Anders Nykjaer The Lundbeck Foundation Research Center MIND, Department of Biomedicine Aarhus University Biography Publications Institution JoVE Articles Anders Nykjaer has not added a biography. If you are Anders Nykjaer and would like to personalize this page please email our Author Liaison for assistance. Publications The Loop Diuretic Bumetanide Blocks Posttraumatic P75NTR Upregulation and Rescues Injured Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2012 | Pubmed ID: 22302815 Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2012 | Pubmed ID: 22279231 Quantitative Modelling of Amyloidogenic Processing and Its Influence by SORLA in Alzheimer's Disease The EMBO Journal. Jan, 2012 | Pubmed ID: 21989385 Neuronal Brain-derived Neurotrophic Factor is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21730062 Proteolytic Processing of the P75 Neurotrophin Receptor: A Prerequisite for Signalling?: Neuronal Life, Growth and Death Signalling Are Crucially Regulated by Intra-membrane Proteolysis and Trafficking of P75(NTR) BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Aug, 2011 | Pubmed ID: 21717487 SorLA Regulates the Activity of Lipoprotein Lipase by Intracellular Trafficking Journal of Cell Science. Apr, 2011 | Pubmed ID: 21385844 Proneurotrophin-3 May Induce Sortilin-dependent Death in Inner Ear Neurons The European Journal of Neuroscience. Feb, 2011 | Pubmed ID: 21261755 Sortilins: New Players in Lipoprotein Metabolism Current Opinion in Lipidology. Apr, 2011 | Pubmed ID: 21124217 Sortilin Associates with Trk Receptors to Enhance Anterograde Transport and Neurotrophin Signaling Nature Neuroscience. Jan, 2011 | Pubmed ID: 21102451 APP Involvement in Retinogenesis of Mice Acta Neuropathologica. Mar, 2011 | Pubmed ID: 20978902 Sortilin-mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin Neuron. Nov, 2010 | Pubmed ID: 21092856 Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, is a Regulator of Hepatic Lipoprotein Export Cell Metabolism. Sep, 2010 | Pubmed ID: 20816088 Golgi-to-phagosome Transport of Acid Sphingomyelinase and Prosaposin is Mediated by Sortilin Journal of Cell Science. Jul, 2010 | Pubmed ID: 20571055 SORLA/SORL1 Functionally Interacts with SPAK to Control Renal Activation of Na(+)-K(+)-Cl(-) Cotransporter 2 Molecular and Cellular Biology. Jun, 2010 | Pubmed ID: 20385770 Identification of a Linear Epitope in Sortilin That Partakes in Pro-neurotrophin Binding The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20159974 Preservation of Cortical Sortilin Protein Levels in MCI and Alzheimer's Disease Neuroscience Letters. Mar, 2010 | Pubmed ID: 20085800 Cellular Uptake of Steroid Carrier Proteins--mechanisms and Implications Molecular and Cellular Endocrinology. Mar, 2010 | Pubmed ID: 19646505 Brain-derived Neurotrophic Factor Reduces Amyloidogenic Processing Through Control of SORLA Gene Expression The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2009 | Pubmed ID: 20007471 Mature BDNF, but Not ProBDNF, Reduces Excitability of Fast-spiking Interneurons in Mouse Dentate Gyrus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19812317 Assessing Low-dose Gentamicin-induced Kidney Injury in Rats by Analysis of Urine Journal of Pharmacological and Toxicological Methods. Nov-Dec, 2009 | Pubmed ID: 19632345 Cubilin and Megalin Co-localize in the Neonatal Inner Ear Audiology & Neuro-otology. 2009 | Pubmed ID: 19202329 VPS10P-domain Receptors - Regulators of Neuronal Viability and Function Nature Reviews. Neuroscience. Dec, 2008 | Pubmed ID: 19002190 Different Motifs Regulate Trafficking of SorCS1 Isoforms Traffic (Copenhagen, Denmark). Jun, 2008 | Pubmed ID: 18315530 Roles for the Pro-neurotrophin Receptor Sortilin in Neuronal Development, Aging and Brain Injury Nature Neuroscience. Nov, 2007 | Pubmed ID: 17934455 Inhibition of PDGF-BB by Factor VII-activating Protease (FSAP) is Neutralized by Protease Nexin-1, and the FSAP-inhibitor Complexes Are Internalized Via LRP The Biochemical Journal. Jun, 2007 | Pubmed ID: 17298300 Hyporesponsiveness to Glucocorticoids in Mice Genetically Deficient for the Corticosteroid Binding Globulin Molecular and Cellular Biology. Oct, 2006 | Pubmed ID: 16980625 Tumour Necrosis Factor Alpha-converting Enzyme Mediates Ectodomain Shedding of Vps10p-domain Receptor Family Members The Biochemical Journal. Apr, 2006 | Pubmed ID: 16393139 Neuronal Sorting Protein-related Receptor SorLA/LR11 Regulates Processing of the Amyloid Precursor Protein Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16174740 Role of Endocytosis in Cellular Uptake of Sex Steroids Cell. Sep, 2005 | Pubmed ID: 16143106 Sortilin Controls Intracellular Sorting of Brain-derived Neurotrophic Factor to the Regulated Secretory Pathway The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2005 | Pubmed ID: 15987945 ProBDNF Induces Neuronal Apoptosis Via Activation of a Receptor Complex of P75NTR and Sortilin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2005 | Pubmed ID: 15930396 P75NTR--live or Let Die Current Opinion in Neurobiology. Feb, 2005 | Pubmed ID: 15721744 Functional Organization of the Sortilin Vps10p Domain The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15364913 The Mosaic Receptor SorLA/LR11 Binds Components of the Plasminogen-activating System and Platelet-derived Growth Factor-BB Similarly to LRP1 (low-density Lipoprotein Receptor-related Protein), but Mediates Slow Internalization of Bound Ligand The Biochemical Journal. Jul, 2004 | Pubmed ID: 15053742 Sortilin is Essential for ProNGF-induced Neuronal Cell Death Nature. Feb, 2004 | Pubmed ID: 14985763 From Holoprosencephaly to Osteopathology: Role of Multifunctional Endocytic Receptors in Absorptive Epithelia Annals of Medicine. 2003 | Pubmed ID: 12952015 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2003 | Pubmed ID: 12475886 Expression Profiling Confirms the Role of Endocytic Receptor Megalin in Renal Vitamin D3 Metabolism Kidney International. Nov, 2002 | Pubmed ID: 12371967 The Low-density Lipoprotein Receptor Gene Family: a Cellular Swiss Army Knife? Trends in Cell Biology. Jun, 2002 | Pubmed ID: 12074887 Pathways for Kidney-specific Uptake of the Steroid Hormone 25-hydroxyvitamin D3 Current Opinion in Lipidology. Jun, 2002 | Pubmed ID: 12045394 De Gespaard Nerve Injury (SNI) Model van Induced mechanische allodynie in Muizen Mette Richner1, Ole J. Bjerrum2, Anders Nykjaer1, Christian B. Vaegter1 1The Lundbeck Foundation Research Center MIND, Department of Biomedicine, Aarhus University, 2Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen JoVE 3092 Médecine
De Gespaard Nerve Injury (SNI) Model van Induced mechanische allodynie in Muizen Mette Richner1, Ole J. Bjerrum2, Anders Nykjaer1, Christian B. Vaegter1 1The Lundbeck Foundation Research Center MIND, Department of Biomedicine, Aarhus University, 2Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen JoVE 3092 Médecine