Alexandre Harari Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne University of Lausanne Biography Publications Institution JoVE Articles Alexandre Harari has not added a biography. If you are Alexandre Harari and would like to personalize this page please email our Author Liaison for assistance. Publications A Phase I/II Trial Comparing Autologous Dendritic Cell Vaccine Pulsed Either with Personalized Peptides (PEP-DC) or with Tumor Lysate (OC-DC) in Patients with Advanced High-grade Ovarian Serous Carcinoma Journal of Translational Medicine. Nov, 2019 | Pubmed ID: 31771601 Robust Prediction of HLA Class II Epitopes by Deep Motif Deconvolution of Immunopeptidomes Nature Biotechnology. Nov, 2019 | Pubmed ID: 31611696 Adenosine Mediates Functional and Metabolic Suppression of Peripheral and Tumor-infiltrating CD8 T Cells Journal for Immunotherapy of Cancer. Oct, 2019 | Pubmed ID: 31601268 A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma-A Proof of Antigen Discovery Feasibility in Three Patients Frontiers in Immunology. 2019 | Pubmed ID: 31440238 High-throughput Screening of Human Tumor Antigen-specific CD4 T Cells, Including Neoantigen-reactive T Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2019 | Pubmed ID: 31015344 Tumor-associated Factors Are Enriched in Lymphatic Exudate Compared to Plasma in Metastatic Melanoma Patients The Journal of Experimental Medicine. May, 2019 | Pubmed ID: 30975896 Computational KIR Copy Number Discovery Reveals Interaction Between Inhibitory Receptor Burden and Survival Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2019 | Pubmed ID: 30864318 Personalized Cancer Vaccine Effectively Mobilizes Antitumor T Cell Immunity in Ovarian Cancer Science Translational Medicine. 04, 2018 | Pubmed ID: 29643231 Sensitive and Frequent Identification of High Avidity Neo-epitope specific CD8 T Cells in Immunotherapy-naive Ovarian Cancer Nature Communications. 03, 2018 | Pubmed ID: 29545564 Cancer Vaccines in Ovarian Cancer: How Can We Improve? Biomedicines. May, 2016 | Pubmed ID: 28536377 Neoantigen-based Cancer Immunotherapy Annals of Translational Medicine. Jul, 2016 | Pubmed ID: 27563649 Personalized Approaches to Active Immunotherapy in Cancer Biochimica Et Biophysica Acta. Jan, 2016 | Pubmed ID: 26241169 Interleukin-1- and Type I Interferon-dependent Enhanced Immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef Vaccine Vector with Dual Deletions of Type I and Type II Interferon-binding Proteins Journal of Virology. Apr, 2015 | Pubmed ID: 25609807 Combined Use of Mycobacterium Tuberculosis-specific CD4 and CD8 T-cell Responses is a Powerful Diagnostic Tool of Active Tuberculosis Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2015 | Pubmed ID: 25362202 CD160-associated CD8 T-cell Functional Impairment is Independent of PD-1 Expression PLoS Pathogens. Sep, 2014 | Pubmed ID: 25255144 Mycobacterium Tuberculosis-specific CD8+ T Cells Are Functionally and Phenotypically Different Between Latent Infection and Active Disease European Journal of Immunology. Jun, 2013 | Pubmed ID: 23456989 Functional Avidity: a Measure to Predict the Efficacy of Effector T Cells? Clinical & Developmental Immunology. 2012 | Pubmed ID: 23227083 DNA/NYVAC Vaccine Regimen Induces HIV-specific CD4 and CD8 T-cell Responses in Intestinal Mucosa Journal of Virology. Oct, 2011 | Pubmed ID: 21775454 Large TCR Diversity of Virus-specific CD8 T Cells Provides the Mechanistic Basis for Massive TCR Renewal After Antigen Exposure Journal of Immunology (Baltimore, Md. : 1950). Jun, 2011 | Pubmed ID: 21555537 Early and Prolonged Antiretroviral Therapy is Associated with an HIV-1-specific T-cell Profile Comparable to That of Long-term Non-progressors PloS One. Apr, 2011 | Pubmed ID: 21483676 Dominant TNF-α+ Mycobacterium Tuberculosis-specific CD4+ T Cell Responses Discriminate Between Latent Infection and Active Disease Nature Medicine. Mar, 2011 | Pubmed ID: 21336285 Proliferation Capacity and Cytotoxic Activity Are Mediated by Functionally and Phenotypically Distinct Virus-specific CD8 T Cells Defined by Interleukin-7R{alpha} (CD127) and Perforin Expression Journal of Virology. Apr, 2010 | Pubmed ID: 20130059 Comparison of Human and Rhesus Macaque T-cell Responses Elicited by Boosting with NYVAC Encoding Human Immunodeficiency Virus Type 1 Clade C Immunogens Journal of Virology. Jun, 2009 | Pubmed ID: 19321612 Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure Journal of Virology. Apr, 2009 | Pubmed ID: 19176626 An HIV-1 Clade C DNA Prime, NYVAC Boost Vaccine Regimen Induces Reliable, Polyfunctional, and Long-lasting T Cell Responses The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195071 HIV-1-specific Immune Response Advances in Pharmacology (San Diego, Calif.). 2008 | Pubmed ID: 18086409 Skewed Association of Polyfunctional Antigen-specific CD8 T Cell Populations with HLA-B Genotype Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17911249 Immunization with Vaccinia Virus Induces Polyfunctional and Phenotypically Distinctive CD8(+) T Cell Responses The Journal of Experimental Medicine. Jun, 2007 | Pubmed ID: 17535971 Functional and Phenotypic Characterization of Tetanus Toxoid-specific Human CD4+ T Cells Following Re-immunization European Journal of Immunology. Apr, 2007 | Pubmed ID: 17372991 Functional Patterns of HIV-1-specific CD4 T-cell Responses in Children Are Influenced by the Extent of Virus Suppression and Exposure AIDS (London, England). Jan, 2007 | Pubmed ID: 17148964 Role of HIV-1-specific CD4 T Cells Current Opinion in HIV and AIDS. Jan, 2006 | Pubmed ID: 19372779 Functional Signatures of Protective Antiviral T-cell Immunity in Human Virus Infections Immunological Reviews. Jun, 2006 | Pubmed ID: 16824132 Functional Signatures in Antiviral T-cell Immunity for Monitoring Virus-associated Diseases Nature Reviews. Immunology. May, 2006 | Pubmed ID: 16622477 Understanding What Makes a Good Versus a Bad Vaccine European Journal of Immunology. Sep, 2005 | Pubmed ID: 16106373 HIV-1-specific IFN-gamma/IL-2-secreting CD8 T Cells Support CD4-independent Proliferation of HIV-1-specific CD8 T Cells Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15872023 Phenotypic Heterogeneity of Antigen-specific CD4 T Cells Under Different Conditions of Antigen Persistence and Antigen Load European Journal of Immunology. Dec, 2004 | Pubmed ID: 15484193 Cytomegalovirus (CMV)-specific Cellular Immune Responses Human Immunology. May, 2004 | Pubmed ID: 15172450 Distribution and Functional Analysis of Memory Antiviral CD8 T Cell Responses in HIV-1 and Cytomegalovirus Infections European Journal of Immunology. Dec, 2002 | Pubmed ID: 12516570 Antiviral Memory T Cell Responses: Correlation with Protective Immunity and Implication for Vaccine Development Advances in Experimental Medicine and Biology. 2002 | Pubmed ID: 12405200 Analysis of HIV-1- and CMV-specific Memory CD4 T-cell Responses During Primary and Chronic Infection Blood. Aug, 2002 | Pubmed ID: 12149221 Transepithelial Transport of HIV-1 by M Cells is Receptor-mediated Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002 | Pubmed ID: 12093918 Treatment of Primary HIV-1 Infection with Cyclosporin A Coupled with Highly Active Antiretroviral Therapy The Journal of Clinical Investigation. Mar, 2002 | Pubmed ID: 11877476 Mätning av mitokondriell massa och membran potential i hematopoietiska stamceller och T-celler med flödescytometri Mukul Girotra*1,2, Anne-Christine Thierry3, Alexandre Harari1,3, George Coukos1, Olaia Naveiras2,4, Nicola Vannini*1 1Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 2Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 3Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois, 4Hematology Service, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV) JoVE 60475 Biologie
Mätning av mitokondriell massa och membran potential i hematopoietiska stamceller och T-celler med flödescytometri Mukul Girotra*1,2, Anne-Christine Thierry3, Alexandre Harari1,3, George Coukos1, Olaia Naveiras2,4, Nicola Vannini*1 1Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, 2Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 3Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois, 4Hematology Service, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV) JoVE 60475 Biologie