Patients--comparison of Alternative Durations of Follow-up: an Exploratory Analysis Critical Care (London, England). 2009 | Pubmed ID: 19653888 Australasian Resuscitation of Sepsis Evaluation (ARISE): A Multi-centre, Prospective, Inception Cohort Study Resuscitation. Jul, 2009 | Pubmed ID: 19467755 A Systematic Review on Clinical Benefits of Continuous Administration of Beta-lactam Antibiotics Critical Care Medicine. Jun, 2009 | Pubmed ID: 19384201 Structural Instability in an Autophosphorylating Kinase Switch Mathematical Biosciences. Jun, 2009 | Pubmed ID: 19303421 The Effect of Comorbidities on Risk of Intensive Care Readmission During the Same Hospitalization: a Linked Data Cohort Study Journal of Critical Care. Mar, 2009 | Pubmed ID: 19272545 A Neisseria Meningitidis NMB1966 Mutant is Impaired for Invasion of Respiratory Epithelial Cells, Survival in Human Blood and for Virulence in Vivo Medical Microbiology and Immunology. Feb, 2009 | Pubmed ID: 19050914 Bone Marrow-derived Cells in the Healing Burn Wound--more Than Just Inflammation Burns : Journal of the International Society for Burn Injuries. May, 2009 | Pubmed ID: 18952376 Bench-to-bedside Review: Bacterial Virulence and Subversion of Host Defences Critical Care (London, England). 2008 | Pubmed ID: 19014410 Estimating Long-term Survival of Critically Ill Patients: the PREDICT Model PloS One. 2008 | Pubmed ID: 18797505 The Effect of Socioeconomic Status on Outcomes for Seriously Ill Patients: a Linked Data Cohort Study The Medical Journal of Australia. Jul, 2008 | Pubmed ID: 18601637 Estimating the Prevalence of Borderline Personality Disorder in Psychiatric Outpatients Using a Two-phase Procedure Comprehensive Psychiatry. Jul-Aug, 2008 | Pubmed ID: 18555059 Determinants of Long-term Survival After Intensive Care Critical Care Medicine. May, 2008 | Pubmed ID: 18434893 C-reactive Protein Concentration As a Predictor of In-hospital Mortality After ICU Discharge: a Prospective Cohort Study Intensive Care Medicine. Mar, 2008 | Pubmed ID: 17992507 Host-parasite Interactions Between the Local and the Mean-field: How and when Does Spatial Population Structure Matter? Journal of Theoretical Biology. Nov, 2007 | Pubmed ID: 17719608 C-reactive Protein Concentration As a Predictor of In-hospital Mortality After ICU Discharge: a Nested Case-control Study Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Mar, 2007 | Pubmed ID: 17352662 Macrophage-based Anti-cancer Therapy: Modelling Different Modes of Tumour Targeting Bulletin of Mathematical Biology. Jul, 2007 | Pubmed ID: 17333419 Cefepime Versus Ceftazidime: Considerations for Empirical Use in Critically Ill Patients International Journal of Antimicrobial Agents. Feb, 2007 | Pubmed ID: 17158033 Spatially Extended Host-parasite Interactions: the Role of Recovery and Immunity Theoretical Population Biology. Mar, 2007 | Pubmed ID: 17084872 Relative Adrenocorticoid Insufficiency Exists and Should Be Treated Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine. Dec, 2006 | Pubmed ID: 17227278 C-reactive Protein Concentration As a Predictor of Intensive Care Unit Readmission: a Nested Case-control Study Journal of Critical Care. Sep, 2006 | Pubmed ID: 16990094 The Outcome of Critically Ill Indigenous Patients The Medical Journal of Australia. May, 2006 | Pubmed ID: 16719746 A Comparison of Early Gastric and Post-pyloric Feeding in Critically Ill Patients: a Meta-analysis Intensive Care Medicine. May, 2006 | Pubmed ID: 16570149 A Comparison of Admission and Worst 24-hour Acute Physiology and Chronic Health Evaluation II Scores in Predicting Hospital Mortality: a Retrospective Cohort Study Critical Care (London, England). Feb, 2006 | Pubmed ID: 16356207 The Use of Prophylactic Fluconazole in Immunocompetent High-risk Surgical Patients: a Meta-analysis Critical Care (London, England). 2005 | Pubmed ID: 16280069 The Next 15 Years: Taking Plant-made Vaccines Beyond Proof of Concept Immunology and Cell Biology. Jun, 2005 | Pubmed ID: 15877602 Intra-membrane Ligand Diffusion and Cell Shape Modulate Juxtacrine Patterning Journal of Theoretical Biology. Sep, 2004 | Pubmed ID: 15276004 Oscillations and Patterns in Spatially Discrete Models for Developmental Intercellular Signalling Journal of Mathematical Biology. Apr, 2004 | Pubmed ID: 15052506 Geophysical Monitoring and Evaluation of Coastal Plain Aquifers Ground Water. Jan-Feb, 2004 | Pubmed ID: 14763617 Cells Behaving Badly: a Theoretical Model for the Fas/FasL System in Tumour Immunology Mathematical Biosciences. Sep-Oct, 2002 | Pubmed ID: 12208611 Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture Michael P. Storm1, Ian Sorrell2, Rebecca Shipley3, Sophie Regan2, Kim A. Luetchford1, Jean Sathish2, Steven Webb4, Marianne J. Ellis1 1Department of Chemical Engineering and Centre for Regenerative Medicine, University of Bath, 2MRC Centre for Drug Safety Science and Institute of Translational Medicine, University of Liverpool, 3Mechanical Engineering, University College London, 4Department of Applied Mathematics, Liverpool John Moores University JoVE 53431 Biotechnik
Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture Michael P. Storm1, Ian Sorrell2, Rebecca Shipley3, Sophie Regan2, Kim A. Luetchford1, Jean Sathish2, Steven Webb4, Marianne J. Ellis1 1Department of Chemical Engineering and Centre for Regenerative Medicine, University of Bath, 2MRC Centre for Drug Safety Science and Institute of Translational Medicine, University of Liverpool, 3Mechanical Engineering, University College London, 4Department of Applied Mathematics, Liverpool John Moores University JoVE 53431 Biotechnik