Antonis K. Hatzopoulos Department of Medicine, Division of Cardiovascular Medicine Vanderbilt University School of Medicine Biography Publications Institution JoVE Articles Antonis K. Hatzopoulos has not added a biography. If you are Antonis K. Hatzopoulos and would like to personalize this page please email our Author Liaison for assistance. Publications Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension Hypertension. Feb, 2016 | Pubmed ID: 26693821 Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis Circulation Research. Oct, 2015 | Pubmed ID: 26338900 Endothelial Cells Contribute to Generation of Adult Ventricular Myocytes During Cardiac Homeostasis Cell Reports. Jul, 2014 | Pubmed ID: 25001281 Endothelial Progenitor Cells Augment Collateralization and Hemodynamic Rescue in a Model of Chronic Cerebral Ischemia Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Aug, 2014 | Pubmed ID: 24780900 Gremlin 2 Promotes Differentiation of Embryonic Stem Cells to Atrial Fate by Activation of the JNK Signaling Pathway Stem Cells (Dayton, Ohio). Jul, 2014 | Pubmed ID: 24648383 SDF-1 Fused to a Fractalkine Stalk and a GPI Anchor Enables Functional Neovascularization Stem Cells (Dayton, Ohio). Sep, 2013 | Pubmed ID: 23744498 Functional Modeling in Zebrafish Demonstrates That the Atrial-fibrillation-associated Gene GREM2 Regulates Cardiac Laterality, Cardiomyocyte Differentiation and Atrial Rhythm Disease Models & Mechanisms. Mar, 2013 | Pubmed ID: 23223679 Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction: the TIME Randomized Trial JAMA : the Journal of the American Medical Association. Dec, 2012 | Pubmed ID: 23129008 Egr-1 Induces DARPP-32 Expression in Striatal Medium Spiny Neurons Via a Conserved Intragenic Element The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2012 | Pubmed ID: 22593050 Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure: The FOCUS-CCTRN Trial JAMA : the Journal of the American Medical Association. Mar, 2012 | Pubmed ID: 22447880 Continuous Antagonism by Dkk1 Counter Activates Canonical Wnt Signaling and Promotes Cardiomyocyte Differentiation of Embryonic Stem Cells Stem Cells and Development. Jan, 2012 | Pubmed ID: 21861760 Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis Recent Patents on Regenerative Medicine. Sep, 2011 | Pubmed ID: 22787575 Combinatorial Polymer Electrospun Matrices Promote Physiologically-relevant Cardiomyogenic Stem Cell Differentiation PloS One. 2011 | Pubmed ID: 22216144 Discovering Small Molecules That Promote Cardiomyocyte Generation by Modulating Wnt Signaling Chemistry & Biology. Dec, 2011 | Pubmed ID: 22195568 Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: the LateTIME Randomized Trial JAMA : the Journal of the American Medical Association. Nov, 2011 | Pubmed ID: 22084195 Programmatic Change: Lung Disease Research in the Era of Induced Pluripotency American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 Tfap2a and Foxd3 Regulate Early Steps in the Development of the Neural Crest Progenitor Population Developmental Biology. Dec, 2011 | Pubmed ID: 21963426 The Feelgood Mutation in Zebrafish Dysregulates COPII-dependent Secretion of Select Extracellular Matrix Proteins in Skeletal Morphogenesis Disease Models & Mechanisms. Nov, 2011 | Pubmed ID: 21729877 Preconditioned Endothelial Progenitor Cells Reduce Formation of Melanoma Metastases Through SPARC-driven Cell-cell Interactions and Endocytosis Cancer Research. Jul, 2011 | Pubmed ID: 21616936 Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation Circulation Research. Jul, 2011 | Pubmed ID: 21597012 Experimental Myocardial Infarction Triggers Canonical Wnt Signaling and Endothelial-to-mesenchymal Transition Disease Models & Mechanisms. Jul, 2011 | Pubmed ID: 21324930 Neuregulin-1β Regulation of Embryonic Endothelial Progenitor Cell Survival American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2011 | Pubmed ID: 21239627 Role of Guanylate Binding Protein-1 in Vascular Defects Associated with Chronic Inflammatory Diseases Journal of Cellular and Molecular Medicine. Jul, 2011 | Pubmed ID: 20716116 Time is Like a Clock in My Heart: Implications for Stem Cell Delivery After Myocardial Infarction Cardiology. 2010 | Pubmed ID: 21042016 LateTIME: a Phase-II, Randomized, Double-blinded, Placebo-controlled, Pilot Trial Evaluating the Safety and Effect of Administration of Bone Marrow Mononuclear Cells 2 to 3 Weeks After Acute Myocardial Infarction Texas Heart Institute Journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. 2010 | Pubmed ID: 20844613 Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells for Patients with Chronic Ischemic Heart Disease and Left Ventricular Dysfunction (First Mononuclear Cells Injected in the US [FOCUS]): Rationale and Design American Heart Journal. Aug, 2010 | Pubmed ID: 20691824 Thymosin Beta4: a Key Factor for Protective Effects of EEPCs in Acute and Chronic Ischemia Annals of the New York Academy of Sciences. Apr, 2010 | Pubmed ID: 20536456 Adriamycin Nephropathy: a Failure of Endothelial Progenitor Cell-induced Repair The American Journal of Pathology. Apr, 2010 | Pubmed ID: 20167859 Stem Cell Therapy: Pieces of the Puzzle Journal of Cardiovascular Translational Research. Feb, 2010 | Pubmed ID: 20119487 NF KappaB Activation in Embryonic Endothelial Progenitor Cells Enhances Neovascularization Via PSGL-1 Mediated Recruitment: Novel Role for LL37 Stem Cells (Dayton, Ohio). Feb, 2010 | Pubmed ID: 20014279 The FunGenES Database: a Genomics Resource for Mouse Embryonic Stem Cell Differentiation PloS One. 2009 | Pubmed ID: 19727443 Rationale and Design for TIME: A Phase II, Randomized, Double-blind, Placebo-controlled Pilot Trial Evaluating the Safety and Effect of Timing of Administration of Bone Marrow Mononuclear Cells After Acute Myocardial Infarction American Heart Journal. Sep, 2009 | Pubmed ID: 19699857 Stem Cell Therapy for Cardiac Repair: Benefits and Barriers Expert Reviews in Molecular Medicine. 2009 | Pubmed ID: 19586557 Cardiac Repair and Regeneration: the Rubik's Cube of Cell Therapy for Heart Disease Disease Models & Mechanisms. Jul-Aug, 2009 | Pubmed ID: 19553696 T17b Murine Embryonal Endothelial Progenitor Cells Can Be Induced Towards Both Proliferation and Differentiation in a Fibrin Matrix Journal of Cellular and Molecular Medicine. May, 2009 | Pubmed ID: 19538255 Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells PloS One. 2008 | Pubmed ID: 18682835 Egr-1 Regulates Expression of the Glial Scar Component Phosphacan in Astrocytes After Experimental Stroke The American Journal of Pathology. Jul, 2008 | Pubmed ID: 18556777 Thymosin Beta4 is an Essential Paracrine Factor of Embryonic Endothelial Progenitor Cell-mediated Cardioprotection Circulation. Apr, 2008 | Pubmed ID: 18427126 B-Raf-mediated Signaling Pathway Regulates T Cell Development European Journal of Immunology. Feb, 2008 | Pubmed ID: 18228248 Adenosine Receptor-mediated Adhesion of Endothelial Progenitors to Cardiac Microvascular Endothelial Cells Circulation Research. Feb, 2008 | Pubmed ID: 18032734 Rafs Constitute a Nodal Point in the Regulation of Embryonic Endothelial Progenitor Cell Growth and Differentiation Journal of Cellular and Molecular Medicine. Nov-Dec, 2007 | Pubmed ID: 18205709 Biologic Properties of Endothelial Progenitor Cells and Their Potential for Cell Therapy Progress in Cardiovascular Diseases. May-Jun, 2007 | Pubmed ID: 17498522 Platelet-induced Differentiation of Endothelial Progenitor Cells Seminars in Thrombosis and Hemostasis. Mar, 2007 | Pubmed ID: 17340461 Hypoxia-mediated Activation of Dll4-Notch-Hey2 Signaling in Endothelial Progenitor Cells and Adoption of Arterial Cell Fate Experimental Cell Research. Jan, 2007 | Pubmed ID: 17045587 The Mother Superior Mutation Ablates Foxd3 Activity in Neural Crest Progenitor Cells and Depletes Neural Crest Derivatives in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Dec, 2006 | Pubmed ID: 17013879 Expression of the Protein Related to Dan and Cerberus Gene--prdc--During Eye, Pharyngeal Arch, Somite, and Swim Bladder Development in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Oct, 2006 | Pubmed ID: 16921498 Coordinated Changes of Histone Modifications and HDAC Mobilization Regulate the Induction of MHC Class II Genes by Trichostatin A Nucleic Acids Research. 2006 | Pubmed ID: 16452299 Adherent Platelets Recruit and Induce Differentiation of Murine Embryonic Endothelial Progenitor Cells to Mature Endothelial Cells in Vitro Circulation Research. Feb, 2006 | Pubmed ID: 16373597 Retroinfusion of Embryonic Endothelial Progenitor Cells Attenuates Ischemia-reperfusion Injury in Pigs: Role of Phosphatidylinositol 3-kinase/AKT Kinase Circulation. Aug, 2005 | Pubmed ID: 16159802 Embryonic Endothelial Progenitor Cells Expressing a Broad Range of Proangiogenic and Remodeling Factors Enhance Vascularization and Tissue Recovery in Acute and Chronic Ischemia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2005 | Pubmed ID: 16009705 Cytoplasmic Thioredoxin Reductase is Essential for Embryogenesis but Dispensable for Cardiac Development Molecular and Cellular Biology. Mar, 2005 | Pubmed ID: 15713651 Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function Molecular and Cellular Biology. Nov, 2004 | Pubmed ID: 15485910 Embryonic Endothelial Progenitor Cells Armed with a Suicide Gene Target Hypoxic Lung Metastases After Intravenous Delivery Cancer Cell. May, 2004 | Pubmed ID: 15144955 Multistep Nature of Microvascular Recruitment of Ex Vivo-expanded Embryonic Endothelial Progenitor Cells During Tumor Angiogenesis The Journal of Experimental Medicine. Jun, 2003 | Pubmed ID: 12810693 Participation of Bone Marrow-derived Cells in Long-term Repair Processes After Experimental Stroke Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jun, 2003 | Pubmed ID: 12796719 Diferenciação de Atrial Cardiomyocytes de células-tronco pluripotentes Usando o BMP Antagonista Grem2 Jeffery B. Bylund1,2, Antonis K. Hatzopoulos1,3 1Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2Department of Pharmacology, Vanderbilt University, 3Department of Cell & Developmental Biology, Vanderbilt University School of Medicine Biologie du développement
Diferenciação de Atrial Cardiomyocytes de células-tronco pluripotentes Usando o BMP Antagonista Grem2 Jeffery B. Bylund1,2, Antonis K. Hatzopoulos1,3 1Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2Department of Pharmacology, Vanderbilt University, 3Department of Cell & Developmental Biology, Vanderbilt University School of Medicine Biologie du développement